Keywords: Inherited arrhythmias; KCNQ1; KCNH2; Long QT; Protein structure;
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: [Ca++]i; intracellular Ca2+ concentration; 2ME2; 2-methoxyestradiol, a natural metabolite of estradiol; 4-OH-Tmx; 4-hydroxytamoxifen, a metabolite of Tmx; 5-HT3R; 5-hydroxytryptamine receptor subtype 3; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropio
Keywords: Gating; hERG; KCNA5; KCNE1; KCNQ1; Pharmacology; Potassium channel;
Keywords: KCNQ1; KCNH2; SCN5A; Mutations; Novel; India
The effects of valproic acid on the mRNA expression of Natriuretic Peptide Receptor A and KQT-like subfamily Q-1 in human colon cancer cell lines
Keywords: Colorectal cancer; Human colorectal cancer cell lines; KCNQ1; Natriuretic Peptide Receptor A; Valproic acid;
A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE1
Keywords: KCNQ1; KCNE1; D609; Open channel blocker;
A challenge for mutation specific risk stratification in long QT syndrome type 1
Keywords: Long QT syndrome; KCNQ1; Mutation location; Sudden death;
Using the genome aggregation database, computational pathogenicity prediction tools, and patch clamp heterologous expression studies to demote previously published long QT syndrome type 1 mutations from pathogenic to benign
Keywords: Arrhythmia; Genetics; Heart arrest; KCNQ1; Long QT syndrome; Pediatrics;
The ADRA2A rs553668 variant is associated with type 2 diabetes and five variants were associated at nominal significance levels in a population-based case-control study from Mexico City
Keywords: ADRA2A; Alpha-2a-adrenergic receptor; BMI; Body mass index; CHO; Cholesterol; DNA; Deoxyribonucleic acid; ENSANUT; National Survey of Health and Nutrition; FPG; Fasting plasma glucose; GWAS; Genome wide association study; HDL-C; Cholesterol high density l
Calcium/calmodulin-dependent protein kinase II regulation of IKs during sustained β-adrenergic receptor stimulation
Keywords: Calcium/calmodulin-dependent protein kinase II; CaMKII; Delayed rectifier; Heart failure; IKs; KCNQ1; β-Adrenergic receptor;
Complex aberrant splicing in the induced pluripotent stem cell-derived cardiomyocytes from a patient with long QT syndrome carrying KCNQ1-A344Aspl mutation
Keywords: Aberrant splicing; IKs activator; Induced pluripotent stem cell; KCNQ1; Long QT syndrome;
The effects of TLR3, TRIF and TRAF3 SNPs and interactions with environmental factors on type 2 diabetes mellitus and vascular complications in a Han Chinese population
Keywords: TLR3; toll-like receptor 3; TRIF; TIR-domain-containing adapter-inducing interferon-β; TRAF3; tumor necrosis factor receptor-associated factor 3; IFN-β; type I interferon -β; NF-κB; nuclear factor-κB; IRF-3/7; interferon regulatory factor 3/7; SN
Insulin treatment augments KCNQ1/KCNE1 currents but not KCNQ1 currents, which is associated with an increase in KCNE1 expression
Keywords: KCNQ1; KCNE1; Insulin; Current augmentation; Protein expression;
Compound heterozygous KCNQ1 mutations (A300T/P535T) in a child with sudden unexplained death: Insights into possible molecular mechanisms based on protein modeling
Keywords: aa; amino acid; BWA; Burrows-Wheeler aligner; CaM; calmodulin; CPR; cardiopulmonary resuscitation; DNA; deoxyribonucleic acid; ECG; electrocardiogram; GOF; gain of function; KCNE1; potassium voltage-gated channel subfamily E member 1; Kv7.1; voltage-gated
KCNQ1 gene polymorphism is associated with glycaemic response to treatment with DPP-4 inhibitors
Keywords: KCNQ1; DPP-4 inhibitors; Pharmacogenetics; Type 2 diabetes;
Glucose ingestion causes cardiac repolarization disturbances in type 1 long QT syndrome patients and healthy subjects
Keywords: Cardiac arrhythmia; Oral glucose tolerance test; T-wave morphology; QT interval; Morphology Combination Score; KCNQ1; Long QT syndrome;
Clinical profile and mutation spectrum of long QT syndrome in Saudi Arabia: The impact of consanguinity
Keywords: Long QT syndrome; KCNQ1; Consanguinity; Homozygous; Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome;
Molecular cloning and functional expression of the K+ channel KV7.1 and the regulatory subunit KCNE1 from equine myocardium
Keywords: KV7.1; KCNQ1; KCNE1; Equine; Horse; Cardiac electrophysiology; IKs; slow delayed rectifier current; LQT1; long QT syndrome; SCD; sudden cardiac death;
Regulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids
Keywords: KCNQ1; Channel; PIP2; PUFA; Voltage-gated; Potassium; Kv7.1; Lipids; Annular; Membrane;
A comprehensive structural model for the human KCNQ1/KCNE1 ion channel
Keywords: KCNQ1; KV7.1; Voltage-gated potassium ion channel; KCNQ1/KCNE1; Homology modeling; Data-driven protein-protein docking;
Familial long QT syndrome and late development of dilated cardiomyopathy in a child with a KCNQ1 mutation: A case report
Keywords: Familial long QT syndrome; Dilated cardiomyopathy; KCNQ1; Voltage-gated potassium channel; Genetics;
Molecular pathogenesis of long QT syndrome type 1
Keywords: LQT1; KCNQ1; Genotype-phenotype correlations; Adrenergic regulation;
Electrophysiological properties of iPS cell-derived cardiomyocytes from a patient with long QT syndrome type 1 harboring the novel mutation M437V of KCNQ1
Keywords: KCNQ1; LQT1; iPS cell; C-terminus mutation; Early afterdepolarization; AP(D); action potential (duration); EAD; early afterdepolarization; EB; embryoid body; ESC; embryonic stem cell; HP; holding potential; ICaL; L-type Ca2+ channel current; IKr; rapidly-
KCNE4 and KCNE5: K+ channel regulation and cardiac arrhythmogenesis
Keywords: AMME; Alport syndrome, intellectual disability, midface hypoplasia and elliptocytosis; CHO; Chinese Hamster ovary; HEK; human embryonic kidney; IKs/IsK; slowly activating K+ current; KChIP; K+ channel interacting protein; Kv channel; voltage-gated potassi
Structural analysis of the S4-S5 linker of the human KCNQ1 potassium channel
Keywords: KCNQ1; Potassium channel; Micelles; NMR; Protein structure;
A single conserved basic residue in the potassium channel filter region controls KCNQ1 insensitivity toward scorpion toxins
Keywords: KCNQ1; Insensitivity; Sensitivity; Peptide design; Potassium channel;
Joint effect of CENTD2 and KCNQ1 polymorphisms on the risk of type 2 diabetes mellitus among Chinese Han population
Keywords: Type 2 diabetes; Association study; Chromosome 11; CENTD2; KCNQ1
Correlation between KCNQ1 and KCNJ11 gene polymorphisms and type 2 and post-transplant diabetes mellitus in the Asian Indian population
Keywords: Asian Indians; KCNJ11; KCNQ1; PTDM; T2DM
Variant rs2237892 of KCNQ1 Is Potentially Associated with Hypertension and Macrovascular Complications in Type 2 Diabetes Mellitus in A Chinese Han Population
Keywords: KCNQ1; Type 2 diabetes mellitus; High-resolution melting analysis; Hypertension; Macrovascular disease; Single nucleotide polymorphism
SjAPI-2 is the first member of a new neurotoxin family with Ascaris-type fold and KCNQ1 inhibitory activity
Keywords: Scorpion toxin; Structural fold; KCNQ1;
Synergistic modulation of KCNQ1/KCNE1 K+ channels (IKs) by phosphatidylinositol 4,5-bisphosphate (PIP2) and [ATP]i
Keywords: PtdIns(4,5)P2, PIP2; phosphatidylinositol 4,5-bisphosphate; PI; phosphoinositide; PI(4)P5-K; phosphatidylinositol-4-phosphate 5-kinase; PLC; phospholipase C; PKC; protein kinase C; Ci-VSP; switchable phosphatase from Ciona intestinalis; AMP-PCP; β,γ-met
BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs)
Keywords: AP; action potential; APP; amyloid precursor protein; BACE1; β-site APP-cleaving enzyme 1; DMEM; Dulbecco's modified Eagle's medium; DTT; dithiothreitol; EGFP; enhanced green fluorescent protein; FRAP; fluorescence recovery after photobleaching; HEK293T;
In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation
Keywords: Atrial fibrillation; AF; IKs; Inherited arrhythmia; KCNQ1; Modelling; Re-entry; Simulation; Spiral wave
A590T mutation in KCNQ1 C-terminal helix D decreases IKs channel trafficking and function but not Yotiao interaction
Keywords: KV7.1; KCNQ1; KCNE1; IKs; LQT; Yotiao;
A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation
Keywords: AKAP9; A-kinase anchoring protein 9 (Yotiao); AP; action potential; APD90; steady-state action potential duration at 90% repolarization; ECG; electrocardiogram/electrocardiographic; HEK293; human embryonic kidney 293; IKs; slowly activating delayed rectif
Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization
Keywords: AP; action potential; APD; action potential duration; CL; cycle length; EAD; early afterdepolarization; ECG; electrocardiogram; Endo; endocardial; Epi; epicardial; ICaL; L-type calcium current; IKs; slow delayed-rectifier potassium current; ISO; isoproter
Rab GTPases are required for early orientation of the left–right axis in Xenopus
Keywords: KCNQ1; Ductin; Planar cell polarity; Chirality; Heterotaxia
Transcriptomic analysis reveals atrial KCNE1 downâregulation following lung lobectomy
Keywords: Arrhythmia; IKs; KCNQ1; MinK; Postoperative atrial fibrillation;
Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs
Keywords: Allele; Haplotype; KCNQ1; Tunisia; Type 2 diabetes
Genotype-phenotype analysis of three Chinese families with Jervell and Lange-Nielsen syndrome
Keywords: Compound heterozygous mutation; frameshift mutation; Jervell and Lange-Nielsen syndrome; KCNQ1; KCNE1; long QT syndrome; Romano-Ward syndrome; single nucleotide polymorphism;
In Silico Cardiac Risk Assessment in Patients With Long QT Syndrome : Type 1: Clinical Predictability of Cardiac Models
Keywords: IKs; KCNQ1; KCNQ2; LQT; QTACA, aborted cardiac arrest; AP, action potential; ECG, electrocardiography; FGM, Flaim-Giles-McCulloch; IKs, rectifier potassium current; LQT1, long QT syndrome type 1; LQTS, long QT syndrome; Q4, upper quartile; QTc, QT interva
Arrhythmogenic mechano-electric heterogeneity in the long-QT syndrome
Keywords: Long-QT syndrome; Electromechanical window; Calcium; Aftercontractions; Torsades de pointes; Ventricular arrhythmia; AP; action potential; APD; action-potential duration; CaMKII; Ca2+/Calmodulin-dependent serine-threonine protein kinase II; CaM; Ca2+/Calm
Chemical control of metabolically-engineered voltage-gated K+ channels
Keywords: KCNQ1; Shaker; Glycosylation; Charybdotoxin; Tethered blockers;
Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 β-cell line
Keywords: Type 2 diabetes; Gene; KCNQ1; Insulin secretion
Protein kinase C downregulates IKs by stimulating KCNQ1-KCNE1 potassium channel endocytosis
Keywords: Endocytosis; IKs; KCNE1; KCNQ1; PKC; TraffickingCHO, Chinese hamster ovary; IKs, slow-activating cardiac delayed rectifier K+ current; LQT, long QT; PBS, phosphate-buffered saline; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate
Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder
Keywords: ADHD; attention-deficit/hyperactivity disorder; MTS; methylphenidate transdermal system; SNP; Single Nucleotide Polymorphism; FERM; Protein 4.1, Ezrin, Radixin, Moesin; bpm; beats per minute; bp; Base Paur; VNTR; Variable Number Tandem Repeat; DSM-IV-TR;
R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation
Keywords: Atrial fibrillation; Familial atrial fibrillation; Genetics; Ion channel; KCNQ1; Long QT syndrome; Long QT syndrome type 1AF, atrial fibrillation; AP, action potential; E1, KCNE1; HEK293, human embryonic kidney 293; IKs, slowly activating delayed rectifie
Cardiac arrhythmia and thyroid dysfunction: A novel genetic link
Keywords: Atrial fibrillation; Hypothyroidism; Hyperthyroidism; KCNE2; KCNQ1; Long QT Syndrome; MiRP1
Structural basis for KV7.1–KCNEx interactions in the IKs channel complex
Keywords: IKs; KCNE1; KCNE2; KCNQ1; KV7.1IKr, cardiac rapid delayed rectifier current; IKs, cardiac slow delayed rectifier current; KV, voltage-gated potassium channel; NMR, nuclear magnetic resonance; PIP2, phosphatidylinositol 4,5-bisphosphate
The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking
Keywords: IKs; KCNQ1; S4-S5 linker; Kv gating;