eIF4F complex disruption causes protein synthesis inhibition during hypoxia in nerve growth factor (NGF)-differentiated PC12 cells

► Hypoxia induces protein synthesis inhibition in differentiated PC12 cells. ► Hypoxia-induced translation inhibition occurs primarily by eIF4F complex disruption. ► Translocation of eIF4E to the nucleus mediates eIF4F complex inhibition. ► Increased levels and dephosphorylation of 4E-BP1 mediate eIF4F complex disruption. ► Inhibition of mTOR by REDD1/HIF1 pathway produces 4E-BP1 dephosphorylation.