Keywords: Pattern-recognition receptors (PRRs); Toll-like receptors (TLRs); RIG-I-like receptors (RLRs); NOD-like receptors (NLRs); Small molecule modulators; BIR; baculovirus inhibitor repeat; CARD; caspase recruitment domains; CFS; chronic fatigue syndrome; CLR;
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Keywords: Ag; antigen; APC; antigen-presenting cells; AIV; avian influenza virus; BM; bone marrow; BALT; bronchus-associated lymphoid tissue; CG; chicken galectin; cLL; chicken lung lectin; CLR; C-type lectin receptors; DC; dendritic cells; DC-SIGN; DC-specific int
PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2
Keywords: LGP2; PACT; MDA5; Type-I interferon; RIG-I-like receptors; Picornavirus; Cardiovirus;
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection
Keywords: acLDL; acylated LDL; AIM2; absent in melanoma 2; AP-1; activator protein 1; BDCA-2; blood DC antigen; BEC; biliary epithelial cells; CARD; caspase recruitment and activation domains; cDC; common dendritic cells; CL-L1; collectin liver 1; CL-K1; collectin
The antiviral signaling mediated by black carp MDA5 is positively regulated by LGP2
Keywords: MDA5; LGP2; Black carp; Innate immunity;
The anticancer functions of RIG-I-like receptors, RIG-I and MDA5, and their applications in cancer therapy
Keywords: 5â²PP; 5â²-diphosphate; 5â²ppp; 5â²triphosphorylated; Bcl2; B-cell lymphoma-2; BIRC3; baculoviral IAP repeat-containing 3; CARDs; caspase activation and recruitment domains; CRC; colorectal cancer; CTD; C-terminal domain; CTLs; cytotoxic T lymphocytes
Identification, ontogeny and expression analysis of a novel laboratory of genetics and physiology 2 (LGP2) transcript in Asian seabass, Lates calcarifer
Keywords: Laboratory of genetics and physiology 2; LGP2; RLR; PRR; Asian seabass; Lates calcarifer; Bacterial infection; Poly I:C; Gene expression; Ontogeny;
LGP2 of black carp plays an important role in the innate immune response against SVCV and GCRV
Keywords: Black carp; LGP2; Innate immunity
Negative regulation of the antiviral response by grouper LGP2 against fish viruses
Keywords: LGP2; Grouper; Iridovirus; RGNNV; Interferon;
The evolution and functional characterization of miiuy croaker cytosolic gene LGP2 involved in immune response
Keywords: LGP2; Miiuy croaker; Expression; Molecular evolution; Immune response; Cellular localization;
Involvement of zebrafish RIG-I in NF-κB and IFN signaling pathways: Insights into functional conservation of RIG-I in antiviral innate immunity
Keywords: RIG-I; retinoic acid-inducible gene I; PRRs; pattern recognition receptors; IFN-I; type I IFN; TLRs; toll-like receptors; RLRs; retinoic acid-inducible gene I (RIG-I)-like receptors; MDA5; melanoma differentiation associated factor 5; LGP2; laboratory of
LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling
Keywords: Antiviral immunity; RIG-I-like receptors; MDA5; LGP2;
LGP2 plays extensive roles in modulating innate immune responses in Ctenopharyngodon idella kidney (CIK) cells
Keywords: Grass carp (Ctenopharyngodon idella); LGP2; RLR pathway; Grass carp reovirus; CIK cells
Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens
Keywords: MAVS; mitochondrial antiviral signaling gene; IFN; type I interferon; SNPs; single nucleotide polymorphisms; CDS; coding region; UTR; untranslated region; PRRs; pathogen recognition receptors; PAMPs; pathogen-associated molecular patterns; TLRs; toll-like
CpG methylation in the 5â²-flanking region of LGP2 gene lacks association with resistance/susceptibility to GCRV but contributes to the differential expression between muscle and spleen tissues in grass carp, Ctenopharyngodon idella
Keywords: Grass carp (Ctenopharyngodon idella); LGP2; DNA methylation; mRNA expression; Grass carp reovirus;
The intricate interplay between RNA viruses and NF-κB
Keywords: ss; single-stranded; ds; double-stranded; HTLV; human T cell leukemia virus; SARS; severe acute respiratory syndrome; IAVs; influenza A viruses; IFN; interferon; IRF3; interferon regulatory factor 3; NF-κB; nuclear factor κB; TLRs; toll-like receptors;
Human DExD/H RNA helicases: Emerging roles in stress survival regulation
Keywords: 5â²ppp; 5â² triphosphate; AMD; ARE-mediated mRNA decay; ARE; AU-rich element; ARE-BP; ARE-binding protein; CARD; caspase activation and recruitment domain; CCCP; carbonyl cyanide m-chlorophenyl hydrazone; CDN; cyclic dinucleotide; CRM1; Chromosome Maint
Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs
Keywords: Poly(I:C); polyinosinic-polycytidylic acid; RLRs; retinoic acid inducible gene I-like receptors; RIG-I; retinoic acid-inducible gene I; MDA-5; melanoma differentiation associated factor 5; LGP2; laboratory of genetics and physiology 2; Poly(I:C); Apopto
Strategies of highly pathogenic RNA viruses to block dsRNA detection by RIG-I-like receptors: Hide, mask, hit
Keywords: Innate immune system evasion; RIG-I; MDA5; LGP2; Viral dsRNA detection; Interferon alpha/beta;
Master sensors of pathogenic RNA – RIG-I like receptors
Keywords: 5′triphosphate RNA; Immunorecognition of RNA; RNA virus; RIG-I; MDA5; Lgp2; Intracellular bacteria
Update on the role of innate immune receptors during Brucella abortus infection
Keywords: TLR; Toll-like receptors; NLR; cytosolic nucleotide binding and oligomerization domain-like receptors; RLR; retinoic acid-inducible gene 1 (RIG-I)-like receptors; MDA5; melanoma differentiation associated gene 5; LGP2; laboratory of genetics and physiolog
Molecular characterisation of RIG-I-like helicases in the black flying fox, Pteropus alecto
Keywords: Innate immunity; Viral infection; Fruit bat; Pteropus alecto; RIG-I; mda5; LGP2;
Pathogen recognition receptors in channel catfish: II. Identification, phylogeny and expression of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs)
Keywords: Fish; Catfish; Retinoic acid-inducible gene I (RIG-I)-like receptors; RLRs; MDA5; LGP2; PRR; Pathogen recognition receptors; Immunity; Infection; Genome; Gene expression
Activation of Toll-like receptor 3 induces apoptosis of oral squamous carcinoma cells in vitro and in vivo
Keywords: TLR3; Toll-like receptor 3; dsRNA; double-stranded RNA; OSCC; oral squamous cell carcinoma; poly I:C; dsRNA-polyinosinic-polycytidilic acid; IFN-β; interferon-β; PRR; pattern recognition receptors; DCs; dendritic cells; siRNA; small interfering RNA; TUN
Transcriptional regulation of type I interferon gene expression by interferon regulatory factor-3 in Japanese flounder, Paralichthys olivaceus
Keywords: ATF2; activating transcription factor 2; BAC; bacterial artificial clone; CpG-ODN; cytosine-phosphate-guanosine oligodeoxynucleotides; dsRNA; double-strand RNA; IFN; interferon; IKKε; IκB kinase epsilon; IPS-1/MAVS/VISA/Cardif; IFN-β promoter stimulato
Toll-like receptors and macrophage activation in atherosclerosis
Keywords: TLR; Toll-like receptor; PAMP; Pathogen associated molecular pattern; LDL; Low density lipoprotein; SMC; Smooth muscle cell; VCAM-1; Vascular cell adhesion molecule-1; M-CSF; Macrophage colony stimulating factor; TCFA; Thin-cap fibroatheroma; MMP; Matrix
Identification and expression profiling analysis of grass carp Ctenopharyngodon idella LGP2 cDNA
Keywords: Grass carp (Ctenopharyngodon idella); LGP2; Gene cloning; mRNA expression; Grass carp reovirus
Innate immune evasion by hepatitis C virus and West Nile virus
Keywords: LGP2; IPS-1; IRF-3; MAVS; RIG-I; Interferon; JAK; STAT