دانلود مقالات ISI درباره Lbd + ترجمه فارسی

Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR

Keywords: Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2018 سفارش ترجمه

Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment

Keywords: AI; aromatase inhibitor; AF; activation function; CBR; clinical benefit rate; CDK; cyclin-dependent kinase; CYP; cytochrome P450; DES; diethylstilbesterol; E2; 17β estradiol; ESR1; gene encoding estrogen receptor alpha; ER; estrogen receptor; ERE; estrog

دانلود رایگان متن کامل مقاله ISI 128 صفحه سال انتشار : 2018 سفارش ترجمه

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner

Keywords: 5-HT; 5-hydroxytryptamine; Aβ; β-amyloid; ABCA8; ATP binding cassette subfamily A member 8; AD; Alzheimer's disease; ADP; adenosine diphosphate; AGD; argyrophilic grain disease; ALS; amyotrophic lateral sclerosis; AMBRA-1; autophagy and beclin 1 regul

دانلود رایگان متن کامل مقاله ISI 131 صفحه سال انتشار : 2018 سفارش ترجمه

Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients

Keywords: AAS; atomic absorption spectroscopy; AD; Alzheimeŕs disease; LBs; Lewy bodies; LBD; Lewy body disease; PD; Parkinsońs disease; SN; substantia nigra; Brain; Iron; AAS; Parkinsońs disease; Lewy body disease;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

SRC2-3 binds to vitamin D receptor with high sensitivity and strong affinity

Keywords: VDR; vitamin D receptor; LBD; ligand-binding domain; DRIP; vitamin D receptor interacting protein; SRC; steroid receptor coactivator; SPR; surface plasmon resonance; AF2; activation-function 2; Vitamin D; Nuclear receptor; Coactivator; SRC2-3; Surface pla

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Structural basis for differential activities of enantiomeric PPARγ agonists: Binding of S35 to the alternate site

Keywords: PPAR; peroxisome proliferator-activated receptor; LBD; ligand-binding domain; LBP; ligand-binding pocket; TZD; thiazolidinedione; Cdk5; cyclin-dependent kinase 5; SRC-1; steroid receptor coactivator-1; r.m.s.; root-mean-square; Crystal structure; Alternat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists

Keywords: FXR; farnesoid X receptor; CDCA; chenodeoxycholic acid; CYP7A1; cholesterol 7α-hydroxylase; SHP; small heterodimer partner; RXRα; retinoid X receptor α; 9-cis-RA; 9-cis-retinoic acid; LBD; ligand binding domain; TR-FRET; time-resolved fluorescence reso

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor

Keywords: β-ABA; β-aminobutyric acid; β-AIBA; β-aminoisobutyric acid; GlyR; glycine receptor; LBD; ligand-binding domain; MBS; Modified Barth's Saline; Popen; probability of channel being open; SEM; standard error of the mean; τ; dwell-time; TM; transmembran

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

GRIN2B gain of function mutations are sensitive to radiprodil, a negative allosteric modulator of GluN2B-containing NMDA receptors

Keywords: GRIN2B; Mutation; Encephalopathy; Electrophysiology; Radiprodil; NMDA inhibitors; ANOVA; analysis of variance; ATD; amino-terminal domain; DMSO; dimethyl sulfoxide; LBD; ligand-binding domain; NAM; negative allosteric modulator; NMDA; N-methyl-d-aspartate

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular insights on xenoestrogenic potential of zearalenone-14-glucoside through a mixed in vitro/in silico approach

Keywords: Masked mycotoxins; Zearalenone; Risk assessment; Human estrogen receptor; MCF-7 cell lines; E2; 17-β-estradiol; ER; Estrogen receptor; LBD; Ligand binding domain; ZEN; Zearalenone; ZEN14Glc; Zearalenone-14-glucoside; ZEN14GlcA; Zearalenone-14-glucuronid

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Cloning and expression characterization of peroxisome proliferator-activated receptors (PPARs) with their agonists, dietary lipids, and ambient salinity in rabbitfish Siganus canaliculatus

Keywords: ARA; Arachidonic acid (20:4n-6); AF1; Activation function 1; AF2; Activation function 2; ALA; α-linolenic; cDNA; Complementary deoxyribonucleic acid; DHA; Docosahexaenoic acid (22:6n-3); DBD; DNA-binding domain; DMEM/F12; Dulbecco's Modified Eagle Medium

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Different epigenetic mechanisms of ERα implicated in the fate of fulvestrant-resistant breast cancer

Keywords: Breast cancer; Fulvestrant; Estrogen receptor α; DNA methylation; Endocrine therapy resistance; AI; aromatase inhibitor; AE; anti-estrogen; ERα; estrogen receptor α; ERE; estrogen-response element; E2; estradiol; GFP; green fluorescent protein; LBD; li

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor

Keywords: BA; bile acid; CA; cholic acid; CDCA; chenodeoxycholic acid; CYP; cytochrome P450; DCA; deoxycholic acid; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid, obeticholic acid; FXR; farnesoid X receptor; LBD; ligand binding domain; LCA; lithocholic acid; PXR; pregna

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Importance of 5/6-aryl substitution on the pharmacological profile of 4ʹ-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1ʹ-biphenyl]-2-carboxylic acid derived PPARγ agonists

Keywords: Peroxisome proliferator-activated receptor γ; Pharmacological profile; Coactivator recruitment; Transactivation assay; Molecular modeling; H; helix; LBD; ligand binding domain; PDB; Protein Data Bank; PPAR; peroxisome proliferator-activated receptor; PPR

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain

Keywords: NMDA receptor; Positive allosteric modulator; Transmembrane domain; ATD; amino terminal domain; iGluR; ionotropic glutamate receptor; LBD; ligand-binding domain; NAM; negative allosteric modulator; PAM; positive allosteric modulator; TMD; transmembrane do

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

OsLBD37 and OsLBD38, two class II type LBD proteins, are involved in the regulation of heading date by controlling the expression of Ehd1 in rice

Keywords: LBD; Heading date; Rice;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor

Keywords: VDR; vitamin D receptor; RXRα; retinoid X receptor α; LBD; ligand binding domain; VDRE; vitamin D responsive element; LucN; N-terminal domain of luciferase; LucC; C-terminal domain of luciferase; Vitamin D receptor; Bioluminescent sensor; Split lucifera

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Iminoenamine based novel androgen receptor antagonist exhibited anti-prostate cancer activity in androgen independent prostate cancer cells through inhibition of AKT pathway

Keywords: Prostate cancer; T877A; Androgen receptor antagonist; Bicalutamide; LNCaP; Apoptosis; AR; Androgen receptor; DHT; Dihydrotestosterone; AIPC; Androgen Independent Prostate Cancer; LBD; Ligand Binding Domain; R-BIC; R-Bicalutamide; ETS; Erythroblast Transfo

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Therapeutic applications of thyroid hormone analogues in resistance to thyroid hormone (RTH) syndromes

Keywords: Thyroid hormone; Thyroid hormone analogues; Resistance to thyroid hormone; RTH-Beta; AHDS; MCT8; Triac; Tetrac; DITPA; TH; thyroid hormone; T3; 3,3′,5-triiodothyronine; TR; T3-receptors; RTH; resistance to thyroid hormone; Triac; 3,3′,5-triiodothyroac

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Characterization of rodent constitutively active estrogen receptor α variants and their constitutive transactivation mechanisms

Keywords: AF-1; activation function-1; AF-2; activation function-2; AR; androgen receptor; CTERP; C-terminally-truncated estrogen receptor α product; E2; 17β-estradiol; ERα; estrogen receptor α; ERα66; 66-kDa estrogen receptor α; ERαΔ5; Δexon 5 estrogen re

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

In vivo and in silico studies to identify mechanisms associated with Nurr1 modulation following early life exposure to permethrin in rats

Keywords: 3-PBA; 3-phenoxybenzoic acid; BBB; blood-brain barrier; DNMTs; DNA methyltransferases; EDTA; ethylenediaminetetraacetic acid; LBD; Ligand Binding Domain; MSP; Methylation-Specific PCR; NOAEL; No Observed Adverse Effect Level; NuIP; Nurr1-interacting pro

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

RNAi suppression of nuclear receptor genes results in increased susceptibility to sulfoxaflor in brown planthopper, Nilaparvata lugens

Keywords: AHR; aryl hydrocarbon receptor; BLAST; basic local alignment search tool; CAR; constitutive androstane receptor; CYP; cytochrome P450; DBD; DNA-binding domain; ERR; estrogen-related receptor; EST; expressed sequence tag; GR; glucocorticoid receptor; HNF4;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular cloning of ESR2 and gene expression analysis of ESR1 and ESR2 in the pituitary gland of the Chinese alligator (Alligator sinensis) during female reproductive cycle

Keywords: ESRs; estrogen receptors; ERα/ESR1; estrogen receptor alpha; ERβ/ ESR2; ESTROGEN receptor beta; cDNA; DNA complementary to RNA; mRNA; Messenger RNA; PCR; polymerase chain reaction; RT; reverse transcription; qPCR; quantitative real-time PCR; 3D; three d

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of novel inverse agonists of estrogen-related receptors ERRγ and ERRβ

Keywords: ERRs; estrogen-related receptors; ER; estrogen receptor; NRs; nuclear receptors; LBD; ligand-binding domain; SAR; structureactivity relationship; MCAD; medium-chain acyl coenzyme A dehydrogenase; IC50; half maximal inhibitory concentration; Estrogen-relat

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2017 سفارش ترجمه

Application of nanocrystalline CdTe quantum dots in chemical analysis: Implementation of chemo-sensing schemes based on analyte-triggered photoluminescence modulation

Keywords: EDC; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; EMIDCA; 1-ethyl-3-methylimidazolium dicyanamide; Phen; 1,10-phenanthroline; BQ; 1,4-benzoquinone; MEA; 2-mercaptoethylamine; MPA; 3-mercaptopropionic acid; 4AT; 4-amino-2,2,6,6-tetramethylpiperidine-N-ox

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2017 سفارش ترجمه

Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents

Keywords: Estrogen-related receptor α; ERRα; Nuclear receptor; Anti-diabetic; Metabolic syndrome; Indazole; Thiazolidenedione; TZD; Insulin resistance; ERR; estrogen-related receptor; ER; estrogen receptor; ERE; estrogen response element; ERRE; estrogen-related r

دانلود رایگان متن کامل مقاله ISI 73 صفحه سال انتشار : 2017 سفارش ترجمه

Radioligand binding assay for accurate determination of nuclear retinoid X receptors: A case of triorganotin endocrine disrupting ligands

Keywords: ATRA; all-trans retinoic acid; Bmax; maximal binding capacity (pmol/mg); DNA; deoxyribonucleic acid; DR; direct repeat; DTT; 1,4-dithiothreitol; FXR; farnesoid X receptor; Ka; affinity (l/mol); LBD; ligand-binding domain; LXR; liver X receptor; PMSF; phen

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

BAP1 Germline Mutations in Finnish Patients with Uveal Melanoma

Keywords: BAP1; BRCA1-associated protein-1; BRCA1; breast cancer 1; CI; confidence interval; ExAC; Exome Aggregation Consortium; LBD; largest basal diameter; TNM; Tumor, Node, Metastasis classification; UCSC; University of California Santa Cruz;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewThe phenotype and function of murine bone marrow-derived dendritic cells is not affected by the absence of VDR or its ability to bind 1α,25-dihydroxyvitamin D3

Keywords: 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; BMDC; bone marrow-derived dendritic cell; DC; dendritic cell; VDR; vitamin D receptor; DBD; DNA binding domain; LBD; ligand binding domain; RXR; retinoid X receptor; VDRE; vitamin D response element; MHC-II; majo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

A novel, fully-automated, chemiluminescent assay for the detection of 1,25-dihydroxyvitamin D in biological samples

Keywords: LBD; ligand binding domain; VDBP; vitamin D binding protein; 25-(OH)D; 25 hydroxyvitamin D; 1,25-(OH)2D; 25-dihydroxyvitamin D; VDR; vitamin D receptor; VDRE; vitamin D response element; LOQ; limit of quantitation; LOB; limit of blank; Mab; monoclonal ant

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies

Keywords: FXR; farnesoid X receptor; HDX-MS; hydrogen deuterium exchange mass spectrometry; MetS; metabolic syndromes; SHP; small heterodimer partner; BSEP; bile salt export pump; LBD; ligand binding domain; XN; xanthohumol; IX; isoxanthohumol; 8-PN; 8-prenylnarige

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Basic ScienceType 2 diabetes mitigation in the diabetic Goto-Kakizaki rat by elevated bile acids following a common-bile-duct surgery

Keywords: T2DM; type 2 diabetes mellitus; FXR; farnesoid-X receptor; LBD; ligation of the common bile duct and external biliary drainage; GK; Goto-Kakizaki; RYGB; Roux-en-Y gastric bypass; VSG; vertical sleeve gastrectomy; PEPCK; phosphoenolpyruvate carboxykinase

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4

Keywords: FLU; flutamide; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; CYP; cytochrome P450; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; 3-MC; 3-methylcholanthrene; ABCC4; ATP-binding cassette sub-family C member 4; MRP4; mul

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

The antiproliferative and proapoptotic effects of cladosporols A and B are related to their different binding mode as PPARγ ligands

Keywords: CAD; caspase-activated deoxyribonuclease; CRC; colorectal cancer; HR-ESI-MS; high resolution electrospray ionization mass; LBD; ligand-binding domain; MDA; malondialdehyde; NCoEx; nuclear corepressor exchange factor; PPARs; peroxisome proliferator-activat

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

New telmisartan-derived PPARγ agonists: Impact of the 3D-binding mode on the pharmacological profile

Keywords: PPARγ; Transactivation; Cytotoxicity; Binding mode; Molecular modeling; Amax; maximum intrinsic activity; BPO; benzoyl peroxide; DMEM; Dulbecco's modified Eagle medium; LBD; ligand binding domaine; mp; melting point; NBS; N-bromosuccinimide; PPAR; peroxi

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor

Keywords: CAS; chemical abstracts service; CYP24A1; cytochrome P450 24A1; DMSO; dimethyl sulfoxide; hRXRα; human retinoid X receptor alpha; hSRC-1; human steroid receptor coactivator-1; hVDR; human vitamin D receptor; mVDR; mouse vitamin D receptor; LBD; ligand-bi

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2016 سفارش ترجمه

The triterpene echinocystic acid and its 3-O-glucoside derivative are revealed as potent and selective glucocorticoid receptor agonists

Keywords: GCs; glucocorticoids; GR; glucocorticoid receptor; SEGRA; selective glucocorticoid receptor agonist; EA; echinocystic acid; EA-3G; echinocystic acid 3-O-glucoside; PEPCK; phosphoenolpyruvate carboxykinase; NF-κB; nuclear factor kappa beta; TNF α; tumour

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects

Keywords: NO; nitric oxide; NO2; dioxide radical; O2; superoxide; ONO2−;  peroxynitrite; 15-dPGJ2; 15-deoxy-Δ12,14-prostaglandin J2; AA; arachidonic acid; ADH; alcohol dehydrogenase; AF-1; ligand-independent activation function; AF-2; ligand-dependent activatio

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2016 سفارش ترجمه

ATF3 inhibits PPARγ-stimulated transactivation in adipocyte cells

Keywords: aP2; adipocyte fatty acid binding protein; ATF3; activation transcription factor 3; ATF/CRE; ATF/CREB responsive element; ChIP; chromatin immunoprecipitation; ER; endoplasmic reticulum; LBD; ligand-binding domain; PPARγ; peroxisome proliferator activated

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

The unfulfilled gene and nervous system development in Drosophila

Keywords: Burs; bursicon; CCAP; crustacean cardioactive peptide; DBD; DNA-binding domain; EH; eclosion hormone; fax-1; fasciculation of axons defective-1; GFP; green fluorescent protein; KC; Kenyon cells; LBD; ligand-binding domain; MARCM; mosaic analysis with a re

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Hazard identification of cis/trans-zearalenone through the looking-glass

Keywords: cis-zearalenone; In silico analysis; Detoxification; Mycotoxins; Hazard characterization; Bioactivity assessment; ER; estrogen receptor; LBD; ligand binding domain; ZEN; zearalenone; ZHD; lactono hydrolase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of evodiamine as the bioactive compound in evodia (Evodia rutaecarpa Benth.) fruit extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ)

Keywords: COX-2; cyclooxygenase-2; ERK; extracellular signal-regulated kinase; EGFR; epidermal growth factor receptor; FABP1; human fatty acid binding protein 1; HMGCS2; 3-hydroxy-3-methylglutaryl-CoA synthase 2; HPRT1; hypoxanthine phosphoribosyltransferase; LBD;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618

Keywords: PPARβ/δ; Antagonist; Covalent; Cys249; LC-MS/MS; PPAR; peroxisome proliferator-activated receptor; LC-MS; liquid chromatography - mass spectrometry; LBD; ligand-binding domain; LBP; ligand-binding pocket; ABC; ammonium bicarbonate;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity

Keywords: VDR; vitamin D receptor; LBD; ligand-binding domain; 1α,25-(OH)2D3; 1α,25-dihydroxyvitamin D3; SERM; selective estrogen receptor modulator; ERα; estrogen receptor α; PPARγ; peroxisome proliferator-activated receptor γ; Vitamin D; Nuclear receptor; X

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

A step ahead of PPARγ full agonists to PPARγ partial agonists: Therapeutic perspectives in the management of diabetic insulin resistance

Keywords: DIO mouse; diet-induced obesity mouse; LBD; ligand-binding domain; PPAR; peroxisome proliferator-activated receptor; RXR; retinoid X receptor; SGK-1; serum/glucocorticoid-regulated kinase-1; T2DM; type 2 diabetes mellitus; ZDF rat; Zucker Diabetic Fatty r

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Different binding and recognition modes of GL479, a dual agonist of Peroxisome Proliferator-Activated Receptor α/γ

Keywords: PPAR; Peroxisome Proliferator-Activated Receptor; LBD; ligand binding domain; DMSO; dimethyl sulfoxide; GL479; (E)-2-methyl-2-(4-(2-(4-(phenyldiazenyl)phenoxy)ethyl)phenoxy)propanoic acid; DTT; dithiothreitol; IPTG; Isopropyl β-D-1-thiogalactopyranoside;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Evolution of a novel nuclear receptor subfamily with emphasis on the member from the Pacific oyster Crassostrea gigas

Keywords: NR; nuclear receptor; NR1-NR8; nuclear receptor subfamily 1-8; CgNR8A1; a member of NR8 subfamily group A from Crassostrea gigas; LBD; ligand binding domain; DBD; DNA binding domain; DR0-DR5; a direct repeat of the half-site AGGTCA separated by 0-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Tunicate pregnane X receptor (PXR) orthologs: Transcript characterization and natural variation

Keywords: AF-1; transcription activation function 1; AR; androgen receptor; BsVDR/PXRα; Botryllus schlosseri VDR/PXR ortholog α; BSA; bovine serum albumin; bp; base pair; CAR; constitutive androstane receptor; CiVDR/PXRα; Ciona intestinalis VDR/PXR ortholog α;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently

Keywords: CMV; cytomegalovirus; DBD; DNA-binding domain; GAL4; yeast regulatory protein GAL4; hPXR; human PXR; LBD; ligand-binding domain; NR1I2; nuclear receptor subfamily 1 group I member 2, a. k. a pregnane X receptor; pbPXR; polar bear PXR; PXR; pregnane X rece

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Pharmacological activation of PPAR gamma ameliorates vascular endothelial insulin resistance via a non-canonical PPAR gamma-dependent nuclear factor-kappa B trans-repression pathway

Keywords: Ang II; angiotensin II; BMI; body mass index; CH; total cholesterol; DMEM; Dulbecco׳s modified Eagle׳s medium; eNOS; endothelial nitric oxide synthase; ET-1; endothelin-1; FBS; fetal bovine serum; FINS; fasting serum insulin; FPG; fasting plasma glucose

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه