دانلود مقالات ISI درباره Mtor + ترجمه فارسی

Synuclein gamma protects HER2 and renders resistance to Hsp90 disruption

Keywords: Synuclein gamma; Chaperone; HER2 signaling; Breast cancer; Therapy resistance; BCSG1; breast cancer specific gene 1; ERα; estrogen receptor α; Hsp; heat shock protein; mTOR; mammalian target of rapamycin; SNCA; synuclein α; SNCB; synuclein β; SNCG; sy

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

WIF1 can effectively co-regulate pro-apoptotic activity through the combination with DKK1

Keywords: WIF1; Wnt inhibitory factor-1; Dvl; disheveled; FRP; Frizzled-related protein; DKK1; Dickkopf-1; VEGF; vascular endothelial growth factor; bFGF; basic fibroblast growth factor; FITC; fluorescein isothiocyanate; PI; propidium iodide; p70S6K; p70 ribosomal

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTOR/S6K1

Keywords: Class III phosphatidylinositol 3-kinase/vacuolar protein sorting 34 (VPS34); Insulin; Src; ptdins(3)p; S6 kinase 1 (S6K1); mTOR;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Tumor exosomes induce tunneling nanotubes in lipid raft-enriched regions of human mesothelioma cells

Keywords: TnTs; Tunneling nanotubes; nm; nanometers; (ATCC); American Type Culture Collection; FBS; fetal bovine serum; MAPK; mitogen-activated protein kinase; AMPK; adenosine monophosphate kinase; mTOR; mammalian target of rapamycin; CTCF; corrected total cell flu

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Necessary, but not sufficient: Insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures

Keywords: Early life seizure; Long-term depression; Metabotropic glutamate receptor; CaMKII; Voltage-gated calcium channels; Autism; ACSF; artificial cerebral spinal fluid; APV; amino-5-phosphonopentanoic acid; CaMKII; calcium-calmodulin kinase II; DMSO; dimethyl s

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Adverse Event Management of mTOR Inhibitors During Treatment of Hormone Receptor–Positive Advanced Breast Cancer: Considerations for Oncologists

Keywords: Advanced breast cancer; Adverse events; Everolimus; Infection; mTOR; Noninfectious pneumonitis; Rash; Stomatitis

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: Findings from 3-D melanoma skin equivalents and computational modeling

Keywords: Fisetin; AKT; mTOR; p70S6K; Melanoma

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions

Keywords: AMPK; AMP-activated protein kinase; BSA; bovine serum albumin; DCFH-DA; dichlorofluorescin diacetate; DR4; death receptor 4; ETC; electron transport chain; FBS; fetal bovine serum; HEGU; hexane/ethanol extract of Glycyrrhiza uralensis Fisch; IAA; isoangus

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

The ever-evolving role of mTOR in translation

Keywords: mRNA translation; Protein synthesis; mTOR;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Growing knowledge of the mTOR signaling network

Keywords: mTOR; mTORC1; mTORC2; Insulin; Amino acids; Energy;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

DHA2, a synthesized derivative of bisbibenzyl, exerts antitumor activity against ovarian cancer through inhibition of XIAP and Akt/mTOR pathway

Keywords: Ovarian cancer; Caspase-independent cell death; Autophagy; Akt; mTOR;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release

Keywords: Lipopolysaccharide (LPS); Neuroinflammation; Epileptogenesis; Absence epilepsy; WAG/Rij rats; mTOR; AKT; AMPK; Cytokines; NF-κB; Rapamycin;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC

Keywords: PI3K; NSCLC; Lung cancer; PI3K inhibition; PIK3CA; mTOR; Co-targeted inhibition; MEK; Chemoresistance; Radioresistance;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Hippocampal granule cell pathology in epilepsy - A possible structural basis for comorbidities of epilepsy?

Keywords: Epilepsy; mTOR; Neurogenesis; Disc1; Reelin; Schizophrenia; Autism;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target

Keywords: Uveal melanoma; BAP1; Everolimus; mTOR; Cell lines; Patients-derived tumor xenografts;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

Keywords: ADAM; a disintegrin and metalloprotease; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AKT; protein kinase B (PKB); ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AMPK; adenosine monophosphate (AMP) activated protein kinase; ANK;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Protein kinase A-mediated cell proliferation in brown preadipocytes is independent of Erk1/2, PI3K and mTOR

Keywords: Brown adipose tissue; Cell proliferation; Adrenergic effects; cAMP; Protein kinase A; Erk 1/2; PI3K; mTOR

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

IL-27 inhibits IFN-γ induced autophagy by concomitant induction of JAK/PI3 K/Akt/mTOR cascade and up-regulation of Mcl-1 in Mycobacterium tuberculosis H37Rv infected macrophages

Keywords: Autophagy; IFN-γ; IL-27; Mycobacteria; mTOR; mammalian target of rapamycin; PI3 K; phosphatidylinositol 3-kinase; JAK; Janus kinase;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy

Keywords: miRNAs; microRNAs; DG; dentate gyrus; PHC; parahippocampal cortex; MAPK; mitogen-activated protein kinase; TGFβ; transforming growth factor beta; mTOR; mammalian target of rapamycin; TLE; temporal lobe epilepsy; SE; status epilepticus; RIN; RNA Integrity

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

BDNF mechanisms in late LTP formation: A synthesis and breakdown

Keywords: Brain-derived neurotrophic factor (BDNF); TrkB signaling; Synaptic plasticity; Long-term potentiation (LTP); Protein synthesis; Translation control; Cytoskeletal dynamics; Arc; activity-regulated cytoskeleton-associated protein; AS; Angelman syndrome; AS-

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Transcriptomics profiling and steroid production in mummichog (Fundulus heteroclitus) testes after treatment with 5α-dihydrotestosterone

Keywords: 11KT; 11-ketotestosterone; ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ABCC3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; ABCG8; ATP-binding cassette, sub-family G (WHITE), member 8; ACY1; aminoacylase 1; ADAR; adenosine d

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics

Keywords: Breast cancer; Receptor tyrosine kinase; Small molecule inhibitor; Senescence; Polyploidy; mTOR signaling; Chemosensitivity; AXL; Greek word anexelekto; BCR; breakpoint cluster region; BRAF; B-Rapidly Accelerated Fibrosarcoma; DAPI; 4′,6′-diamidino-2-

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Yessotoxin induces ER-stress followed by autophagic cell death in glioma cells mediated by mTOR and BNIP3

Keywords: YTX; yessotoxin; DE; differentially expressed; UPR; unfolded protein response; ER-stress; endoplasmic reticulum stress; mTOR; mechanistic target of rapamycin (serine/threonine kinase); LC3; microtubule-associated protein 1 light chain 3 alpha; BNIP3; BCL2

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Human DExD/H RNA helicases: Emerging roles in stress survival regulation

Keywords: 5′ppp; 5′ triphosphate; AMD; ARE-mediated mRNA decay; ARE; AU-rich element; ARE-BP; ARE-binding protein; CARD; caspase activation and recruitment domain; CCCP; carbonyl cyanide m-chlorophenyl hydrazone; CDN; cyclic dinucleotide; CRM1; Chromosome Maint

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

p70S6 kinase mediates breast cancer cell survival in response to surgical wound fluid stimulation

Keywords: Breast cancer; p70S6K; mTOR; Xenograft; Survival; Proliferation;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

mTOR signaling in tumorigenesis

Keywords: mTOR; the mechanistic target of rapamycin or the mammalian target of rapamycin; PIKK; phosphoinositide 3-kinase related protein kinase; ATM; ataxia-telangiectasia mutated; ATR; ataxia-telangiectasia and rad3-related; DNAPK; DNA-dependent protein kinase; R

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

BDNF-induced local protein synthesis and synaptic plasticity

Keywords: Brain-derived neurotrophic factor (BDNF); Synaptic plasticity; Long-term potentiation (LTP); Translation; RNA transport; ADF; actin-depolymerizing factor; A2RE; heterogeneous nuclear ribonucleoprotein (hnRNP) A2 response element; Arc; activity-regulated c

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2014 سفارش ترجمه

microRNA-21-induced dissociation of PDCD4 from rictor contributes to Akt-IKKβ-mTORC1 axis to regulate renal cancer cell invasion

Keywords: Renal carcinoma; miR-21; Akt kinase; mTOR

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2014 سفارش ترجمه

Ribonucleoprotein HNRNPA2B1 Interacts With and Regulates Oncogenic KRAS in Pancreatic Ductal Adenocarcinoma Cells

Keywords: Signal Transduction; Carcinogenesis; Oncogene; Mouse Model; AKT; c-akt murine thymoma oncogene homolog 1; FCS; fetal calf serum; GFP; green fluorescent protein; GTP; guanosine triphosphate; HA; hemagglutinin; hnRNP; heterogeneous nuclear ribonucleoprotein

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2014 سفارش ترجمه

Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis

Keywords: Colon cancer; Apoptosis; PI3K; Autophagy; mTOR; GSK-3β; Aurora-A;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2014 سفارش ترجمه

Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside

Keywords: 6-OHDA; 6-hydroxydopamine; 7-OH-DPAT; 7-hydroxy-N,N-di-n-propyl-2-aminotetralin; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APH-1; anterior pharynx-defective 1; ApoE4; apolipoprotein E ɛ4 allele; APP; amyloid precursor protein; A

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2014 سفارش ترجمه

PARP and other prospective targets for poisoning cancer cell metabolism

Keywords: ATP; adenosine 5′-triphosphate; 3-BrPA; 3-bromopyruvate; EGFR; epidermal growth factor receptor; FDA; food and drug administration; GSH; glutathione; GSSG; oxidized GSH; GST; glutathione S-transferase; HDAC; histone deacetylase; HIF1; hypoxia inducible

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2014 سفارش ترجمه

Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells

Keywords: CRC; colorectal cancer; CPT; camptothecin; DSBs; double-strand breaks; DDR; DNA damage response; γ-H2AX; phosphorylated histone H2AX; ATM; ataxia telangiectasia mutated; Chk2; check-point kinase; AMPK; AMP-activated protein kinase; TSC2; tuberous scleros

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2014 سفارش ترجمه

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

Keywords: PI3K pathway; Targeted therapy; Predictive biomarkers; 4EBP1; 4E-binding protein 1; AKT; protein kinase-B; AMPK; AMP-activated protein kinase; COSMIC; Catalogue of Somatic Mutations in Cancer; eIF4E; eukaryotic initiation factor 4E; ERK; extracellular-sig

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2014 سفارش ترجمه

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Keywords: mTOR; Inhibitor; AZD8055; AZD2014; Kinase;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model

Keywords: RMS; rhabdomyosarcoma; ERMS; embroynal RMS; ARMS; alveolar RMS; VEGF; vascular endothelial growth factor; H&E; hematoxylin & eosin; PCNA; proliferating cell nuclear antigen; Rhabdomyosarcoma; mTOR; Targeted therapy; Proliferation; Apoptosis; Hh signaling;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-β-dependent G1 cell cycle arrest

Keywords: mTOR; eIF4E; Apoptosis; TGF-β; Cell cycle;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Akebia saponin PA induces autophagic and apoptotic cell death in AGS human gastric cancer cells

Keywords: Akebia saponin PA; Autophagy; Apoptosis; mTOR; MAPKs;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression

Keywords: P70S6K; ribosomal protein S6 kinase; mTOR; the mammalian target of rapamycin; SIRT; silent information regulator; Tsc; tuberous sclerosis complex; mTORC1; the mammalian target of rapamycin complex 1; POF; premature ovarian failure; PTEN; phosphatase and t

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Research ArticleHow to decide about liver transplantation in patients with hepatocellular carcinoma: Size and number of lesions or response to TACE?

Keywords: AP; any progression; AUC; area under the curve; CR; complete response; CT; computed tomography; HCC; hepatocellular carcinoma; LT; liver transplantation; MC; Milan criteria; MCin; meeting the Milan criteria; MCout; exceeding the Milan criteria; mTOR; mamm

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Everolimus in hormone receptor-positive advanced breast cancer: Targeting receptor-based mechanisms of resistance

Keywords: Estrogen receptor; Mammalian target of rapamycin; mTOR; Everolimus;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Anti-proliferative effect of (19Z)-halichondramide, a novel marine macrolide isolated from the sponge Chondrosia corticata, is associated with G2/M cell cycle arrest and suppression of mTOR signaling in human lung cancer cells

Keywords: (19Z)-Halichondramide; A549 human lung cancer cells; G2/M cell cycle; GADD45; mTOR; AMPK;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice

Keywords: BrdU; 5-bromo-2-deoxyuridine; DCX; doublecortin; DG; dentate gyrus; GFP; green fluorescent protein; GS; glutamine synthetase; Iba1; ionized calcium binding adaptor molecule 1; mTOR; mammalian target of rapamycin; Neu N; neuronal nuclei; Dentate gyrus; Neu

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA)

Keywords: Rat hepatocytes; Mitochondrial biogenesis; Mitochondrial respiration; PPAR; mTOR; Hypertrophy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Differential anti-tumor activities of curcumin against Ras- and Src-activated human adenocarcinoma cells

Keywords: 4E-BP1; eukaryotic initiation factor 4-binding protein 1; Cdk1; cyclin-dependent kinase 1; EGFR; epidermal growth factor receptor; FACS; fluorescence activated cell sorting; IC50; 50% inhibitory concentration; MAPK; mitogen-activated protein kinase; mTOR;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate

Keywords: AML; acute myeloid leukemia; RTP; ribavirin triphosphate; mTOR; mammalian target of rapamycin; CD; circular dichroism; m7G; 7-methyl-guanosine; m7GTP; 7-methyl-guanosine-5′-triphosphate; HSQC; heteronuclear single quantum coherence; RING; really interes

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Vasopressin activates Akt/mTOR pathway in smooth muscle cells cultured in high glucose concentration

Keywords: AVP; arginine vasopressin; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; PI3K; phosphatidyl inositol-3 kinase; AMPK; AMP-activated protein kinase; PKC; protein kinase C, Akt or protein kinase B; TSC1/TSC2; tubero sclerosis protein 1 and 2;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Pregnane alkaloids from Sarcococca hookeriana var. digyna

Keywords: cAMP; cyclic adenosine monophosphate; PKA; protein kinase A; CREB; cAMP response element binding protein; PI3K; phosphatidylinositol-3 kinase; Akt; protein kinase B; mTOR; mammalian target of rapamycin; MAPK; mitogen-activated protein kinase; ERK; extrace

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Steroid withdrawal and reduction of cyclosporine A under mycophenolate mofetil after heart transplantation

Keywords: AE; adverse events; ANOVA; analysis of variance; AUC; area under curve; BMI; body mass index; BUN; blood urea nitrogen; CAV; chronic allograft vasculopathy; CNI; calcineurin inhibitors; CPET; cardiopulmonary exercise test; CRH; cortisol releasing hormone;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro

Keywords: Head and neck squamous cell carcinoma; AZD8055; mTOR; JNK; Cancer cell death;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه