کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8270639 1534977 2013 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sequestosome1/p62: A regulator of redox-sensitive voltage-activated potassium channels, arterial remodeling, inflammation, and neurite outgrowth
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Sequestosome1/p62: A regulator of redox-sensitive voltage-activated potassium channels, arterial remodeling, inflammation, and neurite outgrowth
چکیده انگلیسی
A stress-inducible protein sequestosome1 (SQSTM1) regulates H2O2-driven intracellular signaling pathways, including proliferation and migration of arterial smooth muscle cells, Th2 skewing T cell differentiation, and NGF-induced neurite outgrowth in PC12 cells. SQSTM1 regulates redox sensitive voltage-activated potassium (Kv) channels as a functional partner of atypical PKCs and tyrosine kinase p56Lck through two different signaling axes, PKCζ-SQSTM1-Kvβ and SQSTM1-Lck-Dlgh1-Kvα1.3. We discuss the hypothesis that SQSTM1 modulates interaction of Kv1.3 with β1 integrin, which plays a critical role in biological responses via these signaling axes.196
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 65, December 2013, Pages 102-116
نویسندگان
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