کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10815421 | 1058473 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The emerging role of microRNAs in the pathogenesis of systemic lupus erythematosus
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کلمات کلیدی
TLRDGCR8RNPsTregTRAF6IRAK1MYD88miRNAspri-miRNAsNF-κBprecursor miRNAsLPSDiGeorge syndrome critical region gene 83′ UTR - 3 UTR3′ untranslated region - 3 منطقه غیر ترجمهRheumatoid arthritis - آرتریتروماتوئیدArgonaute - آرگونوتSTAT - آمارinterferon - اینترفرونIFN - اینترفرون هاtoll like receptor - تلفات مانند گیرندهtumor necrosis factor alpha - تومور نکروز عامل آلفاRISC - خطرmicroRNAs - ریز آرانایSjögren's syndrome - سندرم SjögrenSAP - شیرهmyeloid differentiation factor 88 - عامل تمایز میلوئید 88TNF receptor-associated factor 6 - عامل گیرنده TNF 6TNF-α - فاکتور نکروز توموری آلفاnuclear factor κB - فاکتور هسته ای κBSystemic lupus erythematosus - لوپوس اریتماتوی سیستمیکSLE - لوپوس منتشر یا لوپوس اریتماتوس سیستمیکlipopolysaccharide - لیپوپلی ساکاریدSignal transducer and activator of transcription - مبدل سیگنال و فعال کننده رونویسیRNA-Induced Silencing Complex - مجتمع خاموش کننده RNA inducedRegulatory T - مقررات Tpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازAGO - پیشpre-miRNAs - پیش از miRNAs
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Systemic lupus erythematosus (SLE) is a chronic, multi-system autoimmune disease characterized by disorder of the generation of auto-antibodies to components of cell nucleus, and the exact etiology of this disease is unknown. MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded RNAs about 21 nucleotides in length that play a critical role in the regulation of host genome expression at the post-transcriptional level. Emerging evidence has shown that aberrant miRNAs influence a wide range of biological processes including immune cell lineage commitment, differentiation, maturation, immune homeostasis and normal function. Moreover, miRNAs can be detected in a variety of sources, such as tissues, serum, and other body fluids. The role of miRNAs is evident in various malignant and nonmalignant diseases including cancer, inflammatory, and autoimmune diseases, and there is accumulating evidence also for an important role of miRNAs in SLE. MiRNAs can be aberrantly expressed even in the different stages of SLE, allowing miRNAs to be important biomarkers, to monitor disease activity and effects of treatment, and to help understand the pathogenesis of the disease. Thus, miRNAs are emerging as potential targets for new therapeutic strategies of SLE. During the last several years, there has been rapidly accumulating evidence of an important role of miRNAs in SLE. This review focuses on the current understanding of miRNA biogenesis, the role of miRNAs in the regulation of SLE pathogenesis, with special emphasis on new advances and the association of miRNAs with DNA methylation. The field of miRNAs in mammalian gene regulation has tremendous potential research prospect. Identification of specific miRNA expression patterns in SLE and further a comprehensive understanding of the role of miRNAs in the disease pathogenesis offer promise of not only novel clinical diagnostic markers, but also new gene therapy strategies for patients with SLE.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 25, Issue 9, September 2013, Pages 1828-1836
Journal: Cellular Signalling - Volume 25, Issue 9, September 2013, Pages 1828-1836
نویسندگان
Cheng-gui Miao, Ying-ying Yang, Xu He, Cheng Huang, Yan Huang, Lei Zhang, Xiong-Wen Lv, Yong Jin, Jun Li,