کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10899279 | 1084354 | 2016 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells
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کلمات کلیدی
STAT3dihydroartemisininDeferoxaminecdc2forkhead box protein M1HNSCCDFOFOXM1Bcl-2MMP-9HUVECMdm2 - MDM2MTT - MTTROS - ROSArtemisinin - آرتمیسینینBax - باکسDHA - دوکوساهگزائنوئیک اسیدHead and neck cancer - سرطانهای سر و گردنHuman umbilical vein endothelial cells - سلول های اندوتلیالی ورید ناف انسانAntitumor - ضد تومورVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Ferroptosis - فروتوزیسB-cell lymphoma 2 - لنفوم سلول B 2Matrix metalloproteinase-9 - ماتریکس متالوپروتئیناز -9Mouse double minute 2 - ماوس دو دقیقه 2signal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3ART - هنرBcl-2-associated X protein - پروتئین X مرتبط با Bcl-2Propidium iodide - پروتئین یدیدCell cycle - چرخه سلولیHead and neck squamous cell carcinoma - کارسینوم سلول سنگفرشی سر و گردنReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Head and neck cancer is the sixth most common cancer worldwide. Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, exhibits a wide range of biological roles including a highly efficient and specific anti-tumor activity. Here, we aimed to examine the effect of DHA on head and neck carcinoma cells and elucidate the potential mechanisms. We used five head and neck carcinoma cell lines and two non-tumorigenic normal epithelial cell lines to achieve our goals. Cells were exposed to DHA and subjected to cellular activity assays including viability, cell cycle analysis, cell death, and angiogenic phenotype. Our results show that DHA causes cell cycle arrest which is mediated through Forkhead box protein M1 (FOXM1). We also demonstrate that DHA induces ferroptosis and apoptosis in head and neck carcinoma cells. Lastly, our results show that DHA alters the angiogenic phenotype of cancer cells by reducing the expression of angiogenic factors and the ability of cancer cells to support endothelial cell tubule formation. Our study suggests that DHA specifically causes head and neck cancer cell death through contribution from both ferroptosis and apoptosis. DHA may represent an effective strategy in head and neck cancer treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 381, Issue 1, 10 October 2016, Pages 165-175
Journal: Cancer Letters - Volume 381, Issue 1, 10 October 2016, Pages 165-175
نویسندگان
Renyu Lin, Ziheng Zhang, Lingfeng Chen, Yunfang Zhou, Peng Zou, Chen Feng, Li Wang, Guang Liang,