دانلود مقالات ISI درباره Mk2 + ترجمه فارسی

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Degradation systems in heart failure

Keywords: AMPK; AMP-activated protein kinase; ASK1; apoptosis signal-regulating kinase 1; Atg; autophagy-related; ARE; AU-rich element; AUF; ARE RNA binding protein; BRF; butyrate response factor; CaMK; Ca2 +/calmodulin-dependent protein kinase; CUGBP; CUG-binding

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Age-dependent regulation of antioxidant genes by p38α MAPK in the liver

Keywords: Akt; Protein kinase B; AP-1; Activator protein-1; ASK1; Apoptosis signal-regulating kinase 1; ATF2; activating transcription factor 2;; ChIP; Chromatin immunoprecipitation;; DEN; Diethyl nitrosamine;; EGFR; Epidermal growth factor receptor; G6PDH; Glucose

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

KRAS-Mutant non-small cell lung cancer: From biology to therapy

Keywords: BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Inhibition of MAPKAPK2/MK2 facilitates DNA replication upon cancer cell treatment with gemcitabine but not cisplatin

Keywords: MAPKAPK2; MK2; Gemcitabine; Cisplatin; p38; DNA damage; DNA replication; DNA fiber assays;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

Sec6 enhances cell migration and suppresses apoptosis by elevating the phosphorylation of p38 MAPK, MK2, and HSP27

Keywords: Sec6; p38 MAPK; MK2; HSP27; MAPK; Mitogen-activated protein kinases; MAP3K; MAPK kinase kinase; MAP2K; MAPK kinase; TAK1; TGFβ-activated kinase 1; ASK1; apoptosis signal-regulating kinase 1; MLK; mixed-lineage kinase; CREB; cAMP response element binding

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Umifenovir effectively inhibits IL-10 dependent persistent Coxsackie B4 virus infection

Keywords: Umifenovir; Coxsackie B4; Viral myocarditis; IL-10; P38 MAPK; MAPK-activated protein kinase 2; CVB4; Coxsackie B4; MK2; MAPK-activated protein kinase 2; APC; Antigen presenting cells; LCMV; Lymphocytic choriomeningitis virus; HCV; Hepatitis C virus; CMV;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death

Keywords: 5-ALA; 5-aminolevulinic acid; MK2; MAP Kinase-Activated Protein kinase 2; p38; Mitogen-Activated Protein kinase p38; PDT; Photodynamic Therapy; RIP; Receptor Interacting Protein; TSC; Tuberous Sclerosis; YWHA; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxy

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture

Keywords: MK2; mitogen-activated protein kinase-activated protein kinase 2; p38MAPK; p38 mitogen-activated protein kinase; Erk1/2; extracellular-signal regulated kinase; IEG; immediate early genes; PCLS; precision-cut liver slices; HE; hematoxylin and eosin; In vit

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Treatment with MAPKAP2 (MK2) inhibitor and DNA methylation inhibitor, 5-aza dC, synergistically triggers apoptosis in hepatocellular carcinoma (HCC) via tristetraprolin (TTP)

Keywords: HCC; hepatocellular carcinoma; MK2; MAPKAP kinase 2/mitogen-activated protein kinase-activated protein kinase 2; TTP; tristetraprolin; IEG; immediate early genes; 5-Aza dC; 5-aza-2ʹ-deoxycytidine; HCC; Apoptosis; MK2 inhibitor; TTP; 5-Aza-2ʹ-deoxycytidi

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5

Keywords: PDE4; PKA; ERK1/2; MK2; β2-adrenergic receptors; Acrodysostosis;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2016 سفارش ترجمه

MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition

Keywords: Apoptosis; Cardiac ischemia; Fibrosis; MAPKAP kinase 2; MK2; MMI-0100;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2014 سفارش ترجمه

Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives

Keywords: Heart; MAPK; Cardiac diseases; Mitochondria; Cell signaling; AngII; angiotensin II; CA; constitutively active; CHIP; C terminus of Hsc70-interacting protein; CT-1; cardiotrophin-1; ΔΨmit; mitochondrial membrane potential; DN; dominant negative; ERK1/2;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2014 سفارش ترجمه

Potency switch between CHK1 and MK2: Discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors

Keywords: Potency switch; CHK1; MK2; Kinase; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Rit subfamily small GTPases: Regulators in neuronal differentiation and survival

Keywords: CA; constitutively active; cAMP; cyclic adenosine monophosphate; CaM; calmodulin; CCI; controlled cortical impact; CREB; cAMP response element binding protein; CRIB; Cdc42/Rac interactive binding; DA; dopamine; DAT; dopamine transporter; DN; dominant nega

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Combined CpG and poly I:C stimulation of monocytes results in unique signaling activation not observed with the individual ligands

Keywords: TLRs; Toll-like receptors; CpG; unmethylated CpG oligodeoxynucleotides; poly I:C; polyinosinic-polycytidylic acid; NO; nitric oxide; iNOS; inducible nitric oxide synthase; CREB; cAMP response element-binding protein; NFκB; nuclear factor κB; PRRs; pat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors

Keywords: Azepine; Oxazocine; Tetracyclic; MK2;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

A three-step protocol for lead optimization: Quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors

Keywords: Three-step protocol; SAR; Conformation; MK2; TNFα; Non-ATP competitive; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Fucosterol isolated from Undaria pinnatifida inhibits lipopolysaccharide-induced production of nitric oxide and pro-inflammatory cytokines via the inactivation of nuclear factor-κB and p38 mitogen-activated protein kinase in RAW264.7 macrophages

Keywords: Fucosterol; Inflammation; NF-κB; MKK3/6; MK2; p38 MAPK;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Myocyte enhancer factor-2 and cardiac muscle gene expression during hibernation in thirteen-lined ground squirrels

Keywords: EA; Early arousal; EC; Euthermic in the cold room; EN; Entrance into torpor; ET; Early torpor; GLUT4; Glucose-transporter 4; IA; Interbout arousal; LT; Late torpor; MAPK; Ras/mitogen-activated protein kinase; MEF2; Myocyte enhancer factor-2; MK2; MAPK-act

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors

Keywords: MAPKAPK2; MK2; Anti-TNFα; Oral bioavailability; Rheumatoid arthritis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Structure-based lead identification of ATP-competitive MK2 inhibitors

Keywords: MAPKAPK2; MK2; Anti-TNFα; SBDD; Rheumatoid arthritis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Peptide Inhibitors of MK2 Show Promise for Inhibition of Abdominal Adhesions

Keywords: IL-1β; IL-6; MAPKAP Kinase 2; MK2; TNF-α; abdominal adhesion

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I

Keywords: MAPKAP-K2; MK2; TNFa; Inhibition; Antiinflammatory; In vivo; Rheumatoid arthritis;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization

Keywords: MAPKAP-K2; MK2; TNFα; Diaminopyrimidine

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode

Keywords: MAPKAP-K2; MK2; TNFα; Diaminopyrimidine

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II

Keywords: MAPKAP-K2; MK2; TNFα; Inhibition; Antiinflammatory; In vivo; Rheumatoid arthritis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Mitogen-activated protein kinase p38 and MK2, MK3 and MK5: Ménage à trois or ménage à quatre?

Keywords: Mitogen-activated protein kinase-activated protein kinase; p38MAPK; PRAK; MK2; MK3; MK5;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Characterization of a novel MK3 splice variant from murine ventricular myocardium

Keywords: DMSO; dimethylsulfoxide; DTT; dithiothreitol; ERK; extracellular signal-related kinase; FPLC; fast protein liquid chromatography; GST; glutathione S-transferase; MAPK; mitogen-activated protein kinase; MK2; MAPK-activated protein kinase-2; MK3; MAPK-activ

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Benzothiophene inhibitors of MK2. Part 1: Structure–activity relationships, assessments of selectivity and cellular potency

Keywords: MK2; MAPKAP-K2

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

A p38 mitogen-activated protein kinase inhibitor screening method using growth recovery of Escherichia coli as an index

Keywords: p38; MK2; Inhibitor; Screening; Escherichia coli; Inflammatory diseases; Coumarin; SCADS; NPDepo; HiTS

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5

Keywords: F-actin; Hsp27; MAPKAP-kinase; PRAK; MK2; MK5

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology

Keywords: MAPKAPK2; Cartilage; MK2; Metalloproteinases; PGE2

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Aqueous versus non-aqueous salt delivery strategies to enhance oral bioavailability of a mitogen-activated protein kinase-activated protein kinase (MK-2) inhibitor in rats

Keywords: MK2; inhibitor; in vivo; oral; salt; non-aqueous; bioavailability;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)

Keywords: MAPKAP-K2; MK2; TNF; Squarate

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Pyrrolo-pyrimidones: A novel class of MK2 inhibitors with potent cellular activity

Keywords: MK2; MAPKAPK-2; TNFα inhibition; Inflammation; Rheumatoid arthritis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR

Keywords: AMPK; AMP-activated kinase; ARE; adenosine uridine-rich element; ATP; adenosine 5′triphosphate; Chk2; checkpoint kinase 2; COX-2; cyclooxygenase-2; ELAV; embryonic lethal abnormal vision; ERK; extracellular signal-regulated kinase; HNS; HuR-nucleo-cytop

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells: An obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27

Keywords: Human lung microvascular endothelial cells; MK2; HSP27; siRNA; ICAM-1; IL-8

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

The discovery of carboline analogs as potent MAPKAP-K2 inhibitors

Keywords: MAPKAP-K2; MK2; MK2a; Carboline

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Distinct role of MAPKAPK-2 in the regulation of TNF gene expression by Toll-like receptor 7 and 9 ligands

Keywords: Toll-like receptors; Macrophages; TLR7; TLR9; CpG; S28463; Imidazoquinolines; TNF; mRNA stability; Post-transcriptional regulation; MK2

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Optimal Sox-based fluorescent chemosensor design for serine/threonine protein kinases

Keywords: Serine/Threonine kinase; Fluorescent assay; Akt; Cdk2; PKA; Pim2; PKC; MK2

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه