کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8324642 | 1539915 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activation of Toll-like receptor 3 induces apoptosis of oral squamous carcinoma cells in vitro and in vivo
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کلمات کلیدی
DCsTLR3dsRNAPRRRIG-IIAPSPKCMDA5IFN-βIRFsOSCCLGP2Small interfering RNA - RNA تداخل کوچکdouble-stranded RNA - RNA دو رشته ایsiRNA - siRNATRIF - Trif بهlaboratory of genetics and physiology 2 - آزمایشگاه ژنتیک و فیزیولوژی 2Interferon-β - اینترفرون-βTUNEL - تونلApoptosis - خزان یاختهایDendritic cells - سلول های دندریتیکendoplasmic reticulum - شبکه آندوپلاسمی inhibitor of apoptosis proteins - مهار کننده پروتئین آپوپتوزیسProtein kinase C - پروتئین کیناز سیPoly I:C - پلی I: Cmelanoma differentiation-associated gene 5 - ژن 5 مرتبط با تمایز ملانوم 5retinoic acid-inducible gene I - ژن I القاء شده اسید رتینوئیکoral squamous cell carcinoma - کارسینوم سلول سنگفرشی دهانیcaspase 3 - کاسپاز 3pattern recognition receptors - گیرنده های تشخیص الگوToll-like receptor 3 - گیرنده پولی 3
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Activation of Toll-like receptor 3 induces apoptosis of oral squamous carcinoma cells in vitro and in vivo Activation of Toll-like receptor 3 induces apoptosis of oral squamous carcinoma cells in vitro and in vivo](/preview/png/8324642.png)
چکیده انگلیسی
Toll-like receptors are well known as molecular sensors of pathogen-associated molecular patterns. They control activation of the innate immune response and subsequently shape the adaptive immune response. Recent publications have demonstrated that Toll-like receptors also play important roles in multiple human cancers, yet their function in oral squamous cell carcinoma remains unclear. In this study, we showed that both oral squamous cell carcinoma cell lines and tissues from oral squamous carcinoma patients express relatively high levels of Toll-like receptor 3. We also found that synthetic dsRNA-polyinosinic-polycytidilic acid, a Toll-like receptor 3 ligand, induced apoptosis of oral squamous carcinoma cells mainly via Toll-like receptor 3, through interferon-β production and activation of caspases 3 and 9. Moreover, in an oral squamous cell carcinoma xenograft mouse model, we demonstrated for the first time that activation of Toll-like receptor 3 inhibited oral squamous cell carcinoma tumor growth in vivo. Therefore, the direct proapoptotic activity of Toll-like receptor 3 in human oral squamous carcinoma cells may make this protein a viable therapeutic target in the treatment of oral squamous cell carcinoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 44, Issue 8, August 2012, Pages 1266-1275
Journal: The International Journal of Biochemistry & Cell Biology - Volume 44, Issue 8, August 2012, Pages 1266-1275
نویسندگان
Qingqiong Luo, Shuiqing Hu, Ming Yan, Zujun Sun, Wantao Chen, Fuxiang Chen,