دانلود مقالات ISI درباره Lck + ترجمه فارسی

سیناپس ایمونولوژیک به عنوان هدف دارویی

The immunological synapse as a pharmacological target

Keywords: AP-1; activating protein 1; APC; antigen presenting cell; CAR; chimeric antigen receptors; Cbl-b; casitas B-lineage lymphoma; DAG; diacylglycerol; cSMAC; central supramolecular activation cluster; CTLA4; cytotoxic T lymphocyte antigen 4; dSMAC; distal sup

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2018 سفارش ترجمه

امکان سنجی واکسیناسیون پپتید شخصی برای سرطان های پیشرفته کوچک سلول های ریه

Feasibility Study of Personalized Peptide Vaccination for Advanced Small Cell Lung Cancer

Keywords: Epitope spreading; IgG; Lck; PPV; SCLC;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

نقش پازوپنیب بر آنژیوژنز تومور و در مدیریت سرطان: بررسی

The role of pazopanib on tumour angiogenesis and in the management of cancers: A review

Keywords: VEGF; Vascular Endothelial Growth Factor; MMP; Matrixmetalloproteinases; uPAR; UrokinasePlasminogen Activator Receptor; Ang-1; Angiotensin-1; TGF-β; Transforming Growth Factor-β; VEGFR; Vascular Endothelial Growth Factor Receptor; TKI; Tyrosine Kinase I

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

ریبوزوم های میتوکندری در سرطان

Mitochondrial ribosomes in cancer

Keywords: AIPC; Androgen-independent prostate cancer; AKAP1; cAMP signaling; AML; acute myeloid leukemia; BAK; Bcl-2 homologous antagonist killer; BAX; Bcl-2-associated X protein; BCL-2; B-cell lymphoma 2; BMRP; BCL-2 interacting mitochondrial ribosomal protein; C7

دانلود رایگان متن کامل مقاله ISI 66 صفحه سال انتشار : 2017 سفارش ترجمه

اثر متابولیسم و ​​تنظیم کننده واسطه های پراکسیداسیون لیپید در سلول های بتای پانکراس

Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells

Keywords: Beta cells; Diabetes; Eicosanoids; Fatty aldehyde dehydrogenase; Glutathione peroxidase; Glutathione-S-transferase4-hydroxyalkenals; 4-Hydroxynonenal; Lipid peroxidation; Phospholipase A; 12-HETE (PubChem CID: 5283155); 15-HETE (PubChem CID: 280724); 4-HN

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2016 سفارش ترجمه

هدف قرار دادن پاسخ شوک گرما در ترکیب با پرتودرمانی: حساسیت سلول های سرطانی به مرگ سلولی ناشی از اشعه و افزایش ایمنی بدن آنها

Targeting the heat shock response in combination with radiotherapy: Sensitizing cancer cells to irradiation-induced cell death and heating up their immunogenicity

Keywords: 17-AAG; 17-(Allylamino)-17-demethoxygeldanamycin; 17-DMAG; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin; AKT; v-akt murine thymoma viral oncogene homolog; APC; antigen presenting cell; ATM; Ataxia telangiectasia mutated; ATR; Ataxia telangiectasia

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2015 سفارش ترجمه

دوگانگی عملکرد آنتاگونیستی ژن های سرطانی

Antagonistic functional duality of cancer genes

Keywords: BCR-ABL; breakpoint cluster region-Abelson tyrosine-protein kinase; CD95/FAS; cluster of differentiation 95/cell surface death receptor; DDR1; discoidin domain receptor tyrosine kinase 1; EGFR; epidermal growth factor receptor tyrosine kinase; EF1A2; euka

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Exploration of the therapeutic aspects of Lck: A kinase target in inflammatory mediated pathological conditions

Keywords: LCK; T-cell signaling; Inflammatory disorders; Cancer;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

New insights into the Vav1 activation cycle in lymphocytes

Keywords: Exchange factors; Rac1; JNK; NFAT; Lck; Src family; Zap70; Lat; Phospholipase Cγ; Slp76; Protein tyrosine phosphatases; T cell receptor; B cell receptor; Phosphosites; Conformational states; Signaling diversification; Lymphocytes;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

TCR crosslinking promotes Crk adaptor protein binding to tyrosine-phosphorylated CD3ζ chain

Keywords: T cell activation; TCR/CD3 crosslinking; CD3ζ chain; Crk adaptor proteins; Tyrosine phosphorylation; Signal transduction; C3G; Crk SH3 domain-binding guanine nucleotide-releasing factor; Crk; CT10 (chicken tumor virus number 10) regulator of kinase; CrkL

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Grouper (Epinephelus coioides) TCR signaling pathway was involved in response against Cryptocaryon irritans infection

Keywords: Epinephelus coioides; Cryptocaryon irritans; CD3ε; Lck; Fyn; ZAP70;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Crk adaptor proteins regulate CD3ζ chain phosphorylation and TCR/CD3 down-modulation in activated T cells

Keywords: Abl; Abelson tyrosine kinase; C3G; Crk SH3 domain-binding guanine nucleotide-releasing factor; Cbl; Casitas B-lineage lymphoma; CD3ζY1-6F; CD3ζ mutant in which all 6 tyrosines were replaced by phenylalanine; Crk; CT10 (chicken tumor virus number 10) reg

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Src-family tyrosine kinases and the Ca2 + signal

Keywords: 5-HT6; serotonin receptor 6; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxylic acid; ADPR; ADP-ribose; AMPA; α-amino-3-hydr

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2017 سفارش ترجمه

Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders

Keywords: LCK; FMS; Inflammation; Synthesis; Molecular docking and RAW 264.7 macrophages;

دانلود رایگان متن کامل مقاله ISI 86 صفحه سال انتشار : 2017 سفارش ترجمه

A novel homolog of protein tyrosine kinase Fyn identified in Lampetra japonica with roles in the immune response

Keywords: Fyn; Proto-oncogene tyrosine-protein kinase Fyn; Lja-Fyn; Fyn-like of Lampetra japonica; RACE; Rapid Amplification of cDNA Ends; qPCR; Real-time quantitative PCR detecting system; Src; Proto-oncogene tyrosine-protein kinase Src; Yes; Yamaguschi sarcoma vi

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

A hydrogen peroxide safety valve: The reversible phosphorylation of catalase from the freeze-tolerant North American wood frog, Rana sylvatica

Keywords: Akt; Protein kinase B; AMPK; Adenosine monophosphate-activated protein kinase; cAMP; Cyclic adenosine monophosphate; CAMK; Calmodulin dependent kinase; Cdc2; Cyclin dependent kinase 1; Cdk5; Cyclin dependent kinase 5; cGMP; Cyclic guanidine monophosphate;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway

Keywords: PYGM; glycogen phosphorylase muscle isoform; Lck; lymphocyte-specific protein tyrosine kinase; PLCγ; phospholipase; PI3K; phosphatidylinositide 3-kinase; AKs; Janus kinases; STAT; signal transducer and activator of transcription; GEF; Guanine Nucleotide

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation

Keywords: Akt; protein kinase B; ANP; atrial natriuretic peptide; CaMKII; Ca2 +/calmodulin-dependent protein kinase II; CHP3; calcineurin B homologous protein 3; DAPI; 4′,6-diamidino-2-phenylindole dihydrochloride; DMEM; Dulbecco's modified Eagle's medium; FBS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

The Src tyrosine kinase Lck binds to CD2, CD4-1, and CD4-2 T cell co-receptors in channel catfish, Ictalurus punctatus

Keywords: Catfish; T lymphocytes; Co-receptors; Lck; CD2; T cell signaling;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

The role of CRAC channel in asthma

Keywords: Asthma; Lymphocytes; CRAC channel; Orai channels NF-AT; ACQ; asthma control questionnaire; BAL; bronchoalveolar lavage; CRAC; calcium released activated channel; Dex; dexamethasone; ELISA; enzyme linked immunosorbent assay; FEV; forced expiratory volume;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2015 سفارش ترجمه

GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis

Keywords: Gal-1; galectin-1; TCR; T-cell receptor; HeLamock; mock transfected HeLa cells; HeLaGal-1; Gal-1 transfected HeLa cells; β-CD; β-cyclodextrin; CTX-FITC; cholera toxin B subunit - fluorescein isothiocyanate; Galectin-1; Lck; CD45; GM1; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine

Keywords: α-KG; α-ketoglutarate; AML; acute myeloid leukemia; APOBEC; apolipoprotein B mRNA-editing enzyme complex; ARP; aldehyde reactive probe; β-GT; β-glucosyl transferase; 5-caC; 5-carboxylcytosine; 5-cadCyd; 5-carboxyl-2′-deoxycytidine; C; cytosine; C5-M

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2014 سفارش ترجمه

Sequestosome1/p62: A regulator of redox-sensitive voltage-activated potassium channels, arterial remodeling, inflammation, and neurite outgrowth

Keywords: AP-1; activator protein-1; ARE; antioxidant response element; CDK; cyclin-dependent kinase; EGF; epidermal growth factor; ERK1/2; extracellular regulated kinase 1/2; HNE; 4-hydroxynonenal; HO-1; heme oxygenase-1; IL-1; interleukin-1; Keap1; Kelch-like ECH

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Tau protein kinases: Involvement in Alzheimer's disease

Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; Arg; Abl-related gene; SFK; Src family kinase; Aβ; β-amyloid; BBB; blood brain barrier; LD50; lethal dose 50; c-Abl; c-Abelson; Cables; c-Abl-binding adaptator protein; CaMKII; Ca2+/calmodulin-dep

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2013 سفارش ترجمه

Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis

Keywords: 7-AAD; 7-amino-actinomycin D; Atf2; activating transcription factor 2; Csk; C-terminal Src kinase; Erk; extracellular-signal-regulated kinase; FCB; fluorescent cell barcoding; FSC; forward scatter; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; IL-2; in

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2013 سفارش ترجمه

X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase

Keywords: GBDUVEXHPMNVRW-UHFFFAOYSA-N; UJXIKUVGGQECLJ-UHFFFAOYSA-N; FVSUKLKFSDSIEF-UHFFFAOYSA-N; OHAIFZDRLDEOAC-UHFFFAOYSA-N; PVCKRSKEOOWVMP-UHFFFAOYSA-N; LXMWGYNOGUKODT-UHFFFAOYSA-N; CQZZZUNOWZUNNG-UHFFFAOYSA-N; YBKODNZGBUDZRA-UHFFFAOYSA-N; Itk; interleukin-2-indu

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells

Keywords: TCR; T-cell antigen receptor; MHC; major histocompatibility complex; ZAP-70; zeta-associated protein kinase of 70 kD; IL; interleukin; JAK; Janus kinase; SOCS; suppressor of cytokine signaling; CIS; cytokine-inducible SH2-containing protein; NFAT; nuclea

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Mycobacterium tuberculosis ManLAM inhibits T-cell-receptor signaling by interference with ZAP-70, Lck and LAT phosphorylation

Keywords: Tuberculosis; Immune evasion; T-cell; Signal transduction; LAT; Lck; Zap70; Lipid raft; Glycolipid; ManLAM

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Prohibitin-1 deficiency promotes inflammation and increases sensitivity to liver injury

Keywords: Phb; prohibitin; MCDD; methionine and choline deficient diet; LPS; bacterial lipopolysaccharide; PP2A; protein phosphatase 2 A; GSK; glycogen synthase kinase; ETF; electron transfer flavoportein; ADH; aldehyde dehydrogenase; AMPK; AMP kinase; IPA; Ingenui

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: Suppression of serine/threonine and tyrosine kinases

Keywords: AP-1; activator protein 1; C3-toxin; Clostridium botulinum C3 transferase; CE; cytoplasmic extracts; Cox2; cyclooxygenase 2; ICAM; intercellular adhesion molecule; NF-κB; nuclear transcription factor kappaB; IL; interleukin; IκB; inhibitory subunit of N

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Atlantic halibut experimentally infected with nodavirus shows increased levels of T-cell marker and IFNγ transcripts

Keywords: T-cell receptor; TCRβ; CD4; CD4-2; CD8α; CD8β; Lck; ZAP-70; Interleukin; IL-1β; IL-6; IL-11; IL-12β; IFNγ; Toll like receptor; TLR7; ISG15; Mx; Teleost; Fish; NNV; AHNV; VER; Concanavalin A; PMA; ConA; Imiquimod;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleDown-regulation of intra-hepatic T-cell signaling associated with GB virus C in a HCV/HIV co-infected group with reduced liver disease

Keywords: GBV-C; GB virus C; HCV; hepatitis C virus; HIV; human immunodeficiency virus; AIDS; acquired immunodeficiency syndrome; HBV; hepatitis B virus; PBMCs; peripheral blood mononuclear cells; DOK2; docking protein 2; LCK; lymphocyte-specific protein tyrosine k

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The effects of membrane compartmentalization of csk on TCR signaling

Keywords: DRM, detergent-resistant membrane; SFKs, src-family kinases; LAT, linker for activation of T cells; Csk, C-terminal Src kinase; OFP, orange fluorescent protein; LM, laurylmaltosideLipid rafts; T-cell receptor; Lck; Csk

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Expression of T-cell markers during Atlantic halibut (Hippoglossus hippoglossus L.) ontogenesis

Keywords: Teleost; T-cell receptor; Recombination activation gene; CD3; CD4; CD8; Lck; ZAP-70; T-cell development; T-cell maturation

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge

Keywords: ROS; reactive oxygen species; O2•−; superoxide; SOD2; manganese superoxide dismutase; IAV; influenza A virus; ONOO−; peroxynitrite; •OH; hydroxyl radical; SOD1; copper/zinc superoxide dismutase; SOD3; extracellular superoxide dismutase; SOD2−/âˆ

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Zinc-dependent binding between peptides derived from rainbow trout CD8α and LCK

Keywords: Rainbow trout; CD8α; CD8β; LCK; Cytoplasmic tail; Zinc clasp; Surface plasmon resonance binding assay

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Role of lymphocyte-specific protein tyrosine kinase (LCK) in the expansion of glioma-initiating cells by fractionated radiation

Keywords: LCK, lymphocyte-specific protein tyrosine kinase; siRNA, small interfering RNAFractionated radiation; LCK; Glioma stem-like cells; Resistance to anticancer treatments

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase

Keywords: C-mip; PI3 kinase; Lck; DIP1; DAP-kinase; ERK signaling;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Analysis of novel phospho-ITAM specific antibodies in a S2 reconstitution system for TCR–CD3 signalling

Keywords: BCR, B cell antigen receptor; ITAM, immunoreceptor tyrosine activation motif; TCR–CD3, T cell antigen receptor; WB, Western blottingPhosphorylation; TCR signalling; Lck; Fyn; S2 cells; EM-26

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

The lipid-modulating effects of a CD4-specific recombinant antibody correlate with ZAP-70 segregation outside membrane rafts

Keywords: ADAP; adhesion- and degranulation-promoting adapter protein; Carma1; caspase-recruitment domain [CARD]-membrane-associated guanylate kinase [MAGUK] protein 1; CDR3; complementary determining region 3; GM1; ganglioside M1; GC; gas chromatography; HER2; hum

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Disubstituted pyrimidines as Lck inhibitors

Keywords: Lck; Src; Protein tyrosine kinase; Autoimmune disease; Rheumatoid arthritis; Pyrimidine

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Bacterial expression and purification of Interleukin-2 Tyrosine kinase: Single step separation of the chaperonin impurity

Keywords: Kinase; Bacterial expression; Purification; Chaperonin; Itk; Lck; Src

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Activation of Lck is critically required for sphingosine-induced conformational activation of Bak and mitochondrial cell death

Keywords: Lck; lymphocyte-specific protein tyrosine kinase; DiOC6(3); 3,3′dihexyloxacarbocyanine iodide; TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; Sphingolipid metabolites; Sphingosine-induced mitochondrial cell death; Bak-dependent cell dea

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Reduced expression of SRC family kinases decreases PI3K activity in NBS1−/− lymphoblasts

Keywords: PI3K; NBS1; SFK; LCK; HCK

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses

Keywords: Protein tyrosine phosphatase (PTP); PTP-PEST; PTPN12; Lck; T cell activation

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes

Keywords: LAT; Lck; Syk; Zap70; T lymphocytes

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

A proline to glycine mutation in the Lck SH3-domain affects conformational sampling and increases ligand binding affinity

Keywords: SH3 domain; Lck; Ligand affinity; Molecular dynamics; Conformational sampling

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Nonreceptor Tyrosine Kinases in Prostate

Keywords: Nonreceptor tyrosine kinase; prostate cancer; Src; FAK; ETK; Abl; v-Abl Abelson murine leukemia viral oncogene homolog; At; androgenindependent; Aid; v-akt murine thymoma viral oncogene homolog 1; AR; androgen receptor; ARG; Abelson-related gene; Bcr; bre

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Molecular and biochemical analysis of rainbow trout LCK suggests a conserved mechanism for T-cell signaling in gnathostomes

Keywords: Lck; T lymphocyte; Rainbow trout; Salmonid;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck)

Keywords: Kinase; Lck; Hck; Lymphocyte specific kinase; Hematopoietic cell kinase; Src family kinase; T cell

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه