دانلود مقالات ISI درباره Mtor + ترجمه فارسی

The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells

Keywords: BCS; breast cancer cell; ER; oestrogen receptor; CSC; cancer stem cell; FACS; fluorescence activated cell sorting; γH2AX; gamma-histone 2AX; mTOR; mammalian/mechanistic target of rapamycin; PARP; poly(ADP-ribose) polymerase; BCL-2; B-cell lymphoma-2; Bax

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Trehalose decreases mutant SOD1 expression and alleviates motor deficiency in early but not end-stage amyotrophic lateral sclerosis in a SOD1-G93A mouse model

Keywords: ALS; amyotrophic lateral sclerosis; fALS; familial ALS; HD; Huntington disease; HspB8; heat shock protein B8; LBHI; Lewy body-like inclusions; mTOR; mammalian target of rapamycin; PBS; phosphate-buffered saline; PD; Parkinson disease; SD; standard deviati

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway

Keywords: Leucine deprivation; HepG2 cells; IGFBP-1 phosphorylation; AAR; mTOR;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis and biological evaluation of novel 4-alkynyl-quinoline derivatives as PI3K/mTOR dual inhibitors

Keywords: PI3K; mTOR; Cancer; Inhibitor; 4-Alkynyl-quinoline

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment

Keywords: Europium hydroxide nanorods [EHNs: EuIII(OH)3]; Autophagy; mTOR; p-ERK1/2; Trehalose; Huntingtin protein aggregates

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling

Keywords: ACC; acetyl-CoA carboxylase; Akt; protein kinase B (PKB); α-KG; α-ketoglutarate; AMPK; AMP-activated protein kinase; BPTES; (bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide; DIC; differential interference contrast; DMEM; Dulbecco׳s Modifie

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory

Keywords: 4E-BPs; 4E binding proteins; ACh; acetylcholine; AD; Alzheimer's Disease; APP; amyloid precursor protein; CaMKII; Ca2+/calmodulin-dependent protein kinase II; CREB; cAMP response element-binding protein; DG; dentate gyrus; eEF1A; eukaryotic Elongation F

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition

Keywords: Methylseleninic acid (PubChem CID: 161597); Sodium selenite (PubChem CID: 24934); Cisplatin (PubChem CID: 441203); LY294002 (PubChem CID: 3973); MSA; methylseleninic acid; Se; selenium; PPP; pentose phosphate pathway; TCA; tricarboxylic acid; ROS; reactiv

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs

Keywords: 3MA; 3-methyladenine; Baf (or Baf A1); bafilomycin A1; BSA; bovine serum albumin; GABARAP; γ-aminobutyric acid receptor-associated protein; LC3; microtubule-associated protein 1 light chain 3; LDH; lactate dehydrogenase; MEFs; mouse embryonic fibroblasts

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2015 سفارش ترجمه

Associate editor: B. TeicherTargeting the genetic alterations of the PI3K-AKT-mTOR pathway: Its potential use in the treatment of bladder cancers

Keywords: Urothelial bladder cancer; PI3K; AKT; PTEN; mTOR; TSC1; AMPK; AMP-activated protein kinase; Bad; B cell leukemia/lymphoma-2 associated death agonist; Bcl-2; B cell leukemia-2; Bim; B cell leukemia/lymphoma-2 interacting mediator of cell death; CREB; cycli

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2015 سفارش ترجمه

Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1α pathway

Keywords: CS; citrate synthase; ECAR; extracellular acidification rate; FGF21; fibroblast growth factor; MELAS; mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes; mtDNA; mitochondrial DNA; mTOR; mammalian target of rapamycin; mTORC; mTOR co

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

PEComas of the kidney and of the genitourinary tract

Keywords: Pecoma; HMB45; Cathepsin-k; mTOR;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

Regulation of hippocampal synaptic plasticity by BDNF

Keywords: 4E-BPs; eIF4E-binding proteins; 5-HT; 5-hydroxytryptamine; ADF; actin-depolymerising factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptors; Arc; activity-regulated cytoskeleton-associated protein; BDNF; brain-derived n

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

The hippocampus and TNF: Common links between chronic pain and depression

Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid; AR; adrenergic receptor; BDNF; brain-derived neurotrophic factor; CNS; central nervous system; CREB; cAMP response element-binding protein; cAMP; cyclic adenosine monophosphate; ERK; extracellu

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2015 سفارش ترجمه

Lithium protects against methamphetamine-induced neurotoxicity in PC12 cells via Akt/GSK3β/mTOR pathway

Keywords: Methamphetamine; Lithium; Neurotoxicity; Akt; GSK3β; mTOR;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2015 سفارش ترجمه

The role of autophagic degradation in the heart

Keywords: αMHC-Cre+; transgenic mice expressing Cre recombinase under the control of α-myosin heavy chain promoter; Ambra1; activating molecule in Beclin 1-regulated autophagy; AMPK; AMP-activated protein kinase; Atg; autophagy-related; Bcl; B-cell lymphoma; Bnip

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2015 سفارش ترجمه

Mango polyphenolics suppressed tumor growth in breast cancer xenografts in mice: role of the PI3K/AKT pathway and associated microRNAs

Keywords: Mango; Breast cancer; Xenograft; PI3K/AKT; miR-126; GAE; gallic acid equivalent; HIF-1α; hypoxia inducible factor-1α; MS; mass spectrometry; mTOR; mammalian target of rapamycin; NF-κB; nuclear factor-kappa B; PI3K; phosphoinositide 3-kinase; VEGF;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2015 سفارش ترجمه

Targeting strategies on miRNA-21 and PDCD4 for glioblastoma

Keywords: GBM; glioblastoma multiforme; miRNAs; microRNAs; PDCD4; programmed cell death 4; EMT; epithelial-mesenchymal transition; JNK; Jun N-terminal protein kinase; PTEN; phosphatase and tensin homolog; PI3K/AKT; phosphatidylinositol-3 kinase/Akt; MAPK/ERK; mit

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2015 سفارش ترجمه

1, 25(OH)2D3 protects β cell against high glucose-induced apoptosis through mTOR suppressing

Keywords: 1, 25-Dihydroxyvitamin D3; Diabetes mellitus; mTOR; β-Cell apoptosis;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2015 سفارش ترجمه

SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells

Keywords: AMPK; AMP-activated protein kinase; ACC; Acyl COA Carboxylase; BSA; Bovine Serum Albumin; DHE; Dihydroethidium; DPI; Diphenylene iodonium; ERK; Extracellular signal-regulated kinase; FAS; Fatty Acid Synthase; FBS; Fetal bovine serum; FOXO1; Forkhead box p

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2015 سفارش ترجمه

Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training?

Keywords: Akt; protein kinase B; AMPK; 5′-AMP-activated protein kinase; AP-1; activator protein 1; COX IV; cytochrome c oxidase; CuZnSOD; copper/zinc superoxide dismutase; DMSO; dimethyl sulfoxide; eNOS; endothelial nitric oxide synthase; ERK; extracellular signa

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2015 سفارش ترجمه

SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway

Keywords: AMPK; AMP-activated protein kinase; AKT; v-akt murine thymoma viral oncogene homolog; Atg; autophagy-related gene; CAY; CAY-10566; CC; compound C; CQ; chloroquine; DAB; 3,3′-diaminobenzidine tetrahydrochloride; ECL; electrochemiluminescence; FBS; fetal

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2015 سفارش ترجمه

The MANDELA study: A multicenter, randomized, open-label, parallel group trial to refine the use of everolimus after heart transplantation

Keywords: BPAR; biopsy-proven acute rejection; CAV; cardiac allograft vasculopathy; CMV; cytomegalovirus; CNI; calcineurin inhibitor; CsA; cyclosporine; eGFR; estimated glomerular filtration rate; IVUS; intravascular ultrasound; LVAD; left ventricular assist device

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2015 سفارش ترجمه

mTor mediates tau localization and secretion: Implication for Alzheimer's disease

Keywords: mTor; Tau secretion; Autophagy; Tau phosphorylation; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2015 سفارش ترجمه

4-O-methylascochlorin suppresses differentiation of 3T3-L1 preadipocytes by inhibiting PPARγ expression through regulation of AMPK/mTOR signaling pathways

Keywords: Adipocyte; Differentiation; PPARγ; AMPK; mTOR;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2015 سفارش ترجمه

Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation

Keywords: Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; ATP; adenosine triphosphate; Bci3; Bax cannel inhibitor 3; cAMP; cyclic adenosine monophosphate; CMA; chaperone-mediated autophagy; DLB; dement

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2015 سفارش ترجمه

Autophagy plays a protective role in cell death of osteoblasts exposure to lead chloride

Keywords: Lead chloride (PbCl2); Osteoblasts; Autophagy; Apoptosis; Autophagic flux; mTOR;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2015 سفارش ترجمه

MYC and metabolism on the path to cancer

Keywords: 2-DG; 2-deoxyglucose; 4E-BP; eIF4E-binding protein; 5,10-methylene THF; 5,10-methylenetetrahydrofolate; ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ChIP-seq; chromatin immunoprecip

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

PIM kinase (and Akt) biology and signaling in tumors

Keywords: PIM kinases; Akt; Oncogenes; Cancer; Therapeutic resistance; AML; acute myeloid leukemia; AMPK; AMP activated protein kinase; CXCR-4; C-X-C chemokine receptor type 4; EGFR; epidermal growth factor receptor; EBV; Epstein-Barr virus; FLT3; FMS-like ty

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis

Keywords: Potassium channels; miRNA; Rapamycin; mTOR; Temporal lobe epilepsy;

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2015 سفارش ترجمه

Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease

Keywords: A; adult; AET; aerobic exercise training; AUC; area under the curve; CI-MPR; cation-independent mannose-6-phosphate receptor; CLEAR; coordinated lysosomal expression and regulation transcriptome; ERT; enzyme replacement therapy; FA; fatty acid; FG; fast-t

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2015 سفارش ترجمه

mTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice

Keywords: Liver Cancer; Mouse Model; Drug; Signal Transduction; DEN; diethylnitrosamine; GP73; Golgi protein 73; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; MEF; mouse embryonic fibroblast; MMP; matrix metalloproteinase; mTOR; mec

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2015 سفارش ترجمه

Chromosome-Associated Protein D3 Promotes Bacterial Clearance in Human Intestinal Epithelial Cells by Repressing Expression of Amino Acid Transporters

Keywords: Condensin; Inflammatory Bowel Disease; Innate Immunity; Dysbiosis; AIEC; adherent-invasive Escherichia coli; BCH; 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid; dCAP-D3; Drosophila chromosome-associated protein-D3; CAP-D3; human chromosome associated p

دانلود رایگان متن کامل مقاله ISI 2460 صفحه سال انتشار : 2015 سفارش ترجمه

STAT signaling in different breast cancer sub-types

Keywords: STAT; Signal Transducer and Activator of Transcription; ER; Estrogen Receptor; HER2; human epidermal growth factor 2; TNBC; Triple Negative Breast Cancer; IL; interleukin; PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; JAK; Janu

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

NMDA receptors on the surface of cancer cells: Target for chemotherapy?

Keywords: NMDA receptor; Cancer; mTOR; Chemotherapy

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Angio-œdème bradykinique lors de l'association d'un inhibiteur de l'enzyme de conversion et d'un traitement immunosuppresseur

Keywords: inhibiteurs de l'enzyme de conversion; dipeptidyl-peptidase IV; angio-œdème; bradykinine; immunosuppresseurs; angiotensin-converting enzyme inhibitors; dipeptidyl-peptidases IV; angioedema; bradykinin; immunosuppressive agents; ACE; angiotensin conver

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Virtual screening and biochemical evaluation to identify new inhibitors of mammalian target of rapamycin (mTOR)

Keywords: Virtual screening; mTOR; Docking; Kinase inhibitor; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Peroxisome proliferator activated receptor gamma (PPARγ) as a therapeutic target for improvement of cognitive performance in Fragile-X

Keywords: AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CNS; central nervous system; ECM; extra cellular matrix; FMR1 gene; Fragile X mental retardation 1 gene; FMRP; Fragile-X mental retardation protein; FXS; Fragile X syndrome; GLUT-3; gl

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Phosphorylation dynamics of eukaryotic initiation factor 4E binding protein 1 (4E-BP1) is discordant with its potential to interact with eukaryotic initiation factor 4E (eIF4E)

Keywords: 4E-BP1; mTOR; 4E; Rapamycin; S6 kinase;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

The role of mTOR in depression and antidepressant responses

Keywords: mTOR; Antidepressants; Ketamine; Depression

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Role of GAS5 Noncoding RNA in Mediating the Effects of Rapamycin and Its Analogues on Mantle Cell Lymphoma Cells

Keywords: Chemotherapy; mTOR; ncRNA; Non-Hodgkin lymphoma; Rapamycin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling

Keywords: mTOR; Akt; ERK1/2; RTP801; Insulin action;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

The novel mTORC1/2 dual inhibitor INK-128 suppresses survival and proliferation of primary and transformed human pancreatic cancer cells

Keywords: MTT; 3-[4,5-Dimethylthylthiazol-2-yl]-2,5 diphenyltetrazolium bromide; FACS; fluorescence-activated cell sorting; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; 4E-BP1; 4E-binding protein; OD; optical density; IP; imm

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling

Keywords: ANOVA; analysis of variance; BCA; bicinchoninic acid; FACS; fluorescence-activated cell sorting; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HPRT; hypoxanthine-guanine phosphoribosyltransferase; M-CSF; macrophage-colony stimulating factor; NF-κB; nu

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Alpha-melanocyte stimulating hormone protects retinal pigment epithelium cells from oxidative stress through activation of melanocortin 1 receptor-Akt-mTOR signaling

Keywords: AMD; age-related macular degeneration; RPE; retinal pigment epithelium; α-MSH; α-melanocyte stimulating hormone; mTOR; mammalian target of rapamycin; MC1R; melanocortin 1 receptor; H2O2; hydrogen peroxide; Age related macular degeneration (AMD); Retinal

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Dihydroartemisinin potentiates the anticancer effect of cisplatin via mTOR inhibition in cisplatin-resistant ovarian cancer cells: involvement of apoptosis and autophagy

Keywords: Dihydroartemisinin; Cisplatin; Apoptosis; Autophagy; mTOR; Ovarian cancer;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Labor inhibits placental mechanistic target of rapamycin complex 1 signaling

Keywords: PPARγ; NFĸB; MAPK; mTOR; STAT; Insulin;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Temsirolimus, the mTOR inhibitor, induces autophagy in adenoid cystic carcinoma: In vitro and in vivo

Keywords: Autophagy; mTOR; Adenoid cystic carcinoma; Temsirolimus

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Gβγ interacts with mTOR and promotes its activation

Keywords: Gβγ; G-protein; mTOR; AKT; G-protein coupled receptor; Raptor; Rictor; Cell signaling

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

microRNA-7: A tumor suppressor miRNA with therapeutic potential

Keywords: ACK1; activated CDC42 kinase 1; Akt; V-Akt murine thymoma viral oncogene homolog; BCL-2; B-cell CLL/lymphoma 2; CCNE1; cyclin E1; ciRS-7; circular RNA sponge 7; c-Myc; V-Myc avian myelocytomatosis viral oncogene homolog; EGFR; epidermal growth factor rece

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه