IRAK-4 inhibitors. Part 1: A series of amides

The synthesis and profile of a series of amides are described. Some of these compounds were potent IRAK-4 inhibitors and two examples were evaluated in vivo.

A series of amides, based on the screening hit 2a, were prepared and profiled. Some potent IRAK-4-inhibitors were identified and two examples, 4a and 4b, were progressed into an in vivo PK study.Figure optionsDownload as PowerPoint slide