Chronic Pain: Pathophysiology and Treatment Implications
Keywords: درد التهابی; chronic pain; inflammatory pain; cancer pain; neuropathic pain; analgesia; pain pathway
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Prostaglandin E2 synthases in neurologic homeostasis and disease
Keywords: درد التهابی; Prostaglandins; Fever; Sickness behavior; Inflammatory pain; Neurodegeneration; Prostaglandin E synthase
Enriched environment and the recovery from inflammatory pain: Social versus physical aspects and their interaction
Keywords: درد التهابی; Inflammatory pain; Enriched environment; Physical enrichment; Social enrichment; Anxiety
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil
Keywords: درد التهابی; Analgesia; Inflammatory pain; Ketamine; Ifenprodil; (Rat)
Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist
Keywords: درد التهابی; P2X3; Ion channel; RO-85; Inflammatory pain; Neuropathic pain; Drug-like; P2X3 receptor antagonist
Laser acupuncture for acute inflammatory, visceral and neuropathic pain relief: An experimental study in the laboratory rat
Keywords: درد التهابی; Laser; Acupuncture; Rats; Inflammatory pain; Neuropathic pain; Visceral pain
Pulpitis increases the proportion of atypical nodes of Ranvier in human dental pulp axons without a change in Nav1.6 sodium channel expression
Keywords: درد التهابی; inflammatory pain; pulpitis; trigeminal; caspr; NaCh(s); sodium channel(s); PB; phosphate buffer; PBS; phosphate buffered saline; PNS; peripheral nervous system; SEM; standard error of the mean;
Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO–cGMP–ATP-sensitive-K+ channel activation
Keywords: درد التهابی; Dioscorea bulbifera; Neuropathic pain; Inflammatory pain; Antinociceptive; NO–cGMP–K+
Intra-periaqueductal grey microinjections of an imidazo[1,2-b]pyridazine derivative, DM2, affects rostral ventromedial medulla cell activity and shows antinociceptive effect
Keywords: درد التهابی; Imidazo[1,2-b]pyridazine; Inflammatory pain; PAG; RVM; Ethosuximide;
Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats
Keywords: درد التهابی; MIF; macrophage migration inhibitory factor; NMDAR; NMDA receptor; CSF; cerebrospinal fluid; rMIF; recombinant rat MIF; MAPK; mitogen-activated protein kinase; p-p38 MAPK; phosphorylated p38 MAPK; ERK; extracellular signal regulated kinase; PI3K; phosphoi
Electroacupuncture Increases CB2 Receptor Expression on Keratinocytes and Infiltrating Inflammatory Cells in Inflamed Skin Tissues of Rats
Keywords: درد التهابی; Electroacupuncture; analgesia; hyperalgesia; inflammatory pain; inflammatory cells; cannabinoid CB2 receptors;
Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain
Keywords: درد التهابی; Protein interacting with C kinase 1; AMPA receptors; Protein kinase Cα; Spinal cord; Inflammatory pain; Incisional pain;
H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats
Keywords: درد التهابی; Histamine receptors; H4; Inflammatory pain; Neuropathic pain; Osteoarthritis; JNJ7777120; Mast cells
Direct blockade of inflammatory hypernociception by peripheral A1 adenosine receptors: Involvement of the NO/cGMP/PKG/KATP signaling pathway
Keywords: درد التهابی; Adenosine A1 receptor; Antinociception; Inflammatory pain; Hyperalgesia; Nitric oxide; KATP;
Spinal hyperpolarization-activated cyclic nucleotide-gated cation channels at primary afferent terminals contribute to chronic pain
Keywords: درد التهابی; Neuropathic pain; Inflammatory pain; Hyperpolarization-activated cation channels; ZD7288; Spinal slice; Synaptic transmission;
Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems
Keywords: درد التهابی; Histamine; H3 receptor antagonist; Noradrenergic system; Osteoarthritic pain; Inflammatory pain; Neuropathic pain
Nociceptive behaviour upon modulation of mu-opioid receptors in the ventrobasal complex of the thalamus of rats
Keywords: درد التهابی; Inflammatory pain; DAMGO; Pain thalamic processing; Opioid receptors; Ankle-bend test; Formalin test;
Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons
Keywords: درد التهابی; Ras; sensitization; inflammatory pain; ERK; PKC; Src; BIM; bisindolylmaleimide; CGRP; calcitonin gene-related peptide; iCGRP; calcitonin gene-release peptide like immunoreactivity; MTS; 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophe
Laminitic Pain: Parallels with Pain States in Humans and Other Species
Keywords: درد التهابی; Laminitis; Neuropathic pain; Inflammatory pain; Nociception; Dorsal root ganglia;
Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X3/P2X2/3 antagonist for the treatment of pain
Keywords: درد التهابی; P2X3; Purinoceptors; ATP; RO-4; Chronic pain; Inflammatory pain; Neuropathic pain; Drug-like; P2X3 antagonist
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain
Keywords: درد التهابی; Voltage gated sodium channel blocker; Neuropathic pain; Inflammatory pain; Amide replacement; Heterocycles; Isoxazole
Naltrexone fails to increase pain affect in response to inflammatory pain in a novel escape/avoidance paradigm
Keywords: درد التهابی; Naltrexone; Carrageenan; Inflammatory pain; Naloxone; Place Escape Avoidance Paradigm; Opioid antagonist; Morphine; MPWT; Mechanical hypersensitivity
Voltage-gated sodium channels in nociception and their potential as targets for new drugs in treatment of chronic neuropathic pain
Keywords: درد التهابی; Voltage-gated sodium channel (VGSC); Neuropathic pain; Inflammatory pain; Analgesic; Ion channels
Evaluation of the antinociceptive activity of extracts of Sonchus oleraceus L. in mice
Keywords: درد التهابی; Analgesia; Asteraceae; Inflammatory pain; Nociception; Tail flick assay; Tail formalin test; Sonchus oleraceus; Writhing test
Synergism between NSAIDs in the orofacial formalin test in mice
Keywords: درد التهابی; Synergism; Acute pain; Inflammatory pain; Orofacial pain; NSAIDs; Dexketoprofen;
Pyridine-3-carboxamides as novel CB2 agonists for analgesia
Keywords: درد التهابی; Analgesia; CB2 agonist; Inflammatory pain; Cannabinoid receptors; GW842166X; Structure–activity-relationships; Pharmacokinetics; Solubility; Weinreb reaction; Cytochrome P450, in vitro clearance; Hyperalgesia; Complete Freund’s Adjuvant; Bioavailability;
Discovery of GSK345931A: An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain
Keywords: درد التهابی; EP1 antagonist; Pain; Inflammatory pain; CNS penetration; Free concentration
Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP1 receptor antagonist for the treatment of inflammatory pain
Keywords: درد التهابی; EP1 antagonist; Inflammatory pain; Pain; CNS penetration; Microdose
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers
Keywords: درد التهابی; Voltage gated sodium channel blocker; Neuropathic pain; Inflammatory pain; Amide replacement; Heterocycles; Isoxazoline
Acid increases inflammatory pain in rats: Effect of local peripheral ASICs inhibitors
Keywords: درد التهابی; Amiloride; Benzamil; Inflammatory pain; ASICs [acid sensing ion channels]; Peripheral sensitization
Alterations of AQP2 expression in trigeminal ganglia in a murine inflammation model
Keywords: درد التهابی; Aquaporins; Trigeminal ganglia; Inflammatory pain;
Effects of transgene-mediated endomorphin-2 in inflammatory pain
Keywords: درد التهابی; Inflammatory pain; Opiates; Endomorphin-2; Gene therapy; Herpes simplex virus;
The nociceptive mechanism of 5-hydroxytryptamine released into the peripheral tissue in acute inflammatory pain in rats
Keywords: درد التهابی; Pain transmission; Inflammatory pain; Formalin test; 5-HT2A receptors; 5-HT2C receptors; Microdialysis;
Additive anti-hyperalgesia of electroacupuncture and intrathecal antisense oligodeoxynucleotide to interleukin-1 receptor type I on carrageenan-induced inflammatory pain in rats
Keywords: درد التهابی; Interleukin-1β; Interleukin-1 receptor type I; Electroacupuncture; Carrageenan; Inflammatory pain; Spinal cord
Long-lasting neonatal inflammation enhances pain responses to subsequent inflammation, but not peripheral nerve injury in adult rats
Keywords: درد التهابی; Neonatal inflammation; Inflammatory pain; Peripheral nerve injury; Neuropathic pain; Neonate
Environmental housing affects the duration of mechanical allodynia and the spinal astroglial activation in a rat model of chronic inflammatory pain
Keywords: درد التهابی; Enriched environment; Inflammatory pain; Astrocyte; Housing; Mechanical allodynia;
Endogenous Anandamide and Cannabinoid Receptor-2 Contribute to Electroacupuncture Analgesia in Rats
Keywords: درد التهابی; Anandamide; hyperalgesia; inflammatory pain; acupuncture; analgesia; cannabinoid receptor-2 (CB2)
Evaluation of the pro-inflammatory potential of nanostructured drug carriers in knee-joints of rats: Effect on nociception, edema, and cell migration
Keywords: درد التهابی; nanocarrier; nanoparticle; arthritis; inflammatory pain; drug delivery;
Rôle du récepteur 5-HT2A de la sérotonine dans la douleur neuropathique périphérique
Keywords: درد التهابی; Sérotonine (5-HT); Récepteur 5-HT2A; Mode d'action paracrine; Douleur inflammatoire; Douleur neuropathique; Serotonin (5-HT); 5-HT2A receptor; Paracrine mode; Inflammatory pain; Neuropathic pain;
Additive Antinociceptive Effects of the Selective Nav1.8 Blocker A-803467 and Selective TRPV1 Antagonists in Rat Inflammatory and Neuropathic Pain Models
Keywords: درد التهابی; Nociception; transient receptor potential channels; sodium channels; inflammatory pain; neuropathic pain; analgesia
Melatonin: A hormone that modulates pain
Keywords: درد التهابی; Melatonin receptors; Inflammatory pain; Neuropathic pain; Antioxidant; Central sensitization; Melatonin
Differences in the sensitivity of behavioural measures of pain to the selectivity of cyclo-oxygenase inhibitors
Keywords: درد التهابی; NSAIDs; Hyperalgesia; Allodynia; Freund's complete adjuvant; Biomarker; In vivo pharmacology; COX-inhibitors; Inflammatory pain; Drug screening;
Endometriosis and Mechanisms of Pelvic Pain
Keywords: درد التهابی; Endometriosis; Chronic pelvic pain; Pelvic pain; Neuropathic pain; Inflammatory pain; Nociceptive pain; Laparoscopy
Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis
Keywords: درد التهابی; Translocator protein 18 kDa; TSPO; Peripheral benzodiazepine receptor; Pain; Inflammation; Inflammatory pain; Arthritis; Spinal cord
The peripheral pro-nociceptive state induced by repetitive inflammatory stimuli involves continuous activation of protein kinase A and protein kinase C epsilon and its NaV1.8 sodium channel functional regulation in the primary sensory neuron
Keywords: درد التهابی; Inflammatory pain; Chronic pain; NaV1.8 sodium channel; PKA; PKCɛ; Primary sensory neuron
Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
Keywords: درد التهابی; Cannabinoid; Anandamide; CB2 receptor; Fatty acid amide hydrolase; Neuropathic pain; Inflammatory pain
MAP kinase and pain
Keywords: درد التهابی; MAPK; Neural plasticity; Central sensitization; Spinal cord; Amygdala; Microglia; Astrocyte; Inflammatory pain; Neuropathic pain
Chloride regulation in the pain pathway
Keywords: درد التهابی; Cation-chloride cotransporters; NKCC1; KCC2; Disinhibition; Neuropathic pain; Inflammatory pain
Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity
Keywords: درد التهابی; Central sensitization; inflammatory pain; neuropathic pain; scaffolding protein; heterosynaptic facilitation
Activation of spinal microglia in a murine model of peripheral inflammation-induced, long-lasting contralateral allodynia
Keywords: درد التهابی; Contralateral allodynia; Inflammatory pain; Microglia; Mouse; Spinal cord; Carrageenan