Glutathione S-transferase pi regulates UV-induced JNK signaling in SH-SY5Y neuroblastoma cells
Keywords: GSTpi; JNK; Apoptosis; SH-SY5Y cells
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Cross-linking of SIGNR1 activates JNK and induces TNF-α production in RAW264.7 cells that express SIGNR1
Keywords: JNK; Lectin-like receptors; Lipid raft; Macrophages; SIGNR1; Src family kinases; TNF-α;
SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression
Keywords: ATF4; JNK; Mammalian target of rapamycin; Redd1; SP600125;
Increased expressions and activations of apoptosis-related factors in cell signaling during incised skin wound healing in mice: A preliminary study for forensic wound age estimation
Keywords: Skin wound healing; MAPK; JNK; NOS; Calpain; Caspase; Wound age estimation
Cucurbitacin D isolated from Trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitro
Keywords: Cucurbitacin D; Trichosanthes kirilowii; Hepatocellular carcinoma; Apoptosis; Caspase-3; JNK
Protective effects of a polysaccharide from Hizikia fusiformis against ethanol toxicity in rats
Keywords: Seaweed; Polysaccharide; Hizikia fusiformis; Protectant; JNK
Activation of c-Jun-N-terminal kinase in a rat model of intracerebral hemorrhage: The role of iron
Keywords: ATPase; adenosine triphosphatase; CSF; cerebrospinal fluid; DFX; deferoxamine; ECL; enhanced chemiluminescence; FDA; food and drug administration; holo-Tf; holo-transferrin; ICH; intracerebral hemorrhage; IgG; immunoglobulin G; i.p.; intraperitoneal injec
Cationic lipids activate cellular cascades. Which receptors are involved?
Keywords: AP-1; activator protein 1; CD 14/80/86; cluster of differentiation 14/80/86; diC14-amidine; N-t-butyl-Nâ²-tetradecyl-3-tetradecylaminopropionamidine; DAG; diacylglycerol; DMPC; dimyristoyl-phosphatidylcholine; DMPG; dimyristoyl-phosphatidylglycerol; DMKD
Blockade of constitutively activated ERK signaling enhances cytotoxicity of microtubule-destabilizing agents in tumor cells
Keywords: MEK inhibitor; Microtubule-destabilizing agent; Apoptosis; Combination therapy; JNK
The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9
Keywords: Planar cell polarity; JNK; c-JUN; Non-canonical Wnt signaling
Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation
Keywords: Luteolin; Macrophage; Adipocyte; JNK; Inflammation;
Research ReportDelta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway
Keywords: DADLE; Neuron; Neuroprotection; ERK; P38; JNK;
Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes
Keywords: MMP; matrix-metalloproteinases; ADAMTS; a disintegrin and MMP with thrombospondin motifs; PHCs; primary human chondrocytes; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; JNK; c-Jun NH2-terminal kinase; LPS; lipopolysa
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model
Keywords: Caspase; Bax; Bcl-2; Bcl-xL; JNK; AKT; ERK
Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells
Keywords: Mycotoxin; Citrinin; ERK1/2; JNK; Immediate-early gene; Gadd45β; MMP3
A scanning peptide array approach uncovers association sites within the JNK/βarrestin signalling complex
Keywords: MAPK; Map kinase; JNK; c-Jun N-terminal kinase; ASK1; apoptosis signal-regulating kinase 1; MKK4; MAPK kinase 4; CD site; common docking site; Arrestin; JNK; Scaffold; MKK4; ASK1; Peptide array;
JNK/AP-1 pathway is involved in tumor necrosis factor-α induced expression of vascular endothelial growth factor in MCF7 cells
Keywords: AP-1; JNK; MCF7; VEGFAP-1, activator protein-1; ChIP, chromatin immunoprecipitation; ERK, extracellular signal regulated kinase; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; NF-κB, nuclear factor-κB; TNF-α, tumor necrosis factor-α
Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells
Keywords: Cordycepin; Bladder cancer cells; JNK; G2/M-phase cell-cycle arrest; p21WAF1
dXNP/DATRX increases apoptosis via the JNK and dFOXO pathway in Drosophila neurons
Keywords: ATRX, α-thalassemia X-linked mental retardation; DATRX, Drosophila ATRX; dXNP, Drosophila XNP; JNK, Jun-N-terminal kinase; XNP, X-linked nuclear proteinApoptosis; ATRX; Drosophila; dXNP; dFOXO; JNK; Neuronal development
Requirement of the JNK-associated Bcl-2 pathway for human lactoferrin-induced apoptosis in the Jurkat leukemia T cell line
Keywords: Lactoferrin; Apoptosis; JNK; Bcl-2
Involvement of C-jun NH2-terminal kinase and apoptosis induced factor in apoptosis induced by deglycosylated bleomycin in laryngeal carcinoma cells
Keywords: Bleomycin-A2; Deglycobleomycin-A2; Apoptosis; AIF; JNK; Death receptor ligand; Laryngeal carcinoma cells; BLM; bleomycin; AIF; apoptosis inducing factor; JNK; C-jun NH2-terminal kinase; HEp-2; laryngeal cancer cells;
Reduction in the protein level of c-Jun and phosphorylation of Ser73–c-Jun in rat frontal cortex after repeated MK-801 treatment
Keywords: JNK; MAPK; NMDA receptor antagonist; Psychosis; Psychotomimetic agent
Activation of cell death pathways in the inner ear of the aging CBA/J mouse
Keywords: ABR; auditory brain stem evoked response; Endo G; endonuclease G; JNK; c-Jun-N-terminal kinase; MAPK; mitogen-activated protein kinases; PBS; phosphate-buffered saline; PI; Propidium iodide; ROS; reactive oxygen species; SAPK; stress-activated protein kin
Preconditioning neuroprotection in global cerebral ischemia involves NMDA receptor-mediated ERK-JNK3 crosstalk
Keywords: CREB; cyclic adenosine monophosphate response element binding protein; ERK1/2; extracellular signal-regulated kinase 1/2; JNK; c-Jun-N-terminal kinase; NMDA; N-methyl-d-aspartate; MAPK; mitogen-activated protein kinases; TUNEL; terminal deoxynucleotidyl t
JNK and p38 MAPK are independently involved in tributyltin-mediated cell death in rainbow trout (Oncorhynchus mykiss) RTG-2 cells
Keywords: Apoptosis; Caspase; JNK; p38 MAPK; Rainbow trout; Tributyltin
Truncation of the Catalytic Domain of the Cylindromatosis Tumor Suppressor Impairs Lung Maturation
Keywords: JNK; c-Jun kinase; MEF; murine embryonic fibroblast; NF-κB; nuclear factor κB; NSCLC; non-small cell lung cancer; TNF; tumor necrosis factor; TRAF; TNF-receptor-associated factor;
Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes
Keywords: Alzheimer disease; Type 2 diabetes; IB1/JIP-1; Neuron; JNK; Islets
Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes
Keywords: diabetic nephropathy; insulin resistance; inflammation; JNK; podocytes; microalbuminuria
Lipopolysaccharide triggered TNF-α-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model
Keywords: ASK1; apoptosis signal-regulating kinase 1; α-SMA; α-smooth muscle actin; ASH; alcoholic steatohepatitis; H2O2; hydrogen peroxide; JNK; c-Jun N-terminal kinase; MCD; methionine-choline-deficient; NAC; N-acetyl-l-cysteine; NAFLD; non-alcoholic fatty li
Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation
Keywords: Apolipoprotein E; LPS; Alzheimer's disease; Signal transduction; Nitric oxide; JNK
Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death
Keywords: 4-HPR; ARF4; Reactive oxygen species; Apoptosis; Bax; JNK
Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells
Keywords: JNK; c-Jun N-terminal kinase; SH-SY5Y; Neuroblastoma; Cytoskeleton; Cell death; Proliferation
Deoxypodophyllotoxin, flavolignan, from Anthriscus sylvestris Hoffm. inhibits migration and MMP-9 via MAPK pathways in TNF-α-induced HASMC
Keywords: MMP, matrix metalloproteinase; ECM, extracellular matrix; HASMC, human aortic smooth muscle cell; TNF-α, tumor necrosis factor-α; MAPK, mitogen-activated protein kinase; DPD, deoxypodophyllotoxin; ERL1/2, extracellular signal regulated kinase 1 and 2; JNK
PKCη confers protection against apoptosis by inhibiting the pro-apoptotic JNK activity in MCF-7 cells
Keywords: PKC; protein kinase C; JNK; c-Jun N-terminal kinase; PARP-1; Poly ADP-ribose polymerase-1; MAPK; mitogen-activated protein kinase; CPT; Camptothecin; Tet; Tetracycline; PKCη; Apoptosis; UVC irradiation; Camptothecin; Cytochrome c; Caspases; JNK activity;
The RhoGDI-α/JNK signaling pathway plays a significant role in mycophenolic acid-induced apoptosis in an insulin-secreting cell line
Keywords: Mycophenolic acid; Insulin-secreting cells; Apoptosis; RhoGDI-α; JNK
ERK1/2, but not ERK5, is necessary and sufficient for phosphorylation and activation of c-Fos
Keywords: ERK1/2; ERK5; Fos; JNK; Jun; MEF2D; p38
Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging
Keywords: Brain aging; Mitochondria; Pyruvate dehydrogenase; JNK; Neurodegeneration
Characterization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes
Keywords: CRTAM, class-I MHC-restricted T-cell associated molecule; ActD, actinomycin D; CNS, conserved non-coding sequencesCRTAM; AP-1; JNK; Transcription; Human T cells; Promoter
Dosage effects of EGb761 on hydrogen peroxide-induced cell death in SH-SY5Y cells
Keywords: EGb761; H2O2; Apoptosis; Akt; JNK; GSH
Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of α-, β- and γ-secretase expression
Keywords: Human APP; β-Amyloid protein; Oxidative stress; JNK; α, β and γ secretases; Thr668 APP
Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells
Keywords: AP-1; activator protein-1; COX-2; cyclooxygenase-2; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; IBDs; inflammatory bowel diseases; IEC; intestinal epithelial cells; IFN-γ; interferon-γ; IL-1β; interleukin-1β; IL-8; interleuki
NF-κB inhibition leads to increased synthesis and secretion of MIF in human CD4+ T cells
Keywords: MIF; CD4+ T cells; NF-κB; JNK; ROS
Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice
Keywords: CCK; cholecystokinin; CIP; cerulein-induced pancreatitis; CPA; carboxypeptidase; PDGF; platelet-derived growth factor; EGR-1; Early growth response 1; ERK1/2; extracellular regulated kinase 1/2; IL-6; interleukin 6; JNK; Jun N-terminal kinase; PPAR; perox
Regenerative pharmacology in the treatment of genetic diseases: The paradigm of muscular dystrophy
Keywords: MD; muscular dystrophies; DMD; duchenne muscular dystrophy; DAPC; dystrophin-associated protein complex; DGC; dystrophin-glycoprotein complex; DG; dystroglycans; SCG; sarcoglycans; nNOS; neuronal nitric oxide synthase; NO; nitric oxide; HDAC; histone deac
Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways
Keywords: ADAM; a disintegrin and metalloproteinase; α-LA; α-lipoic acid; APC; activated protein C; APMA; 4-aminophenylmercuric acetate; BSA; bovine serum albumin; CV; crystal violet; DHLA; dihydrolipoic acid; DMSO; dimethyl sulfoxide; DPI; diphenylene iodonium;
Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer
Keywords: HCC; hepatocellular carcinoma; JNK; C-Jun N-terminal kinase; H3K4me3; histone H3 lysine 4 tri-methylation; CCNB1; cyclin B1; CCNA; cyclin A2; CDC2; cell division cycle protein 2; JNK; HCC; H3K4me3; EZH2; Tumor suppressor;
Neuroprotection of preconditioning against ischemic brain injury in rat hippocampus through inhibition of the assembly of GluR6-PSD95-mixed lineage kinase 3 signaling module via nuclear and non-nuclear pathways
Keywords: cerebral ischemia; GluR6; c-Jun; preconditioning; JNK3; PSD-95; AP-1; activator-protein 1; DMSO; dimethyl sulfoxide; FasL; Fas ligand; I/R; ischemia/reperfusion; JNK; c-Jun N-terminal kinase; KA; kainite; MLK3; mixed lineage kinase 3; NMDA; N-methyl-d-asp
Inflammatory protein sPLA2-IIA abrogates TNFα-induced apoptosis in human astroglioma cells: Crucial role of ERK
Keywords: ERK; extracellular signal-regulated kinase; JNK; c-Jun N-terminal kinase; MAP; mitogen-activated protein; COX-2; cyclooxygenase-2; IkB; inhibitory kB protein; NF-kB; nuclear factor-kB; TNFα; tumor necrosis factor α; sPLA2-IIA; secreted phospholipase A2-
Netrin-4 regulates angiogenic responses and tumor cell growth
Keywords: HMVECs, human microvascular endothelial cells; Ntn-4, Netrin-4Netrin-4; Angiogenesis; Tumor cells; Jnk; Akt; Phosphorylation
Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells
Keywords: Apoptosis; Cytoprotection; Galectin-13; MAPK; Ask-1; Akt; AIF; JNK; ERK; Taxol