Phospho-mTOR: A novel target in regulation of renal lipid metabolism abnormality of diabetes
Keywords: mTOR; SREBP-1; Lipogenesis; Diabetic nephropathy; Akt;
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Inhibition of LRRK2 kinase activity stimulates macroautophagy
Keywords: LRRK2; Leucine Rich Repeat Kinase 2; mTOR; Mammalian target of rapamycin; ROC; Ras of Complex Proteins; COR; C-terminal of ROC domain; SDS; Sodium dodecyl sulphate; EDTA; Ethylene di-ammonium tetra acetic acid; DPBS; Dulbecco's phosphate buffered saline;
Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: Potential therapeutic targets for cardiac cachexia
Keywords: Ang II; angiotensin II; AT1R; angiotensin II type 1 receptor; CHF; congestive heart failure; ESRD; end-stage renal disease; ACE; angiotensin-converting enzyme; UPS; ubiquitin proteasome system; ROS; reactive oxygen species; IGF-1; insulin-like growth fact
mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK
Keywords: Rapamycin; Sensory neurons; mTOR; ERK; Nav1.7; AMPK;
Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer
Keywords: Breast cancer; PI3K; mTOR; MAPK; Ras/Raf/MEK/ERK; Cross-talk; Dual inhibition; Targeted therapy; Personalized medicine;
Role of the mTOR signaling pathway in epilepsy
Keywords: Epilepsy; mTOR; Epileptogenesis; Rapamycin; Therapy; Seizure; Tuberous sclerosis complex; Focal cortical dysplasias;
Crosstalk between apoptosis, necrosis and autophagy
Keywords: AIF; Apoptosis Inducing Factor; AMPK; Adenosine Monophosphate activated Kinase; APAF1; Apoptotic Protease Activating Factor 1; BCL-2; B-cell lymphoma 2; BCL-Xl; B-cell lymphoma extra large; BEC1; Beclin-1; BH; Bcl-2 homology; cIAP1; cellular inhibitor of
Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in response to formoterol administration in rat skeletal muscle
Keywords: Actb; actin beta; Atg; autophagy-related; Bnip3; BCL2/adenovirus E1B interacting protein 3; BSA; bovine serum albumin; COPD; chronic obstructive pulmonary disease; CREB; cAMP response element binding protein; EDL; extensor digitorum longus; eIF3-f; eukary
Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells
Keywords: nAChR; nicotinic acetylcholine receptor; MLA; methyllycaconitine; MEC; mecamylamine; d-Ser; d-serine; m-SR; monomeric serine racemase; d-SR; dimeric serine racemase; DHNK; dehydronorketamine; Serine racemase; d-Serine; Nicotinic acetylcholine receptors; m
Atteintes rénales de la sclérose tubéreuse de Bourneville : recommandations de prise en charge
Keywords: Sclérose tubéreuse de Bourneville; Rein; Angiomyolipome; Kyste; Embolisation; mTOR; Lymphangioléiomyomatose;
p70S6 kinase is a target of the novel proteasome inhibitor 3,3â²-diamino-4â²-methoxyflavone during apoptosis in human myeloid tumor cells
Keywords: AML; acute myeloid leukemia; DD1; 3,3â²-diamino-4â²-methoxyflavone; DNFAA; 2â²,3-dinitroflavone-8-acetic acid; 4EBP1; eukaryotic translation initiation factor 4E binding protein 1; FCS; fetal calf serum; FITC; fluorescein isothiocyanate; LPS; lipopolys
Sorafenib enhances proteasome inhibitor-mediated cytotoxicity via inhibition of unfolded protein response and keratin phosphorylation
Keywords: Ab; antibody; ALLN; acetyl-leucyl-leucyl-norleucinal; ATF; activating transcription factor; CHOP; C/EBP homologous protein; DAPI; 4', 6-diamidino-2-phenylindole; eIF2; eukaryotic translation-initiation factor 2; ER; endoplasmic reticulum; GADD153; growth
Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle
Keywords: Muscle; Testosterone; FOXO3a; Akt; mTOR; AMPK;
Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion
Keywords: GDF15; mTOR; PI3K; Ovarian cancer; Invasion; Rapamycin;
Research ReportRapamycin inhibits the growth of glioblastoma
Keywords: Glioblastoma; mTOR; Rapamycin; GBM brain xenografts; Human GBM primary cultures;
mTOR-independent autophagy counteracts apoptosis in herpes simplex virus type 1-infected U251 glioma cells
Keywords: HSV-1; Autophagy; Apoptosis; mTOR; AMP-activated protein kinase; Akt;
Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents
Keywords: Akt; protein kinase B; ANCOVA; analyses of covariance; CB; cannabinoid; CB2xP; mice overexpressing CB2 receptors; F1; cytosolic fraction; F2; membrane fraction; F3; nuclear fraction; F4; cytoskeletal fraction; FAAH; fatty acid amide hydrolase; GRK; G prot
Nitric oxide regulates AKT phosphorylation and nuclear translocation in cultured retinal cells
Keywords: AKT; protein kinase B; L-Arg; l-arginine; L-NAME; N-nitro-l-arginine methyl ester; NO; nitric oxide; NMDA; N-methyl-d-aspartate; MK-801; (5R,2S)-(1)5methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine hydrogen maleate; NOS; nitric-oxide synthase;
The sources of salidroside and its targeting for multiple chronic diseases
Keywords: 6-OHDA; 6-hydroxydopamine; Aβ; β-amyloid protein; MPTP; 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine; MPP+; N-methyl-4-phenylpyridine; AD; Alzheimer's disease; PD; Parkinson's disease; STZ; streptozotocin; PI3K; phosphatidylinositol 3-kinase; ROS; react
Hypersensibilité à la radiothérapie chez un patient atteint de la sclérose tubéreuse de Bourneville : réflexions biologiques à partir d’un cas clinique
Keywords: Sclérose tubéreuse; Radiosensibilité; mTORTuberous sclerosis; mTOR; Rapamycine; Radiotherapy
Impaired lipid accumulation in the liver of Tsc2-heterozygous mice during liver regeneration
Keywords: TSC; tuberous sclerosis; mTOR; mammalian target of rapamycin; GAP; GTPase-activating protein; MAPK; mitogen-activated protein kinase; p90 RSK; p90 ribosomal S6 kinase; ERK; extracellular signal-regulated kinase; P70S6K; p70 ribosomal S6 kinase; AMPK; 5â²
Ferulic acid attenuates focal cerebral ischemia-induced decreases in p70S6 kinase and S6 phosphorylation
Keywords: Ferulic acid; Neuroprotection; mTOR; p70S6 kinase; S6;
Cytopenia and autoimmune diseases: A vicious cycle fueled by mTOR dysregulation in hematopoietic stem cells
Keywords: Cytopenia; Homeostatic proliferation; CD24; mTOR; Hematopoietic stem cells; Autoimmune diseases; Inflammatory cytokines; Rapamycin
Adenosine Monophosphate-activated Protein Kinase/Mammalian Target of Rapamycin-dependent Autophagy Protects Human Dental Pulp Cells against Hypoxia
Keywords: AMPK; autophagy; HDPCs; hypoxia; mTOR;
Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway
Keywords: PPP2R2C; B55 Gamma; mTOR; p-S6K;
Everolimus vs. Temsirolimus for Advanced Renal Cell Carcinoma: Use and Use of Resources in the US Oncology Network
Keywords: Cancer; Guidelines; Kidney; mTOR; Resource use
The frontal cortex IGF system is down regulated in the term, intrauterine growth restricted fetal baboon
Keywords: IGF; IGFI; IGF receptors; Binding proteins; mTOR; S6; Baboon fetus; IUGR; Brain
Impact of targeting insulin-like growth factor signaling in head and neck cancers
Keywords: IGF; insulin-like growth factor; IGF-1-R; insulin-like growth factor-1 receptor; IRS; insulin receptor substrate; IGFBP; insulin-like growth factor binding protein; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; MAPK; mitogen-activa
A phase II study of temsirolimus and erlotinib in patients with recurrent and/or metastatic, platinum-refractory head and neck squamous cell carcinoma
Keywords: Temsirolimus; Erlotinib; Platinum-refractory; Head and neck squamous cell carcinoma; mTOR; EGFR; PIK3CA
Mechanistic target of rapamycin (mTOR) dependent regulation of thioredoxin interacting protein (TXNIP) transcription in hypoxia
Keywords: Thioredoxin interacting protein; TXNIP; Mechanistic target of rapamycin; mTOR; Eukaryotic initiation factor 4E binding protein; 4EBP1; Hypoxia; Hypoxia-inducible factor; HIF
Distinct Deleterious Effects of Cyclosporine and Tacrolimus and Combined Tacrolimus–Sirolimus on Endothelial Cells: Protective Effect of Defibrotide
Keywords: Endothelial damage; Immunosuppressive agents; Cyclosporine; Tacrolimus; mTOR; Sirolimus
Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation
Keywords: mTOR; SESN2; Endoplasmic reticulum stress; Autophagy; Nelfinavir; Bortezomib
Diabetic cardiomyopathy and metabolic remodeling of the heart
Keywords: Diabetic cardiomyopathy; Insulin resistance; Heart; Metabolism; FoxO; mTOR
Phospholipase D-mTOR signaling is compromised in a rat model of depression
Keywords: Depression; Phospholipase D; Choline; Phosphatidic acid; mTOR; p70S6 kinase
Phosphatidic acid and lipid-sensing by mTOR
Keywords: mTOR; phosphatidic acid; DG kinase; LPAAT; phospholipase D
Single prolonged stress enhances hippocampal glucocorticoid receptor and phosphorylated protein kinase B levels
Keywords: PTSD; posttraumatic stress disorder; SPS; single prolonged stress; EPM; elevated plus maze; OF; open field; GR; glucocorticoid receptor; Akt; protein kinase B; pAkt; phosphorylated Akt; PI3K; phosphoinositide 3-kinase; mTOR; mammalian target of Rapamycin;
Glycolysis-respiration relationships in a neuroblastoma cell line
Keywords: AMPK; AMP-activated protein kinase; 2-DG; 2-deoxyglucose; ECAR; extracellular acidification rate; ERK; extracellular signal-regulated kinase; HIF1a; hypoxia inducible factor 1 alpha; IA; iodoacetate; mTOR; mammalian target of rapamycin; OCR; oxygen consum
Current and future systemic treatments for renal cell carcinoma
Keywords: Renal cell carcinoma; Metastatic; VEGF; mTOR; Targeted agents
Association of mammalian target of rapamycin with aggressive type II endometrial carcinomas and poor outcome: a potential target treatment
Keywords: Endometrial carcinoma; mTOR; PTEN; β-Catenin; MMR genes; MSI; BRAF-V600E; Outcome
Clinical impacts of mammalian target of rapamycin expression in human colorectal cancers
Keywords: mTOR; Colorectal; Carcinoma; Expression
PI3K/Akt/mTOR pathway inhibitors in the therapy of pancreatic neuroendocrine tumors
Keywords: Neuroendocrine tumors; Pancreatic; PI3K; Akt; mTOR; Inhibitor
Dysregulation of the mammalian target of rapamycin pathway in chromophobe renal cell carcinomas
Keywords: Chromophobe renal cell carcinoma; mTOR; PTEN; AKT; S6; 4EBP1; HIF-1α
A novel imidazopyridine derivative, HS-106, induces apoptosis of breast cancer cells and represses angiogenesis by targeting the PI3K/mTOR pathway
Keywords: PI3K; mTOR; Apoptosis; Angiogenesis; Breast cancer
NK/T-cell lymphomas in children
Keywords: T-lymphoblastic lymphoma; T-LBL; anaplastic large cell lymphoma; ALCL; ALK; PTCL-NOS; angioimmunoblastic T-cell lymphoma; AITL; NOTCH1; mTOR; CD30
From genes to cognition in tuberous sclerosis: Implications for mTOR inhibitor-based treatment approaches
Keywords: Tuberous sclerosis; TSC; mTOR; Rapamycin; Autism; Cognition; Epilepsy
The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway
Keywords: Glucagon-like peptide-1; AMPK; mTOR; Pancreatic beta cell; Proliferation; Apoptosis
Pterostilbene, a natural small-molecular compound, promotes cytoprotective macroautophagy in vascular endothelial cells
Keywords: CaMKKβ; Macroautophagy; mTOR; Pterostilbene; Vascular endothelial cell
CDK2 and mTOR are direct molecular targets of isoangustone A in the suppression of human prostate cancer cell growth
Keywords: CDK2; Licorice; mTOR; p27kip1; Prostate cancer
Clinical Efficacy and Management of Temsirolimus in Patients With Relapsed or Refractory Mantle Cell Lymphoma
Keywords: mTOR; Non-Hodgkin lymphoma
XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons
Keywords: X-linked intellectual disability; Cullin 4B; TSC2; Cyclin E; mTOR; Neocortical neurons