Molecular characterisation of RIG-I-like helicases in the black flying fox, Pteropus alecto

► Molecular characterisation of RIG-I-like helicases in the fruit bat Pteropus alecto. ► Bat RLHs are structurally conserved with those in other vertebrates. ► Bat RLHs are ubiquitously expressed and enriched in immune tissues. ► Treatment of bat kidney cells with poly I:C produces an fibroblast-like IFN response. ► Poly I:C induces upregulation of bat RLHs, indicating they are also ISGs.