Keywords: ABC; ATP binding cassette; AD; Alzheimer's disease; ApoE; Apolipoprotein E; AQP; Aquaporin; Aβ; Amyloid-β; AβPP; Aβ precursor protein; BACE-1; β-site AβPP cleaving enzyme 1; BBB; Blood-brain barrier; CBF; Cerebral blood flow; CSF; Cerebrospinal fl
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Keywords: Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator protein; CFTR2; Correctors; Potentiators; Trial end-points; Amil; Amiloride; AMP; Accelerating Medicine Partnership; ANO; anoctamins; AONs; antisense oligonucleotides; ASL; airway surfac
Keywords: Lacrimal; Calcium signaling; Protein secretion; Fluid secretion; Calcium release; Calcium entry; Calcium oscillations; IP3; STIM; Orai
Keywords: Orexin; Hypocretin; Phospholipase; Endocannabinoid; Ion fluxes; 2-AG; 2-arachidonoylglycerol; AA; arachidonic acid; anandamide; N-arachidonoylethanolamine; CNS; central nervous system; cPLA2 and iPLA2; cytosolic (Ca2+-dependent) and intracellular (Ca2+-in
Keywords: 2-AG; 2-arachidonoylglycerol; CDS; CDP-diacylglycerol synthase; CDP-DAG; CDP-diacylglycerol; DAG; diacylglycerol; DGK; diacylglycerol kinase; ER; endoplasmic reticulum; IP3; inositol triphosphate; LPA; lysophosphatidic acid; LPIAT1; lysophosphatidylinosit
Keywords: DIC; differential interference contrast; HUVECs; human umbilical vein endothelial cells; PIP2; phosphatidylinositol 4,5-bisphosphate; TBS; Tris-buffered saline; DAG; 1,2-diacylglycerol; IP3; inositol 1,4,5-trisphosphate; MβCD; methyl-β-cyclodextrin; PI3
Keywords: AC; adenylate cyclase; β-AR; β-adrenergic receptor; CaM; calmoduline; cAMP; cyclic adenosine monophosphate; CHO; Chinese hamster ovary; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; DAG; diacylglycerol; DR; dopamine
Keywords: Diabetes; Cancer; Insulin; Anti-diabetics; Cannabinoid; Obesity; 2-AG; 2-arachidonoyl glycerol; ACC; acetyl-CoA carboxylase; AMPK; adenosine monophosphate-activated protein kinase; CB1R; cannabinoid 1 receptor; CB2R; cannabinoid 2 receptor; CPT-1; carniti
Keywords: AC; adenylate cyclase; AD; Alzheimer's disease; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; AOAA; aminooxyacetate; cAMP; cyclic adenosine monophosphate; CBS; cystathionine β-synthase; CNS; central nervous system; CSE; cystathionine
Keywords: Cx; connexin; HPV; human papilloma virus; NSHI; non-syndromic hearing impairment; ODDD; oculodentodigital dysplasia; ZO-1; zona occludens 1; E1 and E2; extracellular domains 1 and 2; PPK; palmoplantar hyperkeratinisation; KID; keratitis ichthyosis deafn
Keywords: AC; adenylate cyclase; Ace; acetophenone; 2-APB; 2-aminoethoxydiphenyl borate; Ben; benzaldehyde; [Ca2+]i; intracellular calcium; CC; chelerythrine chloride; cH; cis-4-heptenal; CNG; cyclic nucleotide-gated; DAG; diacylglycerol; DMSO; dimethyl sulfoxide;
Keywords: Aβ; β-amyloid; AGE; advanced glycation end product (here: proteins modified by AGEs); Atg; autophagy-related gene; CMA; chaperone-mediated-autophagy; 3-DG; 3-deoxyglucosone; FIP200; focal adhesion kinase family-interacting protein of 200 kDa; IP3; inos
Keywords: [Ca2+]i; intracellular concentrations of Ca2+; CalC; calphostin C; DAG; diacylglycerol; E2; estradiol; EOG; electro-olfactogram; ER; endoplasmic reticulum; F340/F380; ratio of fluorescence intensity excited at 340Â nm and 380Â nm; HBSS; HEPES buffered sta
Keywords: AC; adenylyl cyclase; cAMP; adenosine 3â²,5â²-cyclic monophosphate; DMEM; Dulbecco's modified Eagle's medium; ERK; extracellular-signal-regulated kinase; F2-IsoP; F2-isoprostane; FSK; forskolin; HSC; hepatic stellate cell; I-BOP; [1S-[1α,2α(Z),3β(1E,
Keywords: Ryanodine receptor; Vascular smooth muscle; Vasoconstriction; Veins; Calcium; Sarcoplasmic reticulum; CA; carotid artery; CICR; calcium-induced calcium release; IP3; inositol 1,4,5-trisphosphate; JV; jugular vein; NE; norepinephrine; PE; phenylephrine; RA
Keywords: APC; adenomatous polyposis coli; bFGF; basic fibroblast growth factor; Ca2Â +i; intracellular calcium; Ca2Â +o; extracellular calcium; CaSR; calcium sensing receptor; CDX-2; caudal type homeobox 2; EGF; epidermal growth factor; ERK; extracellular-signal-r
Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
Keywords: EGFR; Epidermal growth factor receptor; FITC; Fluorescein isothiocyanate; GPCR; G protein coupled receptor; IP3; Inositol-tris-phosphate; PIP2; Phosphatidyl-inositol-bis-phosphate; PLCγ; Phospholipase Cγ; PKA/C; Protein kinase A/C; PDGFR; Platelet-deriv
Keywords: BDNF; brain derived neurotrophic factor; CAMKII; calmodulin-dependent protein kinase II; Ca2+; calcium; cAMP; cyclic adenosine monophosphate; CBS; cystathionine-β-synthase; CCI; chronic constriction injury; CFA; complete Freund's adjuvant; cGMP; cyclic
Respective optimal calcium concentrations for proliferation on type I collagen fibrils in two keratinocyte line cells, HaCaT and FEPE1L-8
Keywords: Type I collagen gel; Keratinocyte proliferation; Calcium concentration; DAG; diacylglycerol; DMEM; Dulbecco's Modified Eagle's Medium; DMEM (0); DMEM supplemented without fetal bovine serum; DMEM (10); DMEM supplemented with 10% fetal bovine serum; ECM; e
Role of SOCE architects STIM and Orai proteins in Cell Death
Keywords: SOCE; store operated Ca2+ entry; STIM1/2; stromal interaction molecule 1/2; NFAT; nuclear factor of activated T-cells; IP3; inositol trisphosphate; ARC; arachidonic acid-regulated channels; LRC; leukotriene C4-regulated channels; PKB; protein kinase B; PK
A critical appraisal of the role of intracellular Ca2+-signaling pathways in Kawasaki disease
Keywords: [Ca2+]cyt; free cytosolic Ca2+ concentration; CRAC; Ca2+-release activated Ca2+ entry; EBV; Epstein-Barr virus; ER; endoplasmic reticulum; IP3; inositol 1,4,5-trisphosphate; IP4; inositol 1,3,4,5-tetrakisphosphate; IP3R; IP3 receptor; KD; Kawasaki disease
Involvement of the NO/sGC/cGMP/K+ channels pathway in vascular relaxation evoked by two non-quinazoline α1-adrenoceptor antagonists
Keywords: 4-AP; 4-amynopiridine; AC; adenylyl cyclase; BPH; benign prostatic hyperplasia; COX; cyclooxygenase; DAG; diacylglycerol; EDHF; endothelium-derived hyperpolarizing factor; eNOS; endothelial NO synthase; GLI; glibenclamide; HAEC; human aortic endothelial c
Ca2+ signaling, apoptosis and autophagy in the developing cochlea: Milestones to hearing acquisition
Keywords: Peripheral auditory system; Development; Morphogenesis; Caspase-3; Mitochondria; Greater epithelial ridge; Lesser epithelial ridge; Ca2+ waves; ATP; IP3; Spiral ganglion neurons; Inner hair cells; Outer hair cells; Connexins; Deafness; Mouse models;
Blocking IP3 signal transduction pathways inhibits melatonin-induced Ca2+ signals and impairs P. falciparum development and proliferation in erythrocytes
Keywords: Plasmodium falciparum; Melatonin; Calcium signaling; IP3; Malaria; 2-APB;
BMP-2 enhances the migration and proliferation of hypoxia-induced VSMCs via actin cytoskeleton, CD44 and matrix metalloproteinase linkage
Keywords: BMP-2; bone morphogenetic protein 2; VMSCs; vascular smooth muscle cells; ECM; extracellular matrix; MMPs; matrix metalloproteinases; PEX; hemopexin-like C-terminal domain; IP3; inositol phosphatidyl 3; CABG; Coronary Artery Bypass Grafting; CCA; Common C
The natural sesquiterpene lactones arglabin, grosheimin, agracin, parthenolide, and estafiatin inhibit T cell receptor (TCR) activation
Keywords: Sesquiterpene lactones; Jurkat T cells; T cell receptor; Kinase; Phosphorylation; Calcium flux; Glutathione; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; FPR; N-formyl peptide receptor; HBSS; Hanks' balanced salt solution; IP3; inositol triphosphate
Apelin, a promising target for Alzheimer disease prevention and treatment
Keywords: Alzheimer disease; Apelin; Amyloid beta; Central nervous system; Oxidative stress; AAA; Abdominal aortic aneurysm; ABCA1; ATP-binding cassette transporter A1; ACE; Angiotensin converting enzyme; ACh; Acetylcholine; AChE; Acetyl choline esterase; AD; Alzhe
Promoter analysis and transcriptional regulation of human carbonic anhydrase VIII gene in a MERRF disease cell model
Keywords: Gene transcription; Promoter; Specificity protein 1 (Sp1); Myoclonus epilepsy with ragged-red fibers (MERRF); Human carbonic anhydrase VIII (CA8); AP-2; activator protein-2; CA8; carbonic anhydrase 8; CARPs; CA-related proteins; DNA; deoxyribonucleic acid
β-Heregulin impairs EGF induced PLC-γ1 signalling in human breast cancer cells
Keywords: ErbB receptors; Breast cancer; EGF; β-Heregulin; Signal transduction; DAG; diacylglycerol; FCS; foetal calf serum; IP3; inositol-1,4,5-trisphosphate; MDA-HER2; MDA-MB-468-HER2; MDA-NEO; MDA-MB-468-NEO; MDA-PM; MDA-MB-468-PM; PI3K; phosphatidyl-inositol-3
Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells
Keywords: AC; adenylyl cyclase; 2-APB; 2-aminoethoxyphenylborane; ASM; airway smooth muscle; cAMP; 3',5'-cyclic AMP; COPD; chronic obstructive pulmonary disease; [Ca2+]i; intracellular free Ca2+ concentration; DMSO; dimethyl sulfoxide; EC50 (IC50); half-maximally e
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells
Keywords: G-protein coupled receptors; Interleukin-1β; C-Jun N-terminal kinase; Purinergic receptors; Inflammation; YM-254890 (PubChem CID: 9919454); H-89 (PubChem CID: 449241); NF340 (PubChem CID: 73755007); MRS2179 (PubChem CID: 24867852); ZM241385 (PubChem CID:
Selectively targeting prostanoid E (EP) receptor-mediated cell signalling pathways: Implications for lung health and disease
Keywords: ASM; airway smooth muscle; BAL; bronchoalveolar; CHO; Chinese hamster ovary; COX; cyclooxygenase; EP; prostanoid E; ERK; extracellular signal-regulated kinase; GPCR; G protein-coupled receptors; GSK-3; glucogen synthase kinase-3; HMLC; human lung mast cel
Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists
Keywords: BBB; Blood-Brain Barrier; CB1; Cannabinoid Receptor 1; CB2; Cannabinoid Receptor 2; CHO-K1; Chinese Hamster Ovary Cells; CNS; Central Nervous System; EtOH; ethanol; EtOAc; ethyl acetate; Ke; apparent affinity constant, MDCK-mdr1, Madin-Darby canine kidney
Do chlorinated insecticides (aldrin and DDT) or products of their transformations (dieldrin and DDE) impair signal transfer from regulators (oxytocin and relaxin) of bovine myometrium motility in vitro?
Keywords: CAV; caveolin; DAG; diacylglycerol; DDE; dichlorodiphenyldichloroethylene; DDT; dichlorodiphenyltrichloroethane; E2; oestradiol; GAP; gap junction protein; IP3; inositol-tris-phosphate; KRS; Krebs-Ringer's solution; OT; oxytocin; MLCK; myosin light-chain
Peptide YY (3-36) modulates intracellular calcium through activation of the phosphatidylinositol pathway in hippocampal neurons
Keywords: PYY; peptide YY; NPY; neuropeptide Y; PP; pancreatic polypeptide; Y2R; Y2 receptor; CNS; central nervous system; Ca2Â +; Â calcium; [Ca2Â +]i; intracellular Ca2Â + concentrations; HBS; HEPES-buffered solution; GPCR; G-protein coupled receptors; ER; endopl
Development of potent and proteolytically stable human neuromedin U receptor agonists
Keywords: Neuromedin U (NMU); NMU-8; Neuromedin U receptor agonists; Plasma stability; 1â²Nal; 1â²-naphtylalanine; 2â²Nal; 2â²-naphtylalanine; 7-OH-Tic; 7-hydroxy-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; ACN; acetonitrile; AUC; area under the curve;
Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide
Keywords: A15; alkylamide 15; Ã-hex; beta-hexosaminidase; BMMC; bone marrow-derived mast cell; CRAC; calcium-release activated calcium; CB2; cannabinoid receptor type 2; ER; endoplasmic reticulum; FcεRI; fragment crystallizable epsilon receptor 1; IACUC; Institut
Pathophysiological consequences of isoform-specific IP3 receptor mutations
Keywords: ALS; amyotrophic lateral sclerosis; Bcl-2; B-cell lymphoma-2; CA8; carbonic anhydrase 8 (carbonic anhydrase-related protein); CSCC; cervical squamous cell carcinoma; CTT; C-terminal tail; DKO; double knockout; FAD; familial Alzheimer's disease; GS; Gilles
α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes
Keywords: AMPK; 5â² adenosine monophosphate-activated protein kinase; AR; adrenoceptor; CaMKK; calmodulin-dependent protein kinase kinase; CHO; Chinese hamster ovary; Comp C; compound C; DAG; diacylglycerol; IP3; inositol 1,4,5-trisphosphate; mTOR; mechanistic tar
Ca2+ signaling and Src-kinases-controlled cellular functions
Keywords: Ca2+ channels; Cell signaling; Phosphatases; Receptors; Src-family kinases; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxyli
Modeling, dynamics and phosphoinositide binding of the pleckstrin homology domain of two novel PLCs: η1 and η2
Keywords: Pleckstrin homology domain; Phosphoinositide binding; Molecular modeling; Docking; MD simulation; PLC; Phospholipase C; PHη1; PH domain of PLCη1; PHη2; PH domain of PHη2; IP3; inositol-(1,4,5)-triphosphate; IP4; Inositol-(1,3,4,5)-tetrakisphosphate; u
The G protein-coupled receptors deorphanization landscape
Keywords: GPCRs; G protein-coupled receptors; GRK; GPCR kinase; IUPHAR; International Union of Basic and Clinical Pharmacology; BPS; British Pharmacological Society; CTR; Calcitonin receptor; CLR; CT Receptor-like; RAMP; Receptor Activity-Modifying Proteins; β2AR;
Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor-transmembrane protein 16A-voltage-dependent Ca2+ channel axis and contribute to bronchial hyperresponsiveness in asthma
Keywords: Airway smooth muscle; asthma; hypersensitivity; inflammatory mediator; TMEM16A; 5-HT; 5-Hydroxytryptamin; Ai38D; Cre-dependent GCaMP3 reporter mouse; ASM; Airway smooth muscle; ASMC; Airway smooth muscle cell; ClCa; Ca2+-activated Clâ; CTR; Control; GCa
The central serotonin2B receptor as a new pharmacological target for the treatment of dopamine-related neuropsychiatric disorders: Rationale and current status of research
Keywords: 5-HT; serotonin; 5-HT2BR; 5-HT2B receptor; AC; adenylate cyclase; APDs; antipsychotic drugs; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; DA; dopamine; DAG; diacylglycerol; DARPP-32; DA and c-AMP-regulated phosphoproteins Mr 32Â kDa;
Cell adhesion and matricellular support by astrocytes of the tripartite synapse
Keywords: β (Greek Small Letter Beta): 03B2; α (Greek Small Letter Alpha): 03B1; δ (Greek Small Letter Delta): 03B4; γ (Greek Small Letter Gamma): 03B3; ACM; astrocyte-conditioned medium; AMIGO; adhesion molecule with IG-like domain; AMOG; A Molecule On Glia; A
Tools and drugs for uracil nucleotide-activated P2Y receptors
Keywords: ADP; Adenosine 5â²-diphosphate; AP4A; P1,P4-Di(adenosine-5â²)-tetraphosphate; AR; Adenosine receptor; AR-C118925; 5-{[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl}-N-(1H-tetrazol-5-yl)-2-furancarbo
Comparison of Ca2+ puffs evoked by extracellular agonists and photoreleased IP3
Keywords: Ca2+ puffs; IP3; GPCRs; Calcium imaging; Signaling nanodomains;
Regulation of IP3 receptors by cyclic AMP
Keywords: AC; adenylyl cyclase; EPAC; exchange protein activated by cAMP; IP3; inositol 1,4,5-trisphosphate; IP3R; IP3 receptor; IRAG; IP3R-associated cGMP kinase substrate; IRBIT; IP3R-binding protein released by IP3; PKA; protein kinase A (cAMP-dependent protein
Acetylcholine-induced ex vivo ATP release from the human nasal mucosa
Keywords: Ach; acetylcholine; M3AchR; M3 acetylcholine receptor; PLC; phospholipase C; PIP2; phosphatidylinositol bisphosphate; DAG; diacylglycerol; IP3; inositol triphosphate; IP3R; inositol triphosphate receptor; P2X7; purinergic P2X7 receptor; Human nasal mucosa