دانلود مقالات ISI درباره Mglu + ترجمه فارسی

مدولاسیون پلاستیسیتی سیناپتیس با پپتیدهای گردش و متاپلاستی: درگیر شدن در بیماری آلزایمر

Synaptic plasticity modulation by circulating peptides and metaplasticity: Involvement in Alzheimer's disease

Keywords: Aβ; β-amyloid; Aβo; oligomers of Aβ; ACTH; adrenocorticotropic hormone; AD; Alzheimer's disease; AMPA; amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid; APP; amyloid-precursor protein; AT; angiotensin; BBB; blood brain barrier; BCM; Bienens

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

طعم، سنجش مواد مغذی و مصرف خوراک در خوک ها (130 سال تحقیق: سپس، اکنون و آینده)

Taste, nutrient sensing and feed intake in pigs (130 years of research: then, now and future)

Keywords: AA; amino acid; ADFI; average daily feed intake; ADG; average daily gain; Ala; alanine; ANFs; anti-nutritive factors; Asn; asparagine; Asp; aspartate; CaSR; calcium sensing receptor; CCK; cholecystokinin; CD36; cluster of differentiation 36; dlM; dl-methi

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

پیشرفت در جهت درک پیشرفته گیرنده های متابوتروپیک گلوتامات: ساختار، سیگنالینگ و علائم درمانی

Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indications

Keywords: mGlu; 7TMR; Pharmacology; Allosteric modulation; Heterodimer; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

نقش گیرنده های متابوتروپیک گلوتامات در شکل های پایدار انعطاف پذیری و یادگیری هیپوکامپ

Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning

Keywords: LTP; LTD; mGlu; Learning; Long-term memory; Hippocampus; In vivo; Review;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

mGlu4 allosteric modulation for treating Parkinson's disease

Keywords: Parkinson's disease; Dyskinesia; Glutamate; Dopamine; mGlu4; 6-OHDA; 6-hydroxydopamine; ADX88178; 4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-yl]pyrimidin-2-amine; AIM; abnormal involuntary movements; CODA-RET; complemented donor acceptor reson

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease

Keywords: mGlu; Metabotropic glutamate receptor; PD; Parkinson's disease; T10; Triptolide; LPS; lipopolysaccharide; NO; nitric oxide; iNOS; inducible nitric oxide synthase; TNF; tumor necrosis factor; IL; interleukin; SN; substantia nigra; COX; cyclooxygenase; JN

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

Research paperPreclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability-related effects

Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; (S)-3,4-DCPG; (S)-3,4-dicarboxyphenylglycine; LY341495; (2S)-2-amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid; mGlu; metabotropic glutamate; LY354740.H2O; bicyclo[3.1.0]

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Review articleChallenges in developing drugs for pediatric CNS disorders: A focus on psychopharmacology

Keywords: ADHD; attention deficit hyperactivity disorder; ASD; autism spectrum disorder; OCD; obsessive compulsive disorder; NAC; N-acetylcysteine; CNS; central nervous system; FXS; Fragile X Syndrome; O3FA; omega-3 fatty acids; MDD; major depressive disorder; mGlu

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular insights into allosteric modulation of Class C G protein-coupled receptors

Keywords: GABAB; γ-aminobutyric acid receptor B; BMD; bone mass and density; CaSR; calcium-sensing receptor; CHO; Chinese hamster ovary; CRD; cysteine-rich domain; ER; endoplasmic reticulum; Ca2+o; extracellular calcium; pERK1/2; extracellular signal-regulated kin

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2017 سفارش ترجمه

Neurochemical and behavioral studies on the 5-HT1A-dependent antipsychotic action of the mGlu4 receptor agonist LSP4-2022

Keywords: Glutamate; Serotonin; Dopamine; GABA; mGlu; 5-HT1A; Schizophrenia;

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

Group 1 mGlu-family proteins promote neuroadaptation to ethanol and withdrawal-associated hippocampal damage

Keywords: CIE; Chronic intermittent ethanol; mGlu; Metabotropic glutamate receptor; NeuN; Neuron specific nuclear protein;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors

Keywords: Mediodorsal thalamus; Metabotropic glutamate receptor; Synaptic inhibition; Burst firing; Schizophrenia; DMSO; dimethyl sulfoxide; GABA; gamma-amino butyric acid; i.p.; intraperitoneal; LY354740; (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The metabotropic glutamate 2/3 receptor agonist LY379268 counteracted ketamine-and apomorphine-induced performance deficits in the object recognition task, but not object location task, in rats

Keywords: mGlu2/3 receptor; LY379268; Ketamine; Apomorphine; Recognition memory; Rat; AKT/GSK-3; glycogen synthase kinase-3; ANOVA; analysis of variance; CNS; central nervous system; D; discrimination; DA; dopamine; DAergic; dopaminergic; F; familiar; FL; familiar

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins

Keywords: mGlu7 receptors; GRK; Arrestins; MAP kinases; Jun kinases; Signaling regulation; GPCR; G protein-coupled receptor; mGlu; metabotropic glutamate receptor; GRK; G protein-coupled receptor kinase; FSK; forskolin; L-AP4; l-2-amino-4-phosphonobutanoate; MAPK;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Development of allosteric modulators of GPCRs for treatment of CNS disorders

Keywords: 5MPEP; 5-methyl-6-(phenylethynyl)-pyridine; 6-OHDA; 6-hydroxydopamine; 7TMR; seven transmembrane receptor; 77-LH-28-1; 1-[3-(4-butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone; AC-42; 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine; ACh

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Short CommunicationTwo newly identified exons in human GRM1 express a novel splice variant of metabotropic glutamate 1 receptor

Keywords: mGlu; metabotropic glutamate; RACE; rapid amplification of cDNA ends; UTR; untranslated region; GPCR; G protein-coupled receptor; PLC; phospholipase C; PCR; polymerase chain reaction; RT; reverse transcription; GRM1; Metabotropic glutamate 1 receptor; mGl

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat

Keywords: mGlu5 receptor; Glutamate; NMDA receptor antagonist; Schizophrenia; Psychosis; ADX47273; [S-(4-fluorophenyl)-{3-[3-(4-fluorophenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]; ANCOVA; analysis of covariance; ANOVA; analysis of variance; CDPPB; 3-C

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia

Keywords: mGlu2/3 receptor agonist; LY2140023; Schizophrenia; Glutamate; mGlu2 positive allosteric modulator; mGlu; metabotropic glutamate; THIIC; N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide; LY40403

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Invited reviewMetabotropic glutamate receptors as therapeutic targets for schizophrenia

Keywords: Metabotropic; Glutamate; Schizophrenia; NMDA; allosteric; CNS; central nervous system; DA; dopamine; mGlu; metabotropic glutamate receptor; PAM; positive allosteric modulator; NAM; negative allosteric modulator; MPEP; 2-methyl-6-(phenylethynyl)pyridine; N

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Role of endocannabinoid and glutamatergic systems in DOI-induced head-twitch response in mice

Keywords: ADHD; Attention-deficit/hyperactivity disorder; AM281; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide; AM404; N-(4-hydroxyphenyl)arachidonylamide; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; Anan

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: Basic characterization and drug pharmacology

Keywords: VSCC; voltage sensitive calcium channels; mGlu; metabotropic glutamate; MEA; microelectrode array; GluOx; glutamate oxidase; S1; first stimulus; S2; second stimulus; aCSF; artificial cerebrospinal fluid; l-glutamate; Voltammetry; Metabotropic glutamate re

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Synergistic interaction of dopamine D1 and glutamate N-methyl-d-aspartate receptors in the rat dorsal striatum controls attention

Keywords: dorsomedial striatum; D1 receptors; NMDA receptors; 5-CSRT task; attention; ANOVA; analysis of variance; APV; (2R)-amino-5-phosphonovaleric acid; CPP; 3-(R)-2-carboxypiperazin-4-propyl-1-phosphonic acid; DA; dopamine; dAC; dorsal anterior cingulate; dl-ST

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2

Keywords: Metabotropic glutamate receptor ligand; Metabotropic glutamate receptor; Positive allosteric modulator; mGluR; mGlu; mGluR2

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)

Keywords: mGlu; Metabotropic glutamate receptor 4; Functional high-throughput screen (HTS)

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

The effects of polyamine agonists and antagonists on N-methyl-d-aspartate-induced depolarizations of amphibian motoneurons in situ

Keywords: Spinal cord; N-methyl-d-aspartate; Polyamine; Motoneuron; Frog; mGlu; ACPD; 5-hydroxytryptamine; 5-HT2B; G-protein coupled receptorNMDA, N-methyl-d-aspartate; SYN, synthalin; ARC, arcaine; iGlu, ionotropic glutamate; mGlu, metabotropic glutamate; IFEN, if

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Research ReportDisruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease

Keywords: AD; Alzheimer's disease; PSD; postsynaptic density; NR1; N-methyl-D-aspartate (NMDA) receptor 1; mGlu; metabotropic glutamate; GluR2; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor 2; NSF; N-ethylmaleimide-sensitive fusion protein;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo

Keywords: mGlu; Anatomy of the basal ganglia; GABA; In vivo microdialysis; (Rat)

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Stimulation of group I metabotropic glutamate receptors evokes calcium signals and c-jun and c-fos gene expression in human T cells

Keywords: iGlu; ionotropic glutamate; mGlu; metabotropic glutamate; NMDA; N-methyl-d-aspartate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; PLC; phospholipase C; AC; adenylate cyclase; [Ca2+]i; intracellular Ca2+ concentration; mAb; monoclonal anti

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat

Keywords: ON-cell; OFF-cell; in vivo extracellular recordings; WIN 55,212-2; metabotropic glutamate receptors; pain; ACSF; artificial cerebrospinal fluid; CFA; complete Freund's adjuvant; CPCCOEt; T7-(hydroxyimino) cyclopropa[b]chromen-1α-carboxylate ethyl ester

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

Glutamate and GABA receptor signalling in the developing brain

Keywords: neurotransmitter receptors; AMPA; NMDA; kainate GABAB receptors; mGlu receptors; development; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; CNS; central nervous system; CP; cortical plate; CR; Cajal-Retzius; GABA; γ-aminobutyric acid; iGl

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه