Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium
Keywords: buy1; Nrf2; Keap1; Exercise; Oxidative stress; ROS; AES
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Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis)
Keywords: buy1; ARE; Antioxidant response element; DCF; 2â²,7â²-dichlorofluorescein; DDC; 2â²,3â²-dihydroxy-4â²,6â²-dimethoxychalcone; DHE; Dihydroethidium; DMSO; Dimethyl sulfoxide; EI; Electron impact; ETH; Ethidium; γ-GCS; âγ-glutamylcysteine synthetase; G
NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes
Keywords: buy1; Nrf2; nuclear factor E2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; NQO1; NAD(P)H:quinine oxidoreductase 1; GSK-3β; glycogen synthase kinase-3β; GST; glutathione S-transferase, HO-1, heme oxygenase-1; ARE; antioxidant response element,
Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells
Keywords: buy1; ARE; antioxidant response element; CCND1; cyclin D1; CSC; cancer stem cell; E-CAD; E-cadherin; FBS; fetal bovine serum; GCLC; glutamate-cysteine ligase catalytic subunit; GCLM; glutamate-cysteine ligase regulatory subunit; GSN; gelsolin; HO-1; heme ox
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
Keywords: buy1; tBHQ; tert-butylhydroquinone; BTB; broad complex-tramtrack-bric a brad; CDDO-Im; 2-cyano-3,12 dioxooleana-1,9 diene-28-imidazolide; CDNB; 1-chloro-2,4-dinitrobenzene; DEM; diethylmaleate; DMF; dimethylfumarate; Gclc; glutamate-cysteine ligase catalytic su
Protective action of nipradilol mediated through S-nitrosylation of Keap1 and HO-1 induction in retinal ganglion cells
Keywords: buy1; ARE; antioxidant response element; ChIP; chromatin immunoprecipitation; c-PTIO; 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide; GCLC; glutamate cysteine ligase catalytic subunit; DeNip; denitro-nipradilol; 4HNE; 4-hydroxy-2-nonenal; HO-
Zinc and the modulation of redox homeostasis
Keywords: buy1; Akt; protein kinase B; BDNF; brain-derived neurotrophic factor; ERK; extracellular signal-regulated kinases; GCL; glutamate-cysteine ligase; GSH; glutathione; GPCR; G-protein-coupled receptor; Keap1; Kelch-like ECH-associated protein; JNK; Jun N-termina
Redox-regulating role of insulin: The essence of insulin effect
Keywords: buy1; 4-HNE; 4-hydroxynonenal; 8-OHdG; 8-hydroxydeoxyguanosine; 8-OHG; 8-hydroxyguanine; 8-iso-PGF2α; 8-iso-prostaglandin F2α; AD; Alzheimer's disease; AIDS; acquired immunodeficiency syndrome; Akt; protein kinase B; AMI; acute myocardial infarction; APS; a
Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters
Keywords: buy1; ROS; reactive oxygen species; KB; cell line derived from a human carcinoma of the nasopharynx; F; flavones studied (apigenin, chrysin, fisetin, kaempferol, quercetin, morin, rutin); HOMO; highest occupied molecular orbital; Q; quinones corresponding to th
Role of the Nrf2-ARE pathway in acrylamide neurotoxicity
Keywords: buy1; Acrylamide; Axonopathy; Phase II enzymes; Keap1; Nrf2; Antioxidant/electrophile response element
Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3â²,5â²-cyclic monophosphate formed in glia cells
Keywords: buy1; iNOS; inducible nitric oxide synthase; sGC; soluble guanylate cyclase; cGMP; guanosine 3â²,5â²-cyclic monophosphate; 8-nitro-cGMP; 8-nitroguanosine 3â²,5â²-cyclic monophosphate; RNOS; reactive nitrogen oxide species; LC-MS/MS; liquid chromatography-ta
Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells
Keywords: buy1; Nrf2; Keap1; Nitric oxide; Nitrosative stress; Nitrosylation; PC12 cells
Resveratrol protects human keratinocytes HaCaT cells from UVA-induced oxidative stress damage by downregulating Keap1 expression
Keywords: buy1; Resveratrol; HaCaT cell; Oxidative stress; Nrf2; Keap1
Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole
Keywords: buy1; tert-Butylbenzoquinone; tert-Butylhydroquinone; Electrophile; Keap1; Nrf2
Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-KappaB Pathway Activation in Lung Cancer
Keywords: buy1; KEAP1; CUL3; RBX1; IKBKB; NF-κB signaling; Genetic disruption
Nuclear factor erythroid 2-related factor-2 activity controls 4-hydroxynonenal metabolism and activity in prostate cancer cells
Keywords: buy1; Prostate cancer; 4-Hydroxynonenal; Nrf2; KEAP1; Oxidative stress; Aldehyde metabolism; Glutathione; GS-HNE adduct; GST A4; DNA damage; Apoptosis; Free radicals;
Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway
Keywords: buy1; ARE; antioxidant responsive element; DEM; diethylmaleate; IL-1β; interleukin-1 beta; Keap1; Kelch-like ECH-associated protein 1; LMB; leptomycin B; Nrf2; NF-E2-related factor 2; PMA; phorbol 12-myristate 13-acetate; tBHQ; tert-butyl hydroxyquinone; TNFα
Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis
Keywords: buy1; NRF2; KEAP1; Oxidative stress; PGAM5; FAC1(BPTF); Prothymosin α; NF-κB; p62; Apoptosis; Autophagy; Free radicals;
Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β
Keywords: buy1; γGCL; gamma-glutamylcysteine ligase; γGCL-C; gamma-glutamylcysteine ligase catalytic subunit; γGCL-M; gamma-glutamylcysteine ligase modulatory subunit; GSH; glutathione; GSK3β; glycogen synthase kinase-3 beta; HAT; histone acetyltransferase; HDAC; his
(â)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68
Keywords: buy1; CBB; Coomassie Brilliant Blue G-250; Chaps; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; CHX; cycloheximide; DAPI; 4â²,6-diamino-2-phenylindole; DTT; dithiothreitol; ECL; enhanced chemiluminescence; EC; (â)-epicatechin; ECG; (â)-epicate
The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: Results of a ring-study in five laboratories
Keywords: buy1; LLNA; local lymph node assay; Nrf2; nuclear factor-erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; ARE; antioxidant response element; SOP; standard operating procedure; WLR; within laboratory reproducibility; BLR; between laborat
Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3–RINGBox1 protein complex and elucidation of its quaternary structure with Keap1
Keywords: buy1; Cullin3; Keap1; Nrf2; Rbx1; Codon-optimized; Quaternary structure; Stoichiometry
Cysteine-based regulation of the CUL3 adaptor protein Keap1
Keywords: buy1; Keap1; CULLIN3; Cysteine adduction/oxidation; Nrf2; Proteomics; Detoxification; Phase II gene expression; Oxidative stress
Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract
Keywords: buy1; Alzheimer's disease; Cataract; NFE2L2; Nrf2; KEAP1; Oxidative stress
Heteroaromatic 4-arylquinols are novel inducers of Nuclear factor-erythroid 2-related factor 2 (Nrf2)
Keywords: buy1; Quinol; Cancer chemoprevention; Nrf2; Keap1; Antioxidant response
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector
Keywords: buy1; Antioxidant response element (ARE); Benzene toxicity; Estrogen quinone; Keap1; Microtubule stability; Nrf2; Oxidative stress; p53; Proteasomal degradation
Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound
Keywords: buy1; Keap1, Kelch-like ECH-associated protein 1; Nrf2, nuclear factor-E2-related factor 2; ARE, antioxidant response element; AOE, antioxidant enzyme; DME, drug-metabolizing enzyme; HMW, high molecular weightFalcarindiol; Alkylation; Keap1; Cysteine; Electroph
A systems biology perspective on Nrf2-mediated antioxidant response
Keywords: buy1; ROS; Keap1; Nrf2; Oxidative stress; Antioxidant; Redox homeostasis; Feedback; Feedforward; Ultrasensitive motif; Loop gain
Nrf2:INrf2 (Keap1) signaling in oxidative stress
Keywords: buy1; ARE, antioxidant-response element; BTB, broad complex, tramtrack, bric-a-brac; Nrf2, NF-E2-related factor 2; INrf2, inhibitor of Nrf2, also known as Keap1; ROS, reactive oxygen speciesNrf2; INrf2; Keap1; Antioxidant response element; Regulation of gene ex
Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma
Keywords: buy1; MRP, multidrug-resistant protein; NSCLC, non-small-cell lung carcinoma; HNE, 4-hydroxynonenal; EpRE, electrophile response elementElectrophile response element; Lung cancer; 4-Hydroxynonenal; Keap1; H460 cell line; H358 cell line; A549 cell line; HBE1 cel
Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells
Keywords: buy1; Act-D; actinomycin D; AhR; aryl hydrocarbon receptor; ARE; antioxidant responsive element; c12; AhR-deficient Hepa 1c1c7 cells; CHX; cycloheximide; DMSO; dimethylsulfoxide; EMSA; Electrophoretic mobility shift assay; Hepa 1c1c7; murine hepatoma Hepa 1c1c7
Nrf2 promotes neuronal cell differentiation
Keywords: buy1; Nrf2; Keap1; Oxidative stress; Neuronal differentiation; SH-SY5Y; NQO1; Free radicals;
Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 signaling
Keywords: buy1; EGCG; Bleomycin; Pulmonary fibrosis; Nrf2; Keap1; Inflammation
Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
Keywords: buy1; Keap1; Methylation; Nrf2; Lung cancer; Bisulfite sequencing (BSG)
Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1–Cul3 interaction
Keywords: buy1; Keap1; Nrf2; Arsenic; Cul3; E3 ubiquitin ligase
Keap1 modification and nuclear accumulation in response to S-nitrosocysteine
Keywords: buy1; Nitric oxide; S-nitrosocysteine; S-nitrosylation; Oxidation; Keap1; Nrf2; Nuclear localization; Free radicals
Dual roles of Nrf2 in cancer
Keywords: buy1; Nrf2; Keap1; ARE; Glutamate cysteine ligase; Glutathione peroxidase; Thioredoxin reductase; Peroxiredoxin; Glutathione S-transferase; NAD(P)H quinone oxidoreductase-1; Heme oxygenase; MRP
The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity
Keywords: buy1; Nrf2; Keap1; Cell defence; Drug-induced toxicity
Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity
Keywords: buy1; AA; arachidonic acid; AKR; aldo-keto reductase; ALDH; aldehyde dehydrogenase; ALEs; advanced lipoxidation end-product; ARE; antioxidant response element; CBP; CREB-binding protein; CR; caloric restriction; CREB; cAMP-responsive element-binding factor; DBI
Extract of Ginkgo biloba induces phase 2 genes through Keap1-Nrf2-ARE signaling pathway
Keywords: buy1; Extract of Ginkgo biloba (EGb); Phase 2 gene; Nrf2; Keap1; Antioxidant response element
Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity
Keywords: buy1; Methylmercury; Nrf2; Keap1; Electrophile; Cyototoxicity
Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity
Keywords: buy1; Nrf2; Keap1; Arsenic; Arsenite; MMA(III); UROtsa
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
Keywords: buy1; Nrf2; Keap1; Alb-Cre; Conditional knockout mice; Acetaminophen; Hepatotoxicity; ARE; Phase2 enzymes; GST; UGT
Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
Keywords: buy1; ARE; Antioxidant-responsive element; BHA; Butylated hydroxyanisole; BTB; Broad complex-tramtrack-bric-a-brac; bZip; Basic leucine zipper; CBP; CREB binding protein; C/EBPβ; CCAAT/enhancer binding protein β; CNC; Cap' n' collar; Cox2; Cyclooxygenase
Ultraviolet A Irradiation Induces NF-E2-Related Factor 2 Activation in Dermal Fibroblasts: Protective Role in UVA-Induced Apoptosis
Keywords: buy1; apoptosis; Keap1; Nrf2; UVA;
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome
Keywords: buy1; Nrf2; Keap1; Degradation; Proteasome; Ubiquitination;
Redox regulation of the transcriptional repressor Bach1
Keywords: buy1; AP-1; activator protein-1; ARE; antioxidant responsive element; Bach1; BTB and CNC homology; bZIP; basic leucine zipper; CNC; Cap'n'Collar; EMSA; electrophoretic mobility shift assay; GCS; γ-glutamylcysteine synthetase; GFP; green fluorescent protein