کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9093960 | 1149664 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Continuous-Infusion Vinorelbine for the Treatment of Advanced Non-Small-Cell Lung Cancer: A Phase I/II Study
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Continuous-Infusion Vinorelbine for the Treatment of Advanced Non-Small-Cell Lung Cancer: A Phase I/II Study Continuous-Infusion Vinorelbine for the Treatment of Advanced Non-Small-Cell Lung Cancer: A Phase I/II Study](/preview/png/9093960.png)
چکیده انگلیسی
BACKGROUND: In this phase I/II trial, the maximum tolerated dose (MTD) and activity of vinorelbine administered in continuous infusion as first-line treatment for advanced non-small-cell lung cancer (NSCLC) was determined in 25 consecutive chemotherapy-naive patients with advanced NSCLC. PATIENTS AND METHODS: Vinorelbine was administered as an initial intravenous (I.V.) bolus of 8 mg/m2 on day 1 followed by a 4-day continuous I.V. infusion at 5 different 24-hour dose levels to be repeated every 21 days. All 25 patients (159 cycles) were evaluable for response. The MTD was 8 mg/m2 bolus followed by a continuous I.V. infusion of 11 mg/m2 per day over 4 days. RESULTS: The dose-limiting toxicities were febrile neutropenia in 6 patients and grade 3 mucositis in 2 patients. There was less neurotoxicity and constipation and more mucositis compared with the weekly bolus scheme. There was no significant cumulative toxicity after 3 cycles. Treatment responses were observed in 6 patients: 1 complete response and 5 partial responses. The overall response rate was 24% (95% confidence interval [CI], 8%-40%). Median time to progression was 4 months (95% CI, 2-11 months), and median survival was 6 months (95% CI, 2-18 months). CONCLUSION: The results demonstrate that, in this setting of first-line treatment of NSCLC, vinorelbine administered as an 8 mg/m2 bolus followed by a continuous infusion of 11 mg/m2 per day over 4 days is the recommended schedule. Further trials are necessary to establish activity and possible benefits of combination with other agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Lung Cancer - Volume 7, Issue 2, September 2005, Pages 121-126
Journal: Clinical Lung Cancer - Volume 7, Issue 2, September 2005, Pages 121-126
نویسندگان
Francisco Carabante-Ocôn, Manuel Cobo-Dols, Manuel Benavides-Orgaz, Silvia Gil-Calle, Inmaculada Alés-DÃaz, Juan J. Bretôn-GarcÃa, Esther Villar-Chamorro, Alvaro Montesa-Pino, Julia Alcalde-GarcÃa, Vanesa Gutiérrez-Calderôn,