دانلود مقالات ISI درباره Mtor + ترجمه فارسی

c-Jun N-terminal kinase controls a negative loop in the regulation of glial fibrillary acidic protein expression by retinoic acid

Keywords: GFAP; c-Jun N-terminal kinase; retinoic acid; neural precursor cells; BMP-2; bone morphogenetic protein-2; DNA-PKcs; DNA-protein kinase catalytic subunit; ERK; extracelular-regulated kinase; GFAP; glial fibrillary acidic protein; GSK-β; glycogen synthase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Preventing retinal apoptosis - Is there a common therapeutic theme?

Keywords: Retina; Apoptosis; Retinitis pigmentosa; Oxidative stress; ROS; mTOR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

mTOR inhibitors in cancer therapy

Keywords: PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; mTORC; mammalian target of rapamycin complex; Raptor; regulatory-associated protein of mTOR; S6K1; S6 kinase 1, 4E-BP1, 4E-binding protein 1; Rictor; rapamycin-insensitive companion

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Chemerin regulates proliferation and differentiation of myoblast cells via ERK1/2 and mTOR signaling pathways

Keywords: Chemerin; C2C12 cells; ERK1/2; mTOR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

mTOR, linking metabolism and immunity

Keywords: mTOR; Rapamycin; T cells; B cells; Metabolism; Autophagy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: Implications for type 2 diabetes

Keywords: HCC; hepatocellular carcinoma; BCAAs; branched-chain amino acids; PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; OGTT; oral glucose tolerance test; IRI; immunoreactive insulin; HOMA-IR; homeostasis model assessment of insulin re

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Insulin-like growth factor-1 (IGF-1) inhibits the basolateral Cl channels in the thick ascending limb of the rat kidney

Keywords: Phosphoinositide 3-kinase; PKD; AKT; mTOR; Cl transport;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold

Keywords: Phosphoinositide 3-kinase; Mammalian target of rapamycin; PI3K; mTOR; Sulfonamide; Triazine; Oncology;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with rapamycin

Keywords: Hh, hedgehog; smo, smoothened; rShh, recombinant sonic hedgehog; PI3K, phosphatidylinositol 3-kinase; mTOR, mammalian target of rapamycin; GSK3β, Glycogen synthase kinase 3β; AML, acute myeloid leukemiaHedgehog/Gli; mTOR; AML; GANT61; Rapamycin; Apoptosis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Cyclosporin A suppresses prostate cancer cell growth through CaMKKβ/AMPK-mediated inhibition of mTORC1 signaling

Keywords: Cyclosporin A; AMPK; Akt; mTOR; Prostate cancer

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Sensing the immune microenvironment to coordinate T cell metabolism, differentiation & function

Keywords: mTOR; Metabolism; CD4; CD8 T cells

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Effect of everolimus on pre-existing atherosclerosis in LDL-receptor deficient mice

Keywords: Everolimus; mTOR; Mammalian target of rapamycin; Atherosclerosis; PSI; Proliferation signal inhibitor; Hypercholesterolemia; Stage-dependent efficiency of treatment;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleInactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways

Keywords: AKT; v-akt murine thymoma viral oncogene homolog; ERK; extracellular-related kinase; GLUT; glucose transporter; HCC; hepatocellular carcinoma; MAPK; mitogen-activated protein kinase; mTOR; mammalian target of rapamycin; mTORC; mTOR complex; RPS6; ribosoma

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory

Keywords: Rapamycin; mTOR; Protein synthesis; Consolidation; Reconsolidation; Inhibitory avoidance;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors

Keywords: mTOR; Kinase inhibitor; Oncology; Imidazopyridine; Imidazopyridazine

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome

Keywords: FXS; fragile X syndrome; FMRP; fragile X mental retardation protein; rCPS; regional rate of cerebral protein synthesis; WT; wild type; KO; knock out; Akt; protein kinase B; mTOR; mammalian target of rapamycin; PI3K; phosphatidylinositol 3-kinase; ERK; ext

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleDual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo

Keywords: mTOR; mammalian target of rapamycin; mTORC1/C2; mammalian target of rapamycin complex 1 and 2; HCC; hepatocellular carcinoma; HDACis; histone deacetylase inhibitors; mTORKis; mTOR kinase inhibitors; PCD; programmed cell death; DMSO; dimethyl sulfoxide; ca

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy

Keywords: AEDs; anti-epileptic drugs; mTOR; mammalian target of rapamycin pathway; SE; status epilepticus; TLE; temporal lobe epilepsy; TSC; tuberous sclerosis complex; mTOR; epilepsy; psychiatric comorbidities; rapamycin; seizure;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Survival by self-destruction: A role for autophagy in the placenta?

Keywords: Placenta; Trophoblast; Autophagy; Apoptosis; mTOR; ATG genes;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Role of JAK3 in myogenic differentiation

Keywords: MRFs; myogenic regulatory factors; MEF2; myocyte enhancer-binding factor 2; MHC; myosin heavy chain; MGN; myogenin; IGF-II; insulin-like growth factor-II; ERK; extracellular signal-regulated kinase; PI3K; phosphatidylinositol 3-kinase; JAK; Janus kinase;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Lack of amino acids in mouse hepatocytes in culture induces the selection of preneoplastic cells

Keywords: Aa; aminoacids; EGFR; Epidermal growth Factor Receptor; FBS; fetal bovine serum; CM; complete medium; PM; aminoacid-starved medium; HCC; Hepatocellular carcinoma; H2DCFDA; 2′,7′-dichlorodihydro-fluorescein diacetate; γ-GCS; gamma glutamylcysteine syn

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Anti-angiogenic effects of thioridazine involving the FAK-mTOR pathway

Keywords: HUVECs; human umbilical vein endothelial cells; Thioridazine; 10-[2-(1-methyl-2-piperidyl) ethyl]-2-methylthiophenothiazine; FAK; focal adhesion kinase; mTOR; the mammalian target of rapamycin; VEGF; vascular endothelial growth factor;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Mitochondrial Ca2+ signals in autophagy

Keywords: mTOR; mammalian target of rapamycin; InsP3R; inositol 1,4,5-trisphosphate receptor; AMPK; adenosine monophosphate activated protein kinase; mTORC1; mammalian target of rapamycin complex 1; GAP; GTPase activating protein; TSC1/TSC2; tuberous sclerosis comp

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Scaffold protein Homer 1: Implications for neurological diseases

Keywords: EVH1; Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1; IEG; immediate-early gene; P motif; proline-containing motif; mGluR; metabotropic glutamate receptor; IP3R; inositol 1,4,5-trisphosphate receptor; TRPC; transient receptor potentia

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

mTOR and metabolic pathways in T cell quiescence and functional activation

Keywords: mTOR; T cell metabolism; T cell quiescence; CD4+ T cell differentiation; CD8+ memory T cell

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Mechanisms of human smooth muscle cell proliferation and transplant vasculopathy induced by HLA class I antibodies: In vitro and in vivo studies

Keywords: TV; transplant vasculopathy; HLA; human leukocyte antigen; SMC; smooth muscle cells; EC; endothelial cells; MMP; matrix metalloproteinases; MMP-2; matrix metalloproteinase 2; FAK; focal adhesion kinase; mTOR; mammalian target of rapamycin; PI3K; phosphati

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells

Keywords: Akt; mTOR; K-ras; Pancreatic cancer; Bcl-xL

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations

Keywords: mTOR; PI3K; MAPK; GDC-0941

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Metformin and neoplasia: Implications and indications

Keywords: Metformin; AMPK; IGF; Rapamycin; mTOR; Cancer; Cancer stem cell; Metastasis; Chemoprevention

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

The combination of RAD001 and NVP-BKM120 synergistically inhibits the growth of lung cancer in vitro and in vivo

Keywords: RAD001; BKM120; PI3 kinase; mTOR; Lung cancer

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Impairment of object recognition memory by rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation

Keywords: Rapamycin; mTOR; Amygdala; Hippocampus; Recognition memory

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

A novel imidazopyridine analogue as a phosphatidylinositol 3-kinase inhibitor against human breast cancer

Keywords: PI3K; mTOR; Apoptosis; Breast cancer

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases

Keywords: Bone metastases; Breast cancer; Osteoclast; mTOR; RapamycinαMEM, Alpha Modification of Eagle Medium; CM, conditioned medium; DMEM, Dulbecco Modified Eagle Medium; mTOR, mammalian Target of Rapamycin; RANKL, Receptor Activator of Nuclear factor κB Ligand;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Biosensor technology in aging research and age-related diseases

Keywords: Biosensors; Lifespan; Biophotonics; Luciferases; TNFα; mTOR

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy

Keywords: Physiological cardiac hypertrophy; Eyes absent 2; Six1; mTOR; Cardiac protection;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

The dual PI3K and mTOR inhibitor NVP-BEZ235 exhibits anti-proliferative activity and overcomes bortezomib resistance in mantle cell lymphoma cells

Keywords: Mantle cell lymphoma; NVP-BEZ235; Akt; mTOR;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Perifosine sensitizes UVB-induced apoptosis in skin cells: New implication of skin cancer prevention?

Keywords: UVB; Ultraviolet B; NAC; N-acetyl-L-cysteine; ROS; reactive oxygen species; JNK; c-Jun-NH2-kinase; PDMP; 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol; AMPK; AMP-activated protein kinas; ACC; Acetyl-CoA carboxylase; mTOR; Mammalian target of rapamycin;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Targeting mTOR in mantle cell lymphoma: Current and future directions

Keywords: mTOR; PI3K; mantle cell lymphoma; mTOR inhibitors

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2

Keywords: mTOR; mammalian target of rapamycin; S6K1; ribosomal p70 S6 kinase; MTT; 3-(4,5-dimethylthiazol-2-yl)-2.5-diphenyl-2H-tetrazolium bromide; HUVECs; human umbilical vein endothelial cells; siRNA; small interfering RNA; PDCD6; programmed cell death 6; Angiog

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

eIF4F complex disruption causes protein synthesis inhibition during hypoxia in nerve growth factor (NGF)-differentiated PC12 cells

Keywords: 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; Akt; serine/threonine kinase B, also termed PKB; AMPK; AMP-activated protein kinase; eIF; eukaryotic initiation factor; eIF2α; subunit α of eIF2; HIF; Hypoxia inducible factor; mTOR; mammalian t

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease

Keywords: Aβ; amyloid-beta peptide; AMC; 7-amino-4-methyl-coumarin; AMPA; 2-amino-3-(5-methyl-3-oxo-1,2- oxazol-4-yl)propanoic acid; ANOVA; analysis of variance; AV; autophagic vacuole; CatB; cathepsin B; EDTA; ethylenediaminetetraacetic acid; FITC; fluorecein; h;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Akt and p53 are potential mediators of reduced mammary tumor growth by Chloroquine and the mTOR inhibitor RAD001

Keywords: RAD001; Chloroquine; mTOR; p53; Breast cancer

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells

Keywords: E Platinum; Autophagy; Cell growth; mTOR; Gastric carcinoma cells

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis

Keywords: mTOR; Rapamycin; EAE; Neuropathic pain; Progressive MS; Myelin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma

Keywords: GBM; glioblastoma; PI3K; phosphatidylinositol-3-kinase; mTOR; mammalian target of rapamycin; MRI; magnetic resonance imaging; CT; computerized axial tomography; FDG-PET; [18F] 2-fluoro-2-deoxy-D-glucose positron emission tomography; MRS; magnetic resonanc

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

The PI3K/AKT/mTOR signalling pathway is active in salivary gland cancer and implies different functions and prognoses depending on cell localisation

Keywords: Salivary gland cancer; AKT; mTOR; PI3K; S6rp; Prognosis

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Caffeic acid phenethyl ester reduces the activation of the nuclear factor κB pathway by high-fat diet-induced obesity in mice

Keywords: CAPE; caffeic acid phenethyl ester; HFD; high-fat diet; AUGC; area under glucose curve; OGTT; Oral glucose tolerance test; IRS; insulin receptor substrate; JNK; c-jun N-terminal kinase; IKKβ; inhibitor of nuclear factor kappa B kinase beta subunit; IκB;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer

Keywords: mTOR; Endometrial cancer; Ovarian cancer; Cervical cancer; Temsirolimus; Everolimus; Ridaforolimus

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Immunoexpression status and prognostic value of mammalian target of rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas

Keywords: Papillary renal cell carcinoma; mTOR; PTEN; AKT; S6; 4EBP1; HIF-1α

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise

Keywords: Aging; Skeletal muscle; AMPK; mTOR; Resistance exercise

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه