دانلود مقالات ISI درباره Mitoq + ترجمه فارسی

در جستجوی جدید آنتی اکسیدان های هدفمند میتوکندری بسیار فعال: تیموویونون و مشتقات کاتیونی آن

In search of novel highly active mitochondria-targeted antioxidants: Thymoquinone and its cationic derivatives

Keywords: Δψ; transmembrane electric potential difference; BLM; bilayer planar phospholipid membrane; C12R1; dodecyl rhodamine 19; C12TPP; dodecyltriphenylphosphonium; DMMQ; 3′-demethoxyMitoQ; MDA; malondialdehyde; MDR; multidrug resistance; MitoQ; 10-(6′-ubi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

باز شدن کانال های آنیونی وابسته به ولتاژ موجب تولید گونه های واکنش پذیر اکسیژن، اختلال عملکرد میتوکندری و مرگ سلولی در سلول های سرطانی می شود

Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells

Keywords: ΔΨ; mitochondrial membrane potential; cmH2DCF; chloromethyl 2′,7′-dichlorodihydro-fluorescein; cmH2DCFDA; chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate; HBSS; Hank's buffered saline solution; MitoQ; mitochondria-targeted ubiquinone;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

تطبیق عملکرد میتوکندری برای درمان نوروپاتی اپتیکی

Targeting mitochondrial function to treat optic neuropathy

Keywords: Retinopathy; Optic neuropathy; Age-related macular degeneration; Diabetic retinopathy; Glaucoma; Leber's hereditary optic neuropathy (LHON); Mitochondrial dysfunction; CoQ10; Idebenone; EPI-743; MitoQ; SkQ1; Ocluvia; MTP-131;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

اختلال میلوچوندری و استرس اکسیداتیو در اختلالات متابولیکی - گامی به سوی استراتژی های درمانی مبتنی بر میتوکندری

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

Keywords: ATP; Adenosine triphosphate; OXPHOS; Oxidative phosphorylation; ROS; Reactive oxygen species; RNS; Reactive nitrogen species; TCA; Tricarboxylic acid; IR; Insulin resistance; MetS; Metabolic syndrome; ETC; Electron transport chain; SOD; Superoxide dismuta

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

تنظیم مقادیر اتوفایگی باعث کاهش آسیب های میتوکندری ناشی از کلر و التهاب ریه می شود

Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation

Keywords: Chlorine; Mitochondrial dysfunction; Lung injury; MitoQ; Trehalose; Autophagy; Bioenergetics; 3-Methyladenine; Free radicals;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

آنتی اکسیدان های کاتیونی به عنوان یک ابزار قدرتمند در برابر استرس اکسیداتیو میتوکندری

Cationic antioxidants as a powerful tool against mitochondrial oxidative stress

Keywords: Δψ; transmembrane electric potential difference; MitoQ; 10-(6′-ubiquinonyl) decyltriphenylphosphonium; mROS; mitochondrial reactive oxygen species; ROS; reactive oxygen species; SkQs; plastoquinonyl conjugates with penetrating cations; SkQ1; 10-(6′-

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

MitoQ improves mitochondrial dysfunction in heart failure induced by pressure overload

Keywords: Heart failure; Mitochondrial dysfunction; MitoQ; Interfibrillar mitochondria; Subsarcolemmal mitochondria; Reactive oxygen species;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease

Keywords: Aldehyde dehydrogenase 2; Posttranslational modification; Alcoholic liver disease; MitoQ;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion 56Fe radiation induced brain injury in mice

Keywords: IR; iron ion 56Fe radiation; ROS; reactive oxygen species; cyto c; cytochrome c; Mfn2; mitofusin2; Drp1; dynamic-like protein; OPA1; andoptic atrophy gene1; ATP; adenosine triphosphate; mtDNA; mitochondrial DNA; nDNA; nuclear DNA; ADP; adenosine 5′-diph

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2018 سفارش ترجمه

MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α

Keywords: MitoQ; Parkinson's disease; Mitochondrial fusion; Mfn2; PGC-1α;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis

Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; BUN; blood urea nitrogen; BW; body weight; BG; blood glucose; DCFDA; dichlorodihydrofluorescein diacetate; DN; diabetic nephropathy; ECL; enhanced chemiluminescence; EM; electron microscopy;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress

Keywords: 4-HNE; 4 hydroxynonenal; apoE; apolipoprotein E; AWTed; anterior wall thickness at end diastole; Ccl5; ligand 5; C-C motif; chemokine; CoQ10; ubiquinone; FS; fractional shortening; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GPX; glutathione peroxida

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium

Keywords: 129; 129S1/SvimJ; B6; C57BL6/J; DKO; double knockout of GPx1 and GPx2 genes; DUOX 2; dual oxidase-2; Duoxa; Duox activator; Duoxa-TKO; triple-knockout mice with disrupted Duoxa, GPx1 and GPx2 genes; DSS; dextran sodium sulfate; DTI; di-2-thienyliodonium;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

Keywords: Mitoq; Diabetic kidney disease; Mitophagy; Tubular;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Redox regulation of cardiovascular inflammation - Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species

Keywords: AP-1; activator protein-1; AT1R; angiotensin II receptor type 1; AT-II; angiotensin II; bFGF; basic fibroblast growth factor; CCR; C-C chemokine receptor; cGMP; cyclic guanosine monophosphate; DC; dendritic cell; eNOS; endothelial nitric oxide synthase;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

Keywords: Kidney; Ischemia–reperfusion injury; Mitochondria; Oxidative damage; Mitochondria targeted antioxidants; MitoQ

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model

Keywords: ischemia; reperfusion; transplantation; mitochondria-targeted anti-oxidants; MitoQ;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

GCDCA down-regulates gene expression by increasing Sp1 binding to the NOS-3 promoter in an oxidative stress dependent manner

Keywords: Cholestatic liver disease; Endothelial nitric oxide synthase; Oxidative stress; Transcription factor Sp1; Glycochenodeoxycholic acid; ADHP; 0-acetyl-3, 7-dihydroxyphenoxazine; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BDL; bile duct

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Antioxidants successfully reduce ROS production in propionic acidemia fibroblasts

Keywords: Propionic acidemia; Antioxidants; Resveratrol; MitoQ; Tiron; Trolox;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibition of ROS production through mitochondria-targeted antioxidant and mitochondrial uncoupling increases post-thaw sperm viability in yellow catfish

Keywords: Sperm cryopreservation; Yellow catfish; Reactive oxygen species (ROS); MitoQ; 2,4-Dinitrophenol (DNP); Uncoupling protein (UCP2);

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

RARγ-C-Fos-PPARγ2 signaling rather than ROS generation is critical for all-trans retinoic acid-inhibited adipocyte differentiation

Keywords: Adipocyte differentiation; All-trans retinoic acid; Retinoic acid receptor; Peroxisome proliferator-activated receptors γ; C-Fos; aP2; adipocyte protein 2; ATRA; all-trans-retinoic acid; C/EBP; CCAAT/ enhancer binding proteins; GCLc; catalytic subunit of

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis

Keywords: ALS; amyotrophic lateral sclerosis; SOD1G93A; ALS-linked superoxide dismutase 1 bearing the G93A mutation; MitoQ; [10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenylphosphonium; TPP; triphenylphosphonium; decylTPP; decyltriphenylp

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease

Keywords: Aβ; β-amyloid peptide; AD; Alzheimer disease; ETC; electron transport chain; DCFDA; 2,7-dichorofluorescein diacetate; mtDNA; mitochondrial DNA; APP; amyloid precursor protein; ROS; reactive oxygen species; MitoQ; mitoquinone mesylate, 10-(4,5-dimethoxy-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain

Keywords: ABC proteins; ATP binding cassette proteins; BBB; blood-brain barrier; Bcrp; breast cancer resistance protein; CsA; cyclosporin A; IP; intra peritoneal; IV; intra venous; Mdr1; multi drug resistance 1; MitoF; 11-fluoroundecyltriphenylphosphonium mesylat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice

Keywords: Metabolic syndrome; MitoQ; Atherosclerosis; Mitochondria

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmacological targeting of mitochondrial complex I deficiency: The cellular level and beyond

Keywords: AMPK; AMP-activated protein kinase; CAT; catalase; CI; complex I; CL; cardiolipin; COX; cytochrome c oxidase; ER; endoplasmic reticulum; ERCa; ER Ca2+ content; ETC; electron transport chain; FAD; flavin adenine dinucleotide; FCS; fluorescence correlation

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Manganese superoxide dismutase, MnSOD and its mimics

Keywords: MnSOD mimics; MnSOD; MitoQ; Mn porphyrins; MnTE-2-PyP; MnTnHex-2-PyP

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2012 سفارش ترجمه

Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain

Keywords: Organophosphate; Dichlorvos; Oxidative stress; Neurodegeneration; MitoQ; ROS; reactive oxygen species; cyt c; cytochrome c; MnSOD; Manganese superoxide dismutase; AD; Alzheimer's disease; PD; Parkinson disease;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

Keywords: BH3; Bcl-2 homology domain 3; CII; complex II; ChIP; chromatin immunoprecipitation; DHE; dihydroethidium; DMPO; 5,5-dimethyl-1-pyrroline N-oxide; EPR; electron paramagnetic resonance; MIM; mitochondrial inner membrane; MitoQ; mitochondrially targeted coen

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Oxidative stress in Alzheimer disease: A possibility for prevention

Keywords: Alzheimer disease; Antioxidants; Coenzyme Q; Dimebon; Mitochondrial antioxidants; MitoQ; Oxidative stress; Reactive oxidative species

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probes

Keywords: DecylTPP, decyltriphenylphosphonium bromide; FluoroUndecylTPP, 11-fluoroundecyltriphenylphosphonium mesylate; IAM, iodoacetamide; IBTP, 4-iodobutylTPP; IDTP, 10-iododecylTPP; iv, intravenous; LC/MS/MS, liquid chromatography–tandem mass spectrometry; MitoQ

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Detection and manipulation of mitochondrial reactive oxygen species in mammalian cells

Keywords: α-KGDH; α-ketoglutarate dehydrogenase; MIM; mitochondrial inner membrane; MOM; mitochondrial outer membrane; RET; reverse electron transfer; ROI; region of interest; t1/2; half-life; TPP+; triphenylphosphonium; Hydroethidine; Redox-sensitive GFP; cpYFP;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Prevention of cardiolipin oxidation and fatty acid cycling as two antioxidant mechanisms of cationic derivatives of plastoquinone (SkQs)

Keywords: ∆ψ; transmembrane electric potential; AAPH; 2,2′-azobis(2-amidinopropane)dihydrochloride; BLM; planar bilayer phospholipid membrane; Cart; carboxyatractyloside; CCCP; carbonyl cyanide m-chlorophenylhydrazone; CTMA; cetyltrimethylammonium; C10TPP; dec

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

An attempt to prevent senescence: A mitochondrial approach

Keywords: Δψ; transmembrane electric potential; BLM; planar bilayer phospholipid membrane; C12TPP; dodecyl-triphenylphosphonium; DCF; 2′,7′-dichlorodihydrofluoroscein diacetate; DMQ; demethoxyMitoQ (MitoQ lacking a methoxy group); DPQ; decyl plastoquinone; FC

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2009 سفارش ترجمه

Mitochondrial targeting of quinones: Therapeutic implications

Keywords: Mitochondria; Antioxidants; MitoQ

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Mitochondrial redox state regulates transcription of the nuclear-encoded mitochondrial protein manganese superoxide dismutase: a proposed adaptive response to mitochondrial redox imbalance

Keywords: AOE; antioxidant enzyme; DCF; 2′,7′-dichlorofluorescein diacetate; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; H2O2; hydrogen peroxide; IPTG; isopropyl β-thiogalactoside; MitoQ; a mitochondrial-specific antioxidant which is a mixture of mitoquin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه