کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5815372 1556649 2013 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
In vitro characterisation of the novel positive allosteric modulators of the mGlu5 receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat
چکیده انگلیسی
► Two novel mGlu5 potentiators are described, LSN2463359 and LSN2814617. ► Both compounds show high in vitro potency and low curve shift ratios. ► Brain penetrance and MPEPy displacement in vivo was dose-dependent. ► Both compounds markedly increased wakefulness without disrupting operant behaviour. ► Both compounds attenuated NMDA antagonist impairments of operant behaviour.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 64, January 2013, Pages 224-239
نویسندگان
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