Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis

► Phosphorylated Hsp27 mimics activate p53/p21. ► Phosphorylated Hsp27 facilitate p53 nuclear importing in an ATM-dependent manner. ► Hsp27 facilitate p53 degradation in MDM2 dependent manner. ► Phosphorylated Hsp27 facilitate interaction of Hsp27-p53-MDM2. ► Phosphorylated Hsp27 regulated p53 pathway and cell survival.