Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2

► DnaJC7 is associated with DNA-binding domain of p53. ► DnaJC7 enhances transcriptional and growth-suppressive activities of p53. ► DnaJC7 stabilizes p53 by inhibiting complex formation between p53 and MDM2.