Keywords: Colorectal cancer (CRC); Biomarkers; KRAS; Monoclonal antibodies (mAbs); Oncotype; Epigenetic markers;
مقالات ISI (ترجمه نشده)
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Keywords: CSC; cancer stem cells; PDAC; pancreatic ductal adenocarcinoma; TSC; tissue stem cells; Insulin; Diabetes; β cells; KRAS; LGR5; Nanog;
Keywords: Lung adenocarcinoma; Terminal respiratory unit (TRU); MUC5B; MUC5AC; EGFR; KRAS; Prognosis
Keywords: KRAS; Lung; Young; Molecular; EGFR; ALK; BRAF; Non-small cell lung carcinoma; Fine needle aspiration
Keywords: EGFR; epidermal growth factor receptor; NSCLC; non-small cell lung cancer; TKI; tyrosine kinase inhibitor; WT; wild type; KRAS; Kirsten RNA associated rat sarcoma 2 virus gene; PTEN; phosphatase and tensin homolog; HGF; hepatocyte growth factor; IGF1R; in
Keywords: Metastatic lung adenocarcinoma; Histopathology; EGFR; KRAS;
Keywords: Asia; Chemotherapy; Epidermal growth factor receptor (EGFR)-specific monoclonal antibody; KRAS; Targeted therapy;
Keywords: Lung cancer; Non-small-cell lung cancer; Never smokers; Epidermal growth factor receptor; EGFR; Anaplastic lymphoma kinase; ALK; KRAS;
Keywords: PIK3CA; KRAS; IDH; MET; Biliary;
Keywords: A2M; alpha-2-macroglobulin; AMACR; alpha-methylacyl-CoA racemase; APOA1; apolipoprotein A-I; AR; androgen receptor; BCL2L1; BCL2-like 1; CAT; catalase; CCNA2; cyclin A2; CCND2; cyclin D2; CCNE1; cyclin E1; CEL; carboxyl ester lipase (bile salt-stimulated
Keywords: 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; ADAM23; ADAM metallopeptidase domain 23; ADAMTS9; ADAM metallopeptidase with thrombospondin type 1 motif, 9; ARID1A; AT rich interactive domain 1A (SWI-like); AML; Acute myelocytic leukemia; ATBF1; A
Keywords: PCR; Cancer; Colorectal; NRAS; KRAS; Lung
Keywords: Somatic mutation; KRAS; lung cancer; next generation sequencing; data mining
Keywords: Serrated polyps; serrated polyposis; appendix; KRAS; BRAF; CIMP
Keywords: Rectal cancer; KRAS; VEGF; Biomarkers; Prognosis
Cetuximab Combined With Induction Oxaliplatin and Capecitabine, Followed by Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer: SWOG 0713
Keywords: Chemotherapy; Cooperative group trial; KRAS; pCR; Phase II;
The presence of KRAS, PPP2R1A and ARID1A mutations in 101 Chinese samples with ovarian endometriosis
Keywords: KRAS; PPP2R1A; ARID1A; Cancer-associated genes; Mutations; Ovarian endometriosis;
Effect of mutant variants of the KRAS gene on PD-L1 expression and on the immune microenvironment and association with clinical outcome in lung adenocarcinoma patients
Keywords: KRAS; PD-L1; Immune microenvironment; Lung adenocarcinoma;
KRAS: Reasons for optimism in lung cancer
Keywords: KRAS; NSCLC; RAS; Non-small cell lung cancer; G12C;
Radiogenomics and IR
Keywords: ALK; anaplastic lymphoma kinase; BAP1; BRCA1-associated protein 1; EGFR; epidermal growth factor receptor; HCC; hepatocellular carcinoma; HIF1a; hypoxia-inducible factor-1-alpha; KDM5C; lysine-specific demethylase 5C; KRAS; Kirsten rat sarcoma viral oncog
Identification of key microRNAs, transcription factors and genes associated with congenital obstructive nephropathy in a mouse model of megabladder
Keywords: CON; Congenital obstructive nephropathy; DEMs; Differentially expressed miRNAs; PPI; Protein-protein interaction; Vegfa; Vascular endothelial growth factor A; Nr4a2; Nuclear receptor subfamily 4, group A, member 2; Jdp2; Jun dimerisation protein 2; Klf6;
Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells
Keywords: Apc; adenomatous polyposis coli; CRC; colorectal cancer; DLD-1; Daniel L. Dexter derived 1; FAD; flavin adenine dinucleotide; 18F-FSPG; (S)-4-(3-[18F]-fluoropropyl)-L-glutamic acid; GLUT-1; glucose transporter 1; KO; knockout; KRAS; Kirsten rat sarcoma vi
PICCA study: panitumumab in combination with cisplatin/gemcitabine chemotherapy in KRAS wild-type patients with biliary cancer-a randomised biomarker-driven clinical phase II AIO study
Keywords: Bilary cancer; Chemotherapy; Panitumumab; Genetic profiling; KRAS; EGFR;
Oncogenic KRAS suppresses store-operated Ca2+ entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines
Keywords: Calcium signalling; STIM; KRAS; Colorectal cancer; ERK; SOCE/ICRAC;
KRAS-Mutant non-small cell lung cancer: From biology to therapy
Keywords: BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete
Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-κB-GCN2/eIF2α signaling pathway in mammary epithelial cells in vitro and in vivo
Keywords: IFN-γ; Interferon gamma; Arg; Arginine; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B cells; GCN2; general control nonderepressible 2; eIF2α; eukaryotic initiation factor 2; BMECs; bovine mammary epithelial cells; BC; breast cancer; R
Eucalyptus microcorys leaf extract derived HPLC-fraction reduces the viability of MIA PaCa-2 cells by inducing apoptosis and arresting cell cycle
Keywords: 7-AAD; 7-aminoactinomycin D; ABTS; 2,2â²-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid; ANOVA; analysis of variance; ATM; ataxia telangiectasia mutated; Bak; Bcl-2 homologous antagonist killer; Bax; Bcl-2-associated protein; Bcl-2; B-cell lymphoma 2;
Dasatinib sensitises KRAS-mutant cancer cells to mitogen-activated protein kinase kinase inhibitor via inhibition of TAZ activity
Keywords: Dasatinib; Trametinib; KRAS; TAZ;
Long-term survival with erlotinib in advanced lung adenocarcinoma harboring synchronous EGFR G719S and KRAS G12C mutations
Keywords: NSCLC; EGFR; KRAS; Erlotinib; NGS;
Recurrently Mutated Genes Differ between Leptomeningeal and Solid Lung Cancer Brain Metastases
Keywords: Non-small cell lung cancer; Leptomeningeal metastases; Whole exome sequencing; KRAS; EGFR;
CT features of HER2-mutant lung adenocarcinomas
Keywords: Lung adenocarcinoma; Radiogenomics; Multidetector computed tomography; HER2; EGFR; KRAS;
Baseline and On-Treatment Characteristics of Serum Tumor Markers in Stage IV Oncogene-Addicted Adenocarcinoma of the Lung
Keywords: Serum tumor marker; CEA; CA125; CA199; CA2729; Non-small cell lung cancer; EGFR; KRAS; ROS1; ALK;
Intratumoral morphological heterogeneity can be an indicator of genetic heterogeneity in colorectal cancer
Keywords: Colorectal cancer; KRAS; Heterogeneity; Morphology; Sequencing;
Combination of Kras activation and PTEN deletion contributes to murine hepatopancreatic ductal malignancy
Keywords: PTEN; Kras; Cholangiocarcinoma; Pancreatic cancer; ICC; Intrahepatic cholangiocarcinoma; HCC; hepatocellular carcinoma; ECC; extrahepatic bile duct carcinoma; PanIN; premalignant pancreatic intraepithelial neoplasms; PDAC; pancreatic ductal adenocarcinoma
Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC
Keywords: ALK; cMET; EGFR; KRAS; Non-small cell lung cancer;
Prognostic value of radiologically enlarged lymph nodes in patients with metastatic colorectal cancer: Subgroup findings of the randomized, open-label FIRE-3/AIO KRK0306 trial
Keywords: AJCC; American Joint Committee on Cancer; AP; alkaline phosphatase; BRAF; v-Raf murine sarcoma viral oncogene homolog B; CI; confidence interval; CRC; (colorectal cancer); CT; computed tomography; ECOG; Eastern Cooperative Oncology Group scale of performa
A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment
Keywords: KRAS; CRISPR-Cas13a; mRNA knockdown; Oncogenic mutation; Pancreatic cancer; Pancreatic ductal adenocarcinoma; PDAC; wild-type; WT; microbial clustered regularly interspaced short palindromic repeats; CRISPR; CRISPR-associated adaptive immune systems; CRIS
Porphyrins to restrict progression of pancreatic cancer by stabilizing KRAS G-quadruplex: In silico, in vitro and in vivo validation of anticancer strategy
Keywords: KRAS; G-quadruplex; Fluorescence intercalator displacement; Pancreatic cancer; Epithelial to messenchymal transition;
Pediatric-onset Evans syndrome: Heterogeneous presentation and high frequency of monogenic disorders including LRBA and CTLA4 mutations
Keywords: Autoimmune cytopenias; Immune checkpoint deficiencies; Extensive genetic screening; LRBA and CTLA-4 deficiencies; ES; Evans syndrome; AIHA; Autoimmune hemolytic anemia; ITP; Immune thrombocytopenia; ALPS; Autoimmune lymphoproliferative syndrome; CTLA-4; C
Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases: A systematic review of the current evidence
Keywords: Colorectal liver metastases; Gene; KRAS; BRAF; TP53; PIK3CA;
Prevalence and Clinicopathologic Significance of BRAF V600E Mutation in Chinese Multiple Myeloma Patients
Keywords: Hypercalcemia; KRAS; NRAS; Prognosis; Survival;
SMAD4 gene mutation predicts poor prognosis in patients undergoing resection for colorectal liver metastases
Keywords: Dorsophilia protein; Mothers against decapentaplegic homolog 4; Colorectal liver metastases; Colorectal cancer; Hepatectomy; KRAS; SMAD4; Dorsophilia protein, mothers against decapentaplegic homolog 4; CRC; colorectal cancer; CLM; colorectal liver metasta
Non-tumor adjacent tissue of advanced stage from CRC shows activated antioxidant response
Keywords: CRC; colorectal cancer; SIRT3; sirtuin 3; MSI; microsatellite instability; NRAS; neuroblastoma RAS viral oncogene homolog; BRAF; v-raf murine sarcoma viral oncogene homolog B; KRAS; Kirsten rat sarcoma viral oncogene homolog; PI3K; phosphatidylinositide 3
Ampullary carcinoma-A genetic perspective
Keywords: AVC; ampulla of vater carcinoma; KRAS; Kirsten rat sarcoma viral oncogene homolog; OS; overall survival; RFS; recurrence free survival; HER2; human epidermal growth factor receptor 2; BRAF; B rapidly activated fibrosarcoma; BRCA2; breast cancer 2; TP53; t
Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice
Keywords: Gene Regulation; Oncogene; Pancreas; Signal Transduction; ADM; acinar-to-ductal metaplasia; CCND1; cyclin D1; ChIP; chromatin immunoprecipitation; DMSO; dimethyl sulfoxide; IF; immunofluorescence; IHC; immunohistochemical; KLF; Krüppel-like factor; KRAS;
ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway
Keywords: Akt; oncogene in the transforming retrovirus, AKT8; AP-1; activator protein 1; ARAF; v-raf murine sarcoma 3611 viral oncogene homologue; ASK1; apoptosis signal-regulating kinase 1; BCL2; B-cell lymphoma 2; BCL-XL; B-cell lymphoma extra large; BRAF; v-raf
Mutation analysis and copy number changes of KRAS and BRAF genes in Taiwanese cases of biliary tract cholangiocarcinoma
Keywords: BRAF; cholangiocarcinoma; KRAS; mutation; survival;
Modulation of RAB5A early endosome trafficking in response to KRas mediated macropinocytic fluxes in pancreatic cancer cells
Keywords: Pancreatic cancer; KRas; Endosome; Rab5; Degradation;
The role of RAS mutations in MLL-rearranged leukaemia: A path to intervention?
Keywords: ALL; acute lymphoblastic leukaemia; iALL; infant ALL; MLL; myeloid/lymphoid leukaemia or mixed lineage leukaemia, also known as KMT2A; RAS; rat sarcoma; BCP-ALL; B-cell precursor ALL; EFS; event-free survival; OS; overall survival; WBC; white blood cell c
Research paperLKB1/STK11 mutations in non-small cell lung cancer patients: Descriptive analysis and prognostic value
Keywords: Non-small cell lung cancer; LKB1/STK11; Advanced stage; Mutations; KRAS; Prognostic biomarker;