Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells

► Silencing KEAP1 in NSCLC cells results in sensitization to chemotherapeutic agents. ► Knockdown of KEAP1 augments expression of PPARγ and cell differentiation-related genes. ► Deficiency of KEAP1 leads to elevated induction of PPARγ in response to As2O3. ► PPARγ agonists augment As2O3-induced cytotoxicity in NSCLC cells. ► NRF2 and KEAP1 are involved in the regulation of PPARγ expression.