The interplay between epigenetic silencing, oncogenic KRas and HIF-1 regulatory pathways in control of BNIP3 expression in human colorectal cancer cells

- 5-Aza-dC-mediated BNIP3 expression is uniquely dependent on the activity of Ras (85).
- Ras dominates over HIF-1 in the control of 5-aza-dC mediated BNIP3 expression in CRC (85).
- 5-Aza-dC-mediated and Ras-dependent BNIP3 expression results in 5-FU-resistance (83).