Keywords: MMP، پتانسیل غشای میتوکندریایی; Store-operated calcium entry; Stromal interaction molecule; High glucose; Neurotoxicity; ApoptosisSOCE, store-operated calcium entry; SOC, store-operated calcium channel; MMP, mitochondrial membrane potential; MPT, mitochondrial permeability transition; S
مقالات ISI MMP، پتانسیل غشای میتوکندریایی (ترجمه نشده)
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Keywords: MMP، پتانسیل غشای میتوکندریایی; ALDH2, aldehyde dehydrogenase; BSA, bovine serum albumin; DNPH, 2,4-dinitrophenylhydrazine; GO, glyoxal; GSH, reduced glutathione; MGO, methyl glyoxal; MMP, mitochondrial membrane potential; ROS, reactive oxygen speciesGlyoxal; Methylglyoxal; Oxidative st
Keywords: MMP، پتانسیل غشای میتوکندریایی; MMP, mitochondrial membrane potential; JC-1, 5,5',6,6' -tetrachloro-1,1',3,3'-tetraethyl benzimidazol carbocyanine iodide; CDK, cyclin dependent kinases; ROS, reactive oxygen species; DCFH-DA, 2', 7'-dichlorofluorescein-diacetate; Caspase, cysteine aspart
Keywords: MMP، پتانسیل غشای میتوکندریایی; ROS, reactive oxygen species; MMP, mitochondrial membrane potential; B2 M, beta-2-microglobulin; KIM-1, kidney injury molecule-1Kidney proximal tubule; Adhatoda zeylanica; Nephrotoxicity; HK-2
Keywords: MMP، پتانسیل غشای میتوکندریایی; MMP, Mitochondrial membrane potential; ROS, Reactive oxygen species; Hb, Haemoglobin; Met-Hb, met-haemoglobin; MT, Metallothioneins; DilC1(5), MitoProbe; DCFDA-H2, 2′-7′-dichlorodihydrofluorescein diacetate; EDTA, Ethylenediaminetetraacetic acid; K-FC, Po
MCL-1 is the key target of adjuvant chemotherapy to reverse the cisplatin-resistance in NSCLC
Keywords: MMP، پتانسیل غشای میتوکندریایی; NSCLC, non-small cell lung cancer; MCL-1, Myeloid cell leukemia-1; IC50, half maximal inhibitory concentration; CDDP, cisplatin; MMP, mitochondrial membrane potential; CPR-A549, cisplatin resistant A549; DMEM, Dulbecco's modified Eagle medium; MTT, 3-(4,5
ZT-25, a new vacuolar H+-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; V-ATPases, vacuolar H+-ATPases; MMP, mitochondrial membrane potential; CQ, chloroquine; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; 3-MA, 3-methyladenine; NAC, N-acetyl-L-cysteine; DMEM, Dulbecco's modified eagle medium; DCFH-DA, 2
Curcumin hampers the antitumor effect of vinblastine via the inhibition of microtubule dynamics and mitochondrial membrane potential in HeLa cervical cancer cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; Curcumin; Vinblastine; Microtubule; Mitochondrial membrane potential; ROS, Antitumor activityROS, Reactive oxygen species; MMP, Mitochondrial membrane potential; NAC, N-acetyl cysteine; PI, Propidium iodide; DAPI, 6-diamidino-2-phenylindole; DCF-DA, 2′,7′
Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway
Keywords: MMP، پتانسیل غشای میتوکندریایی; Brucea javanica; Dehydrobruceine B; Mitochondrial pathway; Pro-apoptotic actionDHB, dehydrobruceine B; MTT, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-2H-tetrazolium bromide; MMP, mitochondrial membrane potential; ROS, reactive oxygen species; PI, propid
Effect of platinum nanoparticles on cell death induced by ultrasound in human lymphoma U937 cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; Pt-NPs, platinum nanoparticles; Au-NPs, gold nanoparticles; US, ultrasound; Nec-1, necrostatin-1; ROS, reactive oxygen species; O2−, superoxide; H2O2, hydrogen peroxide; OH, hydroxyl radical; MMP, mitochondrial membrane potential; SOD, superoxide dismutas
Protective effect of catechin rich extract of Rhizophora mucronata against β-amyloid-induced toxicity in PC12 cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; AD, Alzheimer's disease; Aβ, beta amyloid peptide; MERM, methanolic leaf extract of Rhizophora mucronata; MMP, mitochondrial membrane potential; HPTLC, high performance thin layer chromatography; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbr
Molybdenum induces pancreatic β-cell dysfunction and apoptosis via interdependent of JNK and AMPK activation-regulated mitochondria-dependent and ER stress-triggered pathways
Keywords: MMP، پتانسیل غشای میتوکندریایی; Mo, molybdenum; DM, diabetes mellitus; MMP, mitochondrial membrane potential; PARP, poly (ADP-ribose) polymerase; ER, endoplasmic reticulum; UPR, unfolded protein response; eIF, eukaryotic initiation factor; AFT, activation transcription factor; XBP, X-bo
Asiatic acid uncouples respiration in isolated mouse liver mitochondria and induces HepG2 cells death
Keywords: MMP، پتانسیل غشای میتوکندریایی; MMP, mitochondrial membrane potential; ROS, reactive oxygen species; FCCP, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; UCPs, uncoupling proteins; GDP, guanosine 5′-diphosphate; ANT, adenine nucleotide transporter; Catr, carboxyatractyloside; 6Kc
The cytotoxic nature of Acanthopanax sessiliflorus stem bark extracts in human breast cancer cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; ASSBE, Acanthopanax sessiliflorus stem bark extracts; ASSBE-nHF, normal hexane fraction of Acanthopanax sessiliflorus stem bark extracts; ROS, reactive oxygen species; MMP, mitochondrial membrane potential; JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl
Effects of N-butylphthalide on the activation of Keap1/Nrf-2 signal pathway in rats after carbon monoxide poisoning
Keywords: MMP، پتانسیل غشای میتوکندریایی; CO, carbon monoxide; NBP, N-butylphthalide; HbCO, carboxyhemoglobin; Bcl-2, B-cell lymphoma gene 2; Bax, Bcl-2-associated X protein; MMP, mitochondrial membrane potential; Keapl, Kelch-like ECH-associated protein 1; Nrf-2, nuclear factor erythroid 2-relat
Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model
Keywords: MMP، پتانسیل غشای میتوکندریایی; DLD E3, dihydrolipoyl dehydrogenase, the E3 subunit of pyruvate dehydrogenase complex and 2-oxoglutarate dehydrogenase complex; GPX, glutathione peroxidase; MMP, mitochondrial membrane potential; OCR, oxygen consumption rate; pol γA, catalytic subunit A o
III-10, a newly synthesized flavonoid, induces cell apoptosis with the involvement of reactive oxygen species-mitochondria pathway in human hepatocellular carcinoma cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; AIF, apoptosis-inducing factor; Cyt C, cytochrome c; ERK, extracellular regulated protein kinase; GSH, glutathione; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinases; MMP, mitochondrial membrane potential; NAC, N-acetyl-cysteineApoptos
Novel alkylphospholipid-DTC hybrids as promising agents against endocrine related cancers acting via modulation of Akt-pathway
Keywords: MMP، پتانسیل غشای میتوکندریایی; Alkylphospholipid; Dithiocarbamate; Akt-pathway; Endocrine cancer; Miltefosine; Anti-proliferative agentAPCs, alkylphosphocholines; DDTC, diethyldithiocarbamate; HEK, human embryonic kidney; PI, propidium iodide; MMP, mitochondrial membrane potential; ATC
HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis
Keywords: MMP، پتانسیل غشای میتوکندریایی; Abs, antibodies; LONP1, LON protease 1; MEF, mouse embryonic fibroblast; MMP, mitochondrial membrane potential; OXPHOS, oxidative phosphorylation; PHB, prohibitin; ROS, reactive oxygen speciesHtrA2; Mitochondria; Mnd2; Protein quality control; PHB; Mitoch
Spiruchostatin A and B, novel histone deacetylase inhibitors, induce apoptosis through reactive oxygen species-mitochondria pathway in human lymphoma U937 cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; SP-A, Spiruchostatin A; SP-B, Spiruchostatin B; ROS, reactive oxygen species; HDAC, histone deacetylase; MMP, mitochondrial membrane potential; NAC, N-acetyl-l-cysteine; FITC, fluorescein isothiocyanate; HATs, histone acetyltransferases; HDACi, histone de
Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cell-proliferation in lung cancer, in vitro and in vivo
Keywords: MMP، پتانسیل غشای میتوکندریایی; CGS, Condurango glycoside-rich components; NSCLC, non small cell lung cancer; BaP, benzo[a]pyrene; ROS, reactive oxygen species; MMP, mitochondrial membrane potential; EGFR, epidermal growth factor receptor; CAM, complementary and alternative medicine; RP
Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways
Keywords: MMP، پتانسیل غشای میتوکندریایی; SalB, salvianolic acid B; BM-EPCs, human endothelial progenitor cells; ROS, reactive oxygen species; NADPH oxidase, nicotinamide adenine dinucleotide phosphate-oxidase; MMP, mitochondrial membrane potential; mTOR, mammalian target of rapamycin; p70S6K, ri
Protective effect of polypeptides from larva of housefly (Musca domestica) on hydrogen peroxide-induced oxidative damage in HepG2 cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; BSA, bovine serum albumin; DCF, 2′,7′-dichlorofluorescein; DCFH-DA, 2′,7′-dichlorofluorescein-diacetate; DMEM, Dulbecco’s modified Eagle’s medium; FITC, fluorescein isothiocyanate; MDA, malondialdehyde; MMP, mitochondrial membrane potential; MTT, 3-(4,5-d
Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands
Keywords: MMP، پتانسیل غشای میتوکندریایی; DODC, 3,3′-diethyloxadicarbocyanine iodide; TMPyP4, 5,10,15,20-tetra (N-methyl-4-pyridyl) porphine; ROS, reactive oxygen species; MMP, mitochondrial membrane potential; OCR, oxygen consumption rateTelomerase; G-quadruplex ligand; Mitochondrial function; C
Cytotoxicity of ammonium hexafluorosilicate on human gingival fibroblasts
Keywords: MMP، پتانسیل غشای میتوکندریایی; DH, dentine hypersensitivity; FBS, fetal bovine serum; FCM, flow cytometry; GSH, Glutathione; hGFs, human gingival fibroblasts; JC-1, 5,5,6,6-tetrachloro-1,1,3,3-tetraethylbenzimidazolyl-carbocyanine iodide; MMP, mitochondrial membrane potential; MTT, 3-(
Resistin protection against endogenous Aβ neuronal cytotoxicity from mitochondrial pathway
Keywords: MMP، پتانسیل غشای میتوکندریایی; AD, Alzheimer's disease; Aβ, amyloid beta; LDH, lactate dehydrogenase; ROS, reactive oxygen species; DCFH-DA, 2′,7′-dichlorofluorescein-diacetate; NO, nitric oxide; MMP, mitochondrial membrane potential; ELISA, enzyme-linked immunosorbent assay; RNS, reac
The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; SHK, shikonin; Nec-1, necrostatin-1; ROS, reactive oxygen species; MMP, mitochondrial membrane potential; LDH, lactate dehydrogenase; TMRM, tetramethylrhodamine methyl ester; HPF, hydroxyphenyl fluorescein; GSH-MEE, gluthathione monoethyl ester; GAPDH, gl
GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death
Keywords: MMP، پتانسیل غشای میتوکندریایی; FCS, fetal calf serum; LMP, lysosomal membrane permeabilization; MMP, mitochondrial membrane potential; mTOR, mammalian target of rapamycin; PI3K, phosphatidylinositol-3-kinase; TFEB, Transcription Factor EB; zVAD.fmk, N-benzyloxycarbonyl-Val-Ala-Asp-fluo
Cyclophilin 40 alters UVA-induced apoptosis and mitochondrial ROS generation in keratinocytes
Keywords: MMP، پتانسیل غشای میتوکندریایی; CyP40/PPID, Cytosolic cyclophilin 40; PPIase, Peptidyl-prolyl cis–trans isomerase; MMP, Mitochondrial membrane potential; MPTP, Mitochondrial transition pore; VDAC, Voltage dependent anion channel; ANT, Adenine nucleotide translocator; UV, Ultraviolet; RC
Ethanolic extract of the Goldenseal, Hydrastis canadensis, has demonstrable chemopreventive effects on HeLa cells in vitro: Drug–DNA interaction with calf thymus DNA as target
Keywords: MMP، پتانسیل غشای میتوکندریایی; HC, Hydrastis canadensis; DAPI, 40, 60-diamidino-2 phenyl indole; Ao/Eb, acridine orange/ethidium bromide; MMP, mitochondrial membrane potential; FACS, fluorescence activated cell sorting; TUNEL, terminal deoxynucleotidyltransferase dUTP nick end labellin
Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; QUE, quercetin; RES, resveratrol; RUT, rutin; EGCG, epigallocatechin gallate; PPs, polyphenols; DHE, dihydroethidium; EGTA, ethylene glycol tetraacetic acid; GI, gastrointestinal; INDO, indomethacin; MMP, mitochondrial membrane potential; NSAID, nonsteroi
Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; DMSO, Dimethyl sulfoxide; ER, Estrogen receptor; GADM, Ganoderic acid DM; JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-benzimidazolylcarbocyanine iodide; MMP, Mitochondrial membrane potential; MTT, 3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl tetrazolium
The toxic effects of microcystin-LR on rat spermatogonia in vitro
Keywords: MMP، پتانسیل غشای میتوکندریایی; MC-LR, microcystin-leucine arginine; ROS, reactive oxidative species; MMP, mitochondrial membrane potential; Oatp, organic anion transporting polypeptide; ANOVA, analysis of varianceMicrocystin-LR; Spermatogonia; Cytotoxicity; Oxidative stress; Transport;
Salinomycin-induced apoptosis of human prostate cancer cells due to accumulated reactive oxygen species and mitochondrial membrane depolarization
Keywords: MMP، پتانسیل غشای میتوکندریایی; CSC, cancer stem cell; MMP, mitochondrial membrane potential; ROS, reactive oxygen species; MTT, 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide; NAC, N-acetylcysteine; DAPI, 4′,6-diamidino-2-phenylindole dihydrochloride; DiOC6, 3,3-dihexyl
LFG-500, a newly synthesized flavonoid, induced a reactive oxygen species-mitochondria-mediated apoptosis in hepatocarcinoma cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; Flavonoid; Apoptosis; Mitochondria; Reactive oxygen speciesDAPI, diamidino-phenyl-indole; ROS, reactive oxygen species; Cyt c, cytochrome c; AIF, apoptotic inducing factor; MMP, mitochondrial membrane potential
Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae
Keywords: MMP، پتانسیل غشای میتوکندریایی; CR, caloric restriction; ETC, electron transport chain; MMP, mitochondrial membrane potential; ROS, reactive oxygen species; SGD, Saccharomyces Genome Database; H2DCF, 2,7-dichlorofluorescin; DiOC6, 3,3-dihexyloxacarbocyanine iodide; WGA, wheat germ agglu
A study to evaluate the effect of nootropic drug—Piracetam on DNA damage in leukocytes and macrophages
Keywords: MMP، پتانسیل غشای میتوکندریایی; DNA, deoxyribonucleic acid; EDTA, ethylenediamine tetraacetic acid; LPS, lipopolysaccharide; MMP, mitochondrial membrane potential; NO, nitric oxide; OTM, olive tail moment; PBS, phosphate buffer saline; PI, propidium iodide; RNS, reactive nitrogen specie
Nickel(II) induced JNK activation-regulated mitochondria-dependent apoptotic pathway leading to cultured rat pancreatic β-cell death
Keywords: MMP، پتانسیل غشای میتوکندریایی; Ni, nickel; MMP, mitochondrial membrane potential; PARP, poly(ADP-ribose) polymerase; JNK, c-Jun N-terminal kinases; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; DM, diabetes mellitus; PS, phosphatidylserineNickel (N
Rescuing hepatocytes from iron-catalyzed oxidative stress using vitamins B1 and B6
Keywords: MMP، پتانسیل غشای میتوکندریایی; ROS, reactive oxygen species; LPO, lipid peroxidation; MMP, mitochondrial membrane potential; Fe, iron; NASH, non-alcoholic steatohepatitis; DCFD, 2′,7′-dichlorofluorescin diacetate; PIH, pyridoxal isonicotinoyl hydrazone; BHA, butylated hydroxyanisole; D
In vitro cytotoxicity and phototoxicity study of cosmetics colorants
Keywords: MMP، پتانسیل غشای میتوکندریایی; Colorant; Reactive; Oxygen species; Phototoxicity; Comet assayROS, reactive oxygen species; MMP, mitochondrial membrane potential; UV, ultraviolet; DNA, deoxyribonucleotic acid; DSU, disc scanning unit; CI, color index; CAS, chemical association service;
Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury
Keywords: MMP، پتانسیل غشای میتوکندریایی; LPO, lipid peroxidation; PARP, poly (ADP-ribose) polymerase; NAC, N-acetylcysteine; MAPKs, mitogen-activated protein kinases; ERK, extracellular signal-regulated kinases; JNK, c-Jun N-terminal kinases; MMP, mitochondrial membrane potential; ROS, reactive
Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia
Keywords: MMP، پتانسیل غشای میتوکندریایی; ginsenoside Rd; neuroprotection; mitochondria; strokeAIF, apoptosis-inducing factor; CBF, cerebral blood flow; CytoC, cytochrome c; ETC, electron transport chain; MCAO, middle cerebral artery occlusion; MMP, mitochondrial membrane potential; MPT, mitochon
Neuroprotective effect of modified Wu-Zi-Yan-Zong granule, a traditional Chinese herbal medicine, on CoCl2-induced PC12 cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; MWG, modified Wu-Zi-Yan-Zong granule; MAPK, mitogen-activated protein kinase; CCK-8, Cell Counting Kit-8; MMP, mitochondrial membrane potential; ROS, reactive oxygen species; PARP, poly ADP-ribose polymerase; JNK, c-Jun NH2-terminal kinase; SD, senile dem
3-(4-(Benzo[d]thiazol-2-yl)-1-phenyl-1H-pyrazol-3-yl) phenyl acetate induced Hep G2 cell apoptosis through a ROS-mediated pathway
Keywords: MMP، پتانسیل غشای میتوکندریایی; DPB-5, 3-(4-(benzo[d]thiazol-2-yl)-1-phenyl-1H-pyrazol-3-yl) phenyl acetate; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; ROS, reactive oxygen species; MMP, mitochondrial membrane potential; GSH, reduced glutathione; PI, propidium io
Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; DCF, 2,7-dichlorofluorescein; H2DCFDA, 5-(and-6)-chloromethyl-2′7′-dichlorodihydrofluorescein diacetate acetyl ester; MMP, mitochondrial membrane potential; NAC, N-acetyl-L-cysteine; ROS, reactive oxygen species; S4h, hour-steamed American ginseng root ex
TIP47 confers resistance to taxol-induced cell death by preventing the nuclear translocation of AIF and Endonuclease G
Keywords: MMP، پتانسیل غشای میتوکندریایی; TIP47, tail-interacting protein; ADRP, adipose differentiation-related protein; M6PR, mannose 6-phosphate receptors; PP17b, placental tissue protein 17b; MMP, mitochondrial membrane potential; IPTG, β-d-1-thiogalactopyranoside; MTT, methylthiazolyldipheny
Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic β-cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; C2-CER, C2-Ceramide; DCHFDA, 2′,7′-dichlorodihydrofluorescein diacetate; DHC, Dihydroceramide; DPI, diphenyleneiodonium; FB-1, Fumonisin B-1; GEF, guanine nucleotide exchange factor; MDA, malondialdehyde; MMP, mitochondrial membrane potential; NBT, nitrob
Mitochondrial superoxide dismutase SOD2, but not cytosolic SOD1, plays a critical role in protection against glutamate-induced oxidative stress and cell death in HT22 neuronal cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; SOD, superoxide dismutase; ROS, reactive oxygen species; GSH, glutathione; MMP, mitochondrial membrane potential; shRNA, short-hairpin RNA; siRNA, small interfering RNA; GFP, green fluorescent protein; TEM, transmission electron microscopy; HO-1, heme oxy
Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway
Keywords: MMP، پتانسیل غشای میتوکندریایی; AE, aloe-emodin; NPC, human nasopharyngeal carcinoma; PARP, poly (ADP-ribose) polymerase; siRNA, small interfering RNA; MMP, mitochondrial membrane potential; ROS, reactive oxygen species; CsA, cyclosporine A; FADD, Fas-associated death domain; AIF, apopt
[6]-Gingerol induces reactive oxygen species regulated mitochondrial cell death pathway in human epidermoid carcinoma A431 cells
Keywords: MMP، پتانسیل غشای میتوکندریایی; ROS, Reactive oxygen species; MMP, Mitochondrial membrane potential; Cox-2, Cyclooxygenase-2; HPLC, High-performance liquid-chromatography; DCF-DA, 2′,7′-dichlorodihydrofluorescein diacetate dye; GE, Ginger extractSkin cancer; Anti-cancer activities; A431