Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2

► In the present study, we identify PDCD6 as a key regulator of tumor growth and angiogenesis. ► The increase in endothelial PDCD6 is a direct result of VEGF stimulation and suppress phosphorylation of signaling regulators downstream from PI3K, including Akt, mTOR, and GSK-3β. ► These data provide an important conceptual advance in our understanding of the modulation of cellular angiogenesis in ovarian tumor and support the potential for targeting PI3K/Akt as a therapeutic approach.