کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416142 | 1614330 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity
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کلمات کلیدی
MK-801DABPBS5HTLPSDXMMDMACOX-2HRP3,3′-diaminobenzidine - 3،3'-diaminobenzidine3,4-methylenedioxymethamphetamine - 3،4-methylenedioxymethamphetamineDisorders of the nervous system - اختلالات سیستم عصبیisolectin B4 - ایزوکتین B4tumor necrosis factor-α - تومور نکروز عامل αDopamine - دوپامینDextromethorphan - دکسترومتورفانSerotonin - سروتونینNeurotoxicity - سمیت عصبیCyclooxygenase-2 - سیکلوکوکسیژناز2TNF-α - فاکتور نکروز توموری آلفاPhosphate buffered saline - فسفات بافر شورlipopolysaccharide - لیپوپلی ساکاریدMETH - متهMethamphetamine - متیل آمفتامینMicroglia - میکروگلیاهاHorseradish peroxidase - پراکسیداز هوررادیش
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Methamphetamine causes long-term toxicity to dopamine nerve endings of the striatum. Evidence is emerging that microglia can contribute to the neuronal damage associated with disease, injury, or inflammation, but their role in methamphetamine-induced neurotoxicity has received relatively little attention. Lipopolysaccharide (LPS) and the neurotoxic HIV Tat protein, which cause dopamine neuronal toxicity after direct infusion into brain, cause activation of cultured mouse microglial cells as evidenced by increased expression of intracellular cyclooxygenase-2 and elevated secretion of tumor necrosis factor-α. MK-801, a non-competitive NMDA receptor antagonist that is known to protect against methamphetamine neurotoxicity, prevents microglial activation by LPS and HIV Tat. Dextromethorphan, an antitussive agent with NMDA receptor blocking properties, also prevents microglial activation. In vivo, MK-801 and dextromethorphan reduce methamphetamine-induced activation of microglia in striatum and they protect dopamine nerve endings against drug-induced nerve terminal damage. The present results indicate that the ability of MK-801 and dextromethorphan to protect against methamphetamine neurotoxicity is related to their common property as blockers of microglial activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1050, Issues 1â2, 19 July 2005, Pages 190-198
Journal: Brain Research - Volume 1050, Issues 1â2, 19 July 2005, Pages 190-198
نویسندگان
David M. Thomas, Donald M. Kuhn,