PCL2 regulates p53 stability and functions as a tumor suppressor in breast cancer
Keywords: MDM2; Polycomb repressive complexes; PCL2; p53; MDM2; Breast cancer;
مقالات ISI MDM2 (ترجمه نشده)
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Schisandrin B exhibits potent anticancer activity in triple negative breast cancer by inhibiting STAT3
Keywords: MDM2; Schisandrin B; STAT3; Apoptosis; Triple negative breast cancer; Bax; Bcl-2 associated protein x; Bcl-2; B-cell lymphoma 2; Bcl-xl; B-cell lymphoma-extra large; CDC2; cell division cycle 2; DAPI; 4, 6diamidino-2-phenylindole; DMSO; dimethylsulfoxide; FITC;
Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells
Keywords: MDM2; ac-lys; acetylated lysine; ac-Siah2; acetylated Siah2; ac-K139 Siah2; acetylated K139 Siah2; ASB2; a suppressor of cytokine signalling box 2 gene; cag; cytotoxin-associated gene; CHIP; C-terminus of Hsc70 interacting protein; DAPI; 4',6-Diamidino-2-phenyl
MicroRNA regulation of MDM2-p53 loop in pterygium
Keywords: MDM2; Pterygium; microRNA; miR-145; MDM2-p53 loop; miR-145; MicroRNA-145; CK12; Cytokeratin 12; CX43; Connexin 43; EMT; Epithelial-mesenchymal transition; GFP; Green fluorescence protein; LPC; Limbo-peripheral cornea; MDM2; Murine double minute 2; Pt; Pterygium
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Keywords: MDM2; CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P
β-Arrestin2 directly or through GRK2 inhibits PKCβII activation in a ubiquitination-dependent manner
Keywords: MDM2; PKC; GRK2; β-arrestin; Mdm2; Ubiquitination;
Deubiquitylating enzymes as cancer stem cell therapeutics
Keywords: MDM2; Protein-IPSC; protein-induced pluripotent stem cells; CSCs; cancer stem cells; DUBs; deubiquitylating enzymes; ESCs; embryonic stem cells; PTMs; post-translational modifications; AML; acute myelogenous leukemia; USP/UBP; ubiquitin-specific processing prot
Role of p53 circuitry in tumorigenesis: A brief review
Keywords: MDM2; p53; miRNA; Mdm2; Pirh2; COP1; Ubiquitin; Proteasome; Modulators; Pharmacophore;
Autophagy as a pharmacological target in hematopoiesis and hematological disorders
Keywords: MDM2; 3-MA; 3-methyladenine; ALL; acute lymphoblastic leukemia; AMKL; acute megakaryoblastic leukemia; AML; acute myeloid leukemia; AMPK; 5â²-adenosine monophosphate-activated protein kinase; APL; acute promyelocytic leukemia; Atg; autophagy-related proteins;
Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
Keywords: MDM2; Ubiquitin-like domain; Papain-like protease; Macrodomain; Nucleic-acid binding domain; Innate immunity; Structural biology; 3CLpro; 3C-like protease; 3Ecto; Nsp3 ectodomain; ADPr; ADP-ribose; ADRP; ADP-ribose-1â³-phosphate phosphatase; ARTD; ADP-ribosylt
The interactions of p53 with tau and AÃ as potential therapeutic targets for Alzheimer's disease
Keywords: MDM2; AD; Alzheimer's disease; AICD; amyloid precursor protein intracellular domain; Aβ; amyloid β peptides; ApoE; apolipoprotein E; APP; amyloid precursor proteins; BACE1; β-site APP cleaving enzyme 1; BIN1; bridging integrator 1; CBP; CREB-binding protei
Anisometric cell lipoma: Insight from a case series and review of the literature on adipocytic neoplasms in survivors of retinoblastoma suggest a role for RB1 loss and possible relationship to fat-predominant (“fat-only”) spindle cell lipoma
Keywords: MDM2; Anisometric cell lipoma; Spindle cell lipoma; Retinoblastoma; RB1; MDM2; FISH;
The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2
Keywords: MDM2; DUB; Male infertility; Mdm2; Spermatozoa; USP26;
Proapoptotic modification of substituted isoindolinones as MDM2-p53 inhibitors
Keywords: MDM2; P53; MDM2; Protein-protein interaction; Computer modelling; Apoptosis; RDFQXKACQGFINF-UHFFFAOYSA-N; RYQVQNZUHMWWLH-UHFFFAOYSA-N; RCFNDSQQKSPXBD-UHFFFAOYSA-N; UVEVNAQWFWWPJC-UHFFFAOYSA-N; STFMKINHPFHVMP-UHFFFAOYSA-N; PDJLIWOLUDQPSK-UHFFFAOYSA-N; IJLSDVGVBQ
Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry
Keywords: MDM2; Well-differentiated/dedifferentiated liposarcoma; Differential diagnosis; p16; MDM2; CDK4; Immunohistochemistry; Fluorescence in situ hybridization;
A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore
Keywords: MDM2; CLK; cdc2-like kinase; MDM2; mouse double minute 2 homolog; Luc; luciferase; TEA; triethylamine; DIPEA; diisopropylethylamine; EtOAc; ethyl acetate; Cdc-like kinase (CLK) inhibitors; Modulators of pre-mRNA splicing; High throughput screening; Anti-tumor a
In this issueCorrelation of histological grade of dedifferentiation with clinical outcome in 55 patients with dedifferentiated liposarcomas
Keywords: MDM2; High-grade dedifferentiated liposarcoma; Low-grade dedifferentiated liposarcoma; MDM2; Myxoid liposarcoma; Histological grade; Survival;
Thyroid hormone induce a p53-dependent DNA damage through PI3K/Akt activation in sperm
Keywords: MDM2; TH; thyroid hormone; PI3K; Phosphatidyl Inositol 3-kinase; MDM2; Murine Double Minute 2; TR; thyroxine receptor; TUNEL; terminal deoxynucleotidyl transferase dUTP nick-end labelling; MMP; mitochondrial membrane potential; Sperm motility; DNA damage; l-Thy
Ovarian tumor domain-containing protein 1 deubiquitinates and stabilizes p53
Keywords: MDM2; Mdm2; mouse double minute 2 homolog; RING; really interesting new gene; DUB; deubiquitinase; USP; ubiquitin-specific protease; OTU; ovarian tumor proteases; OTUD1; ovarian tumor domain-containing protein 1; UIM; ubiquitin interacting motif; PI; propidium
Original ResearchA phase I study of SAR405838, a novel human double minute 2 (HDM2) antagonist, in patients with solid tumours
Keywords: MDM2; De-differentiated liposarcoma; HDM2; MDM2; p53; Pharmacokinetics; Pharmacodynamics; SAR405838; Solid tumours;
The good and the bad faces of STAT1 in solid tumours
Keywords: MDM2; BAD; Bcl2-associated agonist of cell death; Bcl; B-cell lymphoma; CD; cluster of differentiation; CDK; cyclin-dependent kinase; CTL; cytotoxic T lymphocyte; CUG; cancer upregulated gene; CXCL; C-X-C motive ligand; DC; dendritic cells; DAMP; danger-associa
E2F6 protein levels modulate drug induced apoptosis in cardiomyocytes
Keywords: MDM2; α-mhc; α-myosin heavy chain; β2-AR; beta-2-adrenergic receptor; Bax; Bcl2 associated protein X; Bcl2; B-cell lymphoma 2; Blm2; bloom syndrome 2 homolog; Bnip3; Bcl2 interacting protein 3; Chk1; checkpoint kinase 1; c-src; proto-oncogene tyrosine protei
Alterations of ubiquitin related proteins in the pathology and development of schizophrenia: Evidence from human and animal studies
Keywords: MDM2; Schizophrenia; Neurodevelopmental animal model; Human brain cohort; E2 ubiquitin conjugating enzyme; E3 ligases; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; DLPFC; dorsolateral prefrontal cortex; FBXL21; F-Box and Leucine rich repeat protein
Reviewp53 dysregulation in B-cell malignancies: More than a single gene in the pathway to hell
Keywords: MDM2; p53 Pathway; MYC; ATM; ARF; MDM2; Survival; B-cell malignancies; Myeloma; Lymphoma;
Targeting Oct2 and P53: Formononetin prevents cisplatin-induced acute kidney injury
Keywords: MDM2; Cisplatin; Regeneration; Apoptosis; Oct2; p53; AKI; acute kidney injury; MDM2; murine double minute 2; Oct2; organic cation transporter 2; Mrp2; multidrug resistance-associated protein 2; BrdU; 5-bromo-2-deoxyuridine;
Tumor suppressor RYBP harbors three nuclear localization signals and its cytoplasm-located mutant exerts more potent anti-cancer activities than corresponding wild type
Keywords: MDM2; BCOR; BCL6 corepressor; DED; death effector domain; DEDD; DED containing DNA-binding protein; DISC; death-inducing signaling complex; EGFP; enhanced green fluorescence protein; FADD; Fas-associated death domain; FANK1; Fibronectin type III and ankyrin rep
PARP, transcription and chromatin modeling
Keywords: MDM2; ABCA1; ATP-binding cassette transporter A1; ADP-ribosylation; adenosine diphosphate ribosylation; ALC1; amplified in-liver-cancer 1; AR; androgen receptor; ARH3; ADP-ribosylhydrolase 3; ART; ADP-ribosyl transferase; ASF/SF2; alternative splicing factor/sp
Original research articleMonitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner
Keywords: MDM2; MDM2; MDMX; p53; Pancreas development; Pancreas function; Type 1-diabetes; High blood glucose level; Metabolism; Glucose tolerance;
ReviewWhen the guardian sleeps: Reactivation of the p53 pathway in cancer
Keywords: MDM2; p53; MDM2; MDMX; TP53 mutation; TP53 gain-of-function; Gene therapy;
Reviving the guardian of the genome: Small molecule activators of p53
Keywords: MDM2; AML; acute myelogenous leukemia; CML; chronic myelogenous leukemia; INZ; inauhzin; p53; Small molecules; MDM2; MDMX; Drug discovery; Inauhzin;
On p53 revival using system oriented drug dosage design
Keywords: MDM2; p53; Mdm2; Cancer; Nutlin; PBK;
Long non-coding RNA ENST00462717 suppresses the proliferation, survival, and migration by inhibiting MDM2/MAPK pathway in glioma
Keywords: MDM2; lnc00462717; Glioma; MDM2; MAPK pathway;
Prevalence of p53 codon 72, p73 G4C14-A4T14 and MDM2 T309G polymorphisms and its association with the risk of oral cancer in South Indians
Keywords: MDM2; P53 or TP53; Tumor Protein 53; P63 or TP63; Tumor Protein 63; P73 or TP73; Tumor Protein 73; MDM2; Mouse Double Minute 2 Homologue; SNP; Single Nucleotide Polymorphism; HPV; Human Papilloma Virus; E6-AP; HPV-E6 Associated Protein; HWE; Hardy Weinberg Equi
LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer
Keywords: MDM2; p53; MDM2; Protein-protein interaction; Quantitative targeted proteomics; Breast cancer;
Polymorphisms of miR-196a2 (rs11614913) and miR-605 (rs2043556) confer susceptibility to gastric cancer
Keywords: MDM2; ANXA1; annexin A1; C; control group; CI; confidence interval; EGF; epidermal growth factor; ESCC; esophageal squamous cell carcinoma; GC; gastric cancer; HER2 (c-erbB2); erb-b2 receptor tyrosine kinase 2; LFS; Li-Fraumeni syndrome; Mdm2; murine double min
Positive effect of Mdm2 on p53 expression explains excitability of p53 in response to DNA damage
Keywords: MDM2; P53; Mdm2; Oscillations; Excitability; Reaction-diffusion model;
Roles of TP53 in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis
Keywords: MDM2; TP53; miRs; MDM2; Nutlin-3 chemosensitivity; Cellular senescence; Invasion; Metastasis;
Molecular design and validation of halogen bonding orthogonal to hydrogen bonding in breast cancer MDM2-peptide complex
Keywords: MDM2; Halogen bonding; Hydrogen bonding; MDM2; Peptide; Breast cancer;
A subset of fat-predominant angiomyolipomas label for MDM2: a potential diagnostic pitfall
Keywords: MDM2; Fat-predominant angiomyolipoma; MDM2; Well-differentiated liposarcoma; Angiomyolipoma; Retroperitoneal tumors; Immunohistochemical pitfalls;
p53 expression and relationship with MDM2 amplification in breast carcinomas
Keywords: MDM2; p53; MDM2; Breast carcinoma
Genome-scale functional analysis of the human genes modulating p53 activity by regulating MDM2 expression in a p53-independent manner
Keywords: MDM2; High-throughput screening; MDM2; p53; Leukemia; MDM2-modulating gene;
Role of 3â² repressor sequences of p53 in anti-cancer drug sensitivity of human lung tumor cells
Keywords: MDM2; NVB; navelbine; PDD; cisplatin; 5FU; 5-fluorouracil; MDM2; mouse double minute 2 homolog; miRNA; microRNAs; lncmRNA; long non-coding mRNAs; p53(wt); full-length p53; p53(del); the deleted-C-terminal p53; ANOVA; analysis of variance; Ad; adenovirus; MOI; m
The Vascular Endothelial Growth Factor-A phosphorylates Murine Double Minute-2 on its Serine 166 via the Extracellular Signal-Regulated Kinase 1/2 and p90 Ribosomal S6 Kinase in primary human endothelial cells
Keywords: MDM2; Angiogenesis; Endothelial cell; Skeletal muscle; ERK1/2; extracellular signal-regulated kinase 1/2; HIF-1α; hypoxia inducible factor-1α; HDMECs; human dermal microvascular endothelial cells; MAPK; mitogen activated protein kinases; Mdm2; murine double m
The viral non-structural protein 1 alpha (Nsp1α) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in porcine reproductive and respiratory syndrome virus (PRRSV) early-infected cells
Keywords: MDM2; Porcine reproductive and respiratory syndrome virus; p53; Apoptosis; mdm2
Follicular dendritic cell sarcoma: clinicopathologic study of 15 cases with emphasis on novel expression of MDM2, somatostatin receptor 2A, and PD-L1
Keywords: MDM2; Follicular dendritic cell sarcoma; FDC tumor; MDM2; Somatostatin receptor; PD-L1; Head and neck; Spleen
Dual inhibition of nuclear factor kappa-B and Mdm2 enhance the antitumor effect of radiation therapy for pancreatic cancer
Keywords: MDM2; Pancreatic cancer; Radiation; NF-κB; Mdm2; Nafamostat mesilate;
Original Article2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol inhibits MDM2 and induces apoptosis in breast cancer cells through a p53-independent pathway
Keywords: MDM2; Combretastatin A-4; MDM2; p53; Apoptosis; Breast cancer;
PRDM1 overexpression induce G0/G1 arrest in DF-1 cell line
Keywords: MDM2; PRDM1; PR domain containing 1; MDM2; mouse double minute 2 homolog; Rb; retinoblastoma; ARF; p15INK4b alternate reading frame; PRDM1; Cell cycle; G0/G1 phase; DF-1 cells; p53; Rb;
Original articleDifferentiation and prognostic markers in ampullary cancer: Role of p53, MDM2, CDX2, mucins and cytokeratins
Keywords: MDM2; Ampullary adenocarcinoma; p53; MDM2; Intestinal; Pancreatobiliary; Prognosis;
Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK
Keywords: MDM2; SIRT1; silent mating type information regulation 2 homolog 1; PPARγ; peroxisome proliferator-activated receptor γ; LPS; lipopolysaccharide; MKP-7; mitogen-activated protein kinase phosphatase-7; PGC-1α; peroxisome proliferator-activated receptor gamma