کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2170963 | 1549505 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Innate immune evasion by hepatitis C virus and West Nile virus
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Antiviral immunity in mammals involves several levels of surveillance and effector actions by host factors to detect viral pathogens, trigger α/β interferon production, and to mediate innate defenses within infected cells. Our studies have focused on understanding how these processes are regulated during infection by hepatitis C virus (HCV) and West Nile virus (WNV). Both viruses are members of the Flaviviridae and are human pathogens, but they each mediate a very different disease and course of infection. Our results demonstrate common and unique innate immune interactions of each virus that govern antiviral immunity and demonstrate the central role of α/β interferon immune defenses in controlling the outcome of infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 18, Issues 5–6, October–December 2007, Pages 535–544
Journal: Cytokine & Growth Factor Reviews - Volume 18, Issues 5–6, October–December 2007, Pages 535–544
نویسندگان
Brian C. Keller, Cynthia L. Johnson, Andrea Kaup Erickson, Michael Gale Jr.,