دانلود مقالات ISI درباره حداکثر دوز قابل تحمل + ترجمه فارسی

Safety assessment of a novel ingredient for removable chewing gum

Keywords: حداکثر دوز قابل تحمل; ADI; acceptable daily intake; BHT; butylated hydroxytoluene; DMSO; dimethyl sulfoxide; EC; European Community; EEC; European Economic Community; EU; European Union; FOB/MAct; functional observational battery/motor activity; GC; gas chromatography; GC/MS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Phase I/II and Pharmacokinetic Study of Intravenous Vinflunine in Combination With Cisplatin for the Treatment of Chemonaive Patients With Advanced Non–Small-Cell Lung Cancer

Keywords: حداکثر دوز قابل تحمل; Drug-drug interaction; Free platinum; Maximum tolerated dose; Neutropenia

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Phase I and Pharmacologic Study of Weekly Bolus Topotecan for Advanced Non-Small-Cell Lung Cancer

Keywords: حداکثر دوز قابل تحمل; Dose-limiting toxicity; Maximum tolerated dose; N-desmethyl topotecan; Pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Hypoxic selectivity and solubility-investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy

Keywords: حداکثر دوز قابل تحمل; AUC; area under the concentration-time curve; CBI; seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one; DEI; 5-[(dimethylamino)ethoxy]indole; EDCI; N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride; EWG; electron-withdrawing group; HAP;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

A simulation-based comparison of the traditional method, Rolling-6 design and a frequentist version of the continual reassessment method with special attention to trial duration in pediatric Phase I oncology trials

Keywords: حداکثر دوز قابل تحمل; Body surface area-based dosing; Pediatric trials; Dose finding; Maximum tolerated dose

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Oncolytic viruses as experimental treatments for malignant gliomas: Using a scourge to treat a devil

Keywords: حداکثر دوز قابل تحمل; AdV; Adenovirus; APC; antigen-presenting cell; BBB; blood-brain barrier; CED; convection-enhanced delivery; CNS; central nervous system; ECM; extracellular matrix; FasL; Fas ligand; GALV; gibbon ape leukemia virus; GBM; glioblastoma mulitforme; GIM; gli

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2010 سفارش ترجمه

Gender-selective toxicity of thimerosal

Keywords: حداکثر دوز قابل تحمل; Thimerosal; Thimerosal toxicity; Gender-selective toxicity; Maximum tolerated dose; Autism

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

A Phase I Study of Topotecan Plus Carboplatin for Relapsed SCLC: WJTOG Trial

Keywords: حداکثر دوز قابل تحمل; Combination phase I study; Maximum tolerated dose; Topotecan; Carboplatin; SCLC

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Range and trend of expected toxicity level (ETL) in standard A + B designs: A report from the children's oncology group

Keywords: حداکثر دوز قابل تحمل; Phase I design; Traditional algorithm-based design; Targeted toxicity level; Expected toxicity level; Simulation; Maximum tolerated dose;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

High dose selection in general toxicity studies for drug development: A pharmaceutical industry perspective

Keywords: حداکثر دوز قابل تحمل; Maximum Tolerated Dose; Maximum Feasible Dose; Limit dose; Drug safety; Clinical relevance

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse

Keywords: حداکثر دوز قابل تحمل; BrdU; 5-bromo-2′-deoxyuridine; CAR; constitutive androstane receptor; CYP; cytochrome P450; MOA; mode of action; MTD; maximum tolerated dose; PB; phenobarbitone; Sodium phenobarbitone; C57BL/10J mice; Mouse liver tumours; Non-genotoxic carcinogenesis; M

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Phosphatidylinositol-3-Kinase/Akt Signaling Pathway and Kidney Cancer, and the Therapeutic Potential of Phosphatidylinositol-3-Kinase/Akt Inhibitors

Keywords: حداکثر دوز قابل تحمل; kidney; carcinoma; renal cell; D 21266; 1-phosphatidylinositol 3-kinase; mTOR protein; 17-HWT; 17-hydroxy-wortmannin; APC; alkylphosphocholine; ERK; extracellular regulated kinase; GSK3; glycogen synthase kinase-3; HIF; hypoxia-inducible factor; IC50; hal

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

l-Histidine-based pH-sensitive anticancer drug carrier micelle: Reconstitution and brief evaluation of its systemic toxicity

Keywords: حداکثر دوز قابل تحمل; Poly(l-histidine)-b-PEG; pH-sensitive micelle; Multidrug resistance; Reconstitution; Pluronic F127; Maximum tolerated dose

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma

Keywords: حداکثر دوز قابل تحمل; Head and neck neoplasms; Antibodies, neoplasm; Maytansine; Clinical trials; Maximum tolerated dose

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

A metronomic schedule of cyclophosphamide combined with PEGylated liposomal doxorubicin has a highly antitumor effect in an experimental pulmonary metastatic mouse model

Keywords: حداکثر دوز قابل تحمل; CHOL; cholesterol; CPA; cyclophosphamide; DXR; doxorubicin; DXR-SL; DXR-containing PEGylated liposomes; EPR; enhanced permeability and retention; HEPC; hydrogenated egg phosphatidylcholine; MPS; mononuclear phagocyte system; mPEG2000-DSPE; 1,2-distearoyl-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Safety of intracerebroventricular copper histidine in adult rats

Keywords: حداکثر دوز قابل تحمل; Copper histidine; Intracerebral administration; Maximum tolerated dose; Menkes disease; Copper transport

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Radiation Dose Limits and Liver Toxicities Resulting from Multiple Yttrium-90 Radioembolization Treatments for Hepatocellular Carcinoma

Keywords: حداکثر دوز قابل تحمل; HCC; hepatocellular carcinoma; MTD; maximum tolerated dose; RILD; radiation-induced liver disease;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

An application of reinforced urn processes to determining maximum tolerated dose

Keywords: حداکثر دوز قابل تحمل; Phase I; Maximum tolerated dose; Urn scheme

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Formation of micronuclei in erythrocytes of the fathead minnow (Pimephales promelas) after acute treatment with mitomycin C or cyclophosphamide

Keywords: حداکثر دوز قابل تحمل; Genotoxicity; Maximum tolerated dose; Micronucleus; Fathead minnow; Mitomycin C; Cyclophosphamide

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Cumulative cohort design for dose-finding

Keywords: حداکثر دوز قابل تحمل; Phase I clinical trials; Group up-and-down designs; Toxicity studies; Delayed responses; Continual reassessment method; Markov chains; Maximum tolerated dose; Non-parametric designs

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Colorectal Cancer

Keywords: حداکثر دوز قابل تحمل; CALGB; Cancer and Leukemia Group B; CRC; colorectal cancer; DFS; disease-free survival; ECOG; Eastern Cooperative Oncology Group; EGFR; epithelial growth factor receptor; FLOX; fluorouracil bolus, leucovorin with oxaliplatin; FOLFIRI; folinic acid with in

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2007 سفارش ترجمه

MS-275, a potent orally available inhibitor of histone deacetylases-The development of an anticancer agent

Keywords: حداکثر دوز قابل تحمل; AML; acute myeloid leukemia; CLL; chronic lymphocytic leukemia; CPA; cyproterone acetate; CRA; cis-retinoic acid; CTCL; cutaneous T-cell lymphoma; DLT; dose limiting toxicity; EGFR; epithelial cell growth factor receptor; FDA; Food and Drug Administration

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2007 سفارش ترجمه

Using the continual reassessment method: Lessons Learned from an EORTC phase I dose finding study

Keywords: حداکثر دوز قابل تحمل; Maximum tolerated dose; Dose-toxicity model; Composite endpoint; Dose finding

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Pre-clinical toxicology and pathology of 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), a novel anti-cancer agent in male Beagle dogs

Keywords: حداکثر دوز قابل تحمل; Chemotherapy; Prostate cancer; Nitroacridine derivative; Toxicity; Maximum tolerated dose

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Theoretical study of the continual reassessment method

Keywords: حداکثر دوز قابل تحمل; Clinical trial; Continual reassessment method; Dose escalation; Dose finding studies; Maximum likelihood; Maximum tolerated dose; Phase 1 trial; Toxicity

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2006 سفارش ترجمه

Plasma acetylcholinesterase as a biomarker of triazophos neurotoxicity in young and adult rats

Keywords: حداکثر دوز قابل تحمل; Organophosphate pesticides; Triazophos; Acetylcholinesterase; Maximum tolerated dose; Biomarker;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Are tumor incidence rates from chronic bioassays telling us what we need to know about carcinogens?

Keywords: حداکثر دوز قابل تحمل; Maximum tolerated dose; Cytotoxicity; Regenerative cell replication; Benchmark dose; Cancer risk assessment; Bioassay;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Continuous-Infusion Vinorelbine for the Treatment of Advanced Non-Small-Cell Lung Cancer: A Phase I/II Study

Keywords: حداکثر دوز قابل تحمل; Dose-limiting toxicity; First-line therapy; Maximum tolerated dose; Mucositis; Neutropenia;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

13-cis Retinoic acid and isomerisation in paediatric oncology-is changing shape the key to success?

Keywords: حداکثر دوز قابل تحمل; AHR; aryl hydrocarbon receptor; APL; acute promyelocytic leukaemia; ATRA; all-trans retinoic acid; CEPT; cholesteryl ester transfer protein; CRABP; cellular retinoic acid binding protein; GST; glutathione S-transferase; IGFBP-3; insulin-like growth factor

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

A phase I and pharmacologic study of idarubicin, cytarabine, etoposide, and the multidrug resistance protein (MDR1/Pgp) inhibitor PSC-833 in patients with refractory leukemia

Keywords: حداکثر دوز قابل تحمل; AML; acute myeloid leukemia; ALL; acute lymphoblastic leukemia; CR; complete response; PR; partial response; ara-C; cytarabine; MDR1; multidrug resistance; Pgp; P-glycoprotein; SWOG; southwest oncology group; DLT; dose limiting toxicity; MTD; maximum tole

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

The retinoid X receptor agonist bexarotene (Targretin) synergistically enhances the growth inhibitory activity of cytotoxic drugs in non-small cell lung cancer cells

Keywords: حداکثر دوز قابل تحمل; AP-1; activator protein-1; ATCC; American Type Culture Collection; CDK4; cyclin-dependent kinase 4; CI; combination index; Cmax; maximum concentration; CTCL; cutaneous T cell lymphoma; DMSO; dimethyl sulfoxide; FAM; 6-carboxy-fluorescein; ICn; concentrati

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Vascular Targeting in Pancreatic Cancer: The Novel Tubulin-Binding Agent ZD6126 Reveals Antitumor Activity in Primary and Metastatic Tumor Models

Keywords: حداکثر دوز قابل تحمل; vascular targeting; pancreatic cancer; cytoskeleton; orthotopic tumor model; dorsal skinfold chamber; IHC; immunohistochemistry; IFP; interstitial fluid pressure; IVM; in vivo video - microscopy; i.p; intrapentoneal; HUVEG; uman umbilical vein endothelial

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Continuous Low-Dose (Metronomic) Chemotherapy on Rat Prostate Tumors Evaluated Using MRI In Vivo and Comparison with Histology

Keywords: حداکثر دوز قابل تحمل; continuous low-dose (metronomic) chemotherapy; prostate tumor; magnetic resonance imaging (MRI); immunohistochemistry; antiangiogenesis; MRI; magnetic resonance imaging; DCE MRI; dynamic contrast-enhanced MRI; BOLD MRI; blood oxygen level-dependent MRI; R

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity

Keywords: حداکثر دوز قابل تحمل; HPMA; N-(2-hydroxypropyl)methacrylamide; DOX; doxorubicin; P-GFLG-DOXAM; conjugate of HPMA copolymer and DOX enabling enzymatically controlled drug release of doxorubicin; P-AH-DOXH; conjugate of HPMA copolymer and DOX enabling pH-controlled drug rele

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Molecular modification of a recombinant, bivalent anti-human CD3 immunotoxin (Bic3) results in reduced in vivo toxicity in mice

Keywords: حداکثر دوز قابل تحمل; ARL; aggregation reducing linker; AML; acute myeloid leukemia; Bic3; DT390 fused to two anti-CD3 sFv with portion of immunoglobulin constant region; CD3ɛ; CD3 epsilon; CH domain; constant-heavy chain domain; DMEM; Dulbecco's minimal essential media; DT;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Detailed review of transgenic rodent mutation assays

Keywords: حداکثر دوز قابل تحمل; AMP; Adenine monophosphate; APRT; Adenine phosphoribosyltransferase; BB; Big Blue®; CA; Chromosomal aberration; CFU; Colony-forming unit; DBA; Dolichos biflorus agglutinin; GGR; Global genomic repair; GLP; Good Laboratory Practice; HPRT; Hypoxanthine-gua

دانلود رایگان متن کامل مقاله ISI 280 صفحه سال انتشار : 2005 سفارش ترجمه