Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: Basic characterization and drug pharmacology

► Glutamate signals in brain slices measured with enzyme-based microelectrode arrays. ► The measured high K+-evoked glutamate signals are calcium dependent. ► mGlu2/3 receptor and α2δ subunits of calcium channels modulate glutamate release.