Keywords: Peroxisome; Cancer; Pexophagy; Plasmalogen; Mitochondrion; Metabolism; AA; arachidonic acid; ABCD; ATP-binding cassette (ABC) transporters subfamily D; ACOX; Acyl Coenzyme-A oxidase; AGPS; alkyl-glycerone phosphate synthase; AMACR; α-Methylacyl-CoA racem
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Keywords: PRR; pattern recognition receptor; PAMP; pathogen-associated molecular pattern; DAMP; danger-associated molecular pattern; NLRP3; NOD-, LRR- and pyrin domain-containing 3; TLR; toll-like receptor; CLR; C-type lectin receptor; NLR; NOD-like receptor; RIG-I
Keywords: ATP; adenosine triphosphate; Ca2+; Â calcium; CamK; calmodulin-dependent kinase; ChREBP; carbohydrate response element binding protein; CypD; cylophilin D; DGAT2; diacylglycerol acyltransferase 2; ER; endoplasmic reticulum; FOXO1; Forkhead box O1; G6P; gl
Keywords: ÎÏ; mitochondrial membrane potential; Bcl-2; B-cell CLL/lymphoma 2; BH; Bcl-2 homology; CJ; crista junction; CM; cristae membrane; Erv1; essential for respiration and viability; ETC; electron transport chain; FAD; flavin adenine dinucleotide; FADH2; fla
Keywords: Pacific oyster; Crassostrea gigas; TRAF2; Innate immunity; MAVS
Keywords: Beetle hind-wing; Unfolding wing; FLUENT; MAVs;
Keywords: Clarithromycin (PubChem CID: 84029); poly I:C (PubChem CID: 32744); Pam3CSK4 (PubChem CID: 130704); CAM; clarithromycin; CARD; caspase activation and recruitment domain; CCL5; chemokine (C-C motif) ligand 5; CF; cystic fibrosis; COPD; chronic obstructive
Keywords: ACP5; Acid phosphatase 5; ADAR1; Adenosine deaminase RNA-specific 1; AGS; Aicardi-Goutières syndrome; ALRs; AIM2-like receptors; AIM2; Absent in melanoma 2; ASC; Apoptosis-associated speck-like protein containing a CARD; CANDLE; Chronic atypical neutroph
Keywords: Antiviral innate immunity; MAVS; Mitochondrial dynamics; RLR pathway; Signal transduction;
Preliminary investigations on the role of Drp-1 dependent mitochondrial fission in attenuating RLR downstream signaling during nervous necrosis virus infection
Keywords: RLR pathway; Nervous necrsis virus; Mitochondrial fission; Drp-1; MAVS;
The mechanisms of Ag85A DNA vaccine activates RNA sensors through new signal transduction
Keywords: DC; dendrite cells; BMDCs; bone-marrow dendrite cells; APC; antigen presenting cell; PRR; pattern recognition receptor; PAMPs; pathogen-associated molecular patterns; RIG-I; retinoic acid-inducible gene I; Mda-5; melanoma differentiation associated gene-5
Aminoacyl-tRNA synthetases, therapeutic targets for infectious diseases
Keywords: ARS; aminoacyl-tRNA synthetase; TLR; toll-like receptor; RIG-I; retinoic acid-inducible gene-I; MAVS; mitochondrial antiviral signaling protein; IFN; interferon; ITCH; E3 ubiquitin-protein ligase Itchy homolog; MSC; multi-tRNA synthetase complex; AIMP; AR
ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication
Keywords: ADAR1; adenosine deaminase acting on RNA 1; AGS; Aicardi-Goutières syndrome; APOBEC3; apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3; ds; double-stranded; dsRBD; dsRNA binding domains; eIF2α; translation initiation factor2; HIV-1; hum
Antiviral activity of transiently expressed mitochondrial antiviral signaling adapter, MAVS orthologue from Asian seabass
Keywords: MAVS; Sea bass; Antiviral signalling; Interferon;
Critical role of MAVS in the protection against Clostridium difficile-induced colitis
Keywords: Clostridium difficile; MAVS; Colitis;
Promising new therapeutic targets for regulation of inflammation and immunity: RING-type E3 ubiquitin ligases
Keywords: ALS; amyotrophiclateral sclerosis; AP-1; activator protein 1; APC; antigen-presenting cell; APC/C; anaphase promoting complex/cyclosome; CLR; C-type lectin receptor; CRL; Cullin RING ligase; ERK; extracellular signalregulated kinase; FANC; Fanconi anemia
DDX3 in HIV-1 infection and sensing: A paradox
Keywords: Dendritic cells; HIV-1; Type I interferon response; RNA sensing; DDX3; MAVS; DC-SIGN; PLK1;
Neuregulin 1 discovered as a cleavage target for the HCV NS3/4A protease by a microfluidic membrane protein array
Keywords: HCV; hepatitis C virus; HCC; hepatocellular carcinoma; NS; nonstructural protein; TIR; toll/interleukin 1 receptor; TRIF; (TIR)-domain-containing adapter-inducing interferon-β; IIR; innate immune response; RIG-I; retinoic acid inducible gene; MAVS; mitoc
Grouper MAVS functions as a crucial antiviral molecule against nervous necrosis virus infection
Keywords: Grouper; MAVS; Antiviral; Nodavirus; Interferon;
Identification, characterization and expression analysis of MAVS in Pelodiscus sinensis after challenge with Poly I:C
Keywords: Pelodiscus sinensis; MAVS; Antiviral innate immunity; Poly I:C; Characterization; Expression analysis;
Mitochondria-associated membranes (MAMs): An emerging platform connecting energy and immune sensing to metabolic flexibility
Keywords: Organelle communication; Mitochondria-associated membranes; Nutrients; Microbiome; Innate immunity; Insulin sensitivity; Metabolic diseases; Ca2+; calcium; CLRs; C-type lectin receptors; CypD; cyclophilin D; DAMPs; Danger-Associated Molecular patterns; ER
Molecular cloning and characterization of APOBEC3 family in tree shrew
Keywords: 3DPCR; differential DNA denaturation PCR; A; adenosine; AID; activation-induced cytidine deaminase; APOBEC; apolipoprotein B mRNA-editing enzyme catalytic polypeptide proteins; APOBEC3; apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 pro
High expression of PCBP2 is associated with progression and poor prognosis in patients with glioblastoma
Keywords: PCBP2; poly(C) binding protein 2; MAVS; MAVS-mediated antiviral signaling; qRT-PCR; quantitative real-time PCR; Poly(C) binding protein 2 (PCBP2); Glioblastoma; Expression; Clinicopathologic parameters; Prognosis;
CARD and TM of MAVS of black carp play the key role in its self-association and antiviral ability
Keywords: Black carp; MAVS; Innate immunity; Self-association;
TRAF2 of black carp upregulates MAVS-mediated antiviral signaling during innate immune response
Keywords: TRAF2; MAVS; Black carp; Interferon;
Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-β expression in cardiac myocytes
Keywords: Cardiac myocyte; Cardiomyocyte; Interferon; Mitochondria; MAVS; MAM; ER; endoplasmic reticulum; IFN; interferon; IKK; IκB kinase; ISG; interferon-stimulated gene; MAM; mitochondrial-associated ER membranes; MAVS; mitochondrial antiviral signaling; MDA5;
Characterization of the black carp TRAF6 signaling molecule in innate immune defense
Keywords: TRAF6; MAVS; Black carp; Interferon;
Expanding perspectives on the significance of mitophagy in cancer
Keywords: ALS; amyotrophic lateral sclerosis; AR; androgen receptor; ASC; apoptosis-associated speck-like protein containing a CARD; ATM; ataxia telangiectasia mutated; BCL-2; breakpoint cluster locus-2; BCL-XL; BCL2-like 1 long; BNIP3; BCL2 interacting protein 3;
Helical reconstruction in RELION
Keywords: CARD; caspase activation and recruitment domain; EM; electron microscopy; FSC; Fourier shell correlation; IHRSR; iterative helical real-space reconstruction; MAVS; mitochondrial antiviral signaling protein; TMV; tobacco mosaic virus; Helical symmetry; Sin
The anticancer functions of RIG-I-like receptors, RIG-I and MDA5, and their applications in cancer therapy
Keywords: 5â²PP; 5â²-diphosphate; 5â²ppp; 5â²triphosphorylated; Bcl2; B-cell lymphoma-2; BIRC3; baculoviral IAP repeat-containing 3; CARDs; caspase activation and recruitment domains; CRC; colorectal cancer; CTD; C-terminal domain; CTLs; cytotoxic T lymphocytes
Energy efficiency of a new distillation process for isopropanol, butanol, and ethanol (IBE) dehydration
Keywords: ABE; acetone, butanol, and ethanol; Col1; column 1; Col2; column 2; DS-I; distillation system 1; DS-II; distillation system 2; IBE; isopropyl alcohol, butanol and ethanol; IES; ideal energy efficiency; MAVS; membrane assisted vapor stripping; TAC; total a
The suppression of innate immune response by human rhinovirus C
Keywords: Interferon response; MAVS; Rhinovirus C; RIG-I signaling pathway; 3C protein;
Multi-camera visual SLAM for autonomous navigation of micro aerial vehicles
Keywords: Visual SLAM; Multiple cameras; MAVs; Autonomous navigation;
Zebrafish STAT6 negatively regulates IFNÏ1 production by attenuating the kinase activity of TANK-binding kinase 1
Keywords: STAT6; Negative regulator; Interferon; TBK1; Zebrafish; CIP; calf intestinal phosphatase; CPE; cytopathic effect; EPC; epithelioma papulosum cyprini; GAS; interferon gamma activated sequence; IFN; interferon; IRF; IFN regulatory factor; IRF3; interferon r
Regulation of type I interferon responses by mitochondria-derived reactive oxygen species in plasmacytoid dendritic cells
Keywords: 7-AAD; 7-aminoactinomycin-D; AMA; Antimycin-A; IFN; interferon; IRF; interferon regulatory factor; MAVS; mitochondrial antiviral-signaling; mtROS; mitochondrial reactive oxygen species; pDCs; plasmacytoid dendritic cells; PI3K; phosphatidylinositol-3-kina
Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China
Keywords: Leprosy; MAVS; MITA; MFN2; SNP; Susceptibility
Molecular cloning and functional characterization of duck mitochondrial antiviral-signaling protein (MAVS)
Keywords: MAVS; Duck; Interferon-β
Short communicationTLR3 signaling is downregulated by a MAVS isoform in epithelial cells
Keywords: TLR3; MAVS; Isoform; Interferon beta; Regulation; Epithelial cells; miniMAVS; HCT116;
Functional motifs responsible for human metapneumovirus M2-2-mediated innate immune evasion
Keywords: hMPV; M2-2 motif; TRAF; MAVS; Innate immune response;
Gene expression profiling reveals the role of RIG1 like receptor signaling in p53 dependent apoptosis induced by PUVA in keratinocytes
Keywords: PUVA; 8-methoxypsoralen plus UVA; RIG-1; retinoic acid induced gene 1; MDA5; melanoma differentiation associated gene 5; MAVS; mitochondrial antiviral signaling protein; TBK; TANK-binding kinase 1; IKKε; inhibitor of kappaB kinase epsilon; IRF3; interfer
Murine gammaherpesvirus targets type I IFN receptor but not type III IFN receptor early in infection
Keywords: EBV; Epstein-Barr virus; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HHV-4; human herpesvirus 4; HHV-8; human herpesvirus 8; hpi; hours post infection; IFN; interferon; IFNAR; interferon α/β receptor; IFN-λR; interferon la
Yersinia YopJ negatively regulates IRF3-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling
Keywords: BMDMs; bone marrow-derived macrophages; c-di-GMP; cyclic diguanylate monophosphate; DMEM; Dulbecco's modified Eagle's medium; ER; endoplasmic reticulum; FBS; fetal bovine serum; GST; Glutathione S-transferase; HEK293T; human embryonic kidney; IB; immunobl
Research ArticleHepatitis C virus variants resistant to macrocyclic NS3-4A inhibitors subvert IFN-β induction by efficient MAVS cleavage
Keywords: CHC; chronic hepatitis C; DAA; direct-acting antiviral agent; HCV; hepatitis C virus; IFN; interferon; IP-10; interferon-γ-induced protein 10; MAVS; mitochondrial antiviral-signaling protein; MD; molecular dynamics; PI; protease inhibitor; RAV; resistanc
Research ArticleMDA5 plays a critical role in interferon response during hepatitis C virus infection
Keywords: HCV; hepatitis C virus; RIG-I; retinoic acid inducible gene I; MDA5; melanoma differentiation-associated gene 5; IFN; interferon; UTR; untranslated region; MAVS; mitochondrial antiviral signaling protein; PAMP; pathogen-associated molecular patterns; HCVc
Insights into antiviral innate immunity revealed by studying hepatitis C virus
Keywords: Hepatitis C virus; NS3/4A; MAVS; Interferon; Innate immunity;
Research ArticleControl of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A
Keywords: HCV; hepatitis C virus; RIG-I; retinoic acid-inducible gene 1; TLR-3; Toll-like receptor 3; RLR; RIG-I like receptor; MDA5; Melanoma Differentiation-Associated protein 5; IFN; interferon; IRF-3; IFN regulatory factor-3; ISG; IFN-induced gene; MAVS; mitoch
Identification and characterization of MAVS from black carp Mylopharyngodon piceus
Keywords: Black carp; MAVS; Innate immunity
Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7
Keywords: MAVS variants; Negative regulator; Interferon; IRF7; Zebrafish; CARD; caspase recruiting domain; CPE; cytopathic effect; DBD; DNA binding domain; EPC; epithelioma papulosum cyprini; GBP4; guanylate binding protein 4; IFN; interferon; IKKε; IkappaB kinase
Hantaan virus can infect human keratinocytes and activate an interferon response through the nuclear translocation of IRF-3
Keywords: HTNV; Hantaan virus; hpi; hours post-infection; RIG-I; retinoic acid inducible gene-I; MAD5; melanoma differentiation-associated gene-5; TLR; Toll-like receptor; MAVS; mitochondrial antiviral signaling protein; PAMPs; pathogen-associated molecular pattern
Mitochondrial antiviral signaling adaptor mediated apoptosis in H3N2 swine influenza virus infection is inhibited by viral protein NS1 in vitro
Keywords: MAVS; Apoptosis; H3N2 swine influenza virus; NS1