دانلود مقالات ISI درباره Kras + ترجمه فارسی

Concordant and Discordant EGFR Mutations in Patients With Multifocal Adenocarcinomas: Implications for EGFR-Targeted Therapy

Keywords: Non-small cell lung cancer; Minimally invasive adenocarcinoma; Bronchioloalveolar carcinoma; Multifocal adenocarcinoma; EGFR (epidermal growth factor receptor); KRAS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations

Keywords: ERK; KRAS; BRAF; Mutations; Colorectal carcinoma; Immunohistochemistry;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Droplet digital PCR of circulating tumor cells from colorectal cancer patients can predict KRAS mutations before surgery

Keywords: Digital PCR; KRAS; Circulating tumor cells; Colorectal cancer; Liquid biopsy;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Identification and characterization of a new G-quadruplex forming region within the kRAS promoter as a transcriptional regulator

Keywords: G-quadruplex; kRAS; Transcriptional control; Cancer therapeutics

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Mutation spectra of RAS gene family in colorectal cancer

Keywords: Colorectal cancer; KRAS; NRAS; HRAS; Survival;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Colorectal poorly differentiated neuroendocrine carcinomas frequently exhibit BRAF mutations and are associated with poor overall survival

Keywords: Colorectal; Neuroendocrine carcinoma; Mixed adenoneuroendocrine carcinoma; BRAF; KRAS; MSI; Overall survival

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Deep Sequencing Analysis Reveals That KRAS Mutation Is a Marker of Poor Prognosis in Patients with Pulmonary Sarcomatoid Carcinoma

Keywords: Pulmonary sarcomatoid tumor; Pulmonary carcinosarcoma; Next-generation sequencing; KRAS; Survival probability;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Low incidence of KRAS, BRAF, and PIK3CA mutations in adenocarcinomas of the ampulla of Vater and their prognostic value

Keywords: Ampulla of Vater; Adenocarcinoma; KRAS; BRAF; PIK3CA; Mutation; Prognosis;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

Keywords: pancreatic cancer; PanIN; Kras; oxidative stress; mitochondria; growth factor signaling

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewLung cancer mutation profile of EGFR, ALK, and KRAS: Meta-analysis and comparison of never and ever smokers

Keywords: Lung cancer; Never smokers; EGFR; ALK; KRAS; Mutation;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

KRAS-related proteins in pancreatic cancer

Keywords: PDAC; pancreatic ductal adenocarcinoma; KRAS; Kirsten rat sarcoma viral oncogene; GEMM; genetically engineered mouse model; SB_PDAC; Sleeping Beauty insertional mutagenesis model of pancreatic cancer; GAP; GTPase activating protein; GEF; guanine nucleotid

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

KRAS Engages AGO2 to Enhance Cellular Transformation

Keywords: cancer; KRAS; EIF2C2; Argonaute 2; RNA silencing

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

Keywords: intravital imaging; FRAP; E-cadherin; Src-kinase; pancreatic cancer; invasion and metastasis; cell adhesion and migration; Kras; p53;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Mucinous adenocarcinoma arising from a residual supratentorial neurenteric cyst and expressing mutated KRAS: a case report

Keywords: Adenocarcinoma; Neurenteric cyst; Recurrence; Immunohistochemistry; KRAS; Mutation;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

Detection of KRAS mutations using double-stranded toehold-exchange probes

Keywords: DNA; Mutation; Toehold-exchange Probe; KRAS;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2016 سفارش ترجمه

Clinicopathological, Immunohistochemical, and Genetic Features of Primary Lung Adenocarcinoma Occurring in the Setting of Usual Interstitial Pneumonia Pattern

Keywords: UIP; IPF; Pulmonary fibrosis; Adenocarcinoma; EGFR; KRAS;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

A Randomized, Phase II Trial of Cetuximab With or Without PX-866, an Irreversible Oral Phosphatidylinositol 3-Kinase Inhibitor, in Patients With Metastatic Colorectal Carcinoma

Keywords: Combination therapy; EGFR; KRAS; PI3K; PIK3CA;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

G4 DNA in ras genes and its potential in cancer therapy

Keywords: KRAS; HRAS; NRAS; G-quadruplex; Antigene strategies; Promoter; 5′-UTR;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2016 سفارش ترجمه

An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy

Keywords: AA; Ascorbic acid; AEM1; ARE expression modulator 1; AEG1; Astrocyte elevated gene-1; Akt; Protein kinase B; AMPK; AMP-activated protein kinase; APL; Acute promyelocytic leukemia; ARE; Antioxidant response element; ATO; Arsenic trioxide; Bach; BTB and CNC

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis

Keywords: ACACB; acetyl-CoA carboxylase beta acetyl-CoA carboxylase beta; ACAT1; acetyl-CoA acetyltransferase 1; ACLY; ATP citrate lyase; AMPK; 5′AMP-activated protein kinase; ASCL1; acyl-CoA synthetase long-chain family member 1; ACSL4; acyl CoA synthetases long

دانلود رایگان متن کامل مقاله ISI 80 صفحه سال انتشار : 2016 سفارش ترجمه

GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report

Keywords: Intraductal papillary neoplasm; Pancreas neoplasm; Bile duct neoplasm; GNAS; KRAS; IPMN;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Activating mutations in the RAS/mitogen-activated protein kinase signaling pathway in sporadic trichoblastoma and syringocystadenoma papilliferum

Keywords: HRAS; KRAS; BRAF; Trichoblastoma; Syringocystadenoma papilliferum

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

KRAS, NRAS, BRAF mutations and high counts of poorly differentiated clusters of neoplastic cells in colorectal cancer: observational analysis of 175 cases

Keywords: BRAF; colorectal cancer; KRAS; NRAS; poorly differentiated clusters;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Somatic c.34G>T KRAS mutation: a new prescreening test for MUTYH-associated polyposis?

Keywords: MUTYH; adenomatous polyposis; colorectal cancer; MUTYH-associated polyposis; KRAS

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

PD-L1 is highly expressed in lung lymphoepithelioma-like carcinoma: A potential rationale for immunotherapy

Keywords: Driver mutation; Immunotherapy; PD-L1; Pulmonary lymphoepithelioma-like carcinoma; Lung cancer; EGFR; KRAS;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Structural dataset for the fast-exchanging KRAS G13D

Keywords: KRAS; GTPase; Cancer; X-ray crystallography

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

KRAS as a predictor of poor prognosis and benefit from postoperative FOLFOX chemotherapy in patients with stage II and III colorectal cancer

Keywords: KRAS; Adjuvant chemotherapy; Colorectal cancer; FOLFOX;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

An update on clinicopathological, immunohistochemical, and molecular profiles of colloid carcinoma of the lung

Keywords: Anaplastic lymphoma kinase; Colloid carcinoma; Epidermal growth factor; Fluorescence in situ hybridization; KRAS

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

AZD6244 inhibits cisplatin-induced ERK1/2 activation and potentiates cisplatin-associated cytotoxicity in K-ras G12D preclinical models

Keywords: Bcl2-like 11 (BIM); MEK1/2 inhibitor; Cisplatin; KRAS; NSCLC

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Is diagnosing cardio-facio-cutaneous (CFC) syndrome still a challenge? Delineation of the phenotype in 15 Polish patients with proven mutations, including novel mutations in the BRAF gene

Keywords: Cardio-facio-cutaneous syndrome; CFC; BRAF; MEK1; MEK2; KRAS; Genotype–phenotype; Novel mutation

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Mutations of p53 and KRAS activate NF-κB to promote chemoresistance and tumorigenesis via dysregulation of cell cycle and suppression of apoptosis in lung cancer cells

Keywords: p53; KRAS; NF-κB; Chemoresistance; Lung cancer

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Comparison of HER2 gene amplification and KRAS alteration in eyelid sebaceous carcinomas with that in other eyelid tumors

Keywords: Eyelid; Sebaceous carcinoma; HER2; KRAS; Amplification

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

A mutation spectrum that includes GNAS, KRAS and TP53 may be shared by mucinous neoplasms of the appendix

Keywords: Appendiceal mucinous neoplasm; TP53; GNAS; KRAS; Mismatch repair gene; Mutation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

HER2 expression and markers of phosphoinositide-3-kinase pathway activation define a favorable subgroup of metastatic pulmonary adenocarcinomas

Keywords: ADCa; denocarcinoma of the lung; ALKa; naplastic lymphoma kinase; (p)AKT; (phospho-)protein kinase B; bpb; ase pair; BRAF; V-Raf murine sarcoma viral oncogene homolog B; (C/F/D)ISH; (chromogenic/fluorescence/dual color) in-situ hybridization; cMETh; epato

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Genetic Evidence for XPC-KRAS Interactions During Lung Cancer Development

Keywords: Lung cancer; XPC; Kras; ROS

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Low Grade Serous Ovarian Carcinoma: From the molecular characterization to the best therapeutic strategy

Keywords: Ovarian cancer; Low-Grade Serous; KRAS; BRAF; Chemoresistance; MEK-inhibitors;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia

Keywords: Autophagy; Intrahepatic cholangiocarcinoma; Biliary intraepithelial neoplasia (BilIN); KRAS; Microtubule-associated proteins light chain 3 beta (LC3); Beclin-1; p62/sequestosome-1

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Profiling of Oncogenic Driver Events in Lung Adenocarcinoma Revealed MET Mutation as Independent Prognostic Factor

Keywords: Lung cancer; EGFR; KRAS; ALK; HER2; BRAF; MET; ROS1; RIT1; TTF-1 lung adenocarcinoma; NRAS; Driver mutations; Oncogenic driver mutation; East Asian lung cancer; MET amplification; Targeted therapy; Genetic marker; Biomarker; Molecular classification lung

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Outcomes by Tumor Histology and KRAS Mutation Status After Lung Stereotactic Body Radiation Therapy for Early-Stage Non–Small-Cell Lung Cancer

Keywords: Early stage; KRAS; Non–small-cell lung cancer; Stereotactic body radiotherapy

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Mutant KRAS as a critical determinant of the therapeutic response of colorectal cancer

Keywords: Colorectal cancer; EGFR; KRAS; Synthetic lethality; Targeted therapy

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor

Keywords: Dual inhibition; Akt; ERK; PI-3 Kinase; MEK1; MAP Kinase; Oncogenic signaling; KRAS; Driven oncogenesis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of miR-143 as a tumour suppressor in nasopharyngeal carcinoma based on microRNA expression profiling

Keywords: Nasopharyngeal carcinoma; Signalling pathway; miR-143; KRAS; Tumour growth

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells

Keywords: TAK1; KRAS; Colorectal cancer; Thioredoxin; Treatment resistance

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Optimization of melting analysis with TaqMan probes for detection of KRAS, NRAS, and BRAF mutations

Keywords: Mutation scanning; DNA melting analysis; TaqMan probes; KRAS; NRAS; BRAFDMA, DNA melting analysis; HRMA, high-resolution melting analysis; Tm, melting temperature; PCR, polymerase chain reaction; FFPE, formalin-fixed paraffin-embedded

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

KRAS Status as an Independent Prognostic Factor for Survival after Yttrium-90 Radioembolization Therapy for Unresectable Colorectal Cancer Liver Metastases

Keywords: CEA; carcinoembryonic antigen; CI; confidence interval; CRC; colorectal cancer; EGFR; epidermal growth factor receptor; KRAS; Kirsten rat sarcoma viral oncogene homolog; OS; overall survival; wt; wild-type; 90Y; yttrium-90;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Prevalence of RAS mutations and individual variation patterns among patients with metastatic colorectal cancer: A pooled analysis of randomised controlled trials

Keywords: Panitumumab; mCRC; RAS prevalence; KRAS; NRAS; BRAF;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Location of colon cancer (right-sided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17

Keywords: Colon cancer; Proximal; Distal; Cetuximab; KRAS; EGFR inhibition;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

FOLFOX4 plus cetuximab treatment and RAS mutations in colorectal cancer

Keywords: Cetuximab; FOLFOX4; KRAS; NRAS; OPUS; RAS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

CHAMP: A Phase II Study of Panitumumab With Pemetrexed and Cisplatin Versus Pemetrexed and Cisplatin in the Treatment of Patients With Advanced-Stage Primary Nonsquamous Non-Small-Cell Lung Cancer With Particular Regard to the KRAS Status

Keywords: Epidermal growth factor receptor; KRAS; Non-small cell lung cancer; Panitumumab; Pemetrexed/cisplatin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Meta-analysis of Epidermal Growth Factor Receptor and KRAS Gene Status between Primary and Corresponding Metastatic Tumours of Non-small Cell Lung Cancer

Keywords: Epidermal growth factor receptor; KRAS; metastasis; non-small cell lung cancer; primary tumour;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه