Expression of KRAS in the endometrium of early pregnant mice and its effect during embryo implantation
Keywords: endometrium; implantation; KRAS; pregnancy;
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Lung adenocarcinoma: Sustained subtyping with immunohistochemistry and EGFR, HER2 and KRAS mutational status
Keywords: Lung; EGFR; KRAS; HER2; Immunohistochemistry; Adenocarcinomas
Sp1 transcription factor: A long-standing target in cancer chemotherapy
Keywords: Anticancer drugs; Prognosis; Sp1; Sp3; Transcription factors; Targeted therapy; AMPKα; AMP-activated protein kinase alpha catalytic subunit; Bcl-2; B cell/lymphoma 2; Bcl-w; member of the Bcl-2 family; Bid; BH3 interacting domain death agonist; CDK; cycl
Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells
Keywords: EGFR; KRas; GSK-3; Drug resistance; Cancer stem cells; Metformin; miRs
Predictive and Prognostic Markers in the Treatment of Metastatic Colorectal Cancer (mCRC)
Keywords: Colorectal cancer; BRAF; KRAS; NRAS; Biomarker;
Clinical relevance of KRAS mutations in codon 13: Where are we?
Keywords: Anti-EGFR therapies; Codon 12 and 13; Colorectal cancer; KRAS
Gene mutations in small-cell lung cancer (SCLC): Results of a panel of 6 genes in a cohort of Italian patients
Keywords: SCLC; Gene mutations; EGFR; c-MET; BRAF; KRAS; PDGFRa; c-KIT
Effectiveness of erlotinib treatment in advanced KRAS mutation-negative lung adenocarcinoma patients: Results of a multicenter observational cohort study (MOTIVATE)
Keywords: Non-small cell lung cancer; Lung adenocarcinoma; KRAS; EGFR; Mutation status; Erlotinib;
EGFR, KRAS, BRAF-mutations and microsatellite instability are absent in goblet cell carcinoids of the appendix
Keywords: Goblet cell carcinoid; EGFR; KRAS; BRAF; MSI; Pyrosequencing;
Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras
Keywords: Apc, adenomatous polyposis coli; CRC, colorectal cancer; GEM, genetically engineered mouse; CAC, carbonic anhydrase 1-coupled Cre transgene; SI, small intestineColorectal cancer; Apc; Mouse model; Tumor; Adenoma; Kras
Silver nanoparticles induced changes in the expression of NF-κB related genes are cell type specific and related to the basal activity of NF-κB
Keywords: NF-κB; nuclear factor kappa B; AgNPs; silver nanoparticles; NRF2; nuclear factor (erythroid-derived 2)-like 2; KEAP1; kelch like-ECH-associated protein 1; KRAS; kirsten rat sarcoma viral oncogene; Gene expression; Luciferase; Reporter assay; Cell signali
Does KRAS mutational status predict chemoresistance in advanced non-small cell lung cancer (NSCLC)?
Keywords: KRAS; Advanced non-small cell lung cancer; Platinum-based chemotherapy; Chemoresistance; Tumor aggressiveness; Specific point mutations
EGFR mutated non-small cell lung cancer patients: More prone to development of bone and brain metastases?
Keywords: NSCLC; EGFR; KRAS; Brain metastases; Bone metastases; Survival;
Ganetespib, a Novel Hsp90 Inhibitor in Patients With KRAS Mutated and Wild Type, Refractory Metastatic Colorectal Cancer
Keywords: Ganetespib; HSP 90; Metastatic colorectal cancer; KRAS; Single agent
Comparison of KRAS mutation analysis of primary tumors and matched circulating cell-free DNA in plasmas of patients with colorectal cancer
Keywords: Colorectal cancer; EGFR; KRAS; Mutation; PNA-mediated PCR;
Adenoma and carcinoma components in colonic tumors show discordance for KRAS mutation
Keywords: KRAS; Colon carcinoma; Adenoma-carcinoma sequence; Discordance; Targeted therapy
Intermediate serrated polyp as an intermediate lesion of hyperplastic polyp and sessile serrated polyp/adenoma in terms of morphological and molecular features
Keywords: Serrated lesion; BRAF; KRAS; CpG island locus; DNA methylation;
The Prognostic Impact of KRAS, Its Codon and Amino Acid Specific Mutations, on Survival in Resected Stage I Lung Adenocarcinoma
Keywords: Lung cancer; KRAS; Survival; lobectomy;
Alterations of LKB1 and KRAS and risk of brain metastasis: Comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma
Keywords: NSCLC; Brain Metastasis; Prognostic model; LKB1; KRAS;
Clinical Outcome With Platinum-Based Chemotherapy in Patients With Advanced Nonsquamous EGFR Wild-Type Non–Small-Cell Lung Cancer Segregated According to KRAS Mutation Status
Keywords: ALK; EGFR; KRAS; Non–small-cell lung cancer; Platinum-based chemotherapy
Mutation of TP53 and Alteration of p14arf Expression in EGFR- and KRAS-Mutated Lung Adenocarcinomas
Keywords: EGFR; KRAS; Lung adenocarcinoma; p53; p14arf
COPD-related adenocarcinoma presents low aggressiveness morphological and molecular features compared to smoker tumours
Keywords: COPD; Adenocarcinoma; Morphological pattern; KRAS; Ki-67/MIB1; Basophils in blood
RAS mutations and cetuximab in locally advanced rectal cancer: Results of the EXPERT-C trial
Keywords: Rectal cancer; Cetuximab; RAS; KRAS; NRAS; BRAF; Neoadjuvant chemotherapy
A let-7 microRNA polymorphism in the KRAS 3â²-UTR is prognostic in oropharyngeal cancer
Keywords: Oropharyngeal cancer; HPV; Prevalence; Prognostic biomarker; Genetic polymorphisms; miRNA; KRAS;
Knockdown or inhibition of aldo-keto reductase 1B10 inhibits pancreatic carcinoma growth via modulating Kras-E-cadherin pathway
Keywords: AKR1B10; KRAS; E-cadherin; Migration; Invasion; Pancreatic adenocarcinoma;
No evidence of oncogenic KRAS mutations in squamous cell carcinomas of the anogenital tract and head and neck region independent of human papillomavirus and p16INK4a status
Keywords: KRAS; BRAF; p16INK4a; HPV; Anogenital; Head and neck
BRAF/KRAS gene sequencing of sebaceous neoplasms after mismatch repair protein analysis
Keywords: Muir-Torre syndrome; Lynch syndrome; Sebaceous neoplasms; Mismatch repair genes; KRAS; BRAF; Microsatellite instability;
Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer
Keywords: CRC; colorectal cancer; APC; adenomatous polyposis coli; KRAS; Kirsten rat sarcoma viral oncogene homolog; TP53; tumor protein p53; IDH1; isocitrate dehydrogenase 1 (NADPÂ +), soluble; IDH2; isocitrate dehydrogenase 2 (NADPÂ +), mitochondrial; DNMT3A; DNA
Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer
Keywords: PI3K; MEK; KRAS; Colorectal cancer; Mouse model of cancer
miR-223: An inflammatory oncomiR enters the cardiovascular field
Keywords: AAA; Abdominal Aortic Aneurysm; AML; Acute Myeloid Leukemia; Apo-E KO; Apolipoprotein-E Knock-Out; C/EBP; CCAAT-Enhancer-Binding Proteins; CKD; Chronic Kidney Disease; D-HF; Diabetic Heart-Failure; DMD; Duchenne Muscular Dystrophy; E2F1; E2F transcription
Antitumor Efficacy of the Anti-Interleukin-6 (IL-6) Antibody Siltuximab in Mouse Xenograft Models of Lung Cancer
Keywords: IL-6; STAT3; Siltuximab; KRAS; Lung cancer;
Mutually exclusive FGFR2, HER2, and KRAS gene amplifications in gastric cancer revealed by multicolour FISH
Keywords: Multicolour FISH; Gastric cancer; Gene amplification; KRAS; FGFR2; HER2
A High Content Clonogenic Survival Drug Screen Identifies MEK Inhibitors as Potent Radiation Sensitizers for KRAS Mutant Non-Small-Cell Lung Cancer
Keywords: Drug screen; Radiation; Clonogenic survival assay; KRAS; Lung cancer;
Plk1-targeted therapies in TP53- or RAS-mutated cancer
Keywords: Polo-like kinase 1; p53; KRAS; Prognosis; Tissue distribution; Structure
Serrated lesions of the appendix frequently harbor KRAS mutations and not BRAF mutations indicating a distinctly different serrated neoplastic pathway in the appendix
Keywords: Appendix; Serrated polyp; Hyperplastic polyp; Sessile serrated adenoma; KRAS; BRAF
GNAS mutation as an alternative mechanism of activation of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type ★
Keywords: Gastric adenocarcinoma of the fundic gland type; CTNNB1; AXIN; APC; GNAS; KRAS; Mutation
Combined Assessment of Endothelial Growth Factor Receptor Dual Color In Situ Hybridization and Immunohistochemistry with Downstream Gene Mutations in Prediction of Response to the Anti-EGFR Therapy for Patients with Metastatic Colorectal Cancer
Keywords: EGFR therapy; DISH; KRAS; BRAF; PIK3CA; NRAS; Colon cancer
Extracellular ATP is internalized by macropinocytosis and induces intracellular ATP increase and drug resistance in cancer cells
Keywords: Warburg effect; Cancer metabolism; Nonhydrolyzable fluorescent ATP; Receptor tyrosine kinase; Kras
From mice to men: GEMMs as trial patients for new NSCLC therapies
Keywords: AdCre; adenovirus Cre recombinase; ALK; anaplastic lymphoma kinase; ANGPTL3; angiopoietin-like 3; Ccsp; Clara cell secretory protein; GEMMs; genetically engineered mouse models; HSP; heat shock family; IN; intranasal; LentiCre; lentivirus Cre recombinase;
DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer
Keywords: PanIN; Kras; Notch; Acetylated TubulinAcTub, acetylated α-tubulin; ADM, acinar-to-ductal metaplasia; Dclk1, doublecortin and Ca2+/calmodulin-dependent kinase-like 1; FACS, fluorescence-activated cell sorting; GFP, green fluorescent protein; mPanIN, murine
FOLFOX4 With Cetuximab vs. UFOX With Cetuximab as First-Line Therapy in Metastatic Colorectal Cancer: The Randomized Phase II FUTURE Study
Keywords: Chemotherapy; EGFR antibody; KRAS; Oxaliplatin; UFT;
Ribonucleoprotein HNRNPA2B1 Interacts With and Regulates Oncogenic KRAS in Pancreatic Ductal Adenocarcinoma Cells
Keywords: Signal Transduction; Carcinogenesis; Oncogene; Mouse Model; AKT; c-akt murine thymoma oncogene homolog 1; FCS; fetal calf serum; GFP; green fluorescent protein; GTP; guanosine triphosphate; HA; hemagglutinin; hnRNP; heterogeneous nuclear ribonucleoprotein
KRAS oncogene substitutions in Korean NSCLC patients: Clinical implication and relationship with pAKT and RalGTPases expression
Keywords: KRAS; pAKT; RalGTPases; NSCLC; RalA; RalB;
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
Keywords: PI3K pathway; Targeted therapy; Predictive biomarkers; 4EBP1; 4E-binding protein 1; AKT; protein kinase-B; AMPK; AMP-activated protein kinase; COSMIC; Catalogue of Somatic Mutations in Cancer; eIF4E; eukaryotic initiation factor 4E; ERK; extracellular-sig
Intratumoral heterogeneity of KRAS mutation is rare in non-small-cell lung cancer
Keywords: KRAS; Non-small cell lung cancer; Heterogeneity; Mutation analysis;
The interplay between epigenetic silencing, oncogenic KRas and HIF-1 regulatory pathways in control of BNIP3 expression in human colorectal cancer cells
Keywords: 5-Aza-2â²-deoxycytidine; BNIP3; Colorectal cancer; HIF-1; Hypoxia; KRas;
HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53
Keywords: HSP27; HSP72; Oncogene induced senescence (OIS); TP53; KRAS; Activated PI3K/AKT;
p16INK4A, p53, EGFR expression and KRAS mutation status in squamous cell cancers of the anus: Correlation with outcomes following chemo-radiotherapy
Keywords: Anal cancer; Chemo-radiotherapy; HPV; KRAS; p16INK4A;
Microsatellite pathologic score does not efficiently identify high microsatellite instability in colorectal serrated adenocarcinoma
Keywords: Colorectal serrated adenocarcinoma; Microsatellite instability; KRAS; BRAF; MsPath score;
Adequacy of CT-guided biopsies with histomolecular subtyping of pulmonary adenocarcinomas: Influence of ATS/ERS/IASLC guidelines
Keywords: TTNB; Trans-Thoracic Needle core Biopsy; ALK; Anaplastic Lymphoma Kinase; FISH; Fluorescent In Situ Hybridization; CISH; Chromogenic In Situ Hybridization; EGFR; Epidermal Growth Factor Receptor; TKI; Tyrosine Kinase Inhibitor; FNA; Fine Needle Aspiration