Keywords: IDO1; PD-L1; Co-expression; Lung adenocarcinoma; Immunotherapy;
مقالات ISI (ترجمه نشده)
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Keywords: APC; antigen presenting cell; APOBEC; apolipoprotein B mRNA editing enzyme catalytic polypeptide-like; BRCA1/2; breast cancer 1/2; BCSS; breast cancer specific survival; B2M; β-2-microglobulin; CAF; cancer associated fibroblast; CCL; chemokine ligand; CD
Keywords: 3-HK; 3-hydroxykynurenine; 3-NP; 3-nitropropionic acid; 6âOHDA; 6-hydroxidopamine; AADC; aromatic amino acid decarboxylase; ACA; anterior cerebral artery; ADP; adenosine-5â²-diphosphate; ALDH; aldehyde dehydrogenases; ALS; amyotrophic lateral sclerosis
Keywords: Immune escape; Crystal structures; IDO1 inhibitors; Cancer immunotherapy; KP; kynurenine pathway; Trp; tryptophan; KYN; kynurenine; IDO1; indoleamine 2,3-dioxygenase 1; IDO2; indoleamine 2,3-dioxygenase 2; TDO; tryptophan 2,3-dioxygenase; IFN; interferon;
Keywords: Chronic rhinosinusitis with nasal polyps; aryl hydrocarbon receptor (AhR); kynurenine; mast cell; calmodulin-dependent protein kinase II (CaMKII); AhR; Aryl hydrocarbon receptor; BMMCs; Bone marrow-derived mast cells; CaMKII; Calmodulin-dependent protei
Keywords: Arg1; IDO1; Immune regulation; Dendritic cell;
Keywords: Corneal endotheliitis; Corneal endothelial cell; Cytomegalovirus; Cytotoxic T lymphocyte reaction; Endotheliitis; Infection; Type I interferon; Innate immune response; Antigen presentation; CMV; cytomegalovirus; HCEn cell; human corneal endothelial cell;
Keywords: M-CSF; macrophage colony-stimulating factor; IFN-γ; interferon-gamma; M-MÏ; macrophage differentiated from CD14 positive monocytes in the presence of M-CSF; Mγ-MÏ; macrophage differentiated from CD14 positive monocytes in the presence of M-CSF and IFN
Keywords: Psychosocial stress; Fear conditioning; Inflammation; IDO1; Kynurenine pathway; Monoamines; Depression; Anxiety;
Keywords: CNS; central nervous system; INS-1; insulin secreting β-cell line originated from a rat insulinoma; GK rat; Goto-Kakizaki rat; NOD mouse; non-obese diabetic mouse; TKP; tryptophan/kynurenine pathway; Trp; tryptophan; KYN; kynurenine; 3HK; 3-OH-kynureni
Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors
Keywords: Indoleamine 2,3-dioxygenase; IDO; IDO1; Immuno-oncology; Kynurenine;
The two-sided role of the vaginal microbiome in Chlamydia trachomatis and Mycoplasma genitalium pathogenesis
Keywords: BV; Bacterial vaginosis; PID; Pelvic Inflammatory Disease; EB; Elementary body; RB; Reticulate body; STI; Sexually transmitted infection; COCP; Combined oral contraceptive pill; IDO1; Indoleamine-2,3-dioxygenase 1; Chlamydia trachomatis; Mycoplasma genita
Selective inhibition of IDO1, D-1-methyl-tryptophan (D-1MT), effectively increased EpCAM/CD3-bispecific BiTE antibody MT110 efficacy against IDO1hibreast cancer via enhancing immune cells activity
Keywords: EpCAM; IDO1; Breast cancer; MT110; D-1MT;
Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips
Keywords: Human Intestinal Organoids; Induced Pluripotent Stem Cells; Small Microengineered Chips; GBP1; guanylate binding protein 1; HIOs; human intestinal organoids; IDO1; indolamine 2,3-dioxygenase 1; IFN-γ; interferon-γ; iPSCs; induced pluripotent stem cells;
IDO1 impairs NK cell cytotoxicity by decreasing NKG2D/NKG2DLs via promoting miR-18a
Keywords: IDO1; miR-18a; NKG2D; NKG2DLs; Immune escape;
microRNA 125a Regulates MHC-I Expression on Esophageal Adenocarcinoma Cells, Associated With Suppression of Antitumor Immune Response and Poor Outcomes of Patients
Keywords: miR-125; miR-148; Antitumor Immune Response; Immune Checkpoints; CTL; cytotoxic T lymphocytes; CTLA-4; cytotoxic T lymphocyte associated protein 4; EAC; esophageal adenocarcinoma; gMFI; geometric mean fluorescence intensity; HLA-A/B/C; human leukocyte ant
From TCDD-mediated toxicity to searches of physiologic AHR functions
Keywords: AHR; aryl hydrocarbon receptor; CAR; constitutive androstane receptor; PXR; pregnane-X-receptor; CYP; cytochrome P450; IDO1; indoleamine-2,3-dioxygenase; UDP; UDP-glucuronosyltransferase; FICZ; 6-formylindolo[3,2-b]carbazole; ICZ; indolo[3,2-b]carbazole;
Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity
Keywords: Kynurenine; Gastritis; SPEM; Humoral Immunity; EBV; Epstein-Barr virus; FACS; fluorescence-activated cell sorting; IDO1; indoleamine-2,3-dioxygenase-1; IFN; interferon; MDSC; myeloid-derived suppressor cell; mRNA; messenger RNA; NK; natural killer; PE; ph
Indoleamine 2,3-dioxygenase 1 inhibition targets anti-PD1-resistant lung tumors by blocking myeloid-derived suppressor cells
Keywords: IDO1; Anti-PD1 resistance; Lung cancer; Immunotherapy; Myeloid-derived suppressor cells;
Non-tumor cell IDO1 predominantly contributes to enzyme activity and response to CTLA-4/PD-L1 inhibition in mouse glioblastoma
Keywords: IDO1; Glioma; Tryptophan; Kynurenine; Immunosuppression; IDO2; TDO2;
Design, synthesis and biological evaluation of 8-substituted-6-hydrazonoindolo[2,1-b]quinazolin-12(6H)-one scaffolds as potential cytotoxic agents: IDO-1 targeting molecular docking studies
Keywords: Tryptanthrin; Cytotoxicity; Anti-oxidant activity; MTT assay; DPPH; Molecular docking; IDO1;
Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases
Keywords: Desipramine; Kynurenine pathway; Ido1; Inflammation; Depression; PBMCs;
Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions
Keywords: IDO; Indoleamine 2,3-dioxygenase; Molecular modeling; Drug screening; Inhibitors; Mutagenesis; ACSRC; Auckland Cancer Society Research Centre; BF; benzofurazan; C129A; alanine-replacement IDO1 mutant of Cys129; GSH; reduced glutathione; IDO1; indoleamine
Novel substituted hydrazono indolo[2,1-b]quinazoline-6,12-dione analogues as cytostatic agents: Synthesis, crystal structure, biological evaluation and molecular docking studies
Keywords: Tryptanthrin; Cytotoxicity; Antibacterial activity; Antifungal activity; Molecular docking; IDO1;
Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors
Keywords: Indoleamine 2; 3-dioxygenase 2; IDO2 bioassay system; IDO2 inhibitor; Tryptanthrin derivatives; hIDO2; human indoleamine 2, 3-dioxygenase 2; IDO1; indoleamine 2, 3-dioxygenase 1; L-1-MT; L-1-methyl-tryptophan; TDO; tryptophan 2, 3-dioxygenase; LLC; Lewis
O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1
Keywords: IDO1 inhibition; O-alkylhydroxylamines; Antitumor therapy; Rational drug design; IDO1; indoleamine 2,3-dioxygenase isoform-1; Trp; tryptophan; UV-vis; ultraviolet-visible; CYP3A4; cytochrome P-450 isoform 3A4;
Nitrobenzofurazan derivatives of Nâ²-hydroxyamidines as potent inhibitors of indoleamine-2,3-dioxygenase 1
Keywords: Nâ²-hydroxyamidines; Mechanism-based drug design; IDO1 inhibition; High selectivity; Low cytotoxicity; IDO1; indoleamine 2,3-dioxygenase 1; TDO; tryptophan 2,3-dioxygenase; L-Trp; L-tryptophan; HTS; High throughput screening; UV-Vis; ultraviolet-visi
Formation of fluorophores from the kynurenine pathway metabolite N-formylkynurenine and cyclic amines involves transamidation and carbon-carbon bond formation at the 2-position of the amine
Keywords: 2-MePIP; (2-methylpiperidine); 3-MePIP; (3-methylpiperidine); 4-MePIP; (4-methylpiperidine); AZP; (azepane); DEA; (diethylamine); DMP; (cis-2,6-dimethylpiperidine); DPA; (dipropylamine); HRMS; (high-resolution mass spectrometry); IDO1; (indoleamine 2,3-di
The hippocampus and TNF: Common links between chronic pain and depression
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid; AR; adrenergic receptor; BDNF; brain-derived neurotrophic factor; CNS; central nervous system; CREB; cAMP response element-binding protein; cAMP; cyclic adenosine monophosphate; ERK; extracellu
The absence of indoleamine 2,3-dioxygenase expression protects against NMDA receptor-mediated excitotoxicity in mouse brain
Keywords: HD; Huntington's disease; Ido1; indoleamine 2,3-dioxygenase (gene); Tdo2; tryptophan 2,3-dioxygenase (gene); Ido2; indoleamine 2,3-dioxygenase 2 (gene); KP; kynurenine pathway; SP; serotonin pathway; Kyn; kynurenine; LC-MS/MS; liquid chromatography tandem
Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A
Keywords: IDO1; indoleamine 2,3-dioxygenase; TDO; tryptophan 2,3-dioxygenase; NHDF; normal fibroblast cell lines; MTT; (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; EDTA; ethylenediaminetetraacetic acid; IMAC; immobilized metal ion affinity chromat
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2
Keywords: Ido1; mouse indoleamine 2,3-dioxygenase 1; Ido2; mouse indoleamine 2,3-dioxygenase 2; Tdo2; mouse tryptophan 2,3-dioxygenase; IC50; half maximal inhibitory concentration; Trp; tryptophan; DMSO; dimethyl sulfoxide; IDO1 or IDO2; human indoleamine 2,3-dioxy