Melanocortin receptors and their accessory proteins
Keywords: MC1R; MC2R; MC3R; MC4R; MC5R; MRAP; MRAP2;
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Melanocortin MC4 receptor expression sites and local function
Keywords: MC4R; Melanocortin MC4 receptor; Melanocortin; Expression; Brain; Human; α-MSH; Melanotan-II; (Rat); (Mouse)
Melanocortin activity in the amygdala influences alcohol intake
Keywords: AgRP; agouti-related protein; AP/L/V; anterior-posterior/lateral/ventral; CeA; central nucleus of amygdala; GABA; gamma amino butyric acid; icv; intracerebroventricular; MC3R; melanocortin 3 receptor; MC4R; melanocortin 4 receptor; αMSH; alpha melanocy
Astma i otyÅoÅÄ - czy można mówiÄ o wspólnych uwarunkowaniach genetycznych tych chorób?
Keywords: astma; otyÅoÅÄ; genetyka; GWAS - badania asocjacji genomu; badania genów-kandydatów; bronchial asthma; obesity; GWAS - genome-wide association study; ACE; angiotensin converting enzyme-enzym konwertujÄ
cy angiotensynÄ; ADR; adrenergic receptor-r
Implication of the melanocortin-3 receptor in the regulation of food intake
Keywords: Melanotropin; MC3R; MC4R; Knockout mice; Obesity; Food intake; Feeding; Energy homeostasis; AGRP; SHU9119
Alternative G protein coupling and biased agonism: New insights into melanocortin-4 receptor signalling
Keywords: ACTH; adrenocorticotropic hormone; cAMP; cyclic 3â²,5â²-adenosine monophosphate; AGRP; agouti-related protein; CTX; cholera toxin; ER; endoplasmic reticulum; ERK-1/2; extracellular signal-regulated kinases; FSK; forskolin; GPCR; G protein-coupled recept
Acute and repeated restraint differentially activate orexigenic pathways in the rat hypothalamus
Keywords: HPA axis; PVH; ARC; LHA; Fos; MC4R; AgRP; GLP1R;
A sucrose-derived scaffold for multimerization of bioactive peptides
Keywords: Boc; tert-butoxycarbonyl; BSA; bovine serum albumin; CCK2R; cholecystokinin 2 receptor; CCK4; Trp-Met-Asp-Phe-NH2; Cl-HOBt; 6-chloro-1-hydroxybenzotriazole; CuAAC; copper(I)-catalyzed azide-alkyne cycloaddition; DCM; dichloromethane; DIC; diisopropyl carb
Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay
Keywords: Melanocortin-4 receptor; MC4R; cAMP assay; Allosteric modulator; High throughput screen
Melanocortin 4 receptor is a transcriptional target of nescient helix-loop-helix-2
Keywords: Nhlh2; Mc4r; Hypothalamus; E-Box; Obesity; Leptin
Characterization of melanocortin 4 receptor in Snakeskin Gourami and its expression in relation to daily feed intake and short-term fasting
Keywords: Melanocortin 4 receptor; MC4R; Gourami; Circadian feeding rhythm; Fasting
Characterization of Kiss1 neurons using transgenic mouse models
Keywords: leptin; melanocortin; Cre-recombinase; reporter mouse; GAD-67; vGluT2; Arc; arcuate nucleus; AVPV; anteroventral periventricular nucleus; BACs; bacterial artificial chromosomes; ERα; estrogen receptor α; FACS; fluorescence activated cell sorting; GFP; g
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands
Keywords: MC4R; Melanocortin; Agonist; Privileged structures; N-acetylated piperazine; Sulfonamide piperazine;
Association of the melanocortin-4 receptor (MC4R) with feed intake, growth, fatness and carcass composition in pigs raised in Poland
Keywords: MC4R; Carcass composition; Pigs; Feed intake
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist
Keywords: Melanocortin subtype-4 receptor; MC4R; Agonist; Spiroindane; Erectile dysfunction
Appetite regulation: The central role of melatonin in Danio rerio
Keywords: Food intake; Melatonin; Leptin; Ghrelin; MC4R; NPY; CB1; Fish
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity
Keywords: Spiroindane; Amide; Privileged structure; Melanocortin subtype-4 receptor; MC4R; Agonist; MK-0489; Obesity;
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity
Keywords: Spiroindane; Triazole; Privileged structure; Melanocortin subtype-4 receptor; MC4R; Agonist; Obesity
Common Variants Near Melanocortin 4 Receptor Are Associated with General and Visceral Adiposity in European- and African-American Youth
Keywords: AA; African-American; APEX; Adiposity Prevention through EXercise; %BF; Percent body fat; BMI; Body mass index; CI; Confidence interval; DXA; Dual-energy X-ray absorptiometry; EA; Europe-American; FTO; Fat mass and obesity-associated; GWAS; Genome-wide as
A concise synthesis of 1,4-dihydro-[1,4]diazepine-5,7-dione, a novel 7-TM receptor ligand core structure with melanocortin receptor agonist activity
Keywords: G protein-coupled receptors; Agonist; MC4R; MC1R; Tetrahydrodiazepine-5,7-dione; Food intake
Gene–environment interactions and obesity—Further aspects of genomewide association studies
Keywords: FTO; INSIG2; MC4R; Body mass index; Genomewide association; Genome
β-Turn secondary structure and melanocortin ligands
Keywords: Obesity; Diabetes; Melanocortin; Melanotropin; Melanocortin receptors; MC4R
Research ReportIntragastric administration of evodiamine suppresses NPY and AgRP gene expression in the hypothalamus and decreases food intake in rats
Keywords: Evo; Evodiamine; NPY; neuropeptide Y; AgRP; agouti-gene related protein; MCH; melanin concentrating hormone; POMC; pro-opiomelanocortin; CART; cocaine- and amphetamine-regulated transcript; α-MSH; α-melanocyte-stimulating hormone; MC4R; melanocortin rec
Key amino acid residues in the melanocortin-4 receptor for nonpeptide THIQ specific binding and signaling
Keywords: Obesity; MSH; GPCR; Nonpeptide; MC4R
Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro5, dNal (2′)8]-γ-MSH selectivity
Keywords: MC4R; γ-MSH; MC1R; Obesity; GPCR; Agonist
Polymorphism and chromosomal location of the MC4R (melanocortin-4 receptor) gene in the dog and red fox
Keywords: PCR, polymerase chain reaction; SNP, single nucleotide polymorphism; SSCP, single strand conformation polymorphism; RFLP, restriction fragment length polymorphismDog; Red fox; MC4R; SNP; FISH
Homozygous Null Mutation of the Melanocortin-4 Receptor and Severe Early-Onset Obesity
Keywords: AGRP; Agouti related peptide; alpha-MSH; alpha-melanocyte stimulating hormone; BMI; Body mass index; BMI-Z; Body mass index Z-score; LEPR; Leptin receptor; MC4R; Melanocortin-4 receptor; PCR; Polymerase chain reaction;
Definable Somatic Disorders in Overweight Children and Adolescents
Keywords: BMI; Body mass index; IGF-1; Insulin-like growth factor I; IQR; Interquartile range; MC4R; Melanocortin-4-receptor gene; SDS-BMI; Body mass index expressed as a standard deviation score;
Synthesis and structure–activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor
Keywords: Melanocortin subtype-4 receptor ligands; MC4R
Association of MC4R gene variants with growth, fatness, carcass composition and meat and fat quality traits in heavy pigs
Keywords: MC4R; Heavy pigs; Carcass composition; Quality traits
Melanocortin-4 receptors, β-MSH and leptin: Key elements in the satiety pathway
Keywords: MC4R; Hypothalamus; Dietary obesity; β-MSH; Leptin; Insulin
Allelic incidence in several pig breeds of a missense variant of pig melanocortin-4 receptor (MC4R) gene associated with carcass and productive traits; its relation to IGF2 genotype
Keywords: MC4R; Pig; RT-PCR; Composition; IGF2
Brainstem mechanisms integrating gut-derived satiety signals and descending forebrain information in the control of meal size
Keywords: MC4R; Satiation; Satiety; Brainstem; CREB; cAMP
Dimerization of the melanocortin 4 receptor: A study using bioluminescence resonance energy transfer
Keywords: Melanocortin; MC4R; G protein coupled receptor; Dimerization; BRET
Functional characterization of the modified melanocortin peptides responsible for ligand selectivity at the human melanocortin receptors
Keywords: Obesity; SHU9119; MC3R; MC4R; GPCR
Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines
Keywords: Melanocortin; MC4R; Agonists; Antagonist;
Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse
Keywords: Melanocortin; POMC; Agouti; AGRP; MC4R; Obesity; Knockout mice; Energy homeostasis; Leptin; Exercise; Running wheel;