Ecstasy: pharmacology and neurotoxicity
Keywords: 5-HT; 5-hydroxytryptamine; DA; dopamine; MDMA; 3,4-methylene-dioxymethamphetamine; NE; norepinephrine; PD; Parkinson's disease;
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Increased sensitivity to the acute effects of MDMA (“ecstasy”) in female rats
Keywords: 3,4-Methylenedioxymethamphetamine; MDMA; Sensitivity; Sex differences; Rats; Behavior; Activity cage; Open field; Locomotion;
S(+)- and R(â)N-Methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) as discriminative stimuli: Effect of cocaine
Keywords: MDMA; 3,4-Methylenedioxymethamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Cocaine; Drug discrimination; Drug abuse; MDMA isomers; MDMA synthesis;
The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent
Keywords: CYP; cytochrome P450; CPR; cytochrome P450 reductase; FU; fluorescence units; HAMC; 7-hydroxy-4-(aminomethyl)-coumarin; MAMC; 7-methoxy-4-(aminomethyl)-coumarin; MDMA; 3,4-methylenedioxy-methylamphetamine; MDA; 3,4-methylenedioxy-amphetamine; 3,4-OH-MA; 3
Is ecstasy perceived to be safe? A critical survey
Keywords: MDMA; Ecstasy; Risk perception; Drug use;
MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity
Keywords: Disorders of the Nervous System; Neurotoxicity; 5HT; serotonin; Cox-2; cyclooxygenase-2; DA; dopamine; DAB; 3,3â²-diaminobenzidine; DXM; dextromethorphan; HRP; horseradish peroxidase; ILB4; isolectin B4; LPS; lipopolysaccharide; MDMA; 3,4-methylenedioxym
Validation of an ELISA-based screening assay for the detection of amphetamine, MDMA and MDA in blood and oral fluid
Keywords: ELISA; Amphetamine; MDMA; Blood; Oral fluid;
Unifying mechanism for toxicity and addiction by abused drugs: electron transfer and reactive oxygen species
Keywords: ET; electron transfer; OS; oxidative stress; ROS; reactive oxygen species; SO; superoxide; CNS; central nervous system; AO; antioxidant; SOD; superoxide dismutase; GSH; glutathione; MA; methamphetamine; MAO; monoamine oxidase; MDMA; methylenedioxymethamph
Age-dependent (+)MDMA-mediated Neurotoxicity in Mice
Keywords: MDMA; Dopamine; Temperature; VMAT2; Microdialysis; Mice;
MDMA (ecstasy) effects in pubescent rats: Males are more sensitive than females
Keywords: Ecstasy; Lethality; Locomotor activity; MDMA; Pubescence; Sexual dimorphism;
Determination of synthesis method of ecstasy based on the basic impurities
Keywords: MDMA; Reductive amination; Leuckart method; Safrole bromination; Route specific impurities;
Acute and chronic effects of MDMA on molecular mechanisms implicated in memory formation in rat hippocampus: Surface expression of CaMKII and NMDA receptor subunits
Keywords: MDMA; Ecstasy; Serotonin; Memory; NMDA receptor; CaMKII; Hippocampus;
Respondent-driven sampling to recruit MDMA users: a methodological assessment
Keywords: Sampling; Respondent-driven sampling; Substance abuse; MDMA; Ecstasy;
3,4-Methylenedioxymethamphetamine increases pro-interleukin-1β production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: Role of interleukin-1β in neurotoxicity
Keywords: MDMA; pro-IL-1β; caspase-1 protease; frontal cortex; hypothalamus; 5-HT neurotoxicity; ANOVA; analysis of variance; ECL; enhanced chemiluminescence; ICE; interleukin-1β converting enzyme; IL-1β; interleukin-1β; MDMA; 3,4-methylenedioxymethamphetamine;
Previous exposure to (±) 3,4-methylenedioxymethamphetamine produces long-lasting alteration in limbic brain excitability measured by electroencephalogram spectrum analysis, brain metabolism and seizure susceptibility
Keywords: ecstasy; epilepsy; limbic epilepsy; EEG synchronization; kainate; [14C]2-DG; DA; dopamine; DG; deoxyglucose; EEG; electroencephalogram; KA; kainate; MDMA; (±) 3,4-methylenedioxymethamphetamine; S.E.M.; standard error of the mean; 5HT; serotonin;
3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity
Keywords: Neural basis of behavior; Drugs of abuse: amphetamine and other stimulants; 5-HT; 5-HIAA; ACTH; Corticosterone; DOPAC; Dopamine; Ecstasy; Hippocampus; MDMA; Neostriatum; 3H-paroxetine binding; Serotonin transporter; Thymus;
Basic and neutral route specific impurities in MDMA prepared by different synthesis methods
Keywords: MDMA; L-L extraction; Reductive amination; Leuckart method; Safrole bromination synthesis; Route specific impurities;
Determination of synthesis route of 1-(3,4-methylenedioxyphenyl)-2-propanone (MDP-2-P) based on impurity profiles of MDMA
Keywords: MDMA; MDP-2-P; Reductive amination; Route specific impurities;
Free radical production induced by methamphetamine in rat striatal synaptosomes
Keywords: AMPT; α-methyl-p-tyrosine; DA; dopamine; DAT; dopamine transporter; DBE; dihydro-β-erythroidine; DCFH-DA; 2â²,7â²-dichlorofluorescin diacetate; DCF; 2â²,7â²-dichlorofluorescein; EGTA; ethylene glycol-bis(2-aminoethylether)-N,N,Nâ²,Nâ²-tetraacetic
MDMA ('Ecstasy') and methamphetamine combined: Order of administration influences hyperthermic and long-term adverse effects in female rats
Keywords: Methamphetamine; MDMA; Ecstasy; Serotonin; Dopamine; Noradrenaline;
Drug use practices among MDMA/ecstasy users in Ohio: a latent class analysis
Keywords: MDMA; Ecstasy; Polydrug use; Latent class analysis;
Differential effects of MDMA, cocaine, and cannabis use severity on distinctive components of the executive functions in polysubstance users: A multiple regression analysis
Keywords: Executive functions; Substance abuse; Severity; MDMA; Cocaine; Cannabis;
Rat brain serotonin neurones that express neuronal nitric oxide synthase have increased sensitivity to the substituted amphetamine serotonin toxins 3,4-methylenedioxymethamphetamine and p-chloroamphetamine
Keywords: 5-hydroxytryptamine; nitric oxide synthase; ecstasy; 5,7-DHT; serotonin transporter; DRd; dorsomedial subdivision of the dorsal raphé nucleus; DRl; lateral subdivision of the dorsal raphé nucleus; DRv; ventromedial subdivision of the dorsal raphé nucle
Mechanisms of neurotransmitter release by amphetamines: A review
Keywords: AMPH; amphetamine; CHO; Chinese hamster ovary; DAT; dopamine (plasma membrane) transporter; GABA; gamma-aminobutyric acid; hDAT; human DAT; MAO; monoamine oxidase; MDMA; 3,4-methylenedioxymethamphetamine; METH; methamphetamine; NET; norepinephrine transpo