دانلود مقالات ISI درباره MDM2 + ترجمه فارسی

Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs

Keywords: MDM2; Fulvestrant; MDM2; Chemotherapy; Estrogen receptor; Breast cancer;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacologic activation of wild-type p53 by nutlin therapy in childhood cancer

Keywords: MDM2; p53; MDM2; Nutlin; Pediatric tumors; Targeted therapy

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Opportunities for translation: Targeting DNA repair pathways in pancreatic cancer

Keywords: MDM2; ATR; ATM-Rad3-related; BER; base excision repair; Chk1; checkpoint kinase 1; DDR; DNA damage response and repair; DNA-PKcs; DNA-PK catalytic subunit; DOT1L; DOT1-like; DSB; double strand break; FOLFIRINOX; folinic acid, 5-FU, irinotecan, oxaliplatin; 5-FU

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Gα12gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR-135b and miR-194 dysregulation

Keywords: MDM2; AP-1; activator protein-1; ASO; antisense oligonucleotide; ChIP; chromatin immunoprecipitation; FOXO1; forkhead box O1; Gα12QL; active mutant of Gα12; GPCR; G protein-coupled receptor; HCC; hepatocellular carcinoma; MDM2; murine double minute 2 homolog;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

DNMT3B Overexpression by Deregulation of FOXO3a-Mediated Transcription Repression and MDM2 Overexpression in Lung Cancer

Keywords: MDM2; DNMT3B; FOXO3a; MDM2; Doxorubicin; Nutlin-3; Prognosis; Lung cancer;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Wild type p53 reactivation: From lab bench to clinic

Keywords: MDM2; p53; Small molecule; Mdm2; MdmX; Apoptosis; ROS;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

The role of ubiquitin ligases in cardiac disease

Keywords: MDM2; AChRs; acetylcholine receptors; AKAP121; A-kinase anchor protein 121; c-Cbl; Casitas b-lineage lymphoma; Cav3; cavelin 3; CHIP; c-terminus of Hsp70-interacting protein; cIAP; cellular inhibitor of apoptosis; cMyBP-C; cardiac myosin binding protein C; Drp1

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Murine Double Minute 2 siRNA and wild-type p53 gene therapy interact positively with zinc on prostate tumours in vitro and in vivo

Keywords: MDM2; Prostate cancer; Zinc; P53 tumour suppressor; MDM2; Gene therapy;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Original ResearchFull Report: Basic and Translational-Alimentary TractTRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53

Keywords: MDM2; Oncogene; Stomach Cancer; Tumor Formation; Progression; MDM2; murine double minute 2; mRNA; messenger RNA; q-PCR; quantitative polymerase chain reaction; shRNA; short hairpin RNA; TRIM; tripartite motif;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis

Keywords: MDM2; Lens; MDM2; MDMX; p53; Eyes; Lens dysmorphogenesis; Apoptosis; Cell proliferation; Lens development;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

Keywords: MDM2; ADAM; a disintegrin and metalloprotease; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AKT; protein kinase B (PKB); ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AMPK; adenosine monophosphate (AMP) activated protein kinase; ANK;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

The role of ubiquitin modification in the regulation of p53

Keywords: MDM2; p53; MDM2; MDMX;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

NR4A nuclear receptors are orphans but not lonesome

Keywords: MDM2; 6-MP; 6-mercaptopurine; 9-cis-RA; 9-cis-retinoic acid; AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; Cam-kinase; calcium/calmodulin-dependent protein kinase; CREB; cAMP response element binding protein; DBD; DNA-binding domain; DSB; DN

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Mdm2 is required for maintenance of the nephrogenic niche

Keywords: MDM2; Metanephric kidney; Nephron progenitor cells; Cap mesenchyme; Mdm2; p53;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2

Keywords: MDM2; MDM2; Interactome; Linear motifs; CypB; Proteomics;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity

Keywords: MDM2; p53; Ubiquitylation; Oligomerization; Transcription; Proteasome; OD; Oligomerization Domain; Bax; Bcl2-associated X protein; Bcl-XL; B-cell lymphoma-extralarge; PUMA; p5pregulated Modulator of Apoptosis; Noxa; Noxious stress induced protein; Bid; BH3 inte

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Role of the ubiquitin-proteasome system in brain ischemia: Friend or foe?

Keywords: MDM2; 3-MA; 3-methyladenine; 15d-PHJ2; 15-deoxy-Δ12,14-prostaglandin J2; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid; AMPAR; AMPA receptors; APC/C; anaphase-promoting complex/cyclosome; APV; D-aminophosphonovalerate; ATF4; activating transcri

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2014 سفارش ترجمه

Nanomedicines in the future of pediatric therapy

Keywords: MDM2; ACTs; artemisinin combined therapies; ALN; alendronate; ANMAT; Administración Nacional de Medicamentos, Alimentos y Tecnología Médica; ARV; antiretrovirals; AS; antisense; AUC; area-under-the-curve; BMS; burning mouth syndrome; CD; cytosine deaminase;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2014 سفارش ترجمه

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

Keywords: MDM2; HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2014 سفارش ترجمه

Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: Identification of novel peptidic inhibitors

Keywords: MDM2; FAM; carboxyfluorescein; FP; fluorescence polarization; HBTU; O-(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate; HOBt; 1-hydroxy-1H-benzotriazole; MDM2; mouse double minute 2 homolog; MDMX; mouse double minute X homolog; TAMRA;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Vitamin D directly regulates Mdm2 gene expression in osteoblasts

Keywords: MDM2; VDR; Mdm2; p53; Osteoblast differentiation; Gene regulation;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Functional consequences of retro-inverso isomerization of a miniature protein inhibitor of the p53-MDM2 interaction

Keywords: MDM2; Retro-inverso peptide; p53; MDM2; MDMX; d-Peptide; Apamin; Stingin;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Acidosis blocks CCAAT/enhancer-binding protein homologous protein (CHOP)- and c-Jun-mediated induction of p53-upregulated mediator of apoptosis (PUMA) during amino acid starvation

Keywords: MDM2; AAR; amino acid response; Apaf-1; apoptotic protease-activating factor-1; ATF; activating transcription factor; Bcl-2; B cell lymphoma-2; Bax; Bcl-2-associated X protein; Bim; Bcl-2-interacting mediator of cell death; CHOP; CCAAT/enhancer-binding protein

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2

Keywords: MDM2; DnaJC7; MDM2; p53; Protein stability; TPR2; Two-hybrid;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity

Keywords: MDM2; Hepatocellular carcinoma; HDAC6; p53; Mdm2;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines

Keywords: MDM2; Diamides; Apoptosis; Cytotoxicity; Cancer; Autophagy; p53; PET; photosynthetic electron transport; CDK; cyclin-dependent kinase; BrdU; 5-bromo-2′-deoxyuridine; SAR; structure-activity relationship; GSK; glycogen synthase kinase; Rb; retinoblastoma pro

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Mdm2 increases cellular invasiveness by binding to and stabilizing the Slug mRNA

Keywords: MDM2; Mdm2; Slug; p53; Cancer; Invasion;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Different expression pattern and significance of p14ARF-Mdm2-p53 pathway and Bmi-1 exist between gastric cardia and distal gastric adenocarcinoma

Keywords: MDM2; p14ARF; Mdm2; p53; Bmi-1; Gastric cardia adenocarcinoma; Distal gastric adenocarcinoma;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The DEAD box proteins DDX5 (p68) and DDX17 (p72): Multi-tasking transcriptional regulators

Keywords: MDM2; ERα; estrogen receptor alpha; CBP; CREB-binding protein; SRC-1; steroid receptor coactivator 1; SRA; steroid receptor RNA activator; RNA Pol II; RNA polymerase II; P/CAF; CBP/p300 associated factor; TFIIA; transcription factor IIA; AR; androgen receptor;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes

Keywords: MDM2; Lymhoproliferation; Theileria parva; MDM2; p53;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitors

Keywords: MDM2; MDM2; p53; Dihydroimidazothiazole; Protein-protein interaction inhibitor;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2013 سفارش ترجمه

Association of p53 and MDM2 polymorphisms with risk of human papillomavirus (HPV)-related esophageal squamous cell carcinoma (ESCC)

Keywords: MDM2; ESCC; HPV; p53; MDM2; Smoking; Drinking; Polymorphism

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Lead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold

Keywords: MDM2; MDM2; p53; Dihydroimidazothiazole; Protein–protein interaction inhibitor

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Label-free impedimetric immunosensor for ultrasensitive detection of cancer marker Murine double minute 2 in brain tissue

Keywords: MDM2; MDM2; Cancer biomarker; Brain tissue; Cysteamine; Immunosensor; 1,4-phenylene diisothiocyanate; Electrochemical impedance spectroscopy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Atypical lipomatous tumor mimicking giant fibrovascular polyp of the esophagus: report of a case and a critical review of literature

Keywords: MDM2; Atypical lipomatous tumor; Liposarcoma; Esophagus; Fibrovascular polyp; MDM2; CDK4

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Sulfite exposure-induced hepatocyte death is not associated with alterations in p53 protein expression

Keywords: MDM2; Sulfite; Hepatocytes; p53; Mdm2; Bcl-2; RIP1

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway

Keywords: MDM2; Bak; Bcl-2 antagonist/killer; Bax; Bcl-2-associated X protein; FADD; Fas-associated death domain; FAM3B; family with sequence similarity 3, member B; LDH; lactate dehydrogenase; MTT; 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; Nec-1; ne

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and evaluation of an imidazole derivative–fluorescein conjugate

Keywords: MDM2; MDM2; p53; Fluorescence imaging; FAM; Nutlin-2; Glycine; PET; SJSA-1; HCT116

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Dedifferentiated liposarcoma of the spermatic cord with a hemangioendothelioma-like component: A case report and review of the literature

Keywords: MDM2; Dedifferentiated liposarcoma; D2-40; MDM2; CDK4; Hemangioendothelioma

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells

Keywords: MDM2; Hispolon; MDM2; p21; Ubiquitination; p53ATM, ataxia telangiectasia-mutated protein; DAPI, 4′,6-diamidino-2-phenylindole; E3 ligase, a ubiquitin ligase; ERK, extracellular signal-regulated kinase; FBS, fetal bovine serum; IC50, 50% inhibitory concentration

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

TPT1/ TCTP-regulated pathways in phenotypic reprogramming

Keywords: MDM2; p53; MDM2; tumor reversion; stem cells

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Induction of apoptosis in non-small cell lung cancer by downregulation of MDM2 using pH-responsive PMPC-b-PDPA/siRNA complex nanoparticles

Keywords: MDM2; Non-small cell lung cancer; MDM2; pH-responsive; Nanoparticles; siRNA

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

The metastatic behavior of osteosarcoma by gene expression and cytogenetic analyses

Keywords: MDM2; Osteosarcoma; Gene expression; Lung metastasis; Cell culture; Fluorescence in situ hybridization; MDM2; CXCR4

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Anti-HER3 Domain 1 and 3 Antibodies Reduce Tumor Growth by Hindering HER2/HER3 Dimerization and AKT-Induced MDM2, XIAP, and FoxO1 Phosphorylation

Keywords: MDM2; Ab; antibody; NRG; neuregulin; PBS; phosphate-buffered saline; TR-FRET; time-resolved fluorescence resonance energy transfer; XIAP; X-linked inhibitor of apoptosis; FoxO1; forkhead box O1; MDM2; murine double minute 2; GSK3; glycogen synthase kinase 3;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Stress-Induced Isoforms of MDM2 and MDM4 Correlate with High-Grade Disease and an Altered Splicing Network in Pediatric Rhabdomyosarcoma

Keywords: MDM2; COG; Children's Oncology Group; MDM2; murine double minute 2; MDM4; murine double minute 4; RMS; rhabdomyosarcoma; STS; soft tissue sarcoma;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2013 سفارش ترجمه

The MDM2 SNP309 G allele is not preferentially amplified in bone and soft tissue tumors

Keywords: MDM2; MDM2; amplification; liposarcoma; atypical lipomatous tumor

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Functionalization of single-walled carbon nanotubes enables efficient intracellular delivery of siRNA targeting MDM2 to inhibit breast cancer cells growth

Keywords: MDM2; Functionalized SWNTs; Delivery of siRNA; MDM2; Breast cancer cells

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells

Keywords: MDM2; MDM2; TP53; Medulloblastoma; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

IGF-1 receptor is down-regulated by sunitinib induces MDM2-dependent ubiquitination

Keywords: MDM2; Tyrosine kinase inhibitor; Insulin like growth factor; Phosphorylation and ubiquitination; MDM2;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of novel dihydroimidazothiazole derivatives as p53–MDM2 protein–protein interaction inhibitors: Synthesis, biological evaluation and structure–activity relationships

Keywords: MDM2; MDM2; p53; Dihydroimidazothiazole; Protein–protein interaction inhibitor

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه