Microsomal oxidative damage promoted by acetaminophen metabolism
Keywords: میکروسوم; Acetaminophen; Biotransformation; Microsomes; ROS; Oxidative stress;
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Comparison of cytochrome P450 concentrations and metabolic activities in porcine hepatic microsomes prepared with two different methods
Keywords: میکروسوم; Pig; Liver; Microsomes; Ultracentrifugation; Calcium aggregation method; Cytochrome P450; Stability
In vivo effect of dried chicory root (Cichorium intybus L.) on xenobiotica metabolising cytochrome P450 enzymes in porcine liver
Keywords: میکروسوم; Chicory; Cytochrome P450; Microsomes; Western blotting; RT-PCR
Enhanced glucose 6-phosphatase activity in liver of rats exposed to Mg2+-deficient diet
Keywords: میکروسوم; Mg2+; G6P; G6Pase; Pyrophosphate; Endoplasmic reticulum; Microsomes; Liver; EDTA; Translocon; Starvation
Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes
Keywords: میکروسوم; Aconitine; Cytochrome P450; Metabolism; Microsomes; LC-MS/MS;
Esterification of okadaic acid in the mussel Mytilus galloprovincialis
Keywords: میکروسوم; Acyltransferase activity; Acyl-CoA:OA acyltransferase; Acylation; Esterification; Bacteria; Endoplasmic reticulum; Microsomes; Okadaic acid; Palmitoyl-OA; Fatty acids; Depuration; Detoxification;
Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase
Keywords: میکروسوم; SDR; short-chain dehydrogenyse/reductase; AKR; aldo-keto reductase; 11β-HSD1; 11β-hydroxysteroid dehydrogenase 1; ANT; anthracycline; DAUN; daunorubicin; DAUNOL; daunorubicinol; ADAUN; aglycone of daunorubicin; ADAUNOL; aglycone of daunorubicinol; DOX;
Identification and Characterization of Oxymetazoline Glucuronidation in Human Liver Microsomes: Evidence for the Involvement of UGT1A9
Keywords: میکروسوم; oxymetazoline; glucuronosyltransferases (UGTs); enzyme kinetics; phase II metabolism; microsomes; glucuronidation; UGT1A9; liquid chromatography; mass spectrometry;
Microsomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species
Keywords: میکروسوم; Hypaconitine; Cytochrome P450; Metabolism; Microsomes; Monoclonal antibody
Inhibition of NADPH-cytochrome P450 reductase by tannic acid in rat liver microsomes and primary hepatocytes: Methodological artifacts and application to ischemia-reperfusion injury
Keywords: میکروسوم; tannic acid; NADPH-Cytochrome P450 reductase; microsomes; hepatocytes; inhibition; protein binding; simulated ischemia-reperfusion injury; cell culture; drug metabolizing enzymes;
Simultaneous Absolute Quantification of 11 Cytochrome P450 Isoforms in Human Liver Microsomes by Liquid Chromatography Tandem Mass Spectrometry with In Silico Target Peptide Selection
Keywords: میکروسوم; CYP enzymes; cytochrome P450; hepatic metabolism; LC-MS/MS; mass spectrometry; metabolism; microsomes; proteomics; quantification
Effects of Normothermic Hepatic Ischemia-Reperfusion Injury on the In Vivo, Isolated Perfused Liver, and Microsomal Disposition of Chlorzoxazone, a Cytochrome P450 2E1 Probe, in Rats
Keywords: میکروسوم; hepatic ischemia-reperfusion injury; pharmacokinetics; isolated perfused rat liver; hepatobiliary disposition; microsomes; cytochrome P450 2E1; cytochrome P450 reductase; chlorzoxazone; hepatic metabolism; metabolite kinetics;
Effects of Uremic Toxins on Transport and Metabolism of Different Biopharmaceutics Drug Disposition Classification System Xenobiotics
Keywords: میکروسوم; disease effects; BDDCS; organic anion-transporter polypeptide transporters; hepatocytes; CYP enzymes; microsomes; phase I metabolism
Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes
Keywords: میکروسوم; distribution; microsomes; clearance; metabolism; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;
Effects of bile acids on rat hepatic microsomal type I 11β-hydroxysteroid dehydrogenase
Keywords: میکروسوم; 11β-Hydroxysteroid dehydrogenase; Bile acid; Rat; Microsomes
Interstrain Differences of In Vitro Metabolic Stability and Impact on Early Drug Discovery
Keywords: میکروسوم; ADME; high-performance/pressure liquid chromatography (HPLC); microsomes; mass spectrometry; in vitro models; metabolic clearance; cytochrome P450; phase I metabolism;
Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats
Keywords: میکروسوم; Reactive metabolite; Electrophile; Glutathione; Microsomes; Cytosol; Glutathione transferase; Pharmacokinetics
2-Arylureidophenyl-4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)triazines as highly potent and selective ATP competitive mTOR inhibitors: Optimization of human microsomal stability
Keywords: میکروسوم; mTOR; PI3K; Kinase inhibitors; Cancer; Oncology; Microsomes
Biopharmaceutical and pharmacokinetic characterization of matrine as determined by a sensitive and robust UPLC–MS/MS method
Keywords: میکروسوم; Matrine; Caco-2 cells; Rat intestine perfusion; Pharmacokinetics; Microsomes; UPLC–MS/MS
Lack of Appreciable Species Differences in Nonspecific Microsomal Binding
Keywords: میکروسوم; protein binding; enzyme kinetics; clearance; microsomes; disposition;
Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver—A comparison with other phenothiazines
Keywords: میکروسوم; Chlorpromazine; Metabolism; Human CYP; Microsomes; Supersomes; Specific inhibitors
Effects of P-glycoprotein and Mrp2 inhibitors on the hepatobiliary disposition of Rhodamine 123 and its glucuronidated metabolite in isolated perfused rat livers
Keywords: میکروسوم; Rhodamine 123; rhodamine 123 glucuronide; cyclosporine; dibromosulfophthalein; isolated rat liver perfusion; microsomes; hepatobiliary disposition; hepatic metabolism; biliary excretion; efflux pumps;
Prediction of In Vivo Enantiomeric Compositions by Modeling In Vitro Metabolic Profiles
Keywords: میکروسوم; ADME; chirality; metabolism; enzyme kinetics; in vitro models; kinetics; microsomes; pharmacokinetics;
The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes
Keywords: میکروسوم; dimemorfan; metabolism; microsomes; CYP enzymes; inhibition; kinetics;
Extrapolating In vitro Metabolic Interactions to Isolated Perfused Liver: Predictions of Metabolic Interactions between R-Bufuralol, Bunitrolol, and Debrisoquine
Keywords: میکروسوم; metabolism in vitro; in vitro-in vivo extrapolation; IVIVE; drug interaction; DDI; microsomes; liver model; isolated perfused liver; metabolic clearance; PBPK modeling;
Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MS
Keywords: میکروسوم; Osthol; Caco-2 cell model; Microsomes; Phase I; HPLC; LC-MS/MS;
High resistance to lipid peroxidation of bird heart mitochondria and microsomes: Effects of mass and maximum lifespan
Keywords: میکروسوم; Birds; Heart; Mitochondria; Microsomes; Fatty acids; Lipid peroxidation; Allometric
Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats
Keywords: میکروسوم; BBR; pharmacokinetics; metabolic clearance; microsomes; enzyme kinetics; CYPs; UGTs;
IRAK-4 inhibitors. Part 1: A series of amides
Keywords: میکروسوم; IRAK; IRAK-4 inhibitor; Inflammation; Kinase; SAR; Thiazole amide; Pyridine amide; Suzuki reaction; Docking; Microsomes; Solubility; In vivo exposure
NADPH- and iron-dependent lipid peroxidation inhibit aromatase activity in human placental microsomes
Keywords: میکروسوم; Aromatase; Cytochrome P450; Free radicals; Iron; Lipid peroxidation; Microsomes; Placenta; Pre-eclampsia; Pregnancy
Species Differences in Inhibition Potential of Nonsteroidal Anti-Inflammatory Drugs Against Estradiol 3β-Glucuronidation Between Rats, Dogs, and Humans
Keywords: میکروسوم; inhibition; glucuronosyltransferases (UGT); metabolite kinetics; microsomes; drug interactions;
An allometric study of fatty acids and sensitivity to lipid peroxidation of brain microsomes and mitochondria isolated from different bird species
Keywords: میکروسوم; Birds; Brain; Mitochondria; Microsomes; Fatty acids; Lipid peroxidation; Allometry
Liquid chromatographic–electrospray mass spectrometric determination (LC–ESI-MS) of phase II metabolites of flobufen in rat liver microsomes—Chiral discrimination
Keywords: میکروسوم; Flobufen; Chiral; Enantiomer; LC–MS/MS; Enzyme kinetics; Microsomes
The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat
Keywords: میکروسوم; Hyperlipidemia; Tissue distribution; Metabolite; Microsomes; Cytochrome P-450
The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes
Keywords: میکروسوم; Tannic acid; Inhibition; CYP; NADPH-CYP reductase; Microsomes
Comparison of genistein metabolism in rats and humans using liver microsomes and hepatocytes
Keywords: میکروسوم; Genistein; Microsomes; Cryopreserved hepatocytes; Cytochrome P450s; In silico approach; MetabolismATP, adenosine triphosphate; CAD, collision-activated dissociation; COMT, catechol-O-methyl transferase; CYP, cytochrome P450; DNA, deoxyribonucleic acid; ER
Metabolism of 17α-hydroxyprogesterone caproate by hepatic and placental microsomes of human and baboons
Keywords: میکروسوم; Preterm delivery; 17α-Hydroxyprogesterone caproate; Metabolism; Microsomes; Human placenta; Baboon placenta; Human liver; Baboon liver
Use of a fluorescent substrate for the selective quantification of rat CYP3A in the liver and the intestine
Keywords: میکروسوم; Cytochrome P450; Drug; Intestine; Liver; Metabolism; Methods; Microsomes; Rat; Specificity
Metabolism, tissue distribution, and pharmacokinetics of N-methyl-N-2,4,6-tetranitroaniline (tetryl)
Keywords: میکروسوم; Tetryl; Elimination; Metabolism; Microsomes; Tissue distribution;
Solid Phase Extraction as a Faster Alternative to HPLC: Application to MS Analysis of Metabolic Stability Samples
Keywords: میکروسوم; high throughput technologies; HPLC; mass spectrometry (MS); microsomes; solid phase extraction (SPE); ADME; hepatic metabolism; stability;
Changes in lipid composition and lipogenic enzyme activities in liver of lambs fed ω-6 polyunsaturated fatty acids
Keywords: میکروسوم; De novo fatty acid synthesis; Fatty acid chain elongation and desaturation; Lamb; Liver; Microsomes; Mitochondria; Safflower oil
Non-enzymatic lipid peroxidation of microsomes and mitochondria from liver, heart and brain of the bird Lonchura striata: Relationship with fatty acid composition
Keywords: میکروسوم; Birds; Fatty acids; Lipid peroxidation; Microsomes; Mitochondria
Validation of a HPLC method for the determination of p-nitrophenol hydroxylase activity in rat hepatic microsomes
Keywords: میکروسوم; p-Nitrophenol; CYP2E1; Microsomes; Metabolism; HPLC; Validation
Ethanol specifically alters the synthesis, acylation and transbilayer movement of aminophospholipids in rat-liver microsomes
Keywords: میکروسوم; Alcohol; Aminophospholipids; Microsomes; Base-exchange reaction; Transbilayer movement
Characterization of human liver cytochromes P450 by combining the biochemical and proteomic approaches
Keywords: میکروسوم; Microsomes; Human liver; Cytochromes P450; Microsomal oxidation; 1D-electrophoresis; Mass spectrometry; Quantitation;
Effects of methotrexate on calcium flux in rat liver mitochondria, microsomes and plasma membrane vesicles
Keywords: میکروسوم; Calcium transport; Liver; Methotrexate; Microsomes; Mitochondria; Plasma membrane;
Characterization of the cytochrome P450 enzymes involved in the metabolism of a new cardioprotective agent KR-33028
Keywords: میکروسوم; KR-33028; Cytochrome P450; Microsomes; Metabolism
In vitro and in vivo assessment of herb drug interactions
Keywords: میکروسوم; Herb drug interaction; Milk thistle; St. John's wort; Hepatocytes; Microsomes
Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance
Keywords: میکروسوم; Hepatocytes; In vivo; In vitro; Intrinsic clearance; Microsomes
Oxygen-insensitive enzymatic reduction of oximes to imines
Keywords: میکروسوم; Aldoxime; Amidoxime; Cytochrome P450; N-reduction; Microsomes; Mitochondria