A phase I-II study on the combination of rapamycin and short course radiotherapy in rectal cancer
Keywords: Rapamycin; mTOR; Rectal cancer; Radiotherapy; Phase I/II;
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CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling
Keywords: lncRNA; CRNDE; Glioma; mTOR; Histone modification;
Role of vacuolar-type proton ATPase in signal transduction
Keywords: V-ATPase; Wnt; mTOR; Notch; Signaling pathway;
PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma
Keywords: Thyroid carcinoma; Tumorigenesis; Therapy resistance; PI3K; Akt; mTOR;
Autophagy inhibition sensitizes KU-0063794-mediated anti-HepG2 hepatocellular carcinoma cell activity in vitro and in vivo
Keywords: Hepatocellular carcinoma; mTOR; KU-0063794; Autophagy; Sensitization;
DNA-PKcs interference sensitizes colorectal cancer cells to a mTOR kinase inhibitor WAY-600
Keywords: Colorectal cancer; mTOR; WAY-600; DNA-PKcs; Chemo-sensitization;
Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways
Keywords: mTOR; Rapamycin; Rb; TGF-β; eIF4E; 4E-BP1; eIF4E-binding protein-1; CDK; cyclin-dependent kinase; eIF4E; eukaryotic initiation factor 4E; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; S6K; S6 kinase; TGF-β; transforming growth factor-β;
Research ReportRegulation on Beclin-1 expression by mTOR in CoCl2-induced HT22 cell ischemia-reperfusion injury
Keywords: Autophagy; Beclin-1; mTOR; Ischemia; Reperfusion;
Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women
Keywords: Protein metabolism; Aging; Sarcopenia; Stable isotopes; mTOR; Gender;
Glyceollin, a novel regulator of mTOR/p70S6 in estrogen receptor positive breast cancer
Keywords: Glyceollin; Endocrine therapy; p70S6; Estrogen receptor (ER); mTOR; Anti-estrogen; Kinase signaling;
Improved autophagic flux is correlated with mTOR activation in the later recovery stage of experimental acute pancreatitis
Keywords: Acute pancreatitis; Lamp-2; mTOR; Autophagic flux; Necrosis; Apoptosis;
Chronic stress enhanced fear memories are associated with increased amygdala zif268 mRNA expression and are resistant to reconsolidation
Keywords: Amygdala; Chronic stress; Fear conditioning; Hippocampus; PTSD; Rapamycin; Reconsolidation; mTOR
1α,25-Dihydroxyvitamin D3 upregulates HIF-1 and TREM-1 via mTOR signaling
Keywords: TREM-1; 1α,25-dihydroxyviamin D3; mTOR; Monocytes; Macrophages;
Potential of overcoming resistance to HER2-targeted therapies through the PI3K/Akt/mTOR pathway
Keywords: Everolimus; Breast cancer; mTOR; HER2; Resistance; AE; adverse event; Akt; protein kinase B; CI; confidence interval; CBR; clinical benefit rate; DLT; dose-limiting toxicities; EGFR; epidermal growth factor receptor; HER2; human epidermal growth factor re
Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy
Keywords: SPC; sphingosylphosphorylcholine; I/R; ischemia/reperfusion; MTOR; mammalian target of rapamycin; MTORC1; mTOR complex 1; MTORC2; mTOR complex 2; MI; myocardial infarction; PI3K; phosphatidylinositol 3-kinase; TSC2; tuberous sclerosis complex 2; HUVECs; h
Yeast-based methods to assess PTEN phosphoinositide phosphatase activity in vivo
Keywords: CWI; cell wall integrity; Gal; galactose; MAPK; mitogen-activated protein kinase; mTOR; mammalian target of rapamycin; PDK1; phosphoinositide-dependent kinase; PH; pleckstrin homology; PI3K; phosphoinositide 3-kinase; PtdIns(4,5)P2; phosphatidylinositol (
Citreoviridin induces ROS-dependent autophagic cell death in human liver HepG2 cells
Keywords: Citreoviridin; Autophagy; Reactive oxygen species; Human liver HepG2 cells; CIT; citreoviridin; ROS; reactive oxygen species; NAC; N-acetyl cysteine; 3-MA; 3-methyladenine; MTT; 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; LC50; median
A treadmill exercise reactivates the signaling of the mammalian target of rapamycin (mTor) in the skeletal muscles of starved mice
Keywords: mTor; mammalian target of rapamycin; GFP; green fluorescent protein; LC3; microtubule-associated protein IA/IB light chain 3; IGF-1; insulin-like growth factor 1; Autophagy; Exercise; Treadmill; Skeletal muscle; mTor; GFP-LC3;
Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy
Keywords: ULK1; UNC-51 like kinase; AMPK; Adenosine 5â²-monophosphate (AMP)-activated protein kinase; FUNDC1; FUN-14 domain containing protein; mTOR; Mammalian target of rapamycin; LC3; Light chain 3; Mitophagy; UNC-51 like kinase; Adenosine 5â²-monophosphate (AM
De novo hepatocellular carcinoma of liver allograft: A neglected issue
Keywords: CNI; calcineurin-inibitors; FISH; fluorescent in situ hybridization; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; MMF; mycophenolate mofetil; mTOR; target of rapamycin; OLT; orthotopic liver transplant; PCR; polymerase ch
Systems biology of IL-6, IL-12 family cytokines
Keywords: Systems biology; Mathematical modeling; IL-6-type cytokines; Quantitative analyses; Epo; erythropoietin; gp; glycoprotein; hESC; human embryonic stem cells; EGF; epidermal growth factor; ERK; extracellular signal regulated kinase; HGF; hepatocyte growth f
Inhibition of the insulin-like growth factor 1 receptor by CHM-1 blocks proliferation of glioblastoma multiforme cells
Keywords: EGFR; epidermal growth factor receptor; FGFR; fibroblast growth factor receptor; GBM; glioblastoma multiforme; IGF-1R; insulin-like growth factor-1 receptor; IR; insulin receptor; PDGFR; platelet-derived growth factor receptor; PI3K; phosphatidylinositol
Ethanolic Ginkgo biloba leaf extract prevents renal fibrosis through Akt/mTOR signaling in diabetic nephropathy
Keywords: Diabetic nephropathy; Renal fibrosis; Akt; mTOR; Ethanolic ginkgo biloba extractα-SMA, α-smooth muscle actin; AGC, cAMP-dependent, cGMP-dependent and protein kinase C; BCA, bicinchoninic acid; BSA, albumin from bovine serum; BUN, blood urea nitrogen; CMC–
Interleukin-1β plays a role in the pathogenesis of mesial temporal lobe epilepsy through the PI3K/Akt/mTOR signaling pathway in hippocampal neurons
Keywords: Inflammation; Interleukin-1β; MTLE; Epilepsy; Hippocampus; Neuron; Phosphatidylino-sitol 3-kinase; p70S6K; mTOR
Frameshift mutations in mammalian target of rapamycin pathway genes and their regional heterogeneity in sporadic colorectal cancers
Keywords: mTOR; Mutation; Colon cancers; Microsatellite instability; Intratumoral heterogeneity
Cell Cycle Regulation of Smooth Muscle Cells-Searching for Inhibitors of Neointima Formation: Is Combretastatin A4 an Alternative to Sirolimus and Paclitaxel?
Keywords: CA4; combretastatin A4; CDK; cyclin-dependent kinase; CI; confidence interval; mTOR; mammalian target of rapamycin; PPARγ; peroxisome proliferator activated receptor γ; SMC; smooth muscle cell;
p53 inhibition provides a pivotal protective effect against ischemia-reperfusion injury in vitro via mTOR signaling
Keywords: p53; mTOR; OGD; Ischemic reperfusion injury
Regulation of T cells by mTOR: the known knowns and the known unknowns
Keywords: mTOR; T cells; rapamycin
Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells
Keywords: PD; Platycodin D; CQ; chloroquine; DMSO; dimethylsulfoxide; MTT; 3-[4,5-Dimethyl-2-thiazolyl]-2,5-diphenyltetrazolium bromide; MDC; monodansylcadaverin; ERK; extracellular signal-regulated kinase; BAF; bafilomycin A1; LC3; microtubule-associated protein 1
Jinlida granule inhibits palmitic acid induced-intracellular lipid accumulation and enhances autophagy in NIT-1 pancreatic β cells through AMPK activation
Keywords: JLDG; Jinlida granule; TCM; traditional Chinese medicine; ACC; acetyl-coA carboxylase; FAS; fatty acid synthase; CPT-1; carnitine acyl transferase 1; AMPK; AMP activated protein kinase; pAMPK; phospho-AMP activated protein kinase; SREBP-1c; sterol regulat
Noncoding RNAs as regulators of cardiomyocyte proliferation and death
Keywords: miRNAs; microRNAs; lncRNA; long non-coding RNA; LAD; left anterior descending coronary artery; hCMPCs; human Cardiomyocyte Progenitor Cells; CSCs; Cardiac Stem Cells; MI; Myocardial Infarction; MFN1; Mitofusin 1; I/R; Ischemia/Reperfusion; BNIP3; BCL2/ade
Structure-based grafting and identification of kinase–inhibitors to target mTOR signaling pathway as potential therapeutics for glioblastoma
Keywords: Rational drug design; mTOR; Kinase–inhibitor; Glioblastoma
Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies
Keywords: CNTF; ciliary neurotrophic factor; CNTFR; ciliary neurotrophic factor receptor; LIFR; leukemia inhibitor factor receptor; gp130; glycoprotein-130; IL6; Interleukin-6; IFNγ; interferon gamma; JAK; Janus kinases; STAT; signal transducers and activators of
Co-regulation of SREBP-1 and mTOR ameliorates lipid accumulation in kidney of diabetic mice
Keywords: SREBP-1; MTOR; Diabetic mice; Renal tubular cells; Lipid metabolism;
A liaison between mTOR signaling, ribosome biogenesis and cancer
Keywords: mTOR; Ribosome biogenesis; Ribosomal protein; Cancer
Prenatal physical activity and diet composition affect the expression of nutrient transporters and mTOR signaling molecules in the human placenta
Keywords: Placenta; Physical activity; Diet; Nutrient transport; mTOR;
Intersection of mTOR and STAT signaling in immunity
Keywords: mTOR; STAT; immunity; signaling
Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway
Keywords: Acemannan; Wound healing; AKT; mTOR; Cyclin D1
The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors
Keywords: Phosphoinositide 3-kinase; Imidazo[1,2-a]pyridine; Ribose pocket; Affinity pocket; Kinase inhibitor; mTOR;
Pharmacogenetic predictor of extrapyramidal symptoms induced by antipsychotics: Multilocus interaction in the mTOR pathway
Keywords: Antipsychotic; Extrapyramidal symptoms; Pharmacogenetics; Predictors; mTOR; Multifactor dimensionality reduction;
Cardiovascular pharmacologymiR-100 suppresses mTOR signaling in hypoxia-induced pulmonary hypertension in rats
Keywords: mTOR; Mammalian Target of Rapamycin; PASMC; pulmonary arterial vascular smooth muscle cells; PH; pulmonary hypertension; PAs; pulmonary arterial tissues; FITC; fluorescein isothiocyanate; DMEM; Dulbeccoâ²s modified Eagle medium; RVSP; right ventricle sys
Cannabinoid receptor 1 and acute resistance exercise - In vivo and in vitro studies in human skeletal muscle
Keywords: CB1; cannabinoid receptor 1; mTOR; mechanistic target of rapamycin, but initially mammalian target of rapamycin; RE; resistance exercise; S6K1; ribosomal protein S6 kinase; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; ECS; endogenous cannabi
A structural insight into the inhibitory mechanism of an orally active PI3K/mTOR dual inhibitor, PKI-179 using computational approaches
Keywords: PI3K; phosphatidylinositide 3-kinase; PIP2; phosphatidylinositol-4,5-bisphosphate; PIP3; phosphatidylinositol-3,4,5-trisphosphate; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; ASA; accessible surface area; ÎASA; lo
ArticleLife & Medical Sciences1Â T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of mTOR inhibitors in CNE-2Z cells
Keywords: Static magnetic field; Cell proliferation; mTOR; mTOR inhibitor; Feedback reactivation;
PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester
Keywords: Protein kinase D1; mTOR; S6K1; S6; Non-small cell lung cancer;
MicroRNAs in osteosarcoma
Keywords: OS; osteosarcoma; miRNAs; microRNAs; CSCs; cancer stem cells; RNA pol; RNA polymerase; DGCR8; DiGeorge syndrome critical gene 8; RISC; RNA-induced silencing complex; Exp 5; exportin 5; Ago; argonaute; MREs; miRNA recognition elements; APE1; apurinic/apyri
Recherche translationnelle : médecine personnalisée, médecine de précision, thérapies ciblées : marketing ou science ?
Keywords: médecine personnalisée; médecine stratifiée; biomarqueurs; test diagnostique compagnon; suivi thérapeutique pharmacologique; pharmacogénétique; ACP; anatomie et cytologie pathologique; ADN; acide désoxyribonucléique; AMM; autorisation de mise sur
The S6K protein family in health and disease
Keywords: S6K1; S6K2; mTOR; Diabetes; Obesity; Metabolism; Cancer
Neurohormetic phytochemicals: An evolutionary–bioenergetic perspective
Keywords: Adaptive stress response; Alzheimer’s disease; AMPK; Hormesis; mTOR; SirtuinAβ, amyloid beta-peptide; Akt, protein kinase B; AMPK, adenosine monophosphate-activated protein kinase; BDNF, brain-derived neurotrophic factor; CamKKβ, calcium/calmodulin-depend
Design, synthesis and docking studies of novel thienopyrimidine derivatives bearing chromone moiety as mTOR/PI3Kα inhibitors
Keywords: Thienopyrimidine; Chromone; Synthesis; Docking; mTOR; PI3Kα; Cytotoxicity