Keywords: گلوتامات متابوتروپیک; Metabotropic glutamate; mGlu2/3 antagonist; Major depressive disorders; Antidepressant;
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Research paperPreclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability-related effects
Keywords: گلوتامات متابوتروپیک; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; (S)-3,4-DCPG; (S)-3,4-dicarboxyphenylglycine; LY341495; (2S)-2-amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid; mGlu; metabotropic glutamate; LY354740.H2O; bicyclo[3.1.0]
Molecular insights into allosteric modulation of Class C G protein-coupled receptors
Keywords: گلوتامات متابوتروپیک; GABAB; γ-aminobutyric acid receptor B; BMD; bone mass and density; CaSR; calcium-sensing receptor; CHO; Chinese hamster ovary; CRD; cysteine-rich domain; ER; endoplasmic reticulum; Ca2+o; extracellular calcium; pERK1/2; extracellular signal-regulated kin
Glutamatergic regulation of brain histamine neurons: In vivo microdialysis and electrophysiology studies in the rat
Keywords: گلوتامات متابوتروپیک; Histamine; Glutamatergic system; Circadian rhythm; Microdialysis; Electrophysiology; PH-TMN; posterior hypothalamus-tuberomamillary nucleus; mPFC; medial prefrontal cortex; vHipp; ventral hippocampus; NAc; nucleus accumbens; mGluR; metabotropic glutamate
Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors
Keywords: گلوتامات متابوتروپیک; Mediodorsal thalamus; Metabotropic glutamate receptor; Synaptic inhibition; Burst firing; Schizophrenia; DMSO; dimethyl sulfoxide; GABA; gamma-amino butyric acid; i.p.; intraperitoneal; LY354740; (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic
The metabotropic glutamate 2/3 receptor agonist LY379268 counteracted ketamine-and apomorphine-induced performance deficits in the object recognition task, but not object location task, in rats
Keywords: گلوتامات متابوتروپیک; mGlu2/3 receptor; LY379268; Ketamine; Apomorphine; Recognition memory; Rat; AKT/GSK-3; glycogen synthase kinase-3; ANOVA; analysis of variance; CNS; central nervous system; D; discrimination; DA; dopamine; DAergic; dopaminergic; F; familiar; FL; familiar
Short CommunicationTwo newly identified exons in human GRM1 express a novel splice variant of metabotropic glutamate 1 receptor
Keywords: گلوتامات متابوتروپیک; mGlu; metabotropic glutamate; RACE; rapid amplification of cDNA ends; UTR; untranslated region; GPCR; G protein-coupled receptor; PLC; phospholipase C; PCR; polymerase chain reaction; RT; reverse transcription; GRM1; Metabotropic glutamate 1 receptor; mGl
Hippocampal Gαq/11 but not Gαo-coupled receptors are altered in aging
Keywords: گلوتامات متابوتروپیک; Aging; Hippocampus; G-protein; Muscarinic; Metabotropic glutamate; GABAB; Intracellular calcium;
Research ReportEffects of microinjections of Group II metabotropic glutamate agents into the amygdala on sleep
Keywords: گلوتامات متابوتروپیک; Amygdala; Metabotropic glutamate; Rapid eye movement sleep; Sleep;
Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia
Keywords: گلوتامات متابوتروپیک; mGlu2/3 receptor agonist; LY2140023; Schizophrenia; Glutamate; mGlu2 positive allosteric modulator; mGlu; metabotropic glutamate; THIIC; N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide; LY40403
Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice
Keywords: گلوتامات متابوتروپیک; ADHD; Attention-deficit/hyperactivity disorder; AM281; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide; AM404; N-(4-hydroxyphenyl)arachidonylamide; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; Anan
Glutamate-mediated signaling in Schistosoma mansoni: A novel glutamate receptor is expressed in neurons and the female reproductive tract
Keywords: گلوتامات متابوتروپیک; Schistosoma mansoni; Metabotropic glutamate; G protein-coupled receptor (GPCR); Nervous system; Neurotransmitter; Neurons;
Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: Basic characterization and drug pharmacology
Keywords: گلوتامات متابوتروپیک; VSCC; voltage sensitive calcium channels; mGlu; metabotropic glutamate; MEA; microelectrode array; GluOx; glutamate oxidase; S1; first stimulus; S2; second stimulus; aCSF; artificial cerebrospinal fluid; l-glutamate; Voltammetry; Metabotropic glutamate re
The neurochemical basis for the treatment of autism spectrum disorders and Fragile X Syndrome
Keywords: گلوتامات متابوتروپیک; Cerebellum; GABA; GABA(A); GABA(B); GTPase; Metabotropic glutamate; mGluR5; Neurodevelopmental; Dendritic spines
Synergistic interaction of dopamine D1 and glutamate N-methyl-d-aspartate receptors in the rat dorsal striatum controls attention
Keywords: گلوتامات متابوتروپیک; dorsomedial striatum; D1 receptors; NMDA receptors; 5-CSRT task; attention; ANOVA; analysis of variance; APV; (2R)-amino-5-phosphonovaleric acid; CPP; 3-(R)-2-carboxypiperazin-4-propyl-1-phosphonic acid; DA; dopamine; dAC; dorsal anterior cingulate; dl-ST
Research ReportDisruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease
Keywords: گلوتامات متابوتروپیک; AD; Alzheimer's disease; PSD; postsynaptic density; NR1; N-methyl-D-aspartate (NMDA) receptor 1; mGlu; metabotropic glutamate; GluR2; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor 2; NSF; N-ethylmaleimide-sensitive fusion protein;
Group I mGluR signaling in BSE-infected bovine-PrP transgenic mice
Keywords: گلوتامات متابوتروپیک; Prion; Bovine spongiform encephalopathy; Metabotropic glutamate; Receptors; Phospholipase C; Protein kinase C
Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms
Keywords: گلوتامات متابوتروپیک; DAG; diacylglycerol; DHPG; (S)-3,5-dihyidroxyphenylglycine; HBSS; Hanks' buffered saline solution; mGluR; metabotropic glutamate; NMDA; N-methyl-d-aspartate; PAGE; polyacrylamide gel electrophoresis; Sulfo-NHS-SS-biotin; sulfosuccinimydyl-2-(biotinamido
Stimulation of group I metabotropic glutamate receptors evokes calcium signals and c-jun and c-fos gene expression in human T cells
Keywords: گلوتامات متابوتروپیک; iGlu; ionotropic glutamate; mGlu; metabotropic glutamate; NMDA; N-methyl-d-aspartate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; PLC; phospholipase C; AC; adenylate cyclase; [Ca2+]i; intracellular Ca2+ concentration; mAb; monoclonal anti
Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat
Keywords: گلوتامات متابوتروپیک; ON-cell; OFF-cell; in vivo extracellular recordings; WIN 55,212-2; metabotropic glutamate receptors; pain; ACSF; artificial cerebrospinal fluid; CFA; complete Freund's adjuvant; CPCCOEt; T7-(hydroxyimino) cyclopropa[b]chromen-1α-carboxylate ethyl ester
Glutamate and GABA receptor signalling in the developing brain
Keywords: گلوتامات متابوتروپیک; neurotransmitter receptors; AMPA; NMDA; kainate GABAB receptors; mGlu receptors; development; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; CNS; central nervous system; CP; cortical plate; CR; Cajal-Retzius; GABA; γ-aminobutyric acid; iGl