Keywords: AP-1; activator protein 1; DAMP; damage associated molecular patterns; IRAK1; interleukin-1 receptor associated kinase-1; LBP; LPS binding protein; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MD2; myeloid differentiation factor 2; MHC
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Keywords: AKP; alkaline phosphatase; ALA; α-linolenic acid; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BW; body weight; COX2; cyclooxygenase 2; DAMP; damage-associated molecular pattern; ERK1/2; extracellular signal-regulated kinase 1/2; GGT;
Keywords: CRC; colorectal cancer; SNP; single nucleotide polymorphism; CNV; copy number variant; GWAS; genome-wide association studies; GO; gene ontology; BP; biological process; CAM; cell adhesion molecule; CIN; chromosomal instability; MSI; microsatellite instabi
Keywords: Otitis media; miR-146a; miR-146b; IRAK1; TRAF6; Toll-like receptor
Differences in TLR7/8 activation between monocytes and macrophages
Keywords: TLR7; TLR8; Monocytes; Macrophages; Immune modulation; AP-1; activator protein 1; cDNA; complementary DNA; ELISA; enzyme-linked immunosorbent assay; FBS; fetal bovine serum; HEPES; hydroxyethyl piperazineethanesulfonic acid; IFN; interferon; IL-6; interle
Paeoniflorin inhibits activation of the IRAK1-NF-κB signaling pathway in peritoneal macrophages from lupus-prone MRL/lpr mice
Keywords: Paeoniflorin; Systemic lupus erythematosus; IRAK1; NF-κB;
The attenuating effects of 1,2,3,4,6 penta-O-galloyl-β-d-glucose on pro-inflammatory responses of LPS/IFNγ-activated BV-2 microglial cells through NFÆB and MAPK signaling pathways
Keywords: 1,2,3,4,6-penta-O-galloyl-β-d-glucose; Microglia cells; NFÆB and MAP kinase signaling pathways; AD; Alzheimer's Disease; Aβ; Amyloid β; CDKs; Cyclin-dependent kinases; CHUK; Conserved Helix-Loop-Helix Ubiquitous Kinase; ERK; Extracellular signal-regul
miR-146a regulates inflammatory cytokine production in Porphyromonas gingivalis lipopolysaccharide-stimulated B cells by targeting IRAK1 but not TRAF6
Keywords: miRs; microRNAs; P. gingivalis; Porphyromonas gingivalis; LPS; lipopolysaccharide; PBS; phosphate buffer saline; IL; interleukin; IRAK1; IL-1 receptor associated kinase-1; TRAF6; TNF receptor associated factor 6; UTR; untranslated region; A. actinomycetem
Protective effect of dioscin against intestinal ischemia/reperfusion injury via adjusting miR-351-5p-mediated oxidative stress
Keywords: II/R; intestinal ischemia-reperfusion; H/R; hypoxia-reoxygenation; IPC; ischemia-reperfusion precondition; IPO; ischemia-reperfusion post-conditioning; DIC; diffuse intravascular coagulation; SIRS; systemic inflammatory response syndrome; MODS; multiple o
MicroRNA-mediated immune regulation in rheumatic diseases
Keywords: Rheumatism; Small non-coding RNAs; Autoimmunity; Lupus; Rheumatoid arthritis; miR- /miRNA; microRNA; AGO; argonaute; RISC; RNA-induced silencing complex; PBMCs; peripheral blood mononuclear cells; SLE; systemic lupus erythematosus; RA; rheumatoid arthriti
Up-regulation of circulating miRNA146a correlates with viral load via IRAK1 and TRAF6 in hepatitis C virus-infected patients
Keywords: HCV; IRAK1; miRNA146a; TRAF6; Viral load;
Original articlePharmacological effects of β-d-mannuronic acid (M2000) on miR-146a, IRAK1, TRAF6 and NF-κB gene expression, as target molecules in inflammatory reactions
Keywords: ANOVA; analysis of variance; CCL-8; chemokine (C-C motif) ligand 8; CO2; carbon dioxide; FADD; fas-associated protein with death domain; HEK; human embryonic kidney; IRAK1; interleukin-1 receptor-associated kinase 1; IRF5; interferon regulatory factor 5;
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection
Keywords: acLDL; acylated LDL; AIM2; absent in melanoma 2; AP-1; activator protein 1; BDCA-2; blood DC antigen; BEC; biliary epithelial cells; CARD; caspase recruitment and activation domains; cDC; common dendritic cells; CL-L1; collectin liver 1; CL-K1; collectin
Enterovirus 71-induced has-miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1
Keywords: Enterovirus71; MicroRNA-21; MyD88; IRAK1; Type I IFN;
Regulatory effects of miR-146a/b on the function of endothelial progenitor cells in acute ischemic stroke in mice
Keywords: MicroRNA-146a/b; Acute ischemic stroke; Endothelial progenitor cells; TRAF6; IRAK1;
Introduction of β-d-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property based on COX-1/COX-2 activity and gene expression
Keywords: ANOVA; analysis of variance; AA; arachidonic acid; BUN; blood urea nitrogen; COX; cyclooxygenase; EAE; experimental autoimmune encephalomyelitis; IRAK1; interleukin-1 receptor-associated kinase 1; LPS; lipopolysaccharide; LPS-EB; LPS from E. coli O111: B4
Functional integration of complex miRNA networks in central and peripheral lesion and axonal regeneration
Keywords: AAV(s); adeno-associated virus(es); ADAM; a disintegrin and metalloprotease; AGO(2); argonaut (2); AKT; protein kinase B; APC; adenomatous polyposis coli; ASO(s); antisense oligonucleotide(s); ATF3; activating transcription factor 3; BBB; blood brain barr
microRNAs in Psoriasis
Keywords: IRAK1; interleukin-1 receptor-associated kinase 1; miRNA; microRNA; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B cells; PBMCs; peripheral blood mononuclear cells; pre-miRNA; precursor miRNA; pri-miRNA; primary miRNA; TNF-α; tumor nec
Protection of rats spinal cord ischemia-reperfusion injury by inhibition of MiR-497 on inflammation and apoptosis: Possible role in pediatrics
Keywords: miR-497; Spinal cord ischemia–reperfusion; IRAK1; TLR4; CREB
MicroRNA 146a locally mediates distal axonal growth of dorsal root ganglia neurons under high glucose and sildenafil conditions
Keywords: Ago2; Argonaute 2; DIV; day in vitro; DPN; diabetic peripheral neuropathy; DRG; dorsal root ganglia; GAPDH; glyceraldehyde-3-phosphatedehydrogenase; HG; high glucose; IRAK1; interleukin-1 receptor-associated kinase 1; miRNA; MicroRNA; PDE5; phosphodiester
Molecular and functional characterization of Toll-like receptor (Tlr)1 and Tlr2 in common carp (Cyprinus carpio)
Keywords: Toll-like receptor; Innate immunity; Heterodimer; TLR signalling; Teleost; BSA; bovine serum albumin; GFP; green fluorescent protein; IRAK1; interleukin-1 receptor-associated kinase 1; LRR; leucine-rich repeat; LTA; lipoteichoic acid; MYD88; myeloid diffe
The Paracaspase MALT1
Keywords: NF-κB signaling; Protease; Caspase; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1); ABC; activated B cell-like; ABC-DLBCL; activated B cell-like diffuse large B cell lymphoma; Ac; acetyl; ALL; acute lymphomblastic leukemia; AM
The intracerebroventricular injection of rimonabant inhibits systemic lipopolysaccharide-induced lung inflammation
Keywords: ICV; intracerebroventricular; CB1; cannabinoid receptor type 1; LPS; lipopolysaccharide; IV; intravenous; Ppc; pulmonary capillary pressure; TLR4; toll-like receptor 4; IRAK1; interleukin receptor-associated kinase-1; IκBα; inhibitor of nuclear factor o
GABAA currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis
Keywords: Gamma-aminobutyric acid; GABA; GABA type A receptor; GABAA-R; Hippocampal sclerosis; HS; Interleukin-1β; IL-1β; IL-1 receptor type 1; IL-1R1; IL-1 receptor antagonist; IL-1Ra; Interleukin-1 receptor-associated kinase1; IRAK1; N-methyl-d-aspartate; NMDA;
Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells
Keywords: ATM; ataxia telangiectasia mutated; AUC; area under the curve; CD; cluster of differentiation; ECIS; electric cell substrate impedance sensing; EU; endotoxin units; FBS; foetal bovine serum; HEK; human embryonic kidney; IL-1Ra; interleukin 1 receptor anta
Turmerone enriched standardized Curcuma longa extract alleviates LPS induced inflammation and cytokine production by regulating TLR4–IRAK1–ROS–MAPK–NFκB axis
Keywords: Curcuma oil; Endotoxemia; IRAK1; Endothelial dysfunction; Oxidative stress; MAPK
Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6
Keywords: Bd-EE; Boerhavia diffusa L. ethanol extract; HPLC; high performance liquid chromatography; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TLR; Toll-like receptor (TLR); NF-κB; nuclear factor-κB; AP-1; Activat
An anti-interferon activity shared by paramyxovirus C proteins: Inhibition of Toll-like receptor 7/9-dependent alpha interferon induction
Keywords: IFN; interferon; PIVs; parainfluenza viruses; MeV; measles virus; NiV; Nipah virus; ORF; open reading frame; SeV; Sendai virus; ISGs; IFN-stimulated genes; ds; double stranded; PKR; protein kinase R; PAMPs; pathogen-associated molecular patterns; IRF; int
Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood
Keywords: IL33-IL1RL1 pathway; asthma; wheezing phenotypes; children; IL1RL1; IL33; Avon Longitudinal Study of Parents and Children study; Prevalence and Incidence of Asthma and Mite Allergy study; ALSPAC; Avon Longitudinal Study of Parents and Children; eQTL; Expr
The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy
Keywords: cDNA; complementary DNA; DAPI; 4â²,6-diamidino-2-phenylindole; db/db; BKS.Cg-m+/+Leprdb/J; db/m; heterozygote mice; DIG; digoxin; DRG; dorsal root ganglion; HG; high glucose; IRAK1; interleukin-1 receptor-activated kinase; LNA; locked nucleic acid; MCID;
Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways
Keywords: Mangiferin; Colitis; Macrophage; IRAK1; NF-κB; MAP kinaseCOX, cyclooxygenase; ERK, extracellular signal-regulated kinase; IKK, IκB kinase; IL, interleukin; IRAK, interleukin-1 receptor-associated kinase; JNK, c-Jun NH2-terminal kinase; LPS, lipopolysaccha
MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes
Keywords: Allergy; noncoding RNA; atopic eczema; gene therapy; AD; Atopic dermatitis; CARD10; Caspase recruitment domain-containing protein 10; IRAK1; IL-1 receptor-associated kinase 1; LN; Lymph node; miRNA; microRNA; NF-κB; Nuclear factor kappa B; siRNA; Small
The emerging role of microRNAs in the pathogenesis of systemic lupus erythematosus
Keywords: SLE; systemic lupus erythematosus; miRNAs; microRNAs; DGCR8; DiGeorge syndrome critical region gene 8; RISC; RNA-induced silencing complex; LPS; lipopolysaccharide; NF-κB; nuclear factor κB; IRAK1; IL-1 receptorassociated kinase 1; TRAF6; TNF receptor-a
Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse
Keywords: MECP2; IRAK1; Lupus; Epigenetics; Polymorphism; DNA methylation; T cells; Transgenic mouse
Increased microRNA-146a/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sjögren's syndrome
Keywords: MicroRNA-146a; IRAK1; TRAF6; Sjögren's syndrome
The potential of microRNAs in liver fibrosis
Keywords: miRNA; microRNA; ECM; extracellular matrix; HSC; hepatic stellate cell; α-SMA; α-smooth muscle actin; TGF-β; transforming growth factor-β; 3'UTR; 3'untranslated region; PDGF; platelet-derived growth factor; HCC; hepatocellular carcinoma; ACSL1; acyl-C
Lipopolysaccharide Induces the Migration of Human Dental Pulp Cells by Up-regulating miR-146a
Keywords: IRAK1; LPS; migration; miR-146a; pulp; TRAF6
Methanol extract of Osbeckia stellata suppresses lipopolysaccharide- and HCl/ethanol-induced inflammatory responses by inhibiting Src/Syk and IRAK1
Keywords: Os-ME; methanol extract of Osbeckia stellata; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TNF-α; tumor necrosis factor-alpha; ERK; extracellular signal-related kinase; TLR; toll-like receptor; MAPK; mitogen
Xq28 duplications including MECP2 in five females: Expanding the phenotype to severe mental retardation
Keywords: MECP2 duplication; Xq28 duplication; X-inactivation; Mental retardation in females; IRAK1
Dysregulation of miRNA146a versus IRAK1 induces IL-17 persistence in the psoriatic skin lesions
Keywords: Psoriasis; miR-146a; IL-17; IRAK1
Lipopolysaccharide inhibits transforming growth factor-beta1-stimulated Smad6 expression by inducing phosphorylation of the linker region of Smad3 through a TLR4–IRAK1–ERK1/2 pathway
Keywords: TGF-β1; Smad6; LPS; IRAK1; ERK1/2; Smad3 linker phosphorylation
MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4
Keywords: miRNAs; microRNAs; oxLDL; oxidized low-density lipoprotein; TLR2; toll-like receptor 2; TLR3; toll-like receptor 3; TLR4; toll-like receptor 4; TLRs; toll-like receptors; IL-6; interleukin 6; IL-8; interleukin 8; MCP-1; chemokine (C-C motif) ligand 2; M
MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis
Keywords: OA; osteoarthritis; RA; rheumatoid arthritis; DRG; dorsal root ganglia; MMP; matrix metalloproteinase; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; UTRs; untranslated regions; TLR; Toll-like receptor; NFkB; nuclear factor-kappa
TCM grammar systems: An approach to aid the interpretation of the molecular interactions in Chinese herbal medicine
Keywords: TCM; Traditional Chinese medicines; HED; Herba Ephedrae Decoction; EGS; entity grammar systems; ASP; answer set programming; IL1; Interleukin 1; IL1R1; Interleukin 1 receptor 1; IRAK1; Interleukin-1 receptor-associated kinase; TNFR; Tumor Necrosis Factor
TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C)
Keywords: TLR; Toll-like receptor; TNF-α; tumor-necrosis factor α; LPS; lipopolysaccharide; KML-C; Korean mistletoe lectin-C; IRAK1; IL-1R-associated kinase-1; TRAF6; tumor-necrosis factor receptor-associated factor 6; MyD88; myeloid differentiation primary-respo
Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells
Keywords: Helicobacter pylori; miR-146a; Post-transcriptional regulation; Inflammation; IRAK1; TRAF6
Cloning of IRAK1 and its upregulation in symptomatic mandarin fish infected with ISKNV
Keywords: IRAK1; ISKNV; NF-κB; Infection; Mandarin fish
Receptor mosaics of neural and immune communication: Possible implications for basal ganglia functions
Keywords: Ab; amyloid-beta protein; ABGA; antibasal ganglia antibody; AD; Alzheimer's disease; AGE; advanced glycation endproducts; AIDS; acquired immunodeficiency syndrome; ALS; amyotrophic lateral sclerosis; CA; cornu ammonis; CB; cannabinoid; CD; cluster designa
The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study
Keywords: Interleukin-1 receptor-associated kinase-1; IRAK1; C-reactive protein; CRP; Innate immunity
Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants
Keywords: IRAK1; Sumoylation; IRAK1c; Regulation; Innate immunity; Aging