Evidence for the involvement of mTOR inhibition and basal autophagy in familial Mediterranean fever phenotype
Keywords: Familial Mediterranean fever; MEFV; Pyrin; mTOR; Autophagy
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Core signaling pathways of survival/death in autophagy-related cancer networks
Keywords: Autophagy; Cancer; mTOR; Beclin 1; p53
Akt/mammalian target of rapamycin signaling pathway regulates neurite outgrowth in cerebellar granule neurons stimulated by methylcobalamin
Keywords: ANOVA; one way analysis of variance; CGNs; cerebellar granule neurons; DMEM; Dulbecco's modified Eagle's medium; Icmt; isoprenylcysteine carboxyl methyltransferase; MeCbl; methylcobalamin; mTOR; mammalian target of rapamycin; p70S6K; p70 ribosomal S6 prot
Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors
Keywords: PI3K; mTOR; Kinase inhibitor; iMHBS
Avian influenza A virus H5N1 causes autophagy-mediated cell death through suppression of mTOR signaling
Keywords: Avian influenza; H5N1; Autophagy; mTOR; TSC2; PTEN
Inhibitors of phosphatidylinositol 3-kinase and mTOR but not Akt enhance replication of bovine ephemeral fever virus
Keywords: Bovine ephemeral fever virus; Phosphatidylinositol 3-kinase; Akt; mTOR; Inhibitors; Viral replication
PTEN deletion prevents ischemic brain injury by activating the mTOR signaling pathway
Keywords: PTEN; bpv (pic); mTOR
Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists
Keywords: Antidepressant; Depression; MGS0039; LY341495; mGlu2/3 receptor; mTOR;
Genetics and genomics of childhood adrenocortical tumors
Keywords: ACT; adrenocortical tumors; IGF2; Insulin-like Growth Factor-2; LFS; Li-Fraumeni syndrome; mTOR; mammalian Target Of Rapamycin; NOV/CCN3; Nephroblastoma OVerexpressed/CYR61-CTGF-NOV family member 3; SF1; Steroidogenic Factor-1; TP53; tumor protein 53; Adr
The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder
Keywords: MDD; major depressive disorder; PFC; prefrontal cortex; NMDA; N-methyl-d-aspartate; NR2A; NMDA receptor subunit 2A; NR2B; NMDA receptor subunit 2B; mGluR5; metabotropic glutamate receptor subtype 5; PSD-95; postsynaptic density-95Â kDa; mTOR; mammalian ta
Targeting the JNK Signaling Pathway Potentiates the Antiproliferative Efficacy of Rapamycin in LS174T Colon Cancer Cells
Keywords: mTOR; rapamycin; JNK; proliferation; tumor; signaling
Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase
Keywords: Puerarin; Autophagy; AMPK; mTOR; Alcoholic liver damage;
Mammalian Target of Rapamycin Signaling Pathway Contributes to Glioma Progression and Patients' Prognosis
Keywords: glioma; mTOR; S6; Akt; PTEN; p27; prognosis
Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor
Keywords: EGCG; (â)-epigallocatechin-3-gallate; PI3K; phosphoinositide-3-kinase; mTOR; mammalian target of rapamycin; PI(3,4,5)P3; phosphatidylinositol-3,4,5-triphosphate; ATP; adenosine 5â²-triphosphate; mTORC2; mammalian target of rapamycin complex 2; FRAP1; F
Sindbis virus replication, is insensitive to rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells
Keywords: PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex1; mTORC2; mTOR complex2; S6K1; p70 S6 kinase1; S6; ribosomal protein S6; 4E-BP1; eIF4E1 binding protein1; eIF2α; eukaryotic initiation factor 2α; PKR; ds RNA
Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors
Keywords: Oxatriazine scaffold; PI3K; mTOR; Akt; PKI-587; PKI-402
Treating Clostridium difficile Infection With Fecal Microbiota Transplantation
Keywords: Clostridium difficile; Transplantation; Microbiota; Fecal Enema; Recurrent Infection; Diarrhea; CDI; Clostridium difficile infection; EIA; enzyme immunoassay; FDA; Food and Drug Administration; FMT; fecal microbiota transplantation; GI; gastrointestinal;
Clinical presentation and management of mTOR inhibitor-associated stomatitis
Keywords: Aphthous stomatitis; Cancer; Mammalian target of rapamycin inhibitor; mTOR; Mucositis
Polycystic Liver Diseases: Congenital Disorders of Cholangiocyte Signaling
Keywords: AC; adenyl cyclase; AC6; adenylyl-cyclases-6; ADPKD; autosomal-dominant polycystic kidney disease; AKT; v-akt murine thymoma viral oncogene homolog 1; ARPKD; autosomal-recessive polycystic kidney disease; cAMP; cycle adenosine monophosphate; CD; Caroli di
Huntington’s Disease is a disorder of the corpus striatum: Focus on Rhes (Ras homologue enriched in the striatum)
Keywords: Huntington Disease; mutant Huntingtin; HIP; HAP; Rhes; mTOR; Striatum; AtrophymHtt, mutant Huntingtin; HIP, Huntingtin interacting proteins; HAP, Huntingtin associated protein; mTOR, mammalian target of Rapamycin; Rhes, Ras homologue enriched in striatum
RNA interference targeting raptor inhibits proliferation of gastric cancer cells
Keywords: mTOR; Cell cycle; Proliferation; AP-1; Smad; Gastric cancer
Imidazo[1,5-a]pyrazines: Orally efficacious inhibitors of mTORC1 and mTORC2
Keywords: mTOR; mTORC1; mTORC2; Imidazo[1,5-a]pyrazine; Oral inhibitor
4-O-methylascochlorin, methylated derivative of ascochlorin, stabilizes HIF-1α via AMPK activation
Keywords: AMPK; mTOR; HIF-1α; VEGF; 4-O-methylascochlorin
Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation
Keywords: Type 1 diabetes; NOD; Rheb; mTOR; CFA; GLP-1
Arecoline-mediated inhibition of AMP-activated protein kinase through reactive oxygen species is required for apoptosis induction
Keywords: AN; areca nut; ANE; areca nut extract; CE81T/VGH; human esophageal carcinoma cell line; CMT415; primary culture of normal human fibroblasts; HGD; hypoxia and glucose deprivation; IC50; 50% inhibitory concentration; mTOR; mammalian target of rapamycin; NAC
The 14-3-3 proteins in regulation of cellular metabolism
Keywords: 4E-BP1; eIF4E-binding protein 1; AANAT; arylalkylamine N-acetyltransferase; ACC; acetyl-CoA carboxylase; AKT; protein kinase B; AMPK; AMP dependent protein kinase; AS; ATP synthase; AS160; AKT substrate 160; ATG; autophagy related; BAD; Bcl-2 antagonist o
Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction
Keywords: eIF4E; mTOR; Hypoxia; Necrosis; Irradiation;
AMPK regulates metabolism and survival in response to ionizing radiation
Keywords: AMPK; mTOR; Ionizing radiation; Cell-cycle; Metabolism;
Targeting glycolysis in leukemia: A novel inhibitor 3-BrOP in combination with rapamycin
Keywords: ALL; AML; mTOR; ATP;
Discovery of triazine-benzimidazoles as selective inhibitors of mTOR
Keywords: mTOR; Kinase inhibitor; Oncology; Benzimidazole; Triazine
Gadd34 induces autophagy through the suppression of the mTOR pathway during starvation
Keywords: Starvation; Gadd34; Autophagy; mTOR;
Putative roles of cilia in polycystic kidney disease
Keywords: Cilia; Development; Wnt; Hedgehog; mTOR; Ciliopathy
The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells
Keywords: Imipramine; Autophagy; Type II programmed cell death; Glioma; mTOR;
Glycolytic inhibition as a strategy for developing calorie restriction mimetics
Keywords: Calorie restriction; Diet restriction; Insulin; mTOR; Sirtuin; Glucose; Hexokinase; Resveratrol; Metformin
Chronic treatment with PDGF-BB and endothelin-1 synergistically induces vascular hyperplasia and loss of contractility in organ-cultured rat tail artery
Keywords: Vascular smooth muscle; Endothelin-1; PDGF-BB; ERK1/2; Akt; mTOR; Organ-culture;
The l-Ser analog #290 promotes bone recovery in OP and RA mice
Keywords: l-Ser analog; Osteoclastogenesis inhibitor; Mouse models; Bone loss and recovery; Osteoblastic cells; mTOR;
Activation of PI3K/mTOR signaling pathway contributes to induction of vascular endothelial growth factor by hCG in bovine developing luteal cells
Keywords: PI3K; mTOR; HIF-1α; VEGF; Letual cells
Inhibitory effects of the HDAC inhibitor valproic acid on prostate cancer growth are enhanced by simultaneous application of the mTOR inhibitor RAD001
Keywords: HDAC; mTOR; Prostate carcinoma; Cyclins; Cell cycle
Antiapoptotic Intervention in Repeated Blood Cardioplegia: A Porcine Study of Myocardial Function
Keywords: 31; Erk1/2; extracellular signal-regulated kinase; GSK3β; glycogen-synthase kinase; IGF-I/IGF-II; insulin-like growth factor; MEK1/2; mitogen-activated protein kinase; mPTP; mitochondrial permeability transition pore; mTOR; mammalian target of rapamycin;
New therapeutic approaches in breast cancer
Keywords: Breast cancer; Targeted therapy; HER2; EGFR; mTOR
Impairment of IGF-I expression and anabolic signaling following ischemia/reperfusion in skeletal muscle of old mice
Keywords: Tourniquet; Sarcopenia; Muscle regeneration; mTOR; FoxO;
Oleate-enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats
Keywords: Aging; Nutrition; High-fat diet; Skeletal muscle; Protein synthesis; CPT-1b; carnitine palmitoyltransferase-1b; IR; insulin resistance; Il-1β; interleukin-1 beta; mTOR; mammalian target of rapamycin; MCAD; medium-chain acyl-CoA dehydrogenase; MPS; muscle
Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression
Keywords: ANOVA; analysis of variance; mTOR; mammalian target of rapamycin; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; ER; endoplasmic reticulum; GFP; green fluorescent protein; LC3; microtubule-associated protein light chain 3; LT
CUL4B-deficiency in humans: Understanding the clinical consequences of impaired Cullin 4-RING E3 ubiquitin ligase function
Keywords: Cullin 4; Genome stability; Mental retardation; mTOR
Curcumin disrupts uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition
Keywords: Curcumin; Uterine leiomyosarcoma; mTOR; p70S6; S6; Apoptosis
TSC1/TSC2 signaling in the CNS
Keywords: mTOR; Autism; Translation;
Sensitizing effect of 3-methyladenine on radiation-induced cytotoxicity in radio-resistant HepG2 cells in vitro and in tumor xenografts
Keywords: Liver cancer; Radio-resistance; Autophagy; 3-MA; 3-methyladenine; AO; acridine orange; AVOs; acidic vesicular organelles; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HCC; hepatocellular carcinoma; IR; ionizing radiation; mTOR; mammalian target of rap
mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine307 residues after burn
Keywords: Burn; Insulin resistance; IRS-1; Phosphorylation; Serine307; Tyrosine; mTOR
Thromboxane-Induced Contractile Response of Human Coronary Arterioles Is Diminished After Cardioplegic Arrest
Keywords: 31; CABG; coronary artery bypass grafting; CaM PK; calmodulin phosphorylase kinase; CPB; cardiopulmonary bypass; CP/Rep; cardioplegia followed by reperfusion; DAPI; 4',6-diamidino-2-phenylindole; GRK; G protein-coupled receptor kinase; GSK; glycogen synth