Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia
Keywords: PI3K; mTOR; Oxidative metabolism; Hypoxia; Reoxygenation;
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T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8+CD28+ T cells but not in CD8+CD28â T cells
Keywords: mTOR; mammalian target of rapamycin; mTORC1/2; mTOR complex 1/2; TCR; T cell receptor; CMV; cytomegalovirus; PI3K; phosphoinositide 3-kinase; PKB; protein kinase B; PDK; phosphoinositide-dependent protein kinase 1; S6K1; S6 kinase 1; 4E-BP1; 4E-binding pr
Benzofuran derivatives as a novel class of inhibitors of mTOR signaling
Keywords: Benzofuran; Cytotoxicity; mTOR; mTORC1;
Post-transcriptional regulation of autophagy in C2C12 myotubes following starvation and nutrient restoration
Keywords: ACC; acetyl-CoA carboxylase; Akt/PKB; protein kinase B; AMPK; AMP-activated protein kinase; ANOVA; analysis of variance; Atg; autophagy-related gene; Bnip3; B-cell lymphoma 2 interacting protein 3; DMEM; Dulbecco's modified Eagle medium; DPBS; Dulbecco's
Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway
Keywords: AMPK; AMP-activated protein kinase; ATG5; autophagy-related 5; EDTA; ethylenediaminetetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; LDH; lactate dehydrogenase; mTOR; mammalian target of rapamycin; PI; propidium iodide; PrP; pr
mTOR pathway is involved in ADP-evoked astrocyte activation and ATP release in the spinal dorsal horn in a rat neuropathic pain model
Keywords: AMPK; AMP-activated protein kinase; CCI; chronic constriction injury model; CSF; cerebrospinal fluid; GFAP; glial fibrillary acidic protein; mTOR; mammalian target of rapamycin; SD; Sprague Dawley; vFh; Von Frey hairs; adenosine triphosphate; adenosine di
Genetics of rare mesenchymal tumors: Implications for targeted treatment in DFSP, ASPS, CCS, GCTB and PEComa
Keywords: DFSP; dermatofibrosarcoma protuberans; ASPS; alveolar soft part sarcoma; CCS; clear cell sarcoma; GCTB; giant cell tumor of bone; PEComas; perivascular epithelioid cell neoplasm; PDGFRB; platelet-derived growth factor receptor, beta; MET; met proto-oncoge
Research ArticleRapamycin and everolimus facilitate hepatitis E virus replication: Revealing a basal defense mechanism of PI3K-PKB-mTOR pathway
Keywords: mTOR; mammalian target of rapamycin; HEV; hepatitis E virus; PI3K; phosphatidylinositol-3 kinase; PKB; protein kinase B; 4E-BP1; eIF4E-binding protein 1; Hepatitis E virus; Rapamycin; Everolimus; PI3K-PKB-mTOR pathway;
Reprint of: Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells
Keywords: SLRP; small leucine-rich proteoglycan; RTK; receptor tyrosine kinase; HUVEC; human umbilical vein endothelial cells; Peg3; paternally expressed gene 3; AMPK; 5â² adenosine monophosphate-activated protein kinase; mTOR; mammalian target of rapamycin; Vps34
Decorin activates AMPK, an energy sensor kinase, to induce autophagy in endothelial cells
Keywords: SLRP; small leucine-rich proteoglycan; RTK; receptor tyrosine kinase; HUVEC; human umbilical vein endothelial cells; Peg3; paternally expressed gene 3; AMPK; 5â² adenosine monophosphate-activated protein kinase; mTOR; mammalian target of rapamycin; Vps34
mTOR and autophagy: A dynamic relationship governed by nutrients and energy
Keywords: Akt1; v-akt murine thymoma viral oncogene homolog 1; AMBRA; Autophagy/Beclin-1 regulator 1; AMPK; AMP-dependent protein kinase; ATG; autophagy-related; BECN1; beclin 1; DEPTOR; DEP domain containing mTOR-interacting protein; EGFR; epidermal growth factor
Design, synthesis, anticancer activity and docking studies of novel 4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives as mTOR inhibitors
Keywords: 7,8-Dihydro-5H-thiopyrano[4,3-d]pyrimidine; Synthesis; Docking; mTOR; Antitumor activity;
MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch
Keywords: TM; trabecular meshwork; IOP; intraocular pressure; ATG; autophagy-related genes; CTSB; cathepsin B; BECN1; beclin; TUBB; beta tubulin; SQSTM; sequestosome; tfLC3; tandem fluorescence LC3; GFP; green fluorescence protein; RFP; red fluorescence protein; m.
Parkin ubiquitinates mTOR to regulate mTORC1 activity under mitochondrial stress
Keywords: mTOR; mTORC1; Parkin; Ubiquitination; Mitochondrial stress;
Lysyl oxidase-like 2 (LOXL2) controls tumor-associated cell proliferation through the interaction with MARCKSL1
Keywords: LOXL2; lysyl oxidase-like 2; MARCKSL1; myristoylated alanine-rich C kinase substrate-like 1; EMT; epithelial-mesenchymal transition; ECM; extracellular matrix; FAK; focal adhesion kinase; PKC; protein kinase C; siRNA; small interfering RNA; ONPG; o-nitr
p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling networks
Keywords: p70S6K; p70S6 kinase; PI3K; phosphoinositide-3-kinase; RPPA; Reverse Phase Protein Array; mTOR; mammalian target of rapamycin; MAPK; mitogen activated protein kinase; EGFR; epidermal growth factor receptor; NSCLC; non-small cell lung cancer; RTK; receptor
Activation of ERK by sodium tungstate induces protein synthesis and prevents protein degradation in rat L6 myotubes
Keywords: DEX; dexamethasone; ERK; extracellular signal-regulated kinases 1 and 2; eIF4E; eukaryotic initiation factor E; 4E-BP1; eIF4E-binding protein 1; FoxO; Forkhead box O Family of Transcription Factors; IGF-I; Insulin Growth Factor I; MTOR; mechanistic target
mTOR is a promising therapeutical target in a subpopulation of pancreatic adenocarcinoma
Keywords: Pancreatic cancer; Personalized medicine; mTOR; Rapamycin; Flow cytometry;
FOXO1-dependent up-regulation of MAP kinase phosphatase 3 (MKP-3) mediates glucocorticoid-induced hepatic lipid accumulation in mice
Keywords: MKP-3; MAP kinase phosphatase 3; Dex; Dexamethasone; FOXO1; forkhead box protein O1; GC; glucocorticoid; DUSP6; dual specificity protein phosphatase 6; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; PI3K; phosphoinosit
A role for Raptor phosphorylation in the mechanical activation of mTOR signaling
Keywords: EC; eccentric contraction; GβL; G-protein β-subunit-like protein; GFP; green fluorescent protein; JNK; c-jun n-terminal kinase; MAPK; mitogen-activated protein kinase; mLST8; lethal with sec13 protein 8; mTOR; mammalian [or mechanistic] target of rapamy
In vivo hyperoxia induces hypoxia-inducible factor-1α overexpression in LNCaP tumors without affecting the tumor growth rate
Keywords: In vivo hypoxia; In vivo hyperoxia; LNCaP tumor; Angiogenesis; Hypoxia-inducible factor; Akt; phosphatidylinositol-3-phosphate/protein kinase B; Hb; hemoglobin; HIF-1α; hypoxia-inducible factor-1α; Ki67; Antigen anti-KI-67; LNCaP; androgen-sensitive hum
Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; 6-OHDA; 6-hydroxydopamine; ACC; acetyl-CoA carboxylase; AD; Alzheimer's disease; AMPK; AMP-dependent/activated protein kinase; DAB; 3,3â²-diaminobenzidine tetrachloride; DAPI; 4â²,6-diamidino-2-
Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells
Keywords: T-ALL; GLI1; GANT58; AKT inhibitor; Apoptosis; Hh; hedgehog; T-ALL; acute T cell leukemia; SMO; Smoothened; GLI1; GLI family zinc finger 1; SHH; Sonic hedgehog; DHH; Desert hedgehog; IHH; Indian hedgehog; PTCH1; Patched 1; PI3K; phosphatidylinositol 3-kin
Inhibition of mTOR down-regulates scavenger receptor, class B, type I (SR-BI) expression, reduces endothelial cell migration and impairs nitric oxide production
Keywords: ABCG1; ATP binding cassette transporter G1; BP-C; Bodipy-cholesterol; BP-CE; Bodipy-cholesteryl oleate; CETP; cholesteryl ester transfer protein; DAF-2 DA; 4,5-diaminofluorescein diacetate; DiI; 1,1â²-dioctadecyl-3,3,3â²,3â²-tetramethylindocarbocyanine
Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation
Keywords: 12S; mitochondrial rRNA; AICAR; aminoimidazole-4-carboxamide riboside, an adenosine analogue stimulating AMPK; AMPK; catalytic α1/2-subunit of AMP dependent protein kinase; pAMPK; AMPK phosphorylated at serine 172 of the α-subunit; AU; arbitrary units;
mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress – An experimental and modeling study
Keywords: ER, endoplasmic reticulum; mTOR, mammalian target of rapamycin; UPR, unfolded protein responseAutophagy; Apoptosis; Endoplasmic reticulum stress; Metyrapone; Unfolded protein response; mTOR
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain
Keywords: mTOR; Akt; PI3K; Autophagy; Insulin signaling; Trisomy 21;
Poor prognosis and advanced clinicopathological features of clear cell renal cell carcinoma (ccRCC) are associated with cytoplasmic subcellular localisation of Hypoxia inducible factor-2α
Keywords: Renal cell carcinoma; CA-IX; VEGF; mTOR; HIF-1; HIF-2; Tumour suppressor; Tumour promotor; Cancer specific survival
Systemic inhibition of mTOR kinase via rapamycin disrupts consolidation and reconsolidation of auditory fear memory
Keywords: mTOR; Reconsolidation; Consolidation; Auditory fear memory; Posttraumatic stress disorder; Rapamycin;
Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas
Keywords: Myxofibrosarcoma; Akt; mTOR; MAPK;
miR-15/16 complex targets p70S6 kinase1 and controls cell proliferation in MDA-MB-231 breast cancer cells
Keywords: 3′-UTR, 3′ untranslated region; EMT, epithelial to mesenchymal transition; mTOR, mammalian target of rapamycin; miR-15, microRNA-15; miR-16, microRNA-16miR-15; miR-16; RPS6KB1; mTOR; MDA-MB-231
PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways
Keywords: Focal cerebral ischemia; Akt; Stroke; mTOR; PRAS40; PTEN;
PARP-1 activation causes neuronal death in the hippocampal CA1 region by increasing the expression of Ca2Â +-permeable AMPA receptors
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AP5; 2-amino-5-phosphonopentanoate; AMPK; 5ⲠAMP-activated protein kinase; AIF; apoptosis-inducing factor; Cyt-C; cytochrome-C; JNK; Jun N-terminal kinase; GluA1; glutamate AMPA receptor subun
Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer
Keywords: Luminal type; Breast cancer; Phosphatidylinositol 3-kinase; PI3K; AKT; Mammalian target of rapamycin; mTOR; Estrogen receptor; Endocrine therapy; Endocrine resistance
The RNA expression signature of the HepG2 cell line as determined by the integrated analysis of miRNA and mRNA expression profiles
Keywords: KEGG; Kyoto Encyclopedia of Genes and Genomes; DAVID; Database for Annotation, Visualization and Integrated Discovery; ErbB; erythroblastoma virus B; JAK-STAT; Janus kinase/signal transducers and activators of transcription; mTOR; mammalian target of ra
The combination of an mTORc1/TORc2 inhibitor with lapatinib is synergistic in bladder cancer in vitro1
Keywords: Bladder cancer; mTOR; EGFR; Lapatinib; Antitumor synergy
Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats
Keywords: Antidepressant; AMN082; mGlu receptors; MTEP; mTOR;
Steviol retards renal cyst growth through reduction of CFTR expression and inhibition of epithelial cell proliferation in a mouse model of polycystic kidney disease
Keywords: Steviol; CFTR; AMPK; Renal cystogenesis; mTOR;
The structural basis for mTOR function
Keywords: mTOR; PI3K; Rapamycin; 4E-BP1; S6K1; PIKK;
Autophagy in Glomerular Health and Disease
Keywords: Podocyte; kidney; autophagy; mTOR; ATG5; LC3; RAPTOR; FSGS; diabetic nephropathy; glomerulonephritis; lysosomal storage diseases
The PPARβ agonist L-165041 promotes VEGF mRNA stabilization in HPV18-harboring HeLa cells through a receptor-independent mechanism
Keywords: ARE; AU-rich element; CHX; cycloheximide; ELAV; Embryonic Lethal Abnormal Vision; ERK1/2; Extracellular signal Regulated Kinase1/2; HPV; Human Papillomavirus; HuR; Human antigen R; MAPK; Mitogen-Activated Protein Kinase; mTOR; mammalian Target Of Rapamyci
LXR-α antagonist meso-dihydroguaiaretic acid attenuates high-fat diet-induced nonalcoholic fatty liver
Keywords: ABCA1, ABCG1; ATP-binding cassette transporter A1 or G1; AMPK; AMP-activated protein kinase; ACC; acetyl-coenzyme A carboxylase; FAS; fatty acid synthase; HDL; high density lipoprotein; HFD; high fat diet; LBD; ligand binding domain; LXR; liver X receptor
CommentaryTargeting PI3K/AKT/mTOR pathway in non small cell lung cancer
Keywords: AE; adverse event; CR; complete response; EGFR; epidermal growth factor receptor; MTD; maximum tolerated dose; NSCLC; non small cell lung cancer; ORR; overall response rate; OS; overall survival; mTOR; mammalian target of rapamycin; PFS; progression free
Insulin-sensitizing and insulin-mimetic activities of Sarcopoterium spinosum extract
Keywords: AMPK; AMP-activated protein kinase; BAD; Bcl 2-antagonist of cell death; 2-DG; 2-deoxy-d-glucose; FoxO; forkhead transcription factor; GSK3β; glycogen synthase kinase 3β; IBMX; isobutylmethylxanthine; IKK; inhibitor of nuclear factor kappa-B kinase; IR;
AMPK-mediated downregulation of connexin43 and premature senescence of mesangial cells under high-glucose conditions
Keywords: Connexin43; AMPK; mTOR; Mesangial cell senescence; Diabetic nephropathy
Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy
Keywords: Caloric restriction; Akt2; Myocardial; Autophagy; AMPK; mTOR;
The links between AKT and two intracellular proteolytic cascades: Ubiquitination and autophagy
Keywords: BRCA1; breast cancer susceptibility gene 1; BRCT; Brca1 C-terminal; CHIP; chaperone-associated ubiquitin ligase; CYLD; cylindromatosis; DAPK; death-associated protein kinase; DUB; deubiquitinating enzyme); EGF; epidermal growth factor; FADD; fas-associate
ReviewTargeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends
Keywords: mTOR; HCC; Rapamycin; Rapalogs; Second generation mTOR inhibitors;
Benzofuran derivatives as anticancer inhibitors of mTOR signaling
Keywords: Benzofuran; Cytotoxicity; mTOR; Cancer; Rapamycin;
Sirtuin1 and autophagy protect cells from fluoride-induced cell stress
Keywords: AMPK; AMP-activated protein kinase; Atg; autophagy related gene; CR; caloric restriction; eIF2α; eukaryotic initiation factor-2, subunit alpha; ER; endoplasmic reticulum; HF; hydrogen fluoride; JNK1; c-Jun N-terminal kinase-1; LS8; ameloblast-derived cel