دانلود مقالات ISI درباره MDM2 + ترجمه فارسی

Ling Zhi-8 reduces lung cancer mobility and metastasis through disruption of focal adhesion and induction of MDM2-mediated Slug degradation

Keywords: MDM2; Ling Zhi-8; Focal adhesion kinase; MDM2; Slug; Mobility; LZ-8; Ling Zhi-8; FAK; focal adhesion kinase; EMT; epithelial-to-mesenchymal transition; NSCLC; human non-small-cell lung cancer cell; UPP; ubiquitin-proteasome pathway; LLC1 cells; Lewis lung carci

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

PRDM1 overexpression induce G0/G1 arrest in DF-1 cell line

Keywords: MDM2; PRDM1; PR domain containing 1; MDM2; mouse double minute 2 homolog; Rb; retinoblastoma; ARF; p15INK4b alternate reading frame; PRDM1; Cell cycle; G0/G1 phase; DF-1 cells; p53; Rb;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Violacein induces apoptosis in human breast cancer cells through up regulation of BAX, p53 and down regulation of MDM2

Keywords: MDM2; Violacein; MCF-7 cells; Apoptosis; p53; MDM2;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK

Keywords: MDM2; SIRT1; silent mating type information regulation 2 homolog 1; PPARγ; peroxisome proliferator-activated receptor γ; LPS; lipopolysaccharide; MKP-7; mitogen-activated protein kinase phosphatase-7; PGC-1α; peroxisome proliferator-activated receptor gamma

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

TP53 dysfunction in diffuse large B-cell lymphoma

Keywords: MDM2; TP53; miRNA; Copy number alterations; MDM2; Mutation

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Research reportKnockout of programmed cell death 5 (PDCD5) gene attenuates neuron injury after middle cerebral artery occlusion in mice

Keywords: MDM2; PDCD5; programmed cell death 5; RhPDCD5; recombinant human programmed cell death 5; MCAO; middle cerebral artery occlusion; VHL; von Hippel-Lindau tumor suppressor protein; Mdm2; mouse double minute 2 homolog; HIF-1α; hypoxia-inducible factor 1 alpha; BN

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation

Keywords: MDM2; USP7; SUV39H1; H3K9me3; p53; MDM2

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Alteration of canonical and non-canonical WNT-signaling by crystalline silica in human lung epithelial cells

Keywords: MDM2; ACTA2; Actin, alpha, smooth muscle; ANGPTL4; Angiopoietin-like 4; ANOVA; Analysis of variance; AXIN; Axis inhibition protein; BMP; Bone morphogenic protein; BMPR1B; BMP receptor 1B; CACNA2D3; Calcium channel, voltage-dependent, alpha 2/delta subunit 3; CC

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment

Keywords: MDM2; MDM2; Mesothelioma; p53; Neoangiogenesis; Apoptosis

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

TP53 and MDM2 genetic alterations in non-small cell lung cancer: Evaluating their prognostic and predictive value

Keywords: MDM2; P53; MDM2; NSCLC; Prognosis; Predictive;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ0814061), a novel microtubule inhibitor, evokes G2/M cell cycle arrest and apoptosis in human breast cancer cells

Keywords: MDM2; Combretastatin A-4; G2/M arrest; Apoptosis; Breast cancer; MDM2

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation

Keywords: MDM2; mTOR; mammalian target of rapamycin; UVB; ultraviolet-B; NMSC; non-melanoma skin cancer; mTORC1; mTOR complex 1; mTOC2; mTOR complex 2; AKT/PKB; protein kinase B; SCC; squamous cell carcinoma; ERK; extracellular-signal-regulated kinases; MEK; mitogen-acti

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

Akt phosphorylates myc-associated zinc finger protein (MAZ), releases P-MAZ from the p53 promoter, and activates p53 transcription

Keywords: MDM2; p53; Arf; Mdm2; Akt; MAZ; Phosphorylation; ChIP; chromatin immunoprecipitation; Dox; doxycycline; EMSA; electrophoretic mobility shift assay; IB; immunoblotting; IP; immunoprecipitation; Myr-Akt; myristoylatedAkt; siRNA; small interference RNA; WB; Wester

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells

Keywords: MDM2; Head and neck cancer; Dihydroartemisinin; Ferroptosis; Antitumor; Cell cycle; ART; artemisinin; BAX; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; CDC2; cell division cycle protein 2 (also known as cyclin-dependent kinase 1); DFO; deferoxamine; DH

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

Spiro-oxindole derivative 5-chloro-4′,5′-diphenyl-3′-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2′-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function

Keywords: MDM2; Breast cancer; p53; Mdm2; Spiro-oxindole; Apoptosis; Caspase-9; PARP;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

The antioxidant transcription factor Nrf2 contributes to the protective effect of mild thermotolerance (40 °C) against heat shock-induced apoptosis

Keywords: MDM2; ARE; Antioxidant response element; ATF-3; Activating transcription factor-3; BSA; Bovine serum albumin; DAF; Diaminofluorescein; DHE; Dihydroethidium; D-MEM; Dulbecco's modification of Eagle's medium; DTT; Dithiothreitol; EDTA; Ethylene diamine tetraaceti

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

MDM2 and CDK4 expression in periosteal osteosarcoma

Keywords: MDM2; Perisoteal osteosarcoma; Bone; MDM2; CDK4; Immunohistochemistry

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53–MDM2 interaction with a distinct binding mode

Keywords: MDM2; MDM2; p53; Protein–protein interaction inhibitors

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B

Keywords: MDM2; Lipopolysaccharide; MDM2; NF-κB; Nutlin-3; P53;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

2,3′-Bis(1′H-indole) heterocycles: New p53/MDM2/MDMX antagonists

Keywords: MDM2; p53; MDM2; MDMX; Protein-protein interaction; Cancer;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Synaptic structure and function are altered by the neddylation inhibitor MLN4924

Keywords: MDM2; NEDD8; neural precursor cell expressed, developmentally down-regulated 8; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; Ubc12; ubiquitin carrier protein 12; RING; really interesting new gene; HECT; homologous to the E6-AP carboxyl

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation

Keywords: MDM2; MDM2; Rb; Muscle differentiation; Nutlin;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

PI3K/Akt/p53 pathway inhibits reovirus infection

Keywords: MDM2; CHT; α-Chymotrypsin; LY; LY294002; Wort; Wortmannin; p-Akt; phosphorylated Akt; p-MDM2; phosphorylated MDM2; Reovirus; PI3K/Akt; p53; MDM2; Replication;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor

Keywords: MDM2; MDM2; p53; Dihydroimidazothiazole; Protein-protein interaction inhibitor;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells

Keywords: MDM2; DNA damage response (DDR); Cyclic adenosine monophosphate (cAMP); AKT (PKB); Mdm2; p53; NF-κB;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus

Keywords: MDM2; PcG; polycomb group; EZH2; enhancer of zeste homolog 2; shRNA; short hairpin RNA; Rb; retinoblastoma; MDM2; murine double minute 2; CDKIs; cyclin-dependent kinase inhibitors; PRC1; polycomb repressive complex 1; PRC2; polycomb repressive complex 2; H3K27m

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Hypermethylation of potential tumor suppressor miR-34b/c is correlated with late clinical stage in patients with soft tissue sarcomas

Keywords: MDM2; A; adenine; ASPS; alveolar soft part sarcoma; ASS1; argininosuccinate synthetase 1; BMP2; bone morphogenetic protein 2; C; cytosine; Da; Dalton; DFSP; dermatofibrosarcoma protuberan; DNA; deoxyribonucleic acid; EDTA; ethylenediaminetetraacetic acid; ES/pP

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Cadmium at nanomolar concentrations activates Raf-MEK-ERK1/2 MAPKs signaling via EGFR in human cancer cell lines

Keywords: MDM2; Cadmium; Endocrine disruption; EGFR; ERK1/2 MAPKs; Mdm2; p53;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Quality control mechanisms in cellular and systemic DNA damage responses

Keywords: MDM2; DNA damage; Ageing; Ubiquitin proteasome system; DNA repair; Progeroid syndromes; Genome stability; ARF; adenosine diphosphate ribosylation factor; AT; ataxia telangiectasia; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; BER; base excis

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

PI3K/Akt signaling in osteosarcoma

Keywords: MDM2; OS; osteosarcoma; PI3K; phosphatidylinositol 3-kinase; PTEN; phosphatase and tensin homolog; mTOR; mammalian target of rapamycin; RTKs; receptor tyrosine kinases; PDGFR; platelet-derived growth factor receptor; IGF1R; insulin-like growth factor 1 receptor

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Silencing Daxx increases the anti-tumor activity of a TRAIL/shRNA Bcl-xL-expressing oncolytic adenovirus through enhanced viral replication and cellular arrest

Keywords: MDM2; TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; Daxx; death domain-associated protein; STAT; signal transducer and activator of transcription; PI; propidium iodide; FACS; fluorescence-activated cell sorter; MTS; 3-(4,5-dimethylthiazol-2-yl

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin

Keywords: MDM2; p53; MDM2; Nucleolar stress; Serine 46; Apoptosis; Autophagy;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Hypoxia induced E-cadherin involving regulators of Hippo pathway due to HIF-1α stabilization/nuclear translocation in bone metastasis from breast carcinoma

Keywords: MDM2; EMT; epithelial-mesenchymal transition; MET; mesenchymal-epithelial transition; HIF-1; hypoxia inducible factor-1; TAZ; transcriptional co-activator with PDZ-binding motif; YAP; Yes-associated protein; Wwox; WW-domain containing oxidoreductase; MDM2;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Studying p53 family proteins in yeast: Induction of autophagic cell death and modulation by interactors and small molecules

Keywords: MDM2; Autophagy; MDM2; MDMX; p53 family members; Yeast;

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2015 سفارش ترجمه

Interaction between TP63 and MDM2 genes and the risk of recurrent pregnancy loss

Keywords: MDM2; p53 family proteins; TP63; TP73; MDM2; Recurrent pregnancy loss;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Optimization beyond AMG 232: Discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction

Keywords: MDM2; MDM2; p53; Protein-protein interaction; Sulfonamide; Piperidinone;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

The impact of R213 mutation on p53-mediated p21 activity

Keywords: MDM2; p53; Mutation; Arginine; p21; WAF1; wild-type p53-activated fragment 1; MDM2; mouse double minute 2 homolog; GADD45; the growth arrest and DNA damage-inducible 45; Bax; Bcl-2-associated X protein; PRMT5; protein arginine methyltransferase 5; DMEM; Dulbecc

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction

Keywords: MDM2; Protein-protein interaction inhibitors; Structure-based design; p53; MDM2;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Substituted piperidines as HDM2 inhibitors

Keywords: MDM2; HDM2; MDM2; p53; Substituted piperidine; Small molecule inhibitor; Cancer; Oncology;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

A site-directed mutagenesis study of the MdmX RING domain

Keywords: MDM2; Mdm; Murine Double Minute; RING; Really Interesting New Gene; Mdm2; MdmX; E3 ligase; Ubiquitination;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Targeting of p53 peptide analogues to anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy

Keywords: MDM2; p53 Peptide analogue; PMI; pDI; Bcl-2 family proteins; MDM2; NMR spectroscopy; Multi-targeting; Cancer therapy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Restoring the tumour suppressive function of p53 as a parallel strategy in melanoma therapy

Keywords: MDM2; p53 reactivation; ASPP; MDM2; Melanoma therapy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Underwater trauma causes a long-term specific increase in the expression of cyclooxygenase-2 in the ventral CA1 of the hippocampus

Keywords: MDM2; Cyclooxygenase-2; Mdm2; Emotional trauma; Hippocampus; Ubiquitination; Elevated plus maze; Underwater trauma; Post trauma;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Regulation of base excision repair proteins by ubiquitylation

Keywords: MDM2; AP; apurinic/apyrimidinic; APE1; AP endonuclease 1; ARF; alternate reading frame tumour suppressor protein; ATM; ataxia telangiectasia mutated; BER; base excision repair; CHIP; C-terminus of Hsc70-interacting protein; Cul; cullin E3 ligase; DDB1; DNA dama

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Synergistic cooperation of MDM2 and E2F1 contributes to TAp73 transcriptional activity

Keywords: MDM2; MDM2; TAp73; Synergistic effect; E2F1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents

Keywords: MDM2; Spiro compounds; Protein-protein interactions; p53; MDM2; Cancer;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner

Keywords: MDM2; DNAJB1; MDM2; p53; p21; HSP70

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs

Keywords: MDM2; Fulvestrant; MDM2; Chemotherapy; Estrogen receptor; Breast cancer;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy

Keywords: MDM2; MDM2; p53; Protein–protein interaction; Apoptosis; Cancer

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Group-based QSAR and molecular dynamics mechanistic analysis revealing the mode of action of novel piperidinone derived protein–protein inhibitors of p53-MDM2

Keywords: MDM2; MDM2; p53; Cancer; QSAR; Piperidinone; Library

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه